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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Fluorescence Techniques for Exploring Protein Oligomerization
edited by
submission deadline 20 Sep 2025 | Viewed by 375 | Submission Open
Keywords: protein oligomerization; Fö rster Resonance Energy Transfer (FRET); quantifying protein interactions; single molecule fluorescence; super-resolution microscopy; fluorescence fluctuation spectroscopy
(This special issue belongs to the Section Biochemistry)
Mitochondrial Energy Metabolism in Cells and Tissues
edited by
submission deadline 20 Sep 2025 | Viewed by 375 | Submission Open
Keywords: mitochondria; mitophagy; mitochondrial biogenesis; mitochondrial dynamics; fusion; fission; energy metabolism
(This special issue belongs to the Section Molecular Biology)
Molecular Diagnostic and Therapeutic Advances of Type 2 Diabetes and Obesity submission deadline 20 Sep 2025 | Viewed by 371 | Submission Open
Keywords: type 2 diabetes; obesity; diabetes complications; cardiovascular disease; dyslipidemia; non-alcoholic fatty liver disease; metabolic syndrome; retinopathy; nephropathy; neuropathy; pharmacotherapy; insulin resistance
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Defects of Naturally Occurring Mutations
edited by Ya-Xiong Tao
submission deadline 20 Sep 2025 | Viewed by 363 | Submission Open
Keywords: protein misfolding; loss of function; gain of function; pharmacological chaperone; precision medicine
(This special issue belongs to the Section Molecular Genetics and Genomics)
The Future of Drug Discovery and Development, 2nd Edition submission deadline 20 Sep 2025 | Viewed by 359 | Submission Open
Keywords: drug discovery; drug development; biotechnology; target identification; target validation; regulatory affairs; regulatory sciences; drug commercialization; pharmaceutical market access; drug screening; novel nonclinical models/approaches; advanced manufacturing; continuous manufacturing; process analytical technology; adaptive clinical trials; in silico laboratory and clinical development; rolling submissions; accelerated approvals; real-world evidence
(This special issue belongs to the Section Molecular Pharmacology)
Complex Interactions of Plants with Other Organisms: Particular Attention to Carnivorous and Parasitic Plants
edited by
submission deadline 20 Sep 2025 | Viewed by 358 | Submission Open
Keywords: carnivorous plants; parasitic plants; mycotrophic plants; hosts; phytochemistry; molecular biology; genome evolution; organ structure; cellular; genomic
(This special issue belongs to the Section Molecular Plant Sciences)
Prostate Cancer: Molecular Biology, Prognostication and Treatment Approaches
edited by and Gianluigi Taverna
submission deadline 20 Sep 2025 | Viewed by 350 | Submission Open
Keywords: prostate cancer; molecular mechanisms; diagnosis; risk-stratification; genomics; molecular biology; modelling; therapy; microenvironment; immuno-oncology; bioinformatics; imaging; spatial genomics; spatial transcriptomic; tumor complexity; biomarkers
(This special issue belongs to the Section Molecular Oncology)
Research on the Mechanism of Ferroptosis
edited by and
submission deadline 20 Sep 2025 | Viewed by 349 | Submission Open
Keywords: ferroptosis; programmed cell death; targeted drugs; therapeutic targets
(This special issue belongs to the Section Molecular Biology)
Research and Recent Advances of Antimicrobials
edited by
submission deadline 20 Sep 2025 | Viewed by 343 | Submission Open
Keywords: antibiotic; antibacterial; antifungal; antiviral; chemical synthesis; drug discovery; natural products; small molecules; peptides; proteins; oligosaccharides; polysaccharides; drug delivery; nanoparticles; solutions; gels; formulation; nanoparticles; materials; coat-ings; drug release; structure– activity; mechanism of action; clinical application; veterinary applications; agricultural applications; food preservation
(This special issue belongs to the Section Molecular Pharmacology)
Materials for Photobiology—3rd Edition submission deadline 20 Sep 2025 | Viewed by 343 | Submission Open
Keywords: light-responsive materials; phototherapeutics; photodiagnosis; bioimaging; living bioluminescent materials; light-induced therapy; UV-radiation effect; photo-antinfective materials; photosensory biology; molecular optogenetics
(This special issue belongs to the Section Materials Science)
Molecular Basis and Latest Therapeutic Strategies for Genetic Diseases in Children
edited by and Chiara Leoni
submission deadline 20 Sep 2025 | Viewed by 341 | Submission Open
Keywords: rare diseases; genetic disease; gene therapy; drug development; drug repurposing
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Innovative Approaches to Enhancing Bioavailability and Bioaccessibility of Bioactive Compounds from Plant and Food Extracts
edited by
submission deadline 20 Sep 2025 | Viewed by 333 | Submission Open
Keywords: bioactive compounds; nutraceuticals; functional foods; in vitro and in vivo models; bioavailability; bioaccessibility; nanotechnology; delivery systems; molecular mechanisms; proteomics; genomics; metabolomics
(This special issue belongs to the Section Bioactives and Nutraceuticals)
The Impact and Alterations of Hormones in Age-Related Diseases and Comorbidities
edited by
submission deadline 20 Sep 2025 | Viewed by 321 | Submission Open
Keywords: aging; age-related complications; comorbidities; aging and hormones; immunosenescence; impact of hormones in physiology and pathophysiology; immunocompromised conditions; neurodegenerative disorders; bodily homeostasis; healthy aging
(This special issue belongs to the Section Molecular Neurobiology)
Environmental Contributors to Oxidative Stress: Mechanisms and Effects
edited by Halina Tkaczenko and
submission deadline 20 Sep 2025 | Viewed by 320 | Submission Open
Keywords: oxidative stress; environmental pollution; climate change; antioxidants; biological effects; toxicology; health risks; reactive oxygen species (ROS); public health; mitigation strategies; cellular damage in human and animal disorders; environmental stressors in human and animal health
(This special issue belongs to the Section Molecular Biology)
Molecular and Genomics Advances in Behaviours
edited by
submission deadline 20 Sep 2025 | Viewed by 318 | Submission Open
Keywords: unhealthy and healthy behaviors; smoking; sleeping; eating; alcoholism; gambling; aggression; addictive behaviors; physical activity; mental disorders
(This special issue belongs to the Section Molecular Biology)
Thyroid Function in Human Diseases: From Physiopathology to Clinical Impact on Human Health
edited by and Andrea Corsello
submission deadline 20 Sep 2025 | Viewed by 318 | Submission Open
Keywords: thyroid physiology; hypothyroidism; hyperthyroidism; central hypothyroidism; inappropriate TSH secretion syndrome; drugs interfering with thyroid function; sick euthyroid syndrome; consumptive hypothyroidism syndrome
(This special issue belongs to the Section Molecular Biology)
New Insights into Molecular Mechanisms of Chronic Kidney Disease submission deadline 20 Sep 2025 | Viewed by 310 | Submission Open
Keywords: chronic kidney disease; molecular mechanism; signaling pathways; endothelial dysfunction; inflammation; genetic variants; epigenetics; oxidative stress
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Thyroid Cancer: From Pathophysiology to Novel Therapies
edited by Miklós Bodor
submission deadline 20 Sep 2025 | Viewed by 310 | Submission Open
Keywords: thyroid cancer; therapies; cell signaling; biomarker; kinase inhibitors
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Shaping Macrophages Polarization as an Emerging Therapeutic Approach submission deadline 20 Sep 2025 | Viewed by 304 | Submission Open
Keywords: macrophage polarization; M1 macrophages; M2 macrophages; immune modulation; small molecules; therapeutic strategies; inflammation; cancer immunotherapy; drug resistance
(This special issue belongs to the Section Molecular Immunology)
Microbial Mediators: The Bridge Between Soils, Plants, and Animal Infectious Diseases
edited by Wensheng Fang, and Bin Huang
submission deadline 20 Sep 2025 | Viewed by 296 | Submission Open
Keywords: micro-organisms; soil health; plant– microbe interactions; microbial regulation; agricultural ecosystems; animal infectious diseases; microbiome; microbiota
(This special issue belongs to the Section Molecular Microbiology)
Molecular Biology of Chagas Disease, Leishmaniasis, and West Nile Virus Vectors in the Old and New World submission deadline 20 Sep 2025 | Viewed by 293 | Submission Open
Keywords: triatominae; Trypanosoma cruzi; Leishmania; Culex; Lutzomya; phlebotomus; epidemiology; neglected; populations; vectors
(This special issue belongs to the Section Molecular Microbiology)
Transglutaminase 2 and Cellular Functions: 2nd Edition submission deadline 20 Sep 2025 | Viewed by 288 | Submission Open
Keywords: transglutaminase type 2; transglutaminase family; celiac disease; neurodegenerative diseases; multiple sclerosis; central nervous system injuries; TG2
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Effects of Exercise Training in the Prevention and Treatment of Cardiovascular Diseases
edited by
submission deadline 20 Sep 2025 | Viewed by 285 | Submission Open
Keywords: atherosclerosis; cardiovascular disease; exercise training; molecular mechanisms; training modalities
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms and Drug Treatment in Alzheimer’s Disease
edited by and Diego Dolcetta
submission deadline 20 Sep 2025 | Viewed by 284 | Submission Open
Keywords: Alzheimer’ s disease (AD); glia; immune system; neurotoxicity; inflammation; beta-Amyloid (bA); neurofibrillary tangles (NFTs)
(This special issue belongs to the Section Molecular Neurobiology)
Therapeutical Advances in Multiple Sclerosis
edited by Arturo Mangas and
submission deadline 20 Sep 2025 | Viewed by 279 | Submission Open
Keywords: multiple sclerosis; neurodegenerative disease; chronic disease; autoimmune disease; biological markers; new drugs
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Aspects of Environmental Pollutants on Soil Microbial
edited by Elżbieta Wołejko, Urszula Wydro and Agata Jabłońska-Trypuć
submission deadline 20 Sep 2025 | Viewed by 277 | Submission Open
Keywords: biomonitoring; soil contamination; molecular biology techniques; microbiological activity in soil; toxicological tests; bioindication; ecotoxicology; omics
(This special issue belongs to the Section Molecular Toxicology)
Attosecond Science: Toward Applications in Biology, Chemistry and Medicine
edited by
submission deadline 20 Sep 2025 | Viewed by 276 | Submission Open
Keywords: ultrafast light– matter interaction; high-harmonic generation; strong-field ionization; free-electron laser (FEL) ultrafast sources
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Discovery of Proteins Leading to New Asthma Treatments submission deadline 20 Sep 2025 | Viewed by 275 | Submission Open
Keywords: asthma; allergens; proteomic analysis; bioinformatics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advanced Molecular Research in Polymers and Organic Semiconductors
edited by Ovidio Amado Almanza
submission deadline 20 Sep 2025 | Viewed by 273 | Submission Open
Keywords: polymer; organic semiconductors; molecular design; molecular interactions; thermal properties; optical properties; biointerfaces; sustainable materials
(This special issue belongs to the Section Materials Science)
Advanced Molecular Research in Thromboinflammation
edited by Emanuele Valeriani
submission deadline 20 Sep 2025 | Viewed by 266 | Submission Open
Keywords: blood coagulation factors; blood platelets; endothelium; inflammation; thromboinflammation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Immune Regulation in Lung Diseases submission deadline 20 Sep 2025 | Viewed by 262 | Submission Open
Keywords: lung disease; immune system; lung immune cells; lung epithelial cells; therapy
(This special issue belongs to the Section Molecular Immunology)
Pathogenesis and Treatment of Prostate Cancer submission deadline 20 Sep 2025 | Viewed by 259 | Submission Open
Keywords: prostate cancer; pathogenesis; genetic mutations; target therapy; surgery; radiation therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Perspectives in Nanoadsorption
edited by Carmen María Del Hoyo Martinez
submission deadline 20 Sep 2025 | Viewed by 249 | Submission Open
Keywords: nanoadsorption; nanomaterials; molecular mechanism; emerging contaminants removal in pharmaceutical and food industries; X-ray diffraction (XRD); thermal analysis techniques (DSC); Fourier-transform infrared spectroscopy (FTIR); Raman spectroscopy; molecular functionalization in nanoadsorption
(This special issue belongs to the Section Materials Science)
Brain Cancers: Molecular Diagnostic and Therapeutic Approaches submission deadline 20 Sep 2025 | Viewed by 249 | Submission Open
Keywords: brain tumors; gliomas; meningiomas; pituitary tumors; molecular diagnosis; liquid biopsy; targeted therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
A New Era for Structures and Functions of Amyloid Fibrils in Neurodegenerative Diseases
edited by Masahiro Enomoto
submission deadline 20 Sep 2025 | Viewed by 245 | Submission Open
Keywords: neurodegenerative disease; structural mechanisms; super-resolution microscopy; cryo-electron microscopy (cryo-EM); cryo-electron tomography (cryo-ET)
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Insights into Pathogen Dynamics: Enhancing One Health Surveillance submission deadline 20 Sep 2025 | Viewed by 235 | Submission Open
Keywords: pathogens; pathogen dynamics; infectious diseases; molecular omics; wet lab experiments; phenotypic analyses; bacterial; viral; fungal; parasitic pathogens; zoonotic diseases; vector-borne Diseases; antimicrobial resistance; interplay between pathogens and hosts/environment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Mechanism of Cellular Signaling, Dysfunction, and Drug Effects on Alzheimer's Disease
edited by
submission deadline 20 Sep 2025 | Viewed by 234 | Submission Open
Keywords: AD; targeted therapy; Alzheimer's disease; neurodegenerative disease; tau protein
(This special issue belongs to the Section Molecular Neurobiology)
T Cells in Immune Diseases: Regulation and Function
edited by Chia-Rui Shen
submission deadline 20 Sep 2025 | Viewed by 231 | Submission Open
Keywords: T cell function; T cells in immune diseases; regulation and function
(This special issue belongs to the Section Molecular Immunology)
Molecular Advances in Research of Neuroendocrine Tumors
edited by Tania Amin
submission deadline 20 Sep 2025 | Viewed by 228 | Submission Open
Keywords: neuroendocrine tumors; drug resistance; personalized treatment; molecular subtypes
(This special issue belongs to the Section Molecular Neurobiology)
Research on Signal Transduction Mechanisms of Cancer Cells
edited by
submission deadline 20 Sep 2025 | Viewed by 217 | Submission Open
Keywords: signal transduction mechanisms; cancer cell invasion; cancer cell metastasis; tumorigenesis; cell proliferation
(This special issue belongs to the Section Molecular Oncology)
Exploring Molecular-Scale and Nano-Scale Materials: Design, Characterization and Application
edited by Xiaogang Li
submission deadline 20 Sep 2025 | Viewed by 216 | Submission Open
Keywords: molecular scale; nano scale; material design and preparation; characterization; regulation; application
(This special issue belongs to the Section Molecular Nanoscience)
Nanoparticle Systems for Cancer Phototherapy
edited by
submission deadline 20 Sep 2025 | Viewed by 213 | Submission Open
Keywords: nanoparticles; phototherapy; cancer; photodynamic therapy; photosensitiser molecules; biomolecules damage; DNA-intercalators; oxidative stress; cell/tissue specificity; drug delivery systems
(This special issue belongs to the Section Molecular Oncology)
New Insights into Ubiquitination and Deubiquitination in Plants
edited by
submission deadline 20 Sep 2025 | Viewed by 210 | Submission Open
Keywords: ubiquitin; E1; E2; E3; deubiquitination; proteolysis; plants
(This special issue belongs to the Section Biochemistry)
Functional Studies and Deep Phenotyping in Monogenic Forms of Diabetes, Severe Insulin Resistance and Hypoglycemia
edited by Fabrizio Barbetti
submission deadline 20 Sep 2025 | Viewed by 207 | Submission Open
Keywords: monogenic diabetes; neonatal diabetes mellitus; MODY; severe insulin resistance; insulin receptor; lipodystrophy; hyperinsulinemic hypoglycemia; ABCC8/KCNJ11 dominant forms of HH
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Research on the Regulation of Expression Associated with the Mechanism of Multidrug Resistance in Mycobacterium tuberculosis
edited by Maria Del Carmen Muñoz-Egea
submission deadline 20 Sep 2025 | Viewed by 203 | Submission Open
Keywords: multidrug resistance; MDR; XDR; Mycobacterium tuberculosis; molecular research; gene expression; genome sequencing
(This special issue belongs to the Section Molecular Microbiology)
Functional Proteomics: Insights from Biomedical Applications and Beyond
edited by
submission deadline 20 Sep 2025 | Viewed by 203 | Submission Open
Keywords: functional proteomics; drug discovery; biomedicine; biomarker identification; protein molecular functions; pathway investigation
(This special issue belongs to the Section Molecular Immunology)
From Plant Genomics Investigations to Plant Biotechnology Exploitation
edited by
submission deadline 20 Sep 2025 | Viewed by 169 | Submission Open
Keywords: sequencing; plant genomes; biotechnological applications; translational genomics; new discoveries
(This special issue belongs to the Section Molecular Plant Sciences)
Artificial Intelligence in Molecular Biomarker Screening
edited by
submission deadline 20 Sep 2025 | Viewed by 165 | Submission Open
Keywords: molecular biomarkers; imaging biomarkers; screening; artificial intelligence; metaverse
(This special issue belongs to the Section Molecular Informatics)
Forest Tree Genetics, Breeding and Environmental Adaption
edited by and
submission deadline 20 Sep 2025 | Viewed by 153 | Submission Open
Keywords: forest trees; genetic breeding; biotic stress; abiotic stress; tree physiology; gene regulation; genetic engineering
(This special issue belongs to the Section Molecular Plant Sciences)
Immunological Regulation as Determinant of Outcomes in Critically Sick Patients submission deadline 20 Sep 2025 | Viewed by 105 | Submission Open
Keywords: critical illness; outcome; immune system; inflammation; homeostasis; epigenetic; microbiome; central nervous system; dysregulation; recovery
(This special issue belongs to the Section Molecular Immunology)
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