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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Calcium Signaling: Physiological Roles and Implications for Disease

edited by

Adán Dagnino-Acosta

and

Luis Castro-Sánchez

submission deadline 31 Aug 2026 | Viewed by 276 | Submission Open

Keywords: calcium signaling; intracellular calcium; calcium homeostasis; calcium channels; muscle physiology; signal transduction; calcium-related diseases; mitochondrial calcium; genetic control of calcium signaling

(This special issue belongs to the Section Molecular Biology)

Immune Responses as the Central Determinant of Gene Therapy Outcomes

edited by

Manoj Pandey

submission deadline 31 Aug 2026 | Viewed by 275 | Submission Open

Keywords: innate and adaptive immune sensing; TLR signaling; complement activation; antigen presentation; T‑cell cytotoxicity; humoral immunity (IgG, IgM, IgA); pediatric immunology; rare disease; lysosomal storage disease; neuroinflammation; immunomodulatory therapies; complement inhibitors

(This special issue belongs to the Section Molecular Immunology)

Chimeric Antigen Receptors Against Cancers and Autoimmune Diseases: 2nd Edition

edited by

Niels Schaft

submission deadline 31 Aug 2026 | Viewed by 273 | Submission Open

Keywords: chimeric antigen receptor (CAR); cancer; autoimmune disease; solid tumor; effector cell; CAR format; CAR transfer; tumor microenvironment; targeted antigen

(This special issue belongs to the Section Molecular Immunology)

DNA Damage and Repair Mechanisms in Cancer Development

edited by

Mengfan Tang

submission deadline 31 Aug 2026 | Viewed by 271 | Submission Open

Keywords: DNA damage response and repair; DNA replication; genome instability; drug resistance; targeted therapy; cellular senescence; innate immunity; nucleic acid homeostasis

(This special issue belongs to the Section Molecular Oncology)

Emerging Biomarkers in Airway Diseases: From Epigenetic Regulation to Cellular Stress Pathways

edited by

Giusy Daniela Albano

submission deadline 31 Aug 2026 | Viewed by 270 | Submission Open

Keywords: airway diseases; asthma; chronic obstructive pulmonary disease; chronic rhinosinusitis; virus-associated airway disorders

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Schwannomas: So-Called Benign Nervous System Tumors

edited by Sheila Mansouri

submission deadline 31 Aug 2026 | Viewed by 268 | Submission Open

Keywords: schwannoma; omics technology; liquid biopsy; tumour imaging; artificial intelligence; cell biology; tumour microenvironment; model organisms; organoids

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms and Advanced Diagnostic Technologies in Hair Disorders

edited by Maria Fernanda Reis Gavazzoni-Dias

submission deadline 31 Aug 2026 | Viewed by 265 | Submission Open

Keywords: inflammatory hair disorders; scarring and non-scarring alopecias; trichoscopy and scalp pathology; immunologic mechanisms in hair loss

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Oral and Esophageal Disorders: Molecular Induction/Promotion, Treatment, and Prevention

edited by

Takanobu Takata

submission deadline 31 Aug 2026 | Viewed by 262 | Submission Open

Keywords: oral disorders; esophageal disorders; stomatitis; esophagitis; lifestyle-related diseases; advanced glycation-end products; modern European medicines; traditional medicines

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Research on Host–Oral Bacteria Interactions in Periodontal Pathogenesis

edited by

Ana María Fernández Presas

submission deadline 31 Aug 2026 | Viewed by 258 | Submission Open

Keywords: periodontitis; Porphyromonas gingivalis; biofilms; cytokines; dysbiosis; quorum sensing; gingipains; alveolar bone therapeutics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Neuropharmacology: From Molecular Design to Preclinical Models

edited by

Jana Tchekalarova

and Miroslav A. Rangelov

submission deadline 31 Aug 2026 | Viewed by 258 | Submission Open

Keywords: neuropharmacology; drug discovery; molecular modeling; preclinical models

(This special issue belongs to the Section Molecular Neurobiology)

Antibiotic Resistance: Recent Developments and Future Prospects

edited by

Awais Ghaffar

submission deadline 31 Aug 2026 | Viewed by 255 | Submission Open

Keywords: antimicrobial resistance detection; microbial ecology; shotgun metagenomics; genome-resolved metagenomics; microbiome analysis; resistome characterization; One Health

(This special issue belongs to the Section Molecular Pharmacology)

Impact of Maternal Diet and Nutrition on Infant Neurodevelopment

edited by

Ana Sofia Vallés

submission deadline 31 Aug 2026 | Viewed by 253 | Submission Open

Keywords: nutrition; neurodevelopment; molecular mechanisms; epigenetics; neuroinflammation; metabolic programming; brain development; developmental origins of health and disease; pregnancy; maternal diet

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Research on Genomics of Crop Stress Tolerance

edited by

Xi Zhu

submission deadline 31 Aug 2026 | Viewed by 252 | Submission Open

Keywords: crop stress tolerance; genomic research; molecular mechanisms; multi-omics approaches; epigenetic modifications

(This special issue belongs to the Section Molecular Genetics and Genomics)

Gut Microbiota and Host Immune Interactions in Inflammatory Diseases

edited by

Tomomi Kuwahara

submission deadline 31 Aug 2026 | Viewed by 248 | Submission Open

Keywords: gut microbiota; host–microbe interactions; innate and adaptive immunity; microbial metabolites; short-chain fatty acids; intestinal dysbiosis; inflammatory bowel disease (IBD); metabolic syndrome; autoimmune diseases; gut–organ axis; microbiome-targeted therapies

(This special issue belongs to the Section Molecular Microbiology)

Advances in Starch-Based Composite Systems

edited by

Angel H. Cabrera-Ramirez

submission deadline 31 Aug 2026 | Viewed by 246 | Submission Open

Keywords: starch-based composites; biopolymer materials; hydrogels and aerogels; controlled release systems; biodegradable packaging; nanocomposites; structure–property relationships; functional biomaterials; pharmaceutical excipients; sustainable materials

(This special issue belongs to the Section Macromolecules)

Research in Cannabinoid Therapeutics: Novel Insights and Products

edited by

Daniela Sedan

and Dario Andrinolo

submission deadline 31 Aug 2026 | Viewed by 243 | Submission Open

Keywords: cannabinoids; acidic cannabinoids; entourage effect; full spectrum; endocannabinoid system; endocannabinoidome; endocannabinoids; endocannabinoid-like compounds; cannabis derivatives; endocannabinoidome receptors

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms of Protein Inhibition and Metabolism

edited by Song Wang

submission deadline 31 Aug 2026 | Viewed by 242 | Submission Open

Keywords: protein inhibition; metabolism; computational chemistry; molecular modeling; therapeutic targets

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Research in Bamboo, Tree, Grass, and Other Forest Products—2nd Edition

edited by

Huayu Sun

submission deadline 31 Aug 2026 | Viewed by 236 | Submission Open

Keywords: bamboo; tree; grass; molecular biology; gene function

(This special issue belongs to the Section Molecular Plant Sciences)

Tissue Regeneration Mechanisms and Applications in Degenerative and Inflammatory Diseases

edited by

Daiva Bironaite

submission deadline 31 Aug 2026 | Viewed by 233 | Submission Open

Keywords: regenerative medicine; stem cells; inflammation; degenerative disease models; extracellular matrix remodeling and intracellular signaling; tissue engineering; biomaterials and bioactive scaffolds; organoids; translational and cell-based therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Computational Strategies for Antiviral Drug Discovery: QSAR, In Silico Modeling and Data-Driven Approaches

edited by

Mohammed Salah

submission deadline 31 Aug 2026 | Viewed by 230 | Submission Open

Keywords: antiviral drug discovery; viral diseases; computational drug design; in silico modeling; quantitative structure–activity relationship (QSAR); molecular modeling; molecular dynamics simulations; virtual screening; machine learning in drug discovery; bioactive compounds; computer-aided drug design (CADD)

(This special issue belongs to the Section Molecular Informatics)

Bacteriophages in the One Health Perspective: From Infection Therapy to Precision Medicine Through Diagnostics

edited by

Alicja Wegrzyn

submission deadline 31 Aug 2026 | Viewed by 230 | Submission Open

Keywords: bacteriophages; one health concept; bacteriophage therapy

(This special issue belongs to the Section Molecular Microbiology)

Recent Advances in Cancer Immunotherapy Research

edited by

Luigi Pasini

submission deadline 31 Aug 2026 | Viewed by 229 | Submission Open

Keywords: immunotherapy; CAR T-Cell therapy; mRNA cancer vaccines; ICIs; TIL therapy; nanotechnology; antibody discovery; drug discovery; tumor microenvironment; microbiome modulation; metabolic reprogramming

(This special issue belongs to the Section Molecular Oncology)

Advances in Structural, Dynamic, and Functional Biophysics of Membrane Proteins

edited by

F. Luis González Flecha

submission deadline 31 Aug 2026 | Viewed by 229 | Submission Open

Keywords: cryo-EM; x-ray crystallography and scattering; NMR spectroscopy; neutron scattering and reflectometry; single-molecule biophysics; molecular dynamics simulations; membrane protein dynamics; free energy analysis; mechanistic models of transport and signaling; membrane mimetics (nanodiscs, SMALPs, etc)

(This special issue belongs to the Section Molecular Biophysics)

Obesity and Its Associated Diseases: Molecular and Metabolic Pathways

edited by Verónica J. Miksztowicz

submission deadline 31 Aug 2026 | Viewed by 228 | Submission Open

Keywords: obesity; dietary patterns; metabolic pathways; adipose tissue dysfunction; chronic low-grade inflammation; insulin resistance; mitochondrial dysfunction; oxidative stress; adipokine signaling; inter-organ crosstalk

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Exhaustive Chase: Investigation of Striated Muscle Regulation in Health and Disease

edited by P. Bryant Chase,

Maicon Landim-Vieira

and Michael Butcher

submission deadline 31 Aug 2026 | Viewed by 225 | Submission Open

Keywords: striated muscle contractility; thin filament regulation; calcium activation; cardiomyopathy; muscle energetics; muscle fiber mechanics; single fiber mechanics; muscle plasticity; muscle functional adaptation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Contemporary Advancement in Personalized Medicine in Urological Cancers

edited by

Elenko Popov

submission deadline 31 Aug 2026 | Viewed by 223 | Submission Open

Keywords: urological cancers; prostate cancer; bladder cancer; renal/kidney cancer; personalized medicine

(This special issue belongs to the Section Molecular Oncology)

Kidney Transplantation: Current Framework and New Perspectives

edited by Alberto Rosati

submission deadline 31 Aug 2026 | Viewed by 219 | Submission Open

Keywords: renal transplantation; organ donation; living donation; transplant survival; organ preservation; healthcare costs; acute and chronic rejection; immune tolerance; xenotransplantation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Nanocarrier-Based Drug Delivery Systems: Design, Synthesis and Therapeutic Applications

edited by

Stefania Crispi

and

Carla Serri

submission deadline 31 Aug 2026 | Viewed by 218 | Submission Open

Keywords: nanoparticles; nanomedicine; nanotoxicology; cytotoxicity; oxidative stress; cancer; neurodegenerative disorders; inflammation

(This special issue belongs to the Section Molecular Nanoscience)

Forward in Vasculitis: Genetics and Beyond, 2nd Edition

edited by

Marija Jelusic

submission deadline 31 Aug 2026 | Viewed by 216 | Submission Open

Keywords: systemic vasculitides; ethiopathogenesis; risk factors; genetics; genomics; proteomics; transcriptomics; epigenetics; molecular pathways; novel therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Studies of Endothelial Dysfunction

edited by Alexandru Emil Caraba

submission deadline 31 Aug 2026 | Viewed by 214 | Submission Open

Keywords: atherosclerosis; cardiovascular diseases; chronic kidney disease; endothelial dysfunction; inflammation; inflammatory rheumatic diseases; metabolic syndrome; nailfold capillaroscopy; nitric oxide

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Emerging Role of Heterogeneous Catalysis in Materials Science and Application

edited by Alejandro Pérez Larios and

Carlos Soto Robles

submission deadline 31 Aug 2026 | Viewed by 213 | Submission Open

Keywords: heterogeneous photocatalysis; photocatalytic materials; structure–property relationships; catalyst design; surface and interface engineering; operando characterization; charge transfer dynamics; sustainable photocatalysis; CO2 photoconversion; environmental photocatalysis

(This special issue belongs to the Section Materials Science)

DNA Damage, Immune Signaling and Beyond

edited by

Sharbel Weidner Maluf

submission deadline 31 Aug 2026 | Viewed by 212 | Submission Open

Keywords: DNA damage response; immune signaling; genomic instability; cellular senescence; chronic inflammation; cancer and aging

(This special issue belongs to the Section Molecular Immunology)

Bringing New Molecular Insights into Neurodegenerative Diseases

edited by

Daniela Vecchio

submission deadline 31 Aug 2026 | Viewed by 211 | Submission Open

Keywords: neurodegeneration; pathogenic mechanisms; biomarkers; neuroimaging; artificial intelligence; protein aggregation; neuroinflammation; genetics and epigenetics; multi-omics; therapeutic targets

(This special issue belongs to the Section Molecular Neurobiology)

Mycobacterial Infections: Redox Modulation, Cytokine Reprogramming, and Host-Directed Therapy

edited by

Vishwanath Venketaraman

submission deadline 31 Aug 2026 | Viewed by 211 | Submission Open

Keywords: TB; NTM; redox imbalance; cytokine reprogramming; host-directed thera

(This special issue belongs to the Section Molecular Microbiology)

Current Advances and Challenges in Nanomedicine Delivery Systems

edited by

Shiyan Dong

submission deadline 31 Aug 2026 | Viewed by 210 | Submission Open

Keywords: nanomedicine; drug delivery; gene delivery; mRNA delivery; lipid nanoparticles (LNPs); liposomes; extracellular vesicles; biomimetic nanocarriers; targeted delivery; translational nanomedicine

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Determinants of Response and Resistance in Cancer Immunotherapy

edited by

Pamela Salman

submission deadline 31 Aug 2026 | Viewed by 210 | Submission Open

Keywords: immune checkpoint inhibitors; adoptive cell therapies; cancer vaccines; tumor microenvironment remodeling; neoantigen dynamics; biomarker discovery; translational approaches to overcome therapeutic resistance

(This special issue belongs to the Section Molecular Oncology)

Cytokine Signaling in the Bone Marrow Niche: Implications for Hematopoiesis in Health and Disease

edited by

Melinda Varney

submission deadline 31 Aug 2026 | Viewed by 210 | Submission Open

Keywords: bone marrow niche; bone marrow cytokine signaling; hematopoiesis; hematopoietic stem cells; microenvironmental regulation; inflammatory signaling; hematologic disease

(This special issue belongs to the Section Molecular Immunology)

Molecular Regulation of Cancer Stem Cells: Signaling Networks, Metabolism, and Therapeutic Targeting

edited by Shanchun Guo

submission deadline 31 Aug 2026 | Viewed by 209 | Submission Open

Keywords: glioma; cancer stem cell; drug design; small molecular; diagnosis; prognosis; pathology

(This special issue belongs to the Section Molecular Oncology)

Molecular Toxicity and Therapeutic Potential of Hymenoptera Venoms

edited by

Xesús Feás

submission deadline 31 Aug 2026 | Viewed by 207 | Submission Open

Keywords: hymenoptera venom; molecular toxicology; allergenicity; venom peptides; therapeutic applications; drug discovery; envenomation; bioactive compounds

(This special issue belongs to the Section Molecular Toxicology)

Transition Metal Complexes: Recent Advances and Future Perspectives

edited by

Leszek Pazderski

submission deadline 31 Aug 2026 | Viewed by 204 | Submission Open

Keywords: transition metal complexes; crystal and molecular structure; spectroscopic properties; magnetic properties; biological activity; pharmacological application; catalysis

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Research in Nutritional Physiology and Gut Microbiome

edited by

Haiqiang Yao

submission deadline 31 Aug 2026 | Viewed by 200 | Submission Open

Keywords: nutritional physiology; gut microbiome; microbial metabolites; nutrient sensing; metabolic homeostasis; gut–brain axis; prebiotics; probiotics; molecular nutrition

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Histamine Receptors: Biology, Pharmacology, and Therapeutic Potential

edited by

Joachim Neumann

submission deadline 31 Aug 2026 | Viewed by 199 | Submission Open

Keywords: histamine; histamine receptor agonist; histamine receptor antagonist; signal transduction; polymorphisms

(This special issue belongs to the Section Molecular Biology)

Multi-Omics Perspectives on Psychiatric Disorders: From Molecular Mechanisms to Clinical Translation

edited by Veronica Sfredel and Madalina Iuliana Mușat

submission deadline 31 Aug 2026 | Viewed by 199 | Submission Open

Keywords: molecular psychiatry; psychiatric multi-omics; neurobiological pathways; psychiatric biomarkers; gene–environment interactions; translational psychiatry; computational psychiatry

(This special issue belongs to the Section Molecular Neurobiology)

Innovative Advances in Cancer Therapy Through Nano-Based Systems

edited by

Lenuţa-Maria Şuta

and

Claudia Geanina Watz

submission deadline 31 Aug 2026 | Viewed by 198 | Submission Open

Keywords: nano-enabled delivery systems; innovative nanomaterials; smart nanocarriers; cancer nanotherapy; anti-tumorigenic activity

(This special issue belongs to the Section Molecular Nanoscience)

Photoreceptors and the Optic Nerve

edited by Ruth Estela Rosenstein and Damian Dorfman

submission deadline 31 Aug 2026 | Viewed by 194 | Submission Open

Keywords: photoreceptors; optic nerve; neurodegeneration; neuroprotection; experimental models; retina

(This special issue belongs to the Section Molecular Neurobiology)

Recent Advances in Pathophysiology and Immunology Related to Lung Cancer

edited by

Vito D’Agnano

and Luigi Della Gravara

submission deadline 31 Aug 2026 | Viewed by 191 | Submission Open

Keywords: lung cancer; NSCLC; SCLC; tumor immunology; immune checkpoints inhibitors; targeted therapy; epithelial–immune crosstalk; precision oncology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Design, Synthesis and Evaluation of Anticancer Agents

edited by

Gourav Kumar

submission deadline 31 Aug 2026 | Viewed by 191 | Submission Open

Keywords: anticancer drug design; structure–activity relationship (SAR); molecular targets in cancer; synthetic antitumor agents; in vitro and ex vivo cancer models; molecular pharmacology

(This special issue belongs to the Section Molecular Pharmacology)

Advances in Allergen Prediction, Characterization, and Immunoinformatics

edited by

Katarina Smiljanić

submission deadline 31 Aug 2026 | Viewed by 187 | Submission Open

Keywords: allergen prediction; allergen characterization; proteomics; immunoinformatics; environmental allergens; food allergens; IgE epitopes; molecular docking; machine learning; mass spectrometry

(This special issue belongs to the Section Molecular Immunology)

The Effect of Vitamin D on COVID-19 Infection and Progression: An Update

edited by Fábio Falcao

submission deadline 31 Aug 2026 | Viewed by 186 | Submission Open

Keywords: vitamin D; COVID-19; SARS-CoV-2; long COVID; immune regulation; inflammation; nutritional inequality; global health; supplementation; precision medicine

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Research on Insect-Symbiont Interactions

edited by Chen Luo

submission deadline 31 Aug 2026 | Viewed by 184 | Submission Open

Keywords: insect; endosymbiont; phenotypic effects; molecular mechanisms; immunity; resistance

(This special issue belongs to the Section Molecular Plant Sciences)

Displaying special issue 801-850 on page 17 of 66.

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