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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Brain’s Regeneration Potential: The Role of Neural Progenitor Cells in Neuropsychiatric Therapy submission deadline 31 Jul 2026 | 2 articles | Viewed by 2053 | Submission Open
Keywords: neural stem cells; neural progenitor cells; neuropsychiatric disorders; neurodegeneration; neurogenesis; neuroplasticity; melatonin; psychoactive drugs
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Mechanisms and Treatments Targeting Respiratory Diseases
edited by
submission deadline 31 Jul 2026 | 1 articles | Viewed by 2012 | Submission Open
Keywords: respiratory diseases; respiratory infections; COPD; cystic fibrosis; lung tumor; therapy; Afrikaans; Albanian; Amharic; Arabic; Armenian; Azerbaijani; Bengali; Bulgarian; Catalan; Croatian; Czech; Danish; Dutch; English; Estonian; Finnish; French; German; Greek; Gujarati; Haitian Creole; Hebrew; Hindi; Hungarian; Icelandic; Indonesian; Italian; Japanese; Kannada; Kazakh; Khmer; Korean; Kurdish (Kurmanji); Lao; Latvian; Lithuanian; Malagasy; Malay; Malayalam; Maltese; Maori; Marathi; Myanmar (Burmese); Nepali; Norwegian; Pashto; Persian; Polish; Portuguese; Punjabi; Romanian; Russian; Samoan; Simplified Chinese; Slovak; Slovenian; Spanish; Swedish; Tamil; Telugu; Thai; Traditional Chinese; Turkish; Ukrainian; Urdu; Vietnamese; Welsh
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Computational Methodologies for Biomolecule Sequence, Structure and Function Discovery: 2nd Edition
edited by Fei Guo
submission deadline 31 Jul 2026 | 3 articles | Viewed by 2000 | Submission Open
Keywords: bioinformatics; machine learning; deep learning; biomolecule identification; biological networks; structural proteomics; gene expression analysis; molecular docking; post-translational modifications
(This special issue belongs to the Section Molecular Informatics)
Microbial Omics: Decoding Microbial Life
edited by
submission deadline 31 Jul 2026 | 1 articles | Viewed by 1945 | Submission Open
Keywords: omics technologies; omics methodologies; microorganisms; proteomics; genomics; transcriptomics; bioinformatics, artificial intelligence for omics; microbial physiology; microbial adaptation to environmental challenges; interspecies and host-microbe interactions; environmental monitoring
(This special issue belongs to the Section Molecular Microbiology)
Physiology and Molecular Biology of Plant Stress Tolerance: 3rd Edition
edited by
submission deadline 31 Jul 2026 | 3 articles | Viewed by 1884 | Submission Open
Keywords: plant–pathogen interactions; biotic and abiotic stress; plant innate immunity; phytohormones; genes
(This special issue belongs to the Section Molecular Plant Sciences)
The Impact of the Immune System on the Tumor Microenvironment: Relevance to Glioma Development
edited by Gabriela Verónica Salamone
submission deadline 31 Jul 2026 | 1 articles | Viewed by 1768 | Submission Open
Keywords: gliomas
tumor microenvironment
immune
(This special issue belongs to the Section Molecular Oncology)
Cell–Cell Communication Through Extracellular Vesicles
edited by
submission deadline 31 Jul 2026 | 1 articles | Viewed by 1646 | Submission Open
Keywords: EV biomarkers; EV biogenesis; EV drug delivery; EV trafficking; EV immuno escape
(This special issue belongs to the Section Molecular Biology)
Computer-Aided Drug Discovery: Computational Chemistry and Cheminformatics submission deadline 31 Jul 2026 | 3 articles | Viewed by 1626 | Submission Open
Keywords: computer-aided drug discovery; computational chemistry; cheminformatics; conceptual density functional theory (CDFT); molecular docking; molecular dynamics simulations; QSAR/QSPR modeling; ADMET prediction; machine learning in drug design
(This special issue belongs to the Section Molecular Informatics)
Molecular Mechanisms Behind Plant–Virus Interactions: Pathogenesis and Defense submission deadline 31 Jul 2026 | 1 articles | Viewed by 1593 | Submission Open
Keywords: plant viruses; plant resistance; plant signaling; plant defense; biotic stress; plant–virus interactions; molecular mechanism
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Research on PRDM Genes submission deadline 31 Jul 2026 | 1 articles | Viewed by 1556 | Submission Open
Keywords: PRDM; cancer; gene expression regulation; epigenetic modifications; proliferation; differentiation; gene expression regulation; apoptosis; cancer biomarkers; cancer diagnosis
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular and Genomic Basis of Viral Variation and Host Adaptation
edited by In Ohk Ouh
submission deadline 31 Jul 2026 | 1 articles | Viewed by 1543 | Submission Open
Keywords: viral genome evolution mutation and selection dynamics; structure–function relationships of viral proteins; immune evasion; regulatory mechanisms; comparative viral genomics
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Forensics at Trial
edited by
submission deadline 31 Jul 2026 | 1 articles | Viewed by 1490 | Submission Open
Keywords: forensic science; molecular biology; evidence; proof; justice; trial; forensic pathology; forensic genetics; forensic histology; forensic toxicology
(This special issue belongs to the Section Molecular Toxicology)
Molecular Pathogenesis and Novel Therapeutic Targets in Oncologic Cardiotoxicity
edited by
submission deadline 31 Jul 2026 | 1 articles | Viewed by 1488 | Submission Open
Keywords: cardiotoxicity; CTRCD; heart failure; HFrEF; HFpEF
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of Lipids in Health and Diseases: 2nd Volume
edited by
submission deadline 31 Jul 2026 | 2 articles | Viewed by 1475 | Submission Open
Keywords: lipids; triglycerides; phospholipids; cholesterol; sphingolipids; steroids; fatty acids; lipid metabolism
(This special issue belongs to the Section Biochemistry)
Pathogenesis and Molecular Therapy of Inflammatory Bowel Disease
edited by
submission deadline 31 Jul 2026 | 2 articles | Viewed by 1454 | Submission Open
Keywords: intestinal epithelial barrier; gut microbiota; tight junctions; inflammatory bowel disease; mucosal immunity; autophagy; epithelial restitution; host–microbe interaction; barrier dysfunction; gastrointestinal inflammation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insights in Neuro-Ophthalmology
edited by
submission deadline 31 Jul 2026 | 2 articles | Viewed by 1434 | Submission Open
Keywords: neuroprotection; neurodegeneration; neuronal cell death; regeneration; cell death and survival pathways; neurovascular unit; oxidative stress; inflammation; advanced glycation end products; ischemia; optic nerve injuries; glaucoma; optic neuritis; retinitis pigmentosa; diabetic retinopathy; age-related macular degeneration; retinal vein/artery occlusion; gene therapy; cell plantation; nutrients; neuroprotectants; drug delivery; translational research
(This special issue belongs to the Section Molecular Neurobiology)
Natural Product and Enzyme Inhibition for Disease Management submission deadline 31 Jul 2026 | 1 articles | Viewed by 1367 | Submission Open
Keywords: bioactive compounds; natural sources; enzyme inhibition; drug discovery; cancer; cardiovascular diseases
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Liver Transplantation: Pathogenesis, Therapeutic Strategies and Future Challenges
edited by
submission deadline 31 Jul 2026 | 1 articles | Viewed by 1360 | Submission Open
Keywords: MASLD; transplant oncology; machine perfusion; extended-criteria donors; donors after cardiac death
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Autoimmune Disorders: Molecular Mechanisms and Therapeutic Strategies submission deadline 31 Jul 2026 | 1 articles | Viewed by 1348 | Submission Open
Keywords: molecular mechanisms; immune signaling pathways; targeted therapies; biomarkers; autoimmune pathogenesis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Genomic and Proteomic Advances in Tracking Antibiotic Resistance Evolution submission deadline 31 Jul 2026 | Viewed by 1332 | Submission Open
Keywords: antibiotic resistance; genomic; proteomic; one health
(This special issue belongs to the Section Molecular Biology)
Anti-Inflammatory Drugs: New and Old Compounds with Novel Delivery Systems Contributing to Improve the Treatment of Inflammatory Diseases
edited by S. Gorzalczany
submission deadline 31 Jul 2026 | 1 articles | Viewed by 1241 | Submission Open
Keywords: inflammation; new compounds; novel formulation; mechanism of action; biological drug; arthritis; inflammatory bowel disease
(This special issue belongs to the Section Molecular Biology)
Physiology and Pathophysiology of Neurodegeneration: New Insights and Advances from Molecular to Cellular Level submission deadline 31 Jul 2026 | 1 articles | Viewed by 1228 | Submission Open
Keywords: central and peripheral nervous systems; neuron homeostasis; neurodegeneration; neurodegenerative disease; neurophysiology; -omic technologies; induced pluripotent stem cell (iPSC); three-dimensional cell culture; organ-on-a-chip (OoC)
(This special issue belongs to the Section Molecular Neurobiology)
Next-Gen Biomarkers for Cancer Immunotherapy
edited by
submission deadline 31 Jul 2026 | 1 articles | Viewed by 1218 | Submission Open
Keywords: cancer biomarkers; immunotherapy; circulating tumor DNA; exosomes; tumor-specific microRNAs; sin-gle-cell sequencing; spatial transcriptomics; precision oncology
(This special issue belongs to the Section Molecular Immunology)
Molecular Diagnosis and Prevention of Infectious Diseases submission deadline 31 Jul 2026 | 2 articles | Viewed by 1213 | Submission Open
Keywords: host–pathogen interactions; molecular diagnostics; infectious diseases; emerging and reemerging pathogens; prevention; diagnosis; molecular epidemiology; omics; molecular surveillance
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Advances in Protein Analysis in Disease
edited by
submission deadline 31 Jul 2026 | 2 articles | Viewed by 1146 | Submission Open
Keywords: proteomics; protein; profile; molecular mechanism; biomarker; therapeutical agent
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Eukaryotic Mitogenomes: Key Insights
edited by
submission deadline 31 Jul 2026 | 2 articles | Viewed by 1106 | Submission Open
Keywords: eukaria; genomics; mitogenomes; structure; phylogenetic informativeness; evolution; comparative genomics; diversity; biomarker; function; mitonuclear relations
(This special issue belongs to the Section Molecular Biology)
Drug Development and Discovery for Alzheimer's Disease
edited by Martha Cecilia Rosales-Hernández
submission deadline 31 Jul 2026 | 1 articles | Viewed by 1096 | Submission Open
Keywords: Alzheimer's disease; drug design; repurposed molecules; therapeutic targets; amyloid-β; β-secretase; acetylcholin-esterase; in silico studies; oxidative stress; chemical synthesis
(This special issue belongs to the Section Molecular Neurobiology)
Nanoparticle Toxicity: Beyond Chemical Composition—the Critical Role of Physicochemical Properties
edited by
submission deadline 31 Jul 2026 | 1 articles | Viewed by 1081 | Submission Open
Keywords: nanotoxicology; engineered nanomaterials; physicochemical properties; risk assessment; reactive oxygen species (ROS); protein corona; cellular uptake; regulatory science; safe-by-design
(This special issue belongs to the Section Molecular Toxicology)
Molecular Mechanisms and Therapeutic Strategies in Gastrointestinal Cancer submission deadline 31 Jul 2026 | 1 articles | Viewed by 1054 | Submission Open
Keywords: gastrointestinal cancers; pancreatic cancer; gastric cancer; colorectal cancer; hepatobiliary cancers; precision medicine
(This special issue belongs to the Section Molecular Oncology)
Recent Advances in Neuroprotective Drug Development and Therapeutic Applications
edited by Jolanta Helena Kotlińska
submission deadline 31 Jul 2026 | 1 articles | Viewed by 1051 | Submission Open
Keywords: neuropharmacology; neuroprotective drugs; dopaminergic and glutamatergic signaling; endocannabinoid system; neurodevelopmental and stress-related disorders
(This special issue belongs to the Section Molecular Neurobiology)
Mechanistic Insights into Next-Generation Psychobiotics
edited by
submission deadline 31 Jul 2026 | 1 articles | Viewed by 1033 | Submission Open
Keywords: gut–brain axis; psychobiotics; next-generation psychobiotics; microbiota; probiotics; postbiotics; microbial metabolites
(This special issue belongs to the Section Molecular Microbiology)
Advancements in Cytopathology: Challenges and Changes
edited by Panagiota Mikou
submission deadline 31 Jul 2026 | 1 articles | Viewed by 1025 | Submission Open
Keywords: cytopathology; cancer diagnosis; cytology; early cancer detection; exfoliative cytology
(This special issue belongs to the Section Molecular Biology)
Molecular Characterization and Utilization of Plant Genetic Resources
edited by
submission deadline 31 Jul 2026 | 2 articles | Viewed by 997 | Submission Open
Keywords: molecular markers; genetic resources; genomics; transcriptomics; molecular characterization; genetic diversity; transcriptomics; bioinformatics; germplasm enhancement; epigenetics
(This special issue belongs to the Section Molecular Plant Sciences)
New Insights into Antimicrobial Peptides with Anticancer Activity
edited by
submission deadline 31 Jul 2026 | 1 articles | Viewed by 986 | Submission Open
Keywords: antimicrobial peptides; cytotoxicity; selective anticancer drugs; omics approaches; anticancer peptide action
(This special issue belongs to the Section Biochemistry)
Understanding Cardiotoxicity: From Mechanisms to Therapeutic Implications
edited by
submission deadline 31 Jul 2026 | 1 articles | Viewed by 960 | Submission Open
Keywords: cardiotoxicity; mechanisms of cardiotoxicity; cancer-therapy-related cardiac dysfunction; chemotherapy-related cardiotoxicity; radiotherapy-related cardiotoxicity; immunotherapy-related cardiotoxicity; cardioprotection; molecular pathways; oxidative stress; apoptosis; cardiac biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Post-Transcriptional Gene Regulation of mRNA and Protein Expression
edited by Greco Hernández
submission deadline 31 Jul 2026 | 1 articles | Viewed by 922 | Submission Open
Keywords: translational control; protein synthesis; mRNA biochemistry; signal transduction; mTOR pathway; post-transcriptional regulation
(This special issue belongs to the Section Molecular Genetics and Genomics)
Functional and Regulatory Cancer Genomics submission deadline 31 Jul 2026 | 1 articles | Viewed by 909 | Submission Open
Keywords: cancer genomics; functional genomics; regulatory genomics; epigenetics; transcriptomics; non‑coding RNAs; single‑cell genomics; multi‑omics; tumor heterogeneity; precision oncology
(This special issue belongs to the Section Molecular Genetics and Genomics)
Recent Advances in Plant–Microbe Interactions
edited by
submission deadline 31 Jul 2026 | 1 articles | Viewed by 877 | Submission Open
Keywords: plant–microbe interactions; plant defense; pathogenicity; genetics; biochemistry; artificial intelligence; synthetic biology; symbiosis; plant protection
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Insights into Gangliosides submission deadline 31 Jul 2026 | 1 articles | Viewed by 862 | Submission Open
Keywords: gangliosides; sphingolipids; plasma membrane; lysosomes; glycohydrolases; neurodegeneration
(This special issue belongs to the Section Molecular Neurobiology)
Red Blood Cells in Health and Disease
edited by Annamaria Russo and Ester Tellone
submission deadline 31 Jul 2026 | Viewed by 860 | Submission Open
Keywords: oxidative stress; metabolism; hemoglobin; erythrocytes
(This special issue belongs to the Section Biochemistry)
Emerging Insights into Phytohormone Signaling in Plants—2nd Edition
edited by Meng Zhang
submission deadline 31 Jul 2026 | 1 articles | Viewed by 857 | Submission Open
Keywords: phytohormone; signal transduction; evolutionary and functional diversity; implications for plant science and agriculture
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Mechanisms of Early-Life Environmental Effects on Brain Development
edited by
submission deadline 31 Jul 2026 | 1 articles | Viewed by 832 | Submission Open
Keywords: early-life environment; brain development; neurodevelopmental programming; environmental exposures; developmental neurotoxicology; gene–environment interactions; maternal health; epigenetic regulation; neuroimmune interactions; endocrine disruption
(This special issue belongs to the Section Molecular Neurobiology)
Rheumatic Diseases: From Pathophysiology to Novel Therapeutic Approaches
edited by Namrata Singh
submission deadline 31 Jul 2026 | 1 articles | Viewed by 784 | Submission Open
Keywords: rheumatic diseases; disease mechanisms; treatment; long-term outcomes
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Mechanistic and Small Molecule Discoveries for Therapeutic Advances in Hypertrophic and Dilated Cardiomyopathies
edited by Osha Roopnarine
submission deadline 31 Jul 2026 | Viewed by 783 | Submission Open
Keywords: hypertrophic cardiomyopathy; dilated cardiomyopathies; cardiomyopathies
(This special issue belongs to the Section Molecular Pharmacology)
Advances in Molecular Research of Facial Adipose Compartments
edited by Marius Valeriu Hînganu
submission deadline 31 Jul 2026 | Viewed by 771 | Submission Open
Keywords: facial fat; facial adipose tissue; molecular markers of facial fat; hormonal environmental; metabolic disorders; facial deformities; single-cell RNA sequencing; CRISPR-Cas9 gene editing
(This special issue belongs to the Section Molecular Biology)
Latest Advances in Targeted Molecular Therapies for Genetic Disease
edited by Viorica-Elena Rădoi
submission deadline 31 Jul 2026 | 1 articles | Viewed by 750 | Submission Open
Keywords: genetic diseases; precision medicine; gene editing; RNA-based therapeutics; genomic profiling; translational research
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insight into Plant Bioactive Compounds: 2nd Edition submission deadline 31 Jul 2026 | 1 articles | Viewed by 742 | Submission Open
Keywords: bioactivity; disease prevention; herbal medicines; antioxidants; qualitative analysis
(This special issue belongs to the Section Molecular Plant Sciences)
Physiopathology and Therapeutics of HIV Infection
edited by
submission deadline 31 Jul 2026 | Viewed by 708 | Submission Open
Keywords: HIV; physiopathology; ART; HAART; NRTIs; NNRTIs; PIs; INSTIs; fusion inhibitors; CCR5 antagonists; post-attachment inhibitors; capsid inhibitors
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms and Translational Roles of Regulatory Enzyme Superfamilies in Physiology and Disease
edited by
submission deadline 31 Jul 2026 | 1 articles | Viewed by 706 | Submission Open
Keywords: enzyme mechanisms; regulatory enzyme superfamilies; protein structure–function relationship; enzyme regulation and signaling; disease-associated enzymes; translational enzymology
(This special issue belongs to the Section Biochemistry)
Abiotic Stress Tolerance and Genetic Diversity in Plants, 3rd Edition
edited by
submission deadline 31 Jul 2026 | 1 articles | Viewed by 694 | Submission Open
Keywords: biodiversity; molecular breeding; comparative genomics; abiotic stress adaptation; genetic mapping; predictive breeding; genomic prediction; assisted gene flow; plant breeding; restoration ecology; conservation genetics
(This special issue belongs to the Section Molecular Plant Sciences)
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