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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular and Cellular Mechanisms of Intervertebral Disc Disease

edited by

Hosni Cherif

submission deadline 30 Oct 2025 | 2 articles | Viewed by 2557 | Submission Open

Keywords: intervertebral disc; disc degeneration; low back pain; disc aging; disc herniation; disc regeneration; inflammation; extracellular matrix; collagen; proteoglycans; matrix metalloproteinases (MMPs); senescence; quiescence; apoptosis; oxidative stress; senotherapeutics; cytokines; growth factors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Multiomics and Functional Foods: Molecular Characterization, Structures and Biological Activities

edited by

Chuan Li

and Jun Yang

submission deadline 30 Oct 2025 | 2 articles | Viewed by 2531 | Submission Open

Keywords: multiomics technologies; functional foods; characterization; structures; biological activities; molecular mechanisms

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Research on Cyclodextrin: Properties and Biomedical Applications

edited by Jug Mario

submission deadline 30 Oct 2025 | 1 articles | Viewed by 2479 | Submission Open

Keywords: cyclodextrins; cyclodextrin– metal organic framework; cyclodextrin-based polyrotaxane and polycatenane; inclusion complex formation; cholesterol; solubility; chemical stability; bioavailability; drug delivery; modified drug release; gene delivery; wound healing

(This special issue belongs to the Section Materials Science)

Molecular Mechanisms of Vascular Protection by Means of Nutraceuticals

edited by

Roberta Macri

submission deadline 30 Oct 2025 | 1 articles | Viewed by 2420 | Submission Open

Keywords: cardiovascular disease; drugs; nutrients

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Radiation-Induced DNA Damage and Toxicity

edited by

Mohammad Asif Sherwani

and

Muhammad Maqbool

submission deadline 30 Oct 2025 | 2 articles | Viewed by 2355 | Submission Open

Keywords: radiation; DNA damage; toxicity; immune response

(This special issue belongs to the Section Molecular Biology)

Mitochondrial Function and Dynamics During Malignant Transformation

edited by Aleksandr Klepinin

submission deadline 30 Oct 2025 | 1 articles | Viewed by 2198 | Submission Open

Keywords: AMPK; phosphotransfer network; mitochondria; cancer metabolism; glycolysis; metabolic plasticity; cancer cell migration; molecular oncology; cancer treatment strategy

(This special issue belongs to the Section Biochemistry)

Molecular Tools for the Development of Fermented Functional Foods Enriched with Bioactive Compounds

edited by Susana Langa,

Jose Antonio Curiel

and José María Landete

submission deadline 30 Oct 2025 | 1 articles | Viewed by 2079 | Submission Open

Keywords: molecular tools; fermentation; lactic acid bacteria; yeast; fungi; recombinant enzymes; probiotic; prebiotic; polyphenols; vitamins; food by-product valorization; bioactive compounds; antioxidant; anti-hypertensive; anti-carcinogenic; antimicrobial; anti-aging; food and beverages; GABA

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Advances on Cannabinoid and Endocannabinoid Research, 3rd Edition

edited by

Rosaria Meccariello

submission deadline 30 Oct 2025 | 1 articles | Viewed by 2065 | Submission Open

Keywords: cannabinoid; endocannabinoid; cannabinoid receptor; endogenous cannabinoid; pharmacological research

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Characterization of Plant–Microbe Interactions

edited by

Cristina Pinedo-Rivilla

submission deadline 30 Oct 2025 | 3 articles | Viewed by 1931 | Submission Open

Keywords: phytopathogen; plant pathology; phytopathogen fungi; phytopathogen bacteria; phytoalexins; plant defense; allelopathy; fungicides

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research in Prostate Cancer

edited by

Shafiq Khan

submission deadline 30 Oct 2025 | 2 articles | Viewed by 1838 | Submission Open

Keywords: cell proliferation; cell migration and invasion; metastasis; growth factor; TGFβ ; cell signaling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Compounds and Therapeutic Targets in Prostate Cancer: 2nd Edition

edited by

Gnanasekar Munirathinam

submission deadline 30 Oct 2025 | 1 articles | Viewed by 1834 | Submission Open

Keywords: prostate cancer; androgen receptor; AR-V7; castration-resistant prostate cancer; dietary alkaloids; dietary antioxidants; phenolic compounds; terpenoids; phytochemicals; xanthones; probiotics; preclinical; marine bioactive agents; molecular target; signaling pathways

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Unusual DNA and RNA Structures: 2nd Edition

edited by

Martin Bartas

and

Petr Pečinka

submission deadline 30 Oct 2025 | 1 articles | Viewed by 1751 | Submission Open

Keywords: G-quadruplex; i-motifs; R-loops; Z-DNA; A-DNA; cruciforms; nucleic acid structures

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advancement of Understanding Alzheimer’s Disease Susceptibility and Novel Drug Targets

edited by Kunie Ando and Jean-Pierre Brion

submission deadline 30 Oct 2025 | 1 articles | Viewed by 1469 | Submission Open

Keywords: Alzheimer’ s disease; neurodegenerative diseases; tau; amyloid; inflammation; disease modifying treatments; biomarkers; genetic variants; risk factors; mechanisms; protein– protein interactions; post-translational modifications

(This special issue belongs to the Section Molecular Neurobiology)

Complications of Type 1 Diabetes in Pediatric Age: Early Biomarkers and New Insights into Diagnosis and Prevention Strategies

edited by

Enza Mozzillo

and Francesca Di Candia

submission deadline 30 Oct 2025 | 1 articles | Viewed by 1415 | Submission Open

Keywords: pediatrics; endocrinology; diabetology; complications; type 1 diabetes; prevention; early biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Scale Research of Energy Materials

edited by Paolo Umari

submission deadline 30 Oct 2025 | 1 articles | Viewed by 1374 | Submission Open

Keywords: photovoltaics; density functional theory; quantum chemistry; catalysis; surfaces; charge transport; catalytic activity

(This special issue belongs to the Section Materials Science)

Molecular Mechanisms of Extremophilic Bacteria and Their Potential Applications in Biotechnology

edited by

Sathiyaraj Srinivasan

submission deadline 30 Oct 2025 | 1 articles | Viewed by 1320 | Submission Open

Keywords: extremophilic bacteria; molecular mechanisms; genomic analysis; transcriptomic responses; proteomic studies; metabolic adaptations; comparative analysis; regulatory networks; stress response systems; biotechnological applications; bioremediation; bioenergy; industrial bioprocesses

(This special issue belongs to the Section Molecular Microbiology)

Molecular Advances in Abiotic Stress Signaling in Plants: Focus on Atmospheric Stressors, 2nd Edition

edited by

Mateusz Labudda

submission deadline 30 Oct 2025 | 2 articles | Viewed by 1154 | Submission Open

Keywords: abiotic stress; interactomics; gene expression regulation; kinases; oxidative stress; phytohormones; signaling; sugar sensing and signaling; transcription factors

(This special issue belongs to the Section Molecular Plant Sciences)

Horticultural Crop Improvement: A New Era for Plant Molecular Research: Fourth Edition

edited by

Bo Sun

submission deadline 30 Oct 2025 | 2 articles | Viewed by 1140 | Submission Open

Keywords: horticultural plants; whole-genome resequencing; transcriptomics; proteomics; metabolomics; gene editing; gene regulation; growth and development; yield; quality; resistance

(This special issue belongs to the Section Molecular Plant Sciences)

Research on Plant-Microbe Interactions

edited by Lin Chen

submission deadline 30 Oct 2025 | 1 articles | Viewed by 910 | Submission Open

Keywords: beneficial microbes; rhizosphere; phyllosphere; endosphere; colonization; microbiome; root exudates; communication; secondary metabolites; plant immunity; environmental stress; resistance to plant disease

(This special issue belongs to the Section Molecular Plant Sciences)

Advanced Research in Veterinary Drugs

edited by Jianyong Li

submission deadline 30 Oct 2025 | 1 articles | Viewed by 852 | Submission Open

Keywords: veterinary drug; target; chemical structure; mechanism; medicinal chemistry; toxicity; pharmacodynamics; pharmacokinetics; residues

(This special issue belongs to the Section Molecular Pharmacology)

Application of Electrochemical Materials in Molecular Biology

edited by

Robert Ziółkowski

submission deadline 30 Oct 2025 | 1 articles | Viewed by 841 | Submission Open

Keywords: electrochemistry; (bio)analytical chemistry; molecular biology; point-of-care; nanomaterials; (bio)molecules

(This special issue belongs to the Section Materials Science)

Advances in Brassica Crop Metabolism and Genetics (Second Edition)

edited by

Bo Sun

and

Honghao Lv

submission deadline 30 Oct 2025 | 1 articles | Viewed by 839 | Submission Open

Keywords: brassica crop; genomics; transcriptomics; proteomics; metabolomics; gene editing; metabolite synthesis and regulation; phylogeny and taxonomy; physiological traits; biotic/abiotic stresses; biotechnology

(This special issue belongs to the Section Molecular Plant Sciences)

Extracellular Vesicles: Advances in Multi-Omics

edited by

Leo Kei Iwai

submission deadline 30 Oct 2025 | 1 articles | Viewed by 820 | Submission Open

Keywords: extracellular vesicles; omics; mass spectrometry; molecular targets; biomarker

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Laser and Photodynamic Therapy

edited by Rafał Wiench and Aleksandra Kawczyk-Krupka

submission deadline 30 Oct 2025 | 1 articles | Viewed by 817 | Submission Open

Keywords: laser therapy; photodynamic therapy; photosensitizers; drug delivery; biomedical imaging; nanotechnology; combination therapies; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Radiobiology—New Advances

edited by

Marco Calvaruso

and

Luigi Minafra

submission deadline 30 Oct 2025 | 1 articles | Viewed by 744 | Submission Open

Keywords: radiobiology; radiotherapy; radiosensitizing agents; radioresistance; DNA damage; FLASH radiotherapy; particle therapy

(This special issue belongs to the Section Molecular Biology)

Cardiovascular Effects of Newer Glucose-Lowering Therapies: Molecular Mechanisms and Therapeutic Targets

edited by

Paschalis Karakasis

and

Dimitrios Patoulias

submission deadline 30 Oct 2025 | 1 articles | Viewed by 739 | Submission Open

Keywords: sodium-glucose cotransporter 2 (SGLT2) inhibitors; glucagon-like peptide-1 receptor agonists (GLP-1RAs); dual incretin receptor; cardiovascular protection; vascular signaling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Biology of Extremophiles: Recent Advances

edited by

Paulina Corral

submission deadline 30 Oct 2025 | 1 articles | Viewed by 689 | Submission Open

Keywords: extremophiles; multi-omics approaches; secondary metabolites; bioactive compounds; genome mining; phylogeny and evolution; bioprospecting

(This special issue belongs to the Section Molecular Biology)

Modern Chromatography: A Multi-Faceted Approach to the Analysis of Biological Samples

edited by Lucyna Konieczna

submission deadline 30 Oct 2025 | 1 articles | Viewed by 649 | Submission Open

Keywords: modern chromatography; biological sample analysis; biomarker discovery; sample preparation techniques; separation science; quantitative analysis; method validation; microextraction methods; analytical sensitivity

(This special issue belongs to the Section Biochemistry)

Deep Learning and Pathology: Innovative Applications in Cancer Diagnosis and Prognosis

edited by Nicolè Lorenzo

submission deadline 30 Oct 2025 | Viewed by 634 | Submission Open

Keywords: deep learning; pathology; digital pathology; tissue segmentation; cancer diagnosis; prognosis prediction; multi-dimensional analysis

(This special issue belongs to the Section Molecular Informatics)

Focus on Metabolic Research Priorities in PCOS

edited by

Jim Parker

submission deadline 30 Oct 2025 | 1 articles | Viewed by 608 | Submission Open

Keywords: polycystic ovary syndrome; metabolism; insulin resistance; inflammation; hyperandrogenism

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Effects of Chemicals on Brain Health and Development

edited by

Noriyuki Koibuchi

submission deadline 30 Oct 2025 | Viewed by 606 | Submission Open

Keywords: brain development; environmental chemicals; prescribed medicines; addictive drugs; neuronal plasticity; behavior; learning and memory; neurogenesis; cell death (apoptosis and necrosis)

(This special issue belongs to the Section Molecular Neurobiology)

Lipids and Vitamins in Health and Disease

edited by

Elisabetta Albi

and Paola Signorelli

submission deadline 30 Oct 2025 | Viewed by 487 | Submission Open

Keywords: lipid; vitamin; metabolism; diet; nutrition

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Leukemia: Molecular Immune Mechanisms

edited by

Mohammad Hojjat-Farsangi

submission deadline 30 Oct 2025 | Viewed by 414 | Submission Open

Keywords: leukemia; immune system; Genetic Mutations and Alterations; Immune Evasion Mechanisms; Immune Cell Dysfunction; Cytokine Networks; Bone Marrow Microenvironment; immunotherapy strategies

(This special issue belongs to the Section Molecular Immunology)

Bioinspired and Biobased Materials

edited by

Malgorzata Holynska

submission deadline 30 Oct 2025 | Viewed by 411 | Submission Open

Keywords: bioinspired materials; biobased materials; bionic materials; materials design and synthesis

(This special issue belongs to the Section Materials Science)

Molecular Links Between Oral Disease and Diabetes

edited by

Manuel Marques Ferreira

submission deadline 30 Oct 2025 | Viewed by 359 | Submission Open

Keywords: apical periodontitis; diabetes mellitus; oral health

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Impact of Environmental Factors on Male Reproductive Development and Disorders

edited by

Gennaro Lettieri

submission deadline 30 Oct 2025 | Viewed by 354 | Submission Open

Keywords: spermatozoa; DNA; protamine; male reproductive health; pollution; endocrine disruption; heavy metals

(This special issue belongs to the Section Molecular Biology)

Antimicrobial Effects and Immunological Mechanisms of Natural Products

edited by Cassio Almeida-da-Silva and Jan Martel

submission deadline 30 Oct 2025 | Viewed by 328 | Submission Open

Keywords: natural products; antimicrobial; immunology; treatment; microbiology

(This special issue belongs to the Section Molecular Microbiology)

Biomedical Polymer Materials: Design, Synthesis or Applications

edited by Lourdes Franco

submission deadline 30 Oct 2025 | Viewed by 314 | Submission Open

Keywords: biomedical polymeric materials; nanoparticles; drug delivery; smart materials; hydrogels; tissue regeneration; therapeutic applications; dendrimers; MOFs; micelles

(This special issue belongs to the Section Materials Science)

Molecular Research for Cancer Immunotherapy

edited by Mariana Malvicini

submission deadline 30 Oct 2025 | Viewed by 281 | Submission Open

Keywords: cancer immunotherapy; tumor immune microenvironment; tumor immune evasion; adoptive cell therapies; immune checkpoint inhibitors; neoantigen-based vaccines; chemoimmunoresistance; primary immunoresistance; adaptive immunoresistance; tumor associated-macrophages; tumor-immune crosstalk

(This special issue belongs to the Section Molecular Oncology)

Cellular and Molecular Mechanisms in Inflammatory Bowel Disease

edited by Michael Bording-Jorgensen

submission deadline 30 Oct 2025 | Viewed by 251 | Submission Open

Keywords: IBD; cytokines; microbiome; Crohn’ s disease; ulcerative colitis; dysbiosis; mucosal immunity

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Non-Conventional and Complementary Treatments for Inflammatory Bowel Disease

edited by Roberta Ottria and

Giovanni Maconi

submission deadline 30 Oct 2025 | Viewed by 240 | Submission Open

Keywords: inflammatory bowel disease; leaky gut; molecular mechanisms; inflammatory pathways; small molecules in inflammatory bowel disease; non-conventional treatment; complementary medicine; inflammatory cytokines

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Cellular Targets on Anticancer Research and Perspectives

edited by

Apostolos E. Papalois

submission deadline 30 Oct 2025 | Viewed by 229 | Submission Open

Keywords: anticancer; molecular targets; targeted cancer therapies; malignancy

(This special issue belongs to the Section Molecular Oncology)

Liver Diseases: Causes, Molecular Mechanism and Treatment/Prevention

edited by

Munish Puri

submission deadline 30 Oct 2025 | Viewed by 195 | Submission Open

Keywords: liver diseases; pathophysiology; molecular mechanisms; genetics and epigenetics; non-alcoholic fatty liver disease (NAFLD); hepatitis; liver injury and repair; gene therapy; pharmacological interventions; treatment and prevention; gut– liver axis; spleen– liver axis; alcoholic liver disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Compounds in Cancers: Second Edition

edited by

Patrícia M. A. Silva

Hassan Bousbaa

and

Honorina Cidade

submission deadline 30 Oct 2025 | Viewed by 162 | Submission Open

Keywords: anticancer strategies; bioactive compounds; natural products; synthetic products; medicinal chemistry; drug repurposing; drug delivery systems

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Enzymes Involved in Amino Acid Metabolism: Molecular Structure and Function

edited by

Barbara Cellini

and Mirco Dindo

submission deadline 30 Oct 2025 | Viewed by 153 | Submission Open

Keywords: amino acids; enzyme; human disease; protein engineering; protein dynamics

(This special issue belongs to the Section Molecular Biology)

Molecular Basis and Treatment of Skin Diseases and Their Associated Complications (2nd Edition)

edited by

Maria Maisto

and

Vincenzo Piccolo

submission deadline 30 Oct 2025 | Viewed by 137 | Submission Open

Keywords: diagnosis; biomarkers; imaging; histopathology; cutaneous comorbidities complication; therapy; management; clinical Trials

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Dementia with Lewy Bodies and Alzheimer’s Disease

edited by

Kurt A. Jellinger

submission deadline 30 Oct 2025 | Viewed by 130 | Submission Open

Keywords: dementia with Lewy bodies; Alzheimer’ s disease; dementing disorders in advanced age

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Synthesis and Application of Natural and Inspired-Natural Products

edited by Mauro de Nisco

submission deadline 30 Oct 2025 | Viewed by 119 | Submission Open

Keywords: natural products; natural substances; derivative; synthesis; application

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recent Progress in Hypertension Research

edited by

Massimo Volpe

submission deadline 30 Oct 2025 | Viewed by 118 | Submission Open

Keywords: hypertension; organ damage; biomarker; genetics diagnosis; renin– angiotensin– aldosterone system; natriuretic peptides; hypertension therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Antimicrobial and Antiviral Peptides: 2nd Edition

edited by

Tecla Ciociola

submission deadline 30 Oct 2025 | Viewed by 110 | Submission Open

Keywords: antimicrobial peptides; antiviral peptides; peptide mining; molecular mechanism of biological activity; structure– activity relationship; molecular targets; in silico design; in vivo models; peptide delivery strategies; biomedical applications

(This special issue belongs to the Section Biochemistry)

Displaying special issue 1401-1450 on page 29 of 69.

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