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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Functional Analysis and Therapeutic Targets of Long Non-Coding RNAs
edited by Hidenori Tani
submission deadline 20 Aug 2025 | 2 articles | Viewed by 4351 | Submission Open
Keywords: lncRNAs; gene expression; cellular processes; disease dysregulation; therapeutic targets; functional analysis; lncRNA therapeutics; lncRNA modulation; stability; localization
(This special issue belongs to the Section Molecular Genetics and Genomics)
New Insights into the Immunopathology of Autoimmune and Drug Induced Liver Injury
edited by Eleni Geladari
submission deadline 20 Aug 2025 | 2 articles | Viewed by 4241 | Submission Open
Keywords: liver disease; liver injury; immune system; immune dysregulation
(This special issue belongs to the Section Molecular Immunology)
Stem Cells in Human Health and Diseases
edited by Dana Yehudai-Ofir
submission deadline 20 Aug 2025 | 2 articles | Viewed by 4235 | Submission Open
Keywords: stem cells; stem cell biology; stem-cell-based therapy; stem cell regulation; cancer stem cell; tumor-initiating cell  
(This special issue belongs to the Section Molecular Immunology)
Bacteriophage: Molecular Ecology and Pharmacology, 2nd Edition
edited by , and Richard Allen White III
submission deadline 20 Aug 2025 | 2 articles | Viewed by 4217 | Submission Open
Keywords: bacteriophage ecology; bacteriophage pharmacology; intercell communication of bacteria; phage-host interactions; phage-host recognition; phage receptors; phage therapy
(This special issue belongs to the Section Molecular Microbiology)
Bioactive Polymer-Based Materials Dedicated to Wound Healing submission deadline 20 Aug 2025 | 2 articles | Viewed by 4197 | Submission Open
Keywords: wound healing; polymer; bioactive materials; tissue engineering; biomaterials; thin films; scaffolds; hydrogels
(This special issue belongs to the Section Materials Science)
The Role of the IGF Axis in Disease, 4th Edition
edited by Claire M. Perks
submission deadline 20 Aug 2025 | 3 articles | Viewed by 4184 | Submission Open
Keywords: IGF axis; cancer; obesity; hallmarks of cancer
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Signaling Transduction in Health and Disease
edited by and
submission deadline 20 Aug 2025 | 1 articles | Viewed by 4093 | Submission Open
Keywords: signaling pathways; inflammation; human disease; oxidative stress; neurodegeneration; heart disease; antioxidants
(This special issue belongs to the Section Biochemistry)
Molecular Mechanism of Acute Myeloid Leukemia
edited by
submission deadline 20 Aug 2025 | 3 articles | Viewed by 4076 | Submission Open
Keywords: leukemia; cytokine; signal transduction; apoptosis; immune therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Tea Tree Genetics and Breeding: 2nd Edition
edited by and
submission deadline 20 Aug 2025 | 2 articles | Viewed by 3993 | Submission Open
Keywords: tea plant (Camellia sinensis); molecular mechanism; secondary metabolites; stress response; quality-related component; genes identification; QTL mapping; molecular functional markers
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Research Progress of Cereal Crop Disease Resistance
edited by and Zhenqi Su
submission deadline 20 Aug 2025 | 3 articles | Viewed by 3969 | Submission Open
Keywords: cereal crops; disease resistance; resistance genes; breeding; molecular marker-assisted selection; molecular regulatory network
(This special issue belongs to the Section Molecular Plant Sciences)
Cellular and Molecular Mechanisms of Acute Lung Injury submission deadline 20 Aug 2025 | 3 articles | Viewed by 3958 | Submission Open
Keywords: acute lung injury; lung infection; acute respiratory distress syndrom; neutrophil-mediated immune response; alveolar epithelial injury; pulmonary oedema
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Big Data in Multi-Omics submission deadline 20 Aug 2025 | 2 articles | Viewed by 3952 | Submission Open
Keywords: data science; big data; omics; data management; data analytics TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //     This page is in Shona   Translate to Simplified Chinese         Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh   Always translate Shona to Simplified Chinese Never translate Shona Never translate admin.mdpi.com
(This special issue belongs to the Section Molecular Informatics)
Pharmacological Activities of Secondary Metabolites and Derivates of Medicinal Plants Around the World, 2nd Edition
edited by
submission deadline 20 Aug 2025 | 2 articles | Viewed by 3931 | Submission Open
Keywords: natural products; secondary metabolites; medicinal chemistry; worldwide traditional medicine; isolation and identification of secondary metabolites; experimental studies; photochemistry; pharmacognosy; medicinal plants
(This special issue belongs to the Section Molecular Pharmacology)
Male Genitourinary Tumors: Molecular and Cellular Mechanism
edited by
submission deadline 20 Aug 2025 | 2 articles | Viewed by 3871 | Submission Open
Keywords: penile carcinoma; tumor biology; immune modulator; HPV   TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Chronic Pain: Diagnosis, Pathophysiological Mechanisms and Treatment
edited by and Thomas Herdegen
submission deadline 20 Aug 2025 | 3 articles | Viewed by 3866 | Submission Open
Keywords: chronic pain; sex differences; age differences; pain therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Antibody–Drug Conjugates
edited by Bing Sun
submission deadline 20 Aug 2025 | 1 articles | Viewed by 3839 | Submission Open
Keywords: antibody– drug conjugate (ADC); cancer treatment; non-oncology indications; antibody selection; payload; linker; conjugation chemistry
(This special issue belongs to the Section Molecular Immunology)
Cyclodextrin-Based Polymer Systems for Biomedical Applications submission deadline 20 Aug 2025 | 1 articles | Viewed by 3830 | Submission Open
Keywords: cyclodextrins; polymers; grafting; drug delivery; hydrophobic drugs; wound healing; tissue engineering; antimicrobial systems; supramolecular systems
(This special issue belongs to the Section Macromolecules)
Natural Products in Obesity: Novel Strategies and Molecular Mechanisms: 2nd Edition
edited by
submission deadline 20 Aug 2025 | 2 articles | Viewed by 3788 | Submission Open
Keywords: obesity; inflammation; white adipose tissue; adipogenesis; oxidative stress; metabolic disease; molecular mechanisms
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Functional Genomics in Translational Medicine
edited by , Oana Zanoaga and
submission deadline 20 Aug 2025 | 2 articles | Viewed by 3668 | Submission Open
Keywords: functional genomics; omics approaches; drug response/resistance; therapeutic targets; genomics and transcriptomic alteration; bioinformatic analysis; data integration; human disease; personalized medicine
(This special issue belongs to the Section Molecular Genetics and Genomics)
Genetic and Epigenetic Mechanisms in Growth and Neurodevelopmental Disorders
edited by
submission deadline 20 Aug 2025 | 2 articles | Viewed by 3624 | Submission Open
Keywords: growth defects; intellectual disability; epilepsy; autism spectrum disorders; epigenetic variations; copy number variations; next generation sequencing
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Pharmacology of Medicinal Plants
edited by
submission deadline 20 Aug 2025 | 2 articles | Viewed by 3609 | Submission Open
Keywords: medicinal plants; drug development; molecular pharmacology; clinical phytopharmacology
(This special issue belongs to the Section Molecular Pharmacology)
Anxiolytic or Antidepressant Activity from Active Principles in Medicinal Plants
edited by Carolina López-Rubalcava and Erika Estrada Camarena
submission deadline 20 Aug 2025 | 2 articles | Viewed by 3580 | Submission Open
Keywords: phytopharmacology; anxiety; depression; medicinal plants; animal models
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Research on Skin Inflammation
edited by
submission deadline 20 Aug 2025 | 3 articles | Viewed by 3567 | Submission Open
Keywords: skin inflammation; molecular diagnosis; dermatitis; molecular pathogenesis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Regulation and Application of Bioactive Metabolites in Plants
edited by and
submission deadline 20 Aug 2025 | 2 articles | Viewed by 3501 | Submission Open
Keywords: medicinal plants; biosynthesis; biological activity; regulation; pharmacological mechanism
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Current Research on Plants as Natural Antioxidants
edited by
submission deadline 20 Aug 2025 | 2 articles | Viewed by 3493 | Submission Open
Keywords: plant-derived antioxidant; natural products; polyphenols; oxidative stress
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Cellular and Molecular Mechanisms in Oxidative Stress-Related Diseases, 4th Edition submission deadline 20 Aug 2025 | 3 articles | Viewed by 3412 | Submission Open
Keywords: molecular targets of oxidative stress in oxidative stress related-diseases; oxidative stress and oxidative stress-related pathologies; cellular response to oxidative stress; oxidative stress and apoptosis in oxidative stress-related diseases; oxidative stress and related cell signaling; cell adaptation to oxidative stress; biomarkers of oxidative stress in disease; beneficial effects of natural or synthetic antioxidants in oxidative stress-related diseases
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Inflammatory Bowel Disease: Focus on Molecular Research
edited by David Meriwether and
submission deadline 20 Aug 2025 | 2 articles | Viewed by 3383 | Submission Open
Keywords: inflammatory bowel disease; gut microbiota; genomic sequencing; proteomic; lipidomic; metabolomic; therapy; biomarker; animal and organoid model  
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advancing Climate Resilience in Horticultural Crops Through Omics Technologies
edited by and
submission deadline 20 Aug 2025 | 3 articles | Viewed by 3380 | Submission Open
Keywords: horticultural crops; climate change; omics technologies; stress responses; abiotic stresses; food security; agricultural sustainability; genomics; transcriptomic; proteomics
(This special issue belongs to the Section Molecular Plant Sciences)
Dietary Bioactive Components in Inflammatory Bowel Disease, 2nd Edition submission deadline 20 Aug 2025 | 2 articles | Viewed by 3361 | Submission Open
Keywords: IBD; dietary bioactive compounds; molecular mechanisms; health promotion; prevention; antioxidant; anti-inflammatory; nutritional support
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Synthesis, Characterization and Application of Metal and Metal Oxide Nanomaterials submission deadline 20 Aug 2025 | 2 articles | Viewed by 3336 | Submission Open
Keywords: metal nanoparticles; metal nanoclusters; properties of metal nanostructures; optical sensing and bio-sensing; pollutant sensing; metal oxide-based materials; photocatalysis; decomposition of pollutants by photocatalysis; energy production; conversion; and storage; water treatment
(This special issue belongs to the Section Molecular Nanoscience)
New Advances in Autoimmune Diseases submission deadline 20 Aug 2025 | 3 articles | Viewed by 3270 | Submission Open
Keywords: autoimmunity; autoimmune mechanisms; molecular pathogenesis; immune signalling pathways; cytokine regulation; epigenetics in autoimmunity; molecular biomarkers; gene expression profiling; regulatory T cells; immunogenetics; molecular therapeutics; signal transduction; immunometabolism; microRNA in autoimmunity
(This special issue belongs to the Section Molecular Immunology)
New Perspectives in Steroidomics
edited by
submission deadline 20 Aug 2025 | 2 articles | Viewed by 3213 | Submission Open
Keywords: steroidomics; steroids; pathophysiology; physiology; diagnostics; treatment; prediction; prognosis; LC-MS/MS; GC-MS/MS
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Health-Promoting Effects of Medicinal and Edible Plants and Their Molecular Mechanism
edited by and
submission deadline 20 Aug 2025 | 3 articles | Viewed by 3166 | Submission Open
Keywords: medicinal plants; edible plants; health-promoting effect; molecular mechanism; phytochemicals; diseases; curing targets; signaling pathway
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Advances in Computational Biology: Molecular Dynamics Simulation of Biomolecules submission deadline 20 Aug 2025 | 1 articles | Viewed by 3108 | Submission Open
Keywords: computational biology; molecular dynamics; molecular simulation of rare diseases; computational design of antimicrobials; computational design of antivirals; molecular simulation of cancer-related processes; computational design of anti-cancer molecules; molecular simulation of biotechnology processes
(This special issue belongs to the Section Molecular Informatics)
New Molecular Perspectives in Crustacean Neuroendocrinology
edited by
submission deadline 20 Aug 2025 | 3 articles | Viewed by 3061 | Submission Open
Keywords: neuroendocrinology; neuropeptides; functional genomics; arthropods development and reproduction; crustacean aquaculture
(This special issue belongs to the Section Molecular Biology)
Molecular Understanding of Allergen Exposome submission deadline 20 Aug 2025 | 2 articles | Viewed by 3054 | Submission Open
Keywords: allergen exposome; profile allergen exposures; climatic change; airborne allergens; molecular triggers; microbial allergens
(This special issue belongs to the Section Molecular Immunology)
Fish Nutrition Program and Epigenetic Regulation
edited by Linghong Miao
submission deadline 20 Aug 2025 | 2 articles | Viewed by 3035 | Submission Open
Keywords: nutrients; nutritional strategies; molecule regulation; growth; immunity; reproduction; stress response; epigenetic modifications
(This special issue belongs to the Section Molecular Genetics and Genomics)
Advancements in Understanding Protein Misfolding Disorders and Cancer
edited by
submission deadline 20 Aug 2025 | 1 articles | Viewed by 3003 | Submission Open
Keywords: protein misfolding; cancer; amyloidosis
(This special issue belongs to the Section Molecular Oncology)
Bioactive Compounds, Smart Polymers and Functionalised Materials for Drug Delivery
edited by Emilia Szymańska
submission deadline 20 Aug 2025 | 1 articles | Viewed by 2995 | Submission Open
Keywords: drug delivery system; bioactive compound; drug carrier; pharmacological activity; polymer
(This special issue belongs to the Section Materials Science)
Research on Transcriptional Regulation in Reproductive Biology
edited by
submission deadline 20 Aug 2025 | 2 articles | Viewed by 2992 | Submission Open
Keywords: reproductive biology; molecular research; transcriptional regulations; signaling pathways; gene expression; cell biology
(This special issue belongs to the Section Molecular Biology)
Molecular Advances in Combinatorial Therapies for Spinal Cord Injury
edited by
submission deadline 20 Aug 2025 | 1 articles | Viewed by 2945 | Submission Open
Keywords: molecular; cellular; engineering; spinal cord injury
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Retinal Diseases: From Molecular Pathology to Therapies—2nd Edition
edited by
submission deadline 20 Aug 2025 | 2 articles | Viewed by 2914 | Submission Open
Keywords: diabetic retinopathy; age-related macular degeneration; neuroprotection; retina; diabetic macular edema; therapy development; pathophysiology; retinitis pigmentosa; aging; eye trauma; vitreous; macula; choroideremia; stargardt disease; cone– rod dystrophy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Oral Squamous Cell Carcinoma: Insights into Molecular Pathways and Emerging Therapeutic Approaches
edited by
submission deadline 20 Aug 2025 | 3 articles | Viewed by 2905 | Submission Open
Keywords: oral squamous cell carcinoma; epigenetics; molecular genetics; gene expression targeted therapy; molecular biomarkers
(This special issue belongs to the Section Molecular Oncology)
Advances in Pro-Inflammatory and Anti-Inflammatory Cytokines
edited by
submission deadline 20 Aug 2025 | 2 articles | Viewed by 2791 | Submission Open
Keywords: pro-inflammation cytokine; anti-inflammation cytokine; chemotherapy; radiotherapy; signal transduction; microbiome– host response; sepsis; bone marrow; GI; brain
(This special issue belongs to the Section Molecular Immunology)
Advancements in Perovskite and Tandem Solar Cell Technologies
edited by
submission deadline 20 Aug 2025 | 2 articles | Viewed by 2630 | Submission Open
Keywords: perovskite solar cells; tandem photovoltaics; charge transporting materials; interfacial engineering; optoelectronic properties
(This special issue belongs to the Section Materials Science)
Advanced Research on CAR-T Cell Therapy
edited by
submission deadline 20 Aug 2025 | 1 articles | Viewed by 2579 | Submission Open
Keywords: CAR T cell therapy; T cell activation; memory lymphocyte differentiation; cancer vaccine; antigen spread
(This special issue belongs to the Section Molecular Immunology)
Pathogenic Microorganisms, Viruses and Therapeutic Strategies submission deadline 20 Aug 2025 | 1 articles | Viewed by 2546 | Submission Open
Keywords: medicinal chemistry; pathogenic microorganisms; bacteria; fungi; viruses; pathogen; therapeutic
(This special issue belongs to the Section Molecular Microbiology)
Rheumatoid Arthritis: From Molecular Basis to Therapies
edited by
submission deadline 20 Aug 2025 | 3 articles | Viewed by 2543 | Submission Open
Keywords: rheumatoid arthritis; autoimmune; intracellular signaling pathways; targeted therapy; inflammation; immunometabolic reprogramming; CD40; CD40 ligand; GM-CSF; PD-1; inhibitors
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms and Regulation in Blood-Brain Barrier
edited by Rajkumar Vutukuri
submission deadline 20 Aug 2025 | 1 articles | Viewed by 2542 | Submission Open
Keywords: blood brain barrier (BBB); tight junctions; NVU cell types; neurodegenerative diseases; neuro-inflammation
(This special issue belongs to the Section Molecular Neurobiology)
Biological Research of Rhythms in the Nervous System
edited by Bernát Kocsis and Andreas Draguhn
submission deadline 20 Aug 2025 | 2 articles | Viewed by 2539 | Submission Open
Keywords: mechanisms of rhythmic synchronization; rhythmic firing; neural network oscillations; rhythmic components in EEG; oscillopathy; theta and gamma rhythm; sleep spindle; rhythmic activity and cognition; pathology of rhythmic synchronization in the nervous system; altered rhythmic activity in neuropsychiatric disorders
(This special issue belongs to the Section Molecular Neurobiology)
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