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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanisms of the Aging Process: 2nd Edition submission deadline 31 Jan 2026 | Viewed by 3 | Submission Open
Keywords: aging process; molecular mechanisms; epigenetic clock; cancer; metabolic disease
(This special issue belongs to the Section Molecular Biology)
Cell Proliferation and Differentiation in Cancer submission deadline 31 Jan 2026 | Viewed by 3 | Submission Open
Keywords: cell signaling; cell transduction; transcriptional and post-transcriptional pathways; growth factors; second messengers; cell proliferation; cell differentiation; cell metabolism; cell death; cell invasion
(This special issue belongs to the Section Molecular Oncology)
Unraveling Affective Disorders: From Pathogenesis to Drug Therapy
edited by Lawrence Shih-Hsin Wu
submission deadline 31 Jan 2026 | Viewed by 3 | Submission Open
Keywords: affective disorders; depressive disorder; bipolar disorder; neuroinflammation; neurotransmitter dysregulation; gene– environment interactions; therapeutic targets
(This special issue belongs to the Section Molecular Neurobiology)
Structure, Properties, and Applications of Carbon Materials submission deadline 31 Jan 2026 | Viewed by 3 | Submission Open
Keywords: carbon-based structures; activated carbon; biochar; graphene; nanotubes
(This special issue belongs to the Section Materials Science)
The Application of an Electron Microscope in the Study of Cell Structure
edited by
submission deadline 31 Jan 2026 | Viewed by 3 | Submission Open
Keywords: intracellular structure; organelles; cell surface structure; immuno-labeling
(This special issue belongs to the Section Molecular Biophysics)
Macrophage Metabolic Reprogramming in Inflammation submission deadline 31 Jan 2026 | Viewed by 3 | Submission Open
Keywords: inflammation; immunometabolism; metabolic rewiring; glycolysis; krebs cycle; glutaminolysis; innate immune response; macrophages
(This special issue belongs to the Section Molecular Immunology)
New Horizons in Structure and AI-Based Drug Design
edited by
submission deadline 31 Jan 2026 | Viewed by 3 | Submission Open
Keywords: artificial intelligence; machine learning; MD simulation; free energy calculation; drug design
(This special issue belongs to the Section Molecular Informatics)
Molecular Mechanisms in Postharvest Biology
edited by
submission deadline 31 Jan 2026 | Viewed by 3 | Submission Open
Keywords: postharvest biology; fruit ripening; senescence; stress tolerance; disease resistance; molecular biology; gene regulatory networks; genomics; synthetic biology; nanotechnology; controlled atmosphere; biostimulants
(This special issue belongs to the Section Molecular Plant Sciences)
Plant-Based Early Therapeutics for Parasitic Infections Combined with Functional Modern Diagnosis Methods
edited by
submission deadline 31 Jan 2026 | Viewed by 3 | Submission Open
Keywords: active phytocompounds; antiparasitic agents; artificial intelligence; early diagnosis early treatment; life cycle; medicinal plants; parasite and vector; phytogenic feed additives; vision recognition
(This special issue belongs to the Section Molecular Plant Sciences)
Natural Products and Compounds in Anticancer Drug Discovery
edited by
submission deadline 31 Jan 2026 | Viewed by 2 | Submission Open
Keywords: antitumor plant compounds; antitumor plant-derived products; cellular pathways for natural drug apoptosis induction; chromatography of antitumor plant metabolites; modern technologies for recovery of plant anticancer substances; nanotechnology based natural anticancer drug products; plant-derived antitumor drug-protein interactions
(This special issue belongs to the Section Molecular Pharmacology)
Advances in Angiogenesis: From Molecular Insights to Therapeutic Strategies
edited by
submission deadline 31 Jan 2026 | Viewed by 2 | Submission Open
Keywords: angiogenesis; molecular signaling; endothelial cells; tumor microenvironment; pro-angiogenic factors; anti-angiogenic therapy; vascular remodeling; hypoxia; VEGF pathway; translational research
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
MicroRNAs as Biomarkers in Chronic Diseases
edited by
submission deadline 31 Jan 2026 | Viewed by 2 | Submission Open
Keywords: microRNA; biomarker; chronic diseases; cancer; cardiovascular diseases; psychiatric conditions
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular and Cellular Mechanisms Underlying Kidney Disease
edited by
submission deadline 31 Jan 2026 | Viewed by 2 | Submission Open
Keywords: acute kidney injury; molecular mechanisms; therapeutic agents; experimental model; pathophysiology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms of Thromboinflammation
edited by Ana B. Arroyo
submission deadline 31 Jan 2026 | Viewed by 2 | Submission Open
Keywords: thromboinflammation; coagulation; inflammation; immune system; sepsis; stroke; autoimmune diseases; cancer; hematology; biomarkers; translational medicine
(This special issue belongs to the Section Molecular Immunology)
New Computational Methodologies for Biomolecule Sequence, Structure and Function Discovery: 2nd Edition
edited by Fei Guo
submission deadline 31 Jan 2026 | Viewed by 1 | Submission Open
Keywords: bioinformatics; machine learning; deep learning; biomolecule identification; biological networks; structural proteomics; gene expression analysis; molecular docking; post-translational modifications
(This special issue belongs to the Section Molecular Informatics)
Advanced Research on Immune Cells and Cytokines (3rd Edition)
edited by
submission deadline 31 Jan 2026 | Viewed by 1 | Submission Open
Keywords: immune cells; cytokines; immunomodulatory treatments; immune diseases; immune system
(This special issue belongs to the Section Molecular Immunology)
Host–Oral Bacterial Interaction in Periodontal Pathogenesis
edited by Felice Roberto Grassi
submission deadline 31 Jan 2026 | Viewed by 1 | Submission Open
Keywords: periodontitis; oral microbiome; host– pathogen interaction; inflammation; dysbiosis; immune response
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms of Plant Virus Infection, Resistance and Control
edited by
submission deadline 31 Jan 2026 | Submission Open
Keywords: plant virus; host– pathogen interaction; viral replication; virus movement; RNA silencing; molecular virology; CRISPR; resistance
(This special issue belongs to the Section Molecular Plant Sciences)
Macrophage Dysfunction and Cytokine Storm in Pulmonary Disorders submission deadline 31 Jan 2026 | Submission Open
Keywords: macrophage dysfunction; cytokine storm; lung diseases
(This special issue belongs to the Section Molecular Immunology)
Current Research for Ovarian Cancer Biology and Therapeutics (Second Edition) submission deadline 10 Feb 2026 | Viewed by 36 | Submission Open
Keywords: ovarian cancer; chemotherapy resistance; metastasis; novel therapeutic agents; immunotherapy; CAR-T cells; cancer chemotherapy; pre-clinical models
(This special issue belongs to the Section Molecular Oncology)
Novel Mechanisms for the Prevention and Treatment of Stroke
edited by
submission deadline 10 Feb 2026 | Viewed by 31 | Submission Open
Keywords: stroke; pathophysiology; mechanisms; comorbidities; treatments
(This special issue belongs to the Section Molecular Neurobiology)
Cardiovascular Calcification: New Insights into Degenerative Mechanisms and Therapeutic Perspectives
edited by Antonella Bonetti
submission deadline 10 Feb 2026 | Viewed by 22 | Submission Open
Keywords: ectopic calcification; tissue calcinosis; cardiovascular calcification; anti-calcific effect; calcification reduction; anti-calcific model
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advanced Research in Prediction of Protein Structure and Function, 2nd Edition
edited by
submission deadline 20 Feb 2026 | 5 articles | Viewed by 16454 | Submission Open
Keywords: prediction; protein structure; protein function; protein complex; machine learning; deep learning; multiple sequence alignment
(This special issue belongs to the Section Molecular Informatics)
Chimeric Antigen Receptors Against Cancers and Autoimmune Diseases
edited by
submission deadline 20 Feb 2026 | 4 articles | Viewed by 10433 | Submission Open
Keywords: chimeric antigen receptor (CAR); cancer; autoimmune disease; solid tumor; effector cell; CAR format; CAR transfer; tumor microenvironment; targeted antigen
(This special issue belongs to the Section Molecular Immunology)
Probiotics in Health and Disease
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 9909 | Submission Open
Keywords: probiotic; microbiota; quality; dysbiosis
(This special issue belongs to the Section Molecular Microbiology)
New Insights into Aquaporins: 2nd Edition submission deadline 20 Feb 2026 | 5 articles | Viewed by 7657 | Submission Open
Keywords: aquaporin; membrane channel; regulation; pathophysiology; drug target
(This special issue belongs to the Section Molecular Biology)
Genomics and Proteomics of Cancer submission deadline 20 Feb 2026 | 6 articles | Viewed by 7108 | Submission Open
Keywords: cancer; carcinogenesis; genetic; epigenetic modification; protein expression; protein phosphorylation; proteomic
(This special issue belongs to the Section Molecular Oncology)
Organoids and Organs-on-Chip for Medical Research
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 6938 | Submission Open
Keywords: organoids; organs-on-chip; tissue engineering; disease modeling; biomarkers; molecular pathways; nanotechnology; preclinical models; artificial organs; artificial intelligence; personalized medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Molecular Trends and Prospects in Kidney Diseases submission deadline 20 Feb 2026 | 4 articles | Viewed by 6733 | Submission Open
Keywords: nephrology; molecular biology; renal disease; genomic research; kidney molecular pathways; biomarkers in renal disease; transcriptomics of renal dysfunction; omics approaches in kidney research; molecular diagnostics for renal diseases; pharmacogenomics in kidney treatment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Inflammatory Bowel Diseases: Molecular Mechanism and Therapeutics
edited by
submission deadline 20 Feb 2026 | 4 articles | Viewed by 5530 | Submission Open
Keywords: inflammatory bowel disease; IBD; ulcerative colitis; Crohn’ s disease; animal models
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Chronic Rhinosinusitis: Aetiology, Immunology and Treatment, 3rd Edition
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 4981 | Submission Open
Keywords: innate immunity; adaptive immunity; protease; cytokine; inflammation; epithelial cells; fibroblasts; eosinophils; lymphocytes; biologics
(This special issue belongs to the Section Molecular Immunology)
Immunotherapy Versus Immune Modulation of Leukemia
edited by Helga Maria Schmetzer
submission deadline 20 Feb 2026 | 2 articles | Viewed by 4941 | Submission Open
Keywords: leukemia; immunotherapy; immune modulation; antileukemic; drug resistance
(This special issue belongs to the Section Molecular Oncology)
Drug-Induced Modulation and Immunotherapy of Leukemia
edited by Helga Maria Schmetzer
submission deadline 20 Feb 2026 | 2 articles | Viewed by 4635 | Submission Open
Keywords: leukemia; dendritic cells; immunotherapy; immune modulation
(This special issue belongs to the Section Molecular Immunology)
New Advances in Bioactive Compounds in Health and Disease
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 4471 | Submission Open
Keywords: phenolic compounds; bioactive compounds; health-promoting properties; human diseases; chronic diseases
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Exploring Novel Molecular, Metabolic and Cellular Mechanisms for Developing New Therapeutic Targets Against Childhood Cancers, 2nd Edition submission deadline 20 Feb 2026 | 3 articles | Viewed by 4039 | Submission Open
Keywords: childhood cancers; rhabdomyosarcoma; leukemias; lymphomas; central nervous system tumors; sarcomas of bone and soft tissue; neuroblastoma; retinoblastoma; rhabdoid tumors; rare cancers; genomic alterations; molecular drivers; tissue microenvironment; development of drugs; therapies
(This special issue belongs to the Section Molecular Oncology)
Essential Molecules in Life: Regulation, Defense, and Longevity, 2nd Edition submission deadline 20 Feb 2026 | 2 articles | Viewed by 3665 | Submission Open
Keywords: glucose metabolism and its regulation; enzimology and kinetics; metabolism and evolution; cell growth; protein synthesis and degradation; cell proliferation and apoptosis; cancer; metastasis and angiogenesis; oxidative stress; genomic; proteomic and metab
(This special issue belongs to the Section Molecular Immunology)
Molecular Studies in Aging, 2nd Edition
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 3605 | Submission Open
Keywords: senescence; active aging; sarcopenia; osteoporosis; oxidative stress; brain aging; cardiovascular aging
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Fish Genomics and Developmental Biology, 2nd Edition submission deadline 20 Feb 2026 | 4 articles | Viewed by 3535 | Submission Open
Keywords: development; teleost; gene regulation; comparative genomics; genomics; aquaculture; transcriptomics; gene expression; environment; genomes; population genomics; selective breeding; biomarker
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms, Pathophysiology and Therapeutic Strategies of Chronic Obstructive Pulmonary Disease (COPD)
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 3435 | Submission Open
Keywords: chronic obstructive pulmonary disease (COPD); pathophysiology; novel therapeutic approaches; biomarkers; pulmonary rehabilitation; inflammation; oxidative stress; genetic factors
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research of Cancer Metabolism and Biomarkers
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 3258 | Submission Open
Keywords: metabolic reprogramming; tumor microenvironment (TME); resistance; metabolic modulator; multidisciplinary omics approach; cancer metabolism; biomarkers; cancer stem cells
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms and Treatment Strategies of Myocardial Infarction
edited by Abdul-Majeed Salmasi
submission deadline 20 Feb 2026 | 1 articles | Viewed by 3134 | Submission Open
Keywords: myocardial infarction; genetics; molecular biology; chromosomes; genes; atherosclerosis; coronary artery disease; risk factors
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
In Silico Methods of Assessing the Therapeutic Potential of Natural Substances submission deadline 20 Feb 2026 | 3 articles | Viewed by 2915 | Submission Open
Keywords: in silico screening; natural products; molecular docking; computational drug discovery; QSAR modeling; molecular dynamics simulations; natural compounds; drug-target interactions; virtual screening; structure-activity relationships; computational chemistry; cheminformatics; ADMET prediction; bioinformatics; phytochemicals; machine learning in drug discovery; computer-aided drug design; pharmacophore modeling; natural therapeutics; computational pharmacology
(This special issue belongs to the Section Molecular Informatics)
Advances in Insulin Resistance Research: 2nd Edition
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 2826 | Submission Open
Keywords: insulin resistance; obesity; metabolic diseases; diabetes; metabolism; inflammation
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Autoimmune Diseases: From Pathogenesis to Treatment and Prognostic Markers
edited by Alessandra Bettiol
submission deadline 20 Feb 2026 | 4 articles | Viewed by 2757 | Submission Open
Keywords: autoimmune diseases; inflammation; immunity; pathogenesis; immunosuppressants; biologics; biomarkers
(This special issue belongs to the Section Molecular Immunology)
Endothelial Dysfunction and Its Related Cardiometabolic Disorders: From Mechanisms to Targeted Therapies
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 2653 | Submission Open
Keywords: endothelial dysfunction; endothelial activation; endothelial nitric oxide synthase; cardiometabolic disease; vascular inflammation; chemokines; adipocytokines; atherosclerosis; diabetes; biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Sperm Oxidative Stress and Male Infertility
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 2324 | Submission Open
Keywords: oxidative stress; antioxidant system; free radical scavengers; sperm DNA oxidation; sperm DNA fragmentatio; antioxidant therapy; male infertility; male oxidative stress infertility
(This special issue belongs to the Section Molecular Biology)
New Insights in Antibody Therapy
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 2293 | Submission Open
Keywords: biological therapy; antibody therapy; non-communicable diseases; infectious diseases; chronic disease
(This special issue belongs to the Section Molecular Immunology)
Recent Research of Nanomaterials in Molecular Science: 2nd Edition
edited by
submission deadline 20 Feb 2026 | 3 articles | Viewed by 2019 | Submission Open
Keywords: nanomaterials; medical research; synthesis and characterization; molecular formula; molecular dynamics; molecular imaging; cell signaling; cellular metabolism; tissue regeneration; biocompatibility; molecular biology; nanomedicine; functional nanomaterials; drug and gene delivery; tissue engineering; cancer therapy
(This special issue belongs to the Section Molecular Nanoscience)
Progress in the Use of Graphene and Graphene-Like Materials in Various Applications
edited by Piotr Kamedulski
submission deadline 20 Feb 2026 | 2 articles | Viewed by 1996 | Submission Open
Keywords: graphene; porous carbons; carbon-based materials; 3D graphene; graphene exfoliation; nanotubes; nanomaterials; N-rich nano-porous carbon matrixes; N-rich activated carbons; carbon molecular sieves; hybrid materials; medical applications
(This special issue belongs to the Section Materials Science)
Gut Microbiota and Nutrition in Human Health (2nd Edition)
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1945 | Submission Open
Keywords: microbiome; gut; brain; obesity; diabetes; inflammation; liver; nutrition; probiotic; prebiotic
(This special issue belongs to the Section Molecular Microbiology)
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