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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Research of Abiotic Stress in Plants
edited by Deguo Han
submission deadline 20 Dec 2025 | 2 articles | Viewed by 2135 | Submission Open
Keywords: abiotic stress; salt stress; drought stress; plant
(This special issue belongs to the Section Molecular Plant Sciences)
Treatment of Neurodegenerative Diseases with Natural Products
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 2064 | Submission Open
Keywords: neurodegenerative diseases; natural product; misfolding protein aggregation; oxidative stress; neuroinflammation; autophagy; apoptosis; microbiota– gut– brain axis; therapeutic; prevention
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Mechanisms of Esophageal Inflammation, Injury, and Repair
edited by Anisa Shaker
submission deadline 20 Dec 2025 | 1 articles | Viewed by 2063 | Submission Open
Keywords: GERD; eosinophilic esophagitis; achalasia; esophageal cancer; barrett’ s esophagus; microbiome
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms and Signaling Pathways in Alzheimer’s Disease
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 2024 | Submission Open
Keywords: Alzheimer’ s disease; aging; β -amyloid; biomarkers; cell signaling; tau; mitochondrial dysfunction; neuroinflammation; vascular alterations
(This special issue belongs to the Section Molecular Neurobiology)
Antimicrobial Peptides in Reproductive Health and Disease
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 2023 | Submission Open
Keywords: antimicrobial peptides; preterm birth; molecular mechanisms; microbiome; immune system
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Plant Responses to Heavy Metals: From Deficiency to Excess, 2nd Edition submission deadline 20 Dec 2025 | 2 articles | Viewed by 1920 | Submission Open
Keywords: heavy metals; deficiency; metal toxicity; metal (hyper-)accumulation; mechanisms of metal tolerance; metal transport; metal uptake; metal sequestration; metal homeostasis
(This special issue belongs to the Section Molecular Plant Sciences)
Intestinal Diseases and Gut Microbiota
edited by
submission deadline 20 Dec 2025 | 2 articles | Viewed by 1867 | Submission Open
Keywords: gut microbiota; dysbiosis; natural compounds; colorectal cancer; neurological diseases; autoimmune diseases; probiotics; gut-brain axis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Ongoing Anticancer Agents
edited by
submission deadline 20 Dec 2025 | 2 articles | Viewed by 1842 | Submission Open
Keywords: tumorigenesis; anticancer drugs; therapeutic innovation; platinum-based drugs; anticancer therapies
(This special issue belongs to the Section Molecular Oncology)
Sleep and Breathing: From Molecular Perspectives
edited by Alberto Alonso-Fernández
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1758 | Submission Open
Keywords: obstructive sleep apnea; cardiovascular risk; cardiovascular diseases/physiopathology; continuous positive airway pressure; hypertension; biomarkers; diabetes; pregnancy; gene expression profiling; genetic markers; inflammation mediators; oxidative stress; proteomics
(This special issue belongs to the Section Molecular Biology)
Recent Research in Probiotic Yeasts: Molecular Aspects submission deadline 20 Dec 2025 | 1 articles | Viewed by 1745 | Submission Open
Keywords: probiotic yeasts; molecular mechanisms; mycocins active; compounds; functional compounds
(This special issue belongs to the Section Molecular Microbiology)
Biocomposite Hydrogels for Biomedical Applications submission deadline 20 Dec 2025 | 2 articles | Viewed by 1741 | Submission Open
Keywords: hydrogels; biocomposite; micro/nanoparticles; electrospun fibers; inorganic particles; tissue engineering; drug delivery; 3D printing
(This special issue belongs to the Section Materials Science)
New Insights into Photosystem I (Second Edition) submission deadline 20 Dec 2025 | 1 articles | Viewed by 1728 | Submission Open
Keywords: photosystem I; photochemisty; electron transfer; protein– cofactor interaction; reaction kinetics; reaction mechanism; redox tuning; light harvesting; low-energy (red) forms; bioenergetics; cyclic electron transfer
(This special issue belongs to the Section Molecular Plant Sciences)
Immune-Liver Axis—from Disease Pathogenesis to Therapeutic Target submission deadline 20 Dec 2025 | 2 articles | Viewed by 1688 | Submission Open
Keywords: immune response; inflammation; liver disease; liver injury; liver cirrhosis; immune-related liver disease; alcohol-related liver disease; metabolic dysfunction-associated steatotic liver disease (MASLD); Wilson’ s disease; hemochromatosis; liver cancer
(This special issue belongs to the Section Molecular Immunology)
Nitric Oxide and Photosynthetic Machinery: Unveiling Molecular Mechanisms and Redox Balancing
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1673 | Submission Open
Keywords: nitric oxide; photosynthetic machinery; NO signaling pathways; plant physiology
(This special issue belongs to the Section Molecular Plant Sciences)
Metabolomics in Coronary Artery Disease: From Pathogenesis to Personalized Medicine
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1642 | Submission Open
Keywords: coronary artery disease (CAD); atherosclerosis; epicardial disease; CAD pathogenesis; personalized approach; drug response; metabolomic
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Neuroimaging Studies in Exploring the Molecular Mechanisms of Neurological Diseases
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1628 | Submission Open
Keywords: neuroimaging; neurological diseases; brain imaging; biomarkers; functional connectivity; AI in neuroimaging
(This special issue belongs to the Section Molecular Neurobiology)
New Insights into Anticancer Strategies
edited by
submission deadline 20 Dec 2025 | Viewed by 1592 | Submission Open
Keywords: novel targeted therapy; personalized medicine; nanotechnology; AI and machine learning; combination therapy
(This special issue belongs to the Section Molecular Oncology)
Epilepsy: From Molecular Basis to Therapy, 2nd Edition submission deadline 20 Dec 2025 | 2 articles | Viewed by 1570 | Submission Open
Keywords: genetic epilepsy; post-traumatic epilepsy; neurodevelopmental disorder; glutamate; GABA; ionic homeostasis; disease-modifying therapy; in vitro; in vivo; animal model; gene replacement therapy; gene editing; protein misfolding; small molecule; pharmacokinetics; pharmacodynamics; translational research; biomarker; clinical trial
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Role of Ion Channels in Human Health and Diseases
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1520 | Submission Open
Keywords: sodium current; potassium current; ion channel kinetics; excitable cells; treatments; pathophysiology
(This special issue belongs to the Section Molecular Biology)
Insights into Functional Nanomaterials: Application-Related Structural Analysis
edited by Zoltán Dudás
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1499 | Submission Open
Keywords: functional porous nanomaterials; structure– activity relationship; molecular structure; characterization; nanoporous materials
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Research on Cancer Stem Cells
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1495 | Submission Open
Keywords: self-renewal; microenvironment; plasticity; epigenetics; epithelial-mesenchymal transition; heterogeneity; targeting; dormancy
(This special issue belongs to the Section Biochemistry)
Molecular Advances in Plant Reproductive Development
edited by Zsolt Pónya and
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1403 | Submission Open
Keywords: plant reproduction; sexual reproduction; gamete recognition; zygote formation; embryogenesis; endosperm development; seed maturation; plant developmental biology; epigenetic regulation; gene expression; cellular signalling pathways; protein interactions; hormonal controls
(This special issue belongs to the Section Molecular Plant Sciences)
The Role of Non-Coding RNAs in Female Reproduction
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1380 | Submission Open
Keywords: microRNAs; long non-coding RNAs; circular RNAs; female reproduction; reproductive aging; molecular biomarkers; ceRNA network
(This special issue belongs to the Section Molecular Genetics and Genomics)
Regulatory Mechanisms Underlying Tumorigenesis
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1280 | Submission Open
Keywords: tumor suppressor genes; tumor microenviroment; cell-cycle checkpoint; novel fusion genes; novel molecular targets; small-molecule drugs; animal models
(This special issue belongs to the Section Molecular Oncology)
Pharmacokinetics of Psychoactive Substances: Molecular and Forensic Aspects submission deadline 20 Dec 2025 | Viewed by 1149 | Submission Open
Keywords: psychoactive substances; pharmacokinetics; forensic Toxicology; forensic pathology; toxicological biomarkers; cerebral damage; in vitro; in vivo; and in silico models; new Psychoactive Substances (NPS); new synthetic opioids; liquid chromatography-high resolution mass spectrometry (LC-HRMS/MS); liquid chromatography-tandem mass spectrometry (LC-MS/MS) and gas chromatography; tandem mass spectrometry (GC-MS/MS)
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Insight into Natural Nutraceuticals for Cancer Chemoprevention submission deadline 20 Dec 2025 | 1 articles | Viewed by 1060 | Submission Open
Keywords: natural nutraceuticals; cancer; cancer chemoprevention; natural compounds
(This special issue belongs to the Section Molecular Oncology)
Molecular Studies of Skin Diseases: From Mechanisms to Therapy
edited by
submission deadline 20 Dec 2025 | 2 articles | Viewed by 1047 | Submission Open
Keywords: multiomics; genomics; transcriptomics; proteomics; metabolomics; skin diseases
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Proteases and Their Inhibitors: From Biochemistry to Applications
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1038 | Submission Open
Keywords: proteases; peptidases; proteinases; proteolysis; hydrolysis; enzymes; inhibitors; biotechnology; drug discovery; therapeutics
(This special issue belongs to the Section Molecular Biology)
Recent Advances in Biomolecular Recognition: 3rd Edition
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 1004 | Submission Open
Keywords: proteins; nucleic acids; membrane; ligand; binding
(This special issue belongs to the Section Molecular Biophysics)
25th Anniversary of IJMS: Updates and Advances in Molecular Biophysics submission deadline 20 Dec 2025 | 1 articles | Viewed by 994 | Submission Open
Keywords: biomolecular interactions; biomolecular NMR; biophysics; chaperones; computational modeling; computer simulations; crystal thermodynamics; DNA structure and dynamics; drug– receptor interactions; enzymology; fluorescence imaging; genome structure; inter-molecular interactions; intrinsically disordered proteins; ion channels; macromolecular crystallography; macromolecular structure and dynamics; membrane dynamics; microcalorimetry; molecular dynamics; molecular imprinting; molecular mechanics; molecular modeling; molecular simulations; molecular modeling; molecular structure; molecular recognition; nucleic acid– protein interactions; post-translational modifications; protein design; protein– DNA interactions; protein engineering; protein– ligand binding; protein– membrane interactions; protein structure and folding; RNA structure; single-molecule techniques; spectroscopic techniques; statistical mechanics; structure– function relationships; structure prediction; thermodynamics; transient kinetic techniques; transmembrane proteins; x-ray crystallography
(This special issue belongs to the Section Molecular Biophysics)
Recent Advances in Protein Folding and Misfolding
edited by
submission deadline 20 Dec 2025 | Viewed by 854 | Submission Open
Keywords: protein folding; protein misfolding; 3D protein structure; CRISPR/Cas 9
(This special issue belongs to the Section Molecular Biophysics)
Molecular Mechanisms of Action and Cytotoxicity of Platinum-Based Therapeutics
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 825 | Submission Open
Keywords: platinum-based drugs; cancer therapy; cisplatin; drug resistance; nanodrugs; targeted delivery systems; molecular mechanisms; systemic toxicity
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Electron Transport Mechanism in Optoelectronic Materials
edited by Paolo Umari
submission deadline 20 Dec 2025 | Viewed by 807 | Submission Open
Keywords: photovoltaics; density functional theory; quantum chemistry; optoelectronic devices; semiconductors; polymers; charge transport
(This special issue belongs to the Section Materials Science)
Molecular Research Advances in Metabolic Syndrome submission deadline 20 Dec 2025 | 1 articles | Viewed by 766 | Submission Open
Keywords: metabolic syndrome; sepsis; molecular mechanisms; inflammation; insulin resistance; cardiovascular parameters; immune– metabolic crosstalk; experimental models; biomarkers; therapeutic targets
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Tumor Angiogenesis and Metastasis: From Molecular Signalling to Therapeutic Approaches submission deadline 20 Dec 2025 | 1 articles | Viewed by 763 | Submission Open
Keywords: tumour angiogenesis; tumour invasion; tumour metastasis; molecular mechanisms; metabolic patterns; signalling pathways
(This special issue belongs to the Section Molecular Oncology)
Apoptosis and Autophagy in Cancer Research submission deadline 20 Dec 2025 | 1 articles | Viewed by 737 | Submission Open
Keywords: apoptosis; autophagy; cancer biology; coding and noncoding genomes; cell homeostasis; therapeutic strategies; cell death and survival
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms of Age-Related Cognitive Decline submission deadline 20 Dec 2025 | Viewed by 708 | Submission Open
Keywords: cognitive decline; molecular mechanisms; aging individuals; therapeutic targets; neuroinflammation; oxidative stress; protein aggregation; vascular changes
(This special issue belongs to the Section Molecular Neurobiology)
Rethinking Fat: A Deeper Dive into the Diversity and Dynamic Roles of Adipose Tissue
edited by
submission deadline 20 Dec 2025 | Viewed by 682 | Submission Open
Keywords: adipose tissue biology; stem cell commitment and differentiation; thermogenic adipocytes; genetic regulation; metabolic homeostasis; selective targeting
(This special issue belongs to the Section Molecular Biology)
Signaling in GPCR Research
edited by
submission deadline 20 Dec 2025 | Viewed by 681 | Submission Open
Keywords: GPCR; G protein; signaling; drug design; cell surface receptors
(This special issue belongs to the Section Biochemistry)
Biomolecular Condensates and Their Role in Cellular Organization and Disease
edited by Anna Bratek-Skicki
submission deadline 20 Dec 2025 | Viewed by 613 | Submission Open
Keywords: biocondensates; membrane-less organelles; liquid-liquid phase separation; protein aggregation; neurogenerative diseases
(This special issue belongs to the Section Molecular Biology)
Red Blood Cells in Health and Disease
edited by Annamaria Russo and Ester Tellone
submission deadline 20 Dec 2025 | Viewed by 608 | Submission Open
Keywords: oxidative stress; metabolism; hemoglobin; erythrocytes
(This special issue belongs to the Section Biochemistry)
Exploring Natural Products for Antimicrobial Innovation: New Paths and Promising Leads
edited by
submission deadline 20 Dec 2025 | Viewed by 579 | Submission Open
Keywords: antimicrobial agents; drug resistance; plant-derived compounds; bioactive molecules; phytochemicals; marine natural products; fungal metabolites; novel drug discovery; microbial pathogens; natural product isolation; drug development; biotechnology in antimicrobial research
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Histological and Molecular Perspectives on Immune Mechanisms of the Nasal and Bronchial Mucosa Diseases
edited by
submission deadline 20 Dec 2025 | Viewed by 511 | Submission Open
Keywords: nasal and bronchial mucosa; nasal polyposis; bronchial inflammation; immunotherapy; mucosal immunity; inflammatory biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Design, Synthesis and Biological Activity of Heterocyclic Compounds submission deadline 20 Dec 2025 | Viewed by 508 | Submission Open
Keywords: synthesis of new bioactive compounds; biological activity of heterocyclic compounds; structural analysis; pharmacokinetic analysis of potential drugs; molecular docking study of new heterocyclic compounds
(This special issue belongs to the Section Biochemistry)
Mechanotransduction and Tissue Regeneration in Skeletal Muscle
edited by
submission deadline 20 Dec 2025 | Viewed by 496 | Submission Open
Keywords: skeletal muscle tissue regeneration; mechanotransduction; skeletal muscle spindles; tissue-resident macrophages
(This special issue belongs to the Section Molecular Biology)
Collagen-Based Biomaterials in Tissue Engineering and Regenerative Medicine
edited by Martin Braun, and
submission deadline 20 Dec 2025 | Viewed by 489 | Submission Open
Keywords: collagen; tissue engineering; advanced biomaterials; biodegradable composites; scaffolds; protein structure; biochemical analysis; material characterization; medical application; gelatine
(This special issue belongs to the Section Macromolecules)
Physiopathology and Therapeutics of HIV Infection
edited by
submission deadline 20 Dec 2025 | Viewed by 479 | Submission Open
Keywords: HIV; physiopathology; ART; HAART; NRTIs; NNRTIs; PIs; INSTIs; fusion inhibitors; CCR5 antagonists; post-attachment inhibitors; capsid inhibitors
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Molecular Life of Sperm: New Horizons in Male Infertility submission deadline 20 Dec 2025 | 1 articles | Viewed by 478 | Submission Open
Keywords: human sperm; fertilization; infertility; biomarkers; genetics
(This special issue belongs to the Section Molecular Biology)
Role of EGFR in Colorectal Cancer submission deadline 20 Dec 2025 | Viewed by 477 | Submission Open
Keywords: EGFR; RAS; biomarkers/prognosis; resistance mechanisms; tumor microenvironment; EGFR signaling pathways; EGFR inhibitors; onco-immunology
(This special issue belongs to the Section Biochemistry)
Adipose Tissue and Adipose Tissue-Derived Stem Cells in Multidisciplinary Research
edited by Oliver Felthaus
submission deadline 20 Dec 2025 | Viewed by 446 | Submission Open
Keywords: adipose tissue; adipose-derived stem cells; regenerative medicine; tissue engineering
(This special issue belongs to the Section Molecular Biology)
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