Cytokine Signaling in the Bone Marrow Niche: Implications for Hematopoiesis in Health and Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Immunology".
Deadline for manuscript submissions: 31 August 2026 | Viewed by 124
Special Issue Editor
Special Issue Information
Dear Colleagues,
We are pleased to invite you to contribute to this Special Issue devoted to the bone marrow microenvironment and the impact of cytokine signaling in the regulation of hematopoiesis in health and disease. The bone marrow niche is a highly dynamic and complex system composed of hematopoietic and non-hematopoietic cells, extracellular matrix components, and soluble factors that collectively govern hematopoiesis, immune function, and tissue homeostasis. Among these regulatory elements, cytokines play a central role by orchestrating cellular communication, lineage commitment, stress responses, and inflammatory adaptation. Dysregulation of cytokine signaling within the bone marrow microenvironment has been implicated in aging, immune dysfunction, bone marrow failure syndromes, and hematologic malignancies, highlighting the critical importance of this research area. Drug discovery to mitigate cytokine dysregulation in the bone marrow offers promise in treating a variety of pathophysiological issues.
This Special Issue aims to provide a comprehensive and timely overview of emerging concepts, experimental advances, and translational insights related to cytokine-mediated regulation of the bone marrow microenvironment. By integrating mechanistic, systems-level, and disease-focused perspectives, this collection will align closely with the journal’s scope by advancing our understanding of cellular signaling, tissue microenvironments, and pathophysiological processes relevant to hematology, immunology, and regenerative medicine. The focus is designed to be sufficiently targeted to ensure coherence, while broad enough to capture diverse experimental approaches and disease contexts.
In this Special Issue, original research articles and reviews are welcome. Research areas may include, but are not limited to, the following:
- Cytokine signaling networks within the bone marrow niche;
- Regulation of hematopoietic stem and progenitor cells by cytokines;
- Crosstalk between stromal, immune, endothelial, and hematopoietic cells;
- Inflammatory, diet-induced, and/or stress-induced remodeling of the bone marrow microenvironment;
- Cytokine dysregulation in bone marrow failure, aging, and hematologic malignancies;
- Therapeutic targeting of cytokine pathways in the bone marrow niche;
- Emerging technologies and models to study bone marrow cytokine signaling in situ.
We look forward to receiving your contributions and to assembling a Special Issue that will stimulate discussion and advance the field.
Dr. Melinda Varney
Guest Editor
Manuscript Submission Information
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Keywords
- bone marrow niche
- bone marrow cytokine signaling
- hematopoiesis
- hematopoietic stem cells
- microenvironmental regulation
- inflammatory signaling
- hematologic disease
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