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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Regulatory Mechanisms in Kidney Development and Function

edited by Gary F. Gerlach

submission deadline 20 May 2026 | Viewed by 141 | Submission Open

Keywords: drosophila nephrocyte; zebrafish pronephros; mesonephros; murine nephrogenesis; slit diaphragm; podocytes; junctions; tubule; mesenchymal-to-epithelia transition (MET); epithelial-to-mesenchymal transition (EMT); tubule segmentation; transcription factors; signaling pathways; foot processes; cytoskeleton; brush boarder; intercalated cells; renin angiotensin; diabetic kidney disease; podocytopathies; FSGS; minimal change disease; IgAN

(This special issue belongs to the Section Molecular Biology)

Molecular Research and Cellular Biology of Breast Cancer: 2nd Edition

edited by

Andrea Nicolini

and

Cristian Scatena

submission deadline 20 May 2026 | 1 articles | Viewed by 133 | Submission Open

Keywords: molecular mechanisms of tumor growth and diffusion; cancer cell biology; biology of tumor micro-environmental cells; MDR; hormone dependency; HER2 positive breast cancer; TNBC; genetic and epigenetic alterations; pro-tumor and anti-tumor; immune responses; conventional and biological therapies; blood and tissue biomarkers

(This special issue belongs to the Section Molecular Oncology)

Molecular Evolution and Genetic Diversity in Viruses

edited by

Jennifer H. Lun

submission deadline 20 May 2026 | Viewed by 128 | Submission Open

Keywords: viral mutation; recombination reassortment; viral genomics; quasispecies dynamics; antiviral resistance; viral phylogenetics; zoonotic transmission; genomic surveillance

(This special issue belongs to the Section Molecular Microbiology)

Latest Research in Alzheimer’s Disease

edited by

Prashant R Bharadwaj

submission deadline 20 May 2026 | Viewed by 127 | Submission Open

Keywords: Alzheimer’ s disease; neurodegenerative disease; disease diagnosis; biomarker development; drug development; disease models

(This special issue belongs to the Section Molecular Neurobiology)

Immunity and Autoimmunity in Cardiovascular and Respiratory Diseases

edited by

Mizanur Rahman

submission deadline 20 May 2026 | Viewed by 123 | Submission Open

Keywords: cardiovascular diseases; respiratory diseases; autoimmune diseases; T cell; B cell; lipid mediators; autoantibodies; genetic variants; mucin

(This special issue belongs to the Section Molecular Immunology)

Molecular Insights in Renal and Epithelial Physiology

edited by Pedro A. Jose

submission deadline 20 May 2026 | Viewed by 105 | Submission Open

Keywords: renal and epithelial physiology; ion transport; glomerulo-tubular balance

(This special issue belongs to the Section Molecular Biology)

Innovative Nano- and Microcarrier Systems for Targeted Delivery

edited by

Matteo Perra

submission deadline 20 May 2026 | Viewed by 99 | Submission Open

Keywords: drug delivery systems; nanocarriers; microcarriers; targeted delivery; controlled release; bioactive compounds; nanomedicine

(This special issue belongs to the Section Molecular Nanoscience)

Artificial Intelligence and Data Science-Driven Biomarker Discovery in Neurodegenerative Diseases

edited by

Andrzej Kloczkowski

and

Mubashir Hassan

submission deadline 20 May 2026 | Viewed by 91 | Submission Open

Keywords: large language models; big data analytics; Alzheimer’ s disease; Parkinson disease; neurodegeneration; neurogenerative disease; disease diagnosis; biomarker development; drug development

(This special issue belongs to the Section Molecular Informatics)

Tissue Engineering and Advanced Biomaterials for Regenerative Medicine

edited by

Hak Soo Choi

Motoichi Kurisawa

and

Joo Eun Chung

submission deadline 20 May 2026 | Viewed by 84 | Submission Open

Keywords: tissue engineering; regenerative medicine; drug delivery; bioengineering; angiogenesis

(This special issue belongs to the Section Molecular Biology)

Plant Extracts and Their Biological Activities: In Vitro and In Vivo

edited by

Ângelo Luís

submission deadline 20 May 2026 | Viewed by 54 | Submission Open

Keywords: plant extracts; bioactive compounds; molecular mechanisms; in vitro and in vivo studies; biological activities

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Design, Synthesis, and Application of Functional Porous Materials

edited by Qinhe Pan,

Shenzhen Chang

and

Shi-Cheng Wang

submission deadline 20 May 2026 | Viewed by 54 | Submission Open

Keywords: porous materials; functional guest species; functionalization; luminescence; electrochemistry; stimulus response; adsorption; sensing; photoelectric; catalysis

(This special issue belongs to the Section Materials Science)

Epigenetic Mechanisms in Human Diseases: From Molecular Pathogenesis to Therapeutic Interventions

edited by Silvia Consalvi

submission deadline 20 May 2026 | Viewed by 48 | Submission Open

Keywords: epigenetics; DNA methylation; histone modifications; chromatin remodeling; non-coding RNAs; epigenomic profiling; epigenetic biomarkers; epigenetic therapy; epigenetic drugs; epigenome editing; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Smart and Sustainable Hydrogels for Environmental Applications

edited by Rolando Chamy

submission deadline 20 May 2026 | Viewed by 46 | Submission Open

Keywords: hydrogel; biomaterials; sustainable materials; regenerative medicine

(This special issue belongs to the Section Materials Science)

Ligament/Tendon and Cartilage Tissue Engineering and Reconstruction, 2nd Edition

edited by

Clemens Gögele

and

Gundula Schulze-Tanzil

submission deadline 20 May 2026 | Viewed by 42 | Submission Open

Keywords: cartilage; tendon; ligament; anterior cruciate ligament; bioprinting; scaffold; bioreactor; tissue engineering

(This special issue belongs to the Section Molecular Biology)

G Protein-Coupled Receptor Signaling and Regulation, 2nd Edition

edited by

Vsevolod V. Gurevich

submission deadline 20 May 2026 | Viewed by 38 | Submission Open

Keywords: GPCRs; signaling; trafficking; G proteins; arrestins; RGS proteins; GRKs

(This special issue belongs to the Section Biochemistry)

Enzyme Inhibitory Assessment and Molecular Docking Studies of Natural and Synthetic Heterocyclic Compounds

edited by Milen G. Bogdanov

submission deadline 20 May 2026 | Viewed by 34 | Submission Open

Keywords: heterocycles; enzyme inhibition; docking studies; drug discovery

(This special issue belongs to the Section Molecular Pharmacology)

Environmental Microorganisms and Pathogen Infections

edited by

Jadwiga Wyszkowska

and

Magdalena Zaborowska

submission deadline 20 May 2026 | Viewed by 33 | Submission Open

Keywords: environmental microbiome; pathogens; resistance genes; molecular adaptation; microbial interactions; anthropogenic pollution; functional gene expression; ecosystem health

(This special issue belongs to the Section Molecular Microbiology)

Nutrition of Crustaceans: A Molecular Perspective

edited by

Cheng Chi

submission deadline 25 May 2026 | Viewed by 128 | Submission Open

Keywords: crustacean nutrition; molecular mechanisms; aquaculture; nutrient metabolism; reproduction

(This special issue belongs to the Section Molecular Biology)

Cutting-Edge Research and Advancements in Neurodegenerative Diseases

edited by Meera Soundararajan

submission deadline 25 May 2026 | Viewed by 80 | Submission Open

Keywords: neurodegenerative disorders; neurons; Alzheimer’ s disease; Parkinsons disease; Amyotrophic Lateral Sclerosis (ALS); prion diseases; Huntington disease

(This special issue belongs to the Section Molecular Neurobiology)

DNA Damage and Repair Mechanisms in Cancer

edited by

Luigi Alfano

submission deadline 25 May 2026 | Viewed by 69 | Submission Open

Keywords: DNA damage response (DDR); genome instability ; synthethic lethality ; DNA repair

(This special issue belongs to the Section Molecular Oncology)

Cross-Kingdom Conversations: Deciphering Molecular Interactions in Microorganisms and Plants

edited by Eun-Hae Kwon

submission deadline 25 May 2026 | Viewed by 59 | Submission Open

Keywords: plant– microbe interactions; cross-kingdom signaling; plant growth-promoting microorganisms (PGPMs); molecular communication; synthetic microbial communities (SynComs)

(This special issue belongs to the Section Molecular Plant Sciences)

Radiofrequency on Human Health: A Molecular Perspective

edited by

Mariateresa Allocca

submission deadline 25 May 2026 | Viewed by 45 | Submission Open

Keywords: radiofrequency electromagnetic field; bioelectromagnetics; health effects; biological effects; molecular mechanisms; interaction mechanisms; electromagnetic risk assessment; biomedical application

(This special issue belongs to the Section Molecular Biophysics)

Molecular Mechanisms in Mucosal Immunity

edited by

Mónica Vermeulen

submission deadline 25 May 2026 | Viewed by 23 | Submission Open

Keywords: mucosal immunity; metabolism; innate memory; trainers and inflammatory stimuli

(This special issue belongs to the Section Molecular Immunology)

Biogenic and Bioinspired Nanomaterials: Sustainable Strategies for Biomedical Applications

edited by

Cláudia Botelho

submission deadline 25 May 2026 | Viewed by 19 | Submission Open

Keywords: biogenic nanomaterials; bioinspired materials; green synthesis; sustainable biomaterials; bio-medical applications; natural extracts; regenerative medicine

(This special issue belongs to the Section Molecular Nanoscience)

Virus Detection and Analysis: Molecular Investigations

edited by

Hayes Kam-Hei Luk

submission deadline 26 May 2026 | Viewed by 101 | Submission Open

Keywords: virus; molecular detection; nucleic acid amplification; molecular typing; next generation sequencing; metagenomics; point-of-care testing

(This special issue belongs to the Section Molecular Microbiology)

Novel Therapeutic Strategies Targeting Cancer Stem Cells

edited by Luciano Vellón

submission deadline 28 May 2026 | Viewed by 87 | Submission Open

Keywords: cancer stem cells; machine learning; deep learning; therapeutic response; molecular markers; cancer

(This special issue belongs to the Section Molecular Oncology)

Innovative Molecular Target and Therapeutic Approaches in Fatty Liver Disease

edited by

Consolato M. Sergi

submission deadline 30 May 2026 | 1 articles | Viewed by 5122 | Submission Open

Keywords: liver; fatty liver disease; steatosis; rectors; ARA; THR-Beta; IL-22; glucagon; CRISPR-Case9; randomized clinical trials

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Iron Metabolism, Ferritin and Hepcidin Research: 3rd Edition

edited by

Edina Pandur

submission deadline 30 May 2026 | 3 articles | Viewed by 5044 | Submission Open

Keywords: iron; hepcidin; ferroportin; ferritin; regulation; anemia; therapies; cell signaling; inflammation; disorders

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Antimicrobial Materials: Novel Studies and Related Applications

edited by

Iuliana Deleanu

submission deadline 30 May 2026 | 1 articles | Viewed by 904 | Submission Open

Keywords: antimicrobial materials; functional materials; composite materials; contamination; green materials; green technologies; metallic materials; drug resistance; environmental safety; biocompatibility; biodegradability

(This special issue belongs to the Section Materials Science)

Design, Synthesis, and Biological Evaluation of Novel Bioactive Compounds

edited by Monika Wujec and Oleg M. Demchuk

submission deadline 30 May 2026 | Viewed by 568 | Submission Open

Keywords: drug design; organic compounds; heterocyclic compounds; synthetic methodologies; medicinal chemistry; bioactive molecules; pharmaceutical applications; structure– activity relationships (SARs); organic synthesis; natural product

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Evolution of the Vertebrate Immune System

edited by

Pierre Pontarotti

submission deadline 30 May 2026 | Viewed by 324 | Submission Open

Keywords: immune system; molecular evolution; V (D) J recombination; RAG transposon; comparative genomics

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms in Heart Rate Regulation and Cardiac Arrhythmias

edited by Yingjie Liu

submission deadline 30 May 2026 | Viewed by 273 | Submission Open

Keywords: cardiac arrhythmias; heart rate regulation; molecular mechanisms; intrinsic regulation; neurohumoral regulation; arrhythmia development; treatment strategies

(This special issue belongs to the Section Molecular Biology)

The Application of Biomaterials in Bone Tissue Repair and Regeneration, 2nd Edition

edited by

Jacek Matys

submission deadline 30 May 2026 | Viewed by 235 | Submission Open

Keywords: allograft; autograft; autologous bone; bone; graft materials; mineral substitutes; regeneration

(This special issue belongs to the Section Materials Science)

Cytokines and Inflammatory Diseases

edited by

Pio Conti

submission deadline 30 May 2026 | Viewed by 147 | Submission Open

Keywords: inflammation; cytokines; interleukin-6; immune diseases; immune signaling; autoimmunity; brain inflammation

(This special issue belongs to the Section Molecular Immunology)

Atomic-Scale Design of Li-Ion Battery Materials

edited by

Saiful Islam

submission deadline 30 May 2026 | Viewed by 127 | Submission Open

Keywords: lithium-ion batteries; atomic-scale design; electrode– electrolyte interface; electrolyte engineering; defect chemistry; solid-state batteries

(This special issue belongs to the Section Materials Science)

Hormetic Responses of Plants to Environmental Stress

edited by

Michael Moustakas

submission deadline 30 May 2026 | Viewed by 114 | Submission Open

Keywords: hormesis; environmental stress; dose– response; molecular mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

Anticancer, Anti-Inflammatory and Antioxidant Properties of Active Substance and Natural Products

edited by Emira D’Amico

submission deadline 30 May 2026 | Viewed by 97 | Submission Open

Keywords: anticancer activity; anti-inflammatory activity; oxidative stress; immunomodulation; drug discovery; natural products; active substance; plant extracts; phytochemicals

(This special issue belongs to the Section Molecular Biology)

Oral Diseases and Oral Soft Tissue Repair

edited by Diana Russo

submission deadline 30 May 2026 | Viewed by 94 | Submission Open

Keywords: oral medicine; tissue regeneration; photobiomodulation; periodontology; implant dentistry

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Nanostructured Strategies for Bioactive Compounds

edited by

Karen Khachatryan

submission deadline 30 May 2026 | Viewed by 82 | Submission Open

Keywords: nanostructure-bioactive interaction; molecular encapsulation mechanisms; metallic nanoparticles (bioactivity); carbon-based nanocarriers; nano/microcapsule delivery systems; bioactive compound stabilisation; structure-activity relationships; molecular release kinetics

(This special issue belongs to the Section Molecular Biology)

Extracellular Matrix Signalling in Health and Disease

edited by

Helen L. Birch

submission deadline 30 May 2026 | Viewed by 71 | Submission Open

Keywords: extracellular; matrix; mechano-transduction; biochemical signalling; cell– matrix interactions; outside-in signalling; matrix remodelling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Unraveling Immunometabolism in Sepsis: From Cellular Reprogramming to Therapeutic Targets

edited by

Marcello Candelli

submission deadline 30 May 2026 | Viewed by 66 | Submission Open

Keywords: sepsis; immunometabolism; metabolic reprogramming; cellular bioenergetics; innate and adaptive immunity; mitochondrial dysfunction; inflammatory signaling; metabolic biomarkers; therapeutic modulation; host– pathogen interactions

(This special issue belongs to the Section Molecular Immunology)

Atherosclerosis: From Molecular Biology to Therapeutic Perspective: 7th Edition

edited by

Ida Daniela Perrotta

submission deadline 30 May 2026 | Viewed by 63 | Submission Open

Keywords: atherosclerosis; vascular smooth muscle cells; inflammation; endothelium; cell senescence; apoptosis; lipid metabolism; oxidative stress; nitric oxide; exosomes; vascular calcification; cytokines; growth factors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Oxidative Stress and the Kidney: From Physiological Homeostasis to Pathophysiology and Nutraceutical Interventions

edited by

Daniele La Russa

and

Daniela Pellegrino

submission deadline 30 May 2026 | Viewed by 61 | Submission Open

Keywords: oxidative stress; nutraceuticals; CVD risk; CKD; antioxidant

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Retinal Degeneration: From Pathophysiology to Therapeutic Approaches—4th Edition

edited by

Jan Wijnholds

submission deadline 30 May 2026 | Viewed by 57 | Submission Open

Keywords: hereditary retinal disease; retinal inflammation; retinal gene augmentation; editing; optogenetics and splice modulation therapy; natural history studies of the retina; human iPSC-derived retinal organoids and retinal pigment epithelium; retinal iPSC-derived cell therapy; retinal pathology; pre- and clinical gene therapy; animal models for retinal dystrophy; retinal imaging; retina-on-a-chip

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Progress in Regenerative Therapy Using Blood-Derived Biomaterials: 2nd Edition

edited by

Tomoyuki Kawase

Takashi Ushiki

and Tomoharu Mochizuki

submission deadline 30 May 2026 | Viewed by 46 | Submission Open

Keywords: blood-derived biomaterial; platelet-rich plasma; autologous protein solution; mechanism; platelet; coagulation

(This special issue belongs to the Section Materials Science)

Engineering Cell-Derived Nanostructures for Therapeutic Delivery

edited by

Tania Limongi

submission deadline 30 May 2026 | Viewed by 43 | Submission Open

Keywords: extracellular vesicles (EVs); cell membrane-coated nanoparticles; plant-derived nanostructures (PDNSs); bacterial extracellular vesicles (bEVs); drug delivery; nanomedicine; nano-biointerfaces; bioinspired engineering; biomanufacturing; translational nanotechnology

(This special issue belongs to the Section Molecular Nanoscience)

Research on the Molecular Mechanisms Related to Exercise

edited by Kayvan Khoramipour

submission deadline 30 May 2026 | Viewed by 42 | Submission Open

Keywords: exercise; molecules; disease

(This special issue belongs to the Section Molecular Biology)

Recent Research on Metabolomics and Cancer Pathogenesis

edited by

Danuta Dudzik

submission deadline 30 May 2026 | Viewed by 38 | Submission Open

Keywords: cancer metabolomics; metabolic reprogramming; biomarkers; tumor microenvironment; systems biology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Medicinal Plants in Health and Diseases

edited by

Hamza El Moudden

submission deadline 30 May 2026 | Viewed by 37 | Submission Open

Keywords: medicinal plants; phytochemicals; natural products; pharmacological activity; herbal medicine; drug discovery; traditional medicine; therapeutic potential

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Perspectives on Fish Nutrition, Physiology and Molecular Regulatory Networks

edited by Linghong Miao

submission deadline 30 May 2026 | Viewed by 36 | Submission Open

Keywords: fish nutrition; feed ingredients; intestinal physiology; molecular regulation; stress response and welfare; genetic mechanisms; aquaculture sustainability; omics technologies

(This special issue belongs to the Section Molecular Biology)

Displaying special issue 2851-2900 on page 58 of 68.

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