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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Pathology, Diagnosis and Therapeutic Strategies of Thrombotic Diseases

edited by Emanuele Valeriani

submission deadline 30 Apr 2026 | Viewed by 64 | Submission Open

Keywords: anticoagulants; cardiovascular diseases; diagnosis; platelet aggregation inhibitors; venous thromboembolism

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

mRNA Vaccines Against Viral Infectious Diseases: Progress and Prospects

edited by

Barbara Ridolfi

, Maria Teresa Maggiorella and

Ivan Schietroma

submission deadline 30 Apr 2026 | Viewed by 63 | Submission Open

Keywords: viruses; mRNA vaccines; mRNA structure; mRNA platform technologies; lipid nanoparticle (LNP) delivery; immunization strategies; adjuvants; preclinical trials; clinical trials; germline-targeting; broadly neutralizing antibodies; humoral immune response; cellular immune response; host– vaccine interactions

(This special issue belongs to the Section Molecular Microbiology)

The Tumor Microenvironment in Hepatocellular Carcinoma: Mechanistic Insights and Future Therapeutic Approaches

edited by

Agnes Chan

submission deadline 30 Apr 2026 | Viewed by 63 | Submission Open

Keywords: advance or metastatic hepatocellular carcinoma; liver disease; radiotherapy; transarterial chemoembolization (TACE) or SBRT; immune checkpoint inhibitors; tumor microenvironment

(This special issue belongs to the Section Molecular Oncology)

Modern Synthetic Pathways for Anticancer Drug Discovery

edited by

Łukasz Struk

submission deadline 30 Apr 2026 | Viewed by 63 | Submission Open

Keywords: new anticancer agents; bioactive molecules; drug design; drug synthesis; cancer therapy; medicinal chemistry

(This special issue belongs to the Section Molecular Oncology)

Toxicology of Cyanobacterial Toxins

edited by

Carlos García

submission deadline 30 Apr 2026 | Viewed by 62 | Submission Open

Keywords: toxicology; cyanotoxins; cyanobacteria; harmful effects; health risk

(This special issue belongs to the Section Molecular Toxicology)

State-of-the-Art Immunotherapy for Non-Small-Cell Lung Cancer

edited by

Haris Charalambous

submission deadline 30 Apr 2026 | Viewed by 61 | Submission Open

Keywords: immunotherapy; checkpoint inhibitors; vaccines; cellular therapies; predictive biomarkers; chemotherapy; angiogenesis inhibitors; radiotherapy; modulation microbiome

(This special issue belongs to the Section Molecular Oncology)

Molecular Insights into Medicinal Fungi and Plants: From Bioactive Compounds to Therapeutic Mechanisms

edited by

Jasmina Glamočlija

and

Ana Ćirić

submission deadline 30 Apr 2026 | Viewed by 61 | Submission Open

Keywords: medicinal fungi; medicinal plants; molecular mechanisms; bioactive compounds; metabolomics; phytochemistry; natural products; network pharmacology; molecular docking; functional foods; therapeutic development

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Exploring the Gut-Brain Axis: Mechanisms and Implications for Health and Disease

edited by

Martina Vincenzi

submission deadline 30 Apr 2026 | Viewed by 59 | Submission Open

Keywords: gut– brain axis; enteric nervous system; dysbiosis; gut microbiota; neuroinflammation; one health; microbiota– immune crosstalk; metabolic syndromes; cardiovascular diseases; neurodegenerative diseases; cancer

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Integrative Regenerative Medicine: Bridging Molecular Mechanisms and Therapeutic Applications

edited by

Jerran Santos

submission deadline 30 Apr 2026 | Viewed by 59 | Submission Open

Keywords: regenerative medicine; stem cells; molecular mechanisms; tissue engineering; organoids; biomaterials; biofabrication; clinical translation; cell therapy; integrative biology

(This special issue belongs to the Section Molecular Biology)

Advanced Silica-Based Materials: From Molecular Design to Sustainable Applications

edited by Marius Rǎdulescu

submission deadline 30 Apr 2026 | Viewed by 59 | Submission Open

Keywords: silica-based materials; molecular design; hybrid nanomaterials; surface chemistry; structure– property relationships; functionalized silica; sol– gel processes; molecular interactions; green synthesis; sustainable applications; nanostructured systems; catalysis and adsorption; biomedical interfaces; energy and environmental materials; molecular modeling

(This special issue belongs to the Section Molecular Nanoscience)

Research on New Targets and New Drugs for Dementia

edited by

Jianrong Xu

submission deadline 30 Apr 2026 | Viewed by 58 | Submission Open

Keywords: Alzheimer’ s disease; disease-modifying therapy; neuroinflammation; monoclonal antibodies; natural products

(This special issue belongs to the Section Molecular Neurobiology)

Effects of Natural Bioactive Compounds on Cellular Responses

edited by

Amélia M. Silva

submission deadline 30 Apr 2026 | Viewed by 57 | Submission Open

Keywords: cellular targets; cell proliferation; cell death mechanisms; cell signalling; cytokines; vitamins; phytochemicals; venoms; peptides; pharmacological effect

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Research in Orofacial Pain and Headache

edited by Adriana Elena Bulboaca

submission deadline 30 Apr 2026 | Viewed by 57 | Submission Open

Keywords: neuropathic pain; trigeminal neuralgia; temporomandibular joint disorders; headache; migraine; neuroplasticity

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Physiological Effects of Exercise in Cachexia

edited by

Marilia Seelaender

and

Fábio Santos Lira

submission deadline 30 Apr 2026 | Viewed by 56 | Submission Open

Keywords: cachexia; skeletal muscle mass; skeletal muscle strength; exercise; muscle metabolism

(This special issue belongs to the Section Molecular Biology)

KRAS-Associated Cancer Signaling

edited by Sang Hun Lee

submission deadline 30 Apr 2026 | Viewed by 54 | Submission Open

Keywords: KRAS signaling; receptor tyrosine kinases; EGFR; c-MET; PI3K– MAPK pathways; tumor microenvironment; drug resistance and adaptive rewiring; combination therapy; biomarker stratification; prion protein (PrPC)

(This special issue belongs to the Section Molecular Oncology)

Smart Biomolecular Nanocarriers for Precision Cancer Therapy and Diagnosis

edited by

Atul Garkal

submission deadline 30 Apr 2026 | Viewed by 54 | Submission Open

Keywords: nanobiotechnology; anti-cancer agents; nanocarrier; targeted drug delivery

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Advances in Brucella Research

edited by

Angel Oñate

submission deadline 30 Apr 2026 | Viewed by 51 | Submission Open

Keywords: Brucella abortus; molecular pathogenesis; host– pathogen interaction; virulence factors; oxidative stress response; intracellular survival; immune evasion; exosomes; vaccine development

(This special issue belongs to the Section Molecular Microbiology)

Biomass as Feedstock for the Production of High Value-Added Chemicals by Heterogeneous Catalysis

edited by

Cristina García-Sancho

submission deadline 30 Apr 2026 | Viewed by 50 | Submission Open

Keywords: biomass; heterogeneous catalysts; biofuels; bioproducts; platform molecules

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular Mechanisms of Assisted Reproductive Technology

edited by Nuria Marti-Gutierrez

submission deadline 30 Apr 2026 | Viewed by 50 | Submission Open

Keywords: cytoplasm maternal factors; mitochondrial replication; meiosis; chromosome pairing; recombination; gene editors

(This special issue belongs to the Section Molecular Biology)

Molecular Basis of Plant Traits Associated with Responses to Biotic and Abiotic Stress

edited by Nobuhiro Suzuki

submission deadline 30 Apr 2026 | Viewed by 49 | Submission Open

Keywords: molecular mechanisms ; biotic and abiotic stress ; plant trait ; signaling

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms and Treatment Strategies in Diabetic Kidney Disease

edited by

Érika Bevilaqua Rangel

submission deadline 30 Apr 2026 | Viewed by 45 | Submission Open

Keywords: diabetic kidney disease; oxidative stress; autophagy; inflammation; fibrosis; cell therapy; SGLT2 inhibitors and GLP-1 agonists; mesenchymal stem cells; gene therapy; translational nephrology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Lupus Erythematosus and Lupus Nephritis: Pathogenesis, Biomarkers and Treatments, 2nd Edition

edited by

Chi Chiu Mok

submission deadline 30 Apr 2026 | Viewed by 44 | Submission Open

Keywords: lupus erythematosus; lupus nephritis; SLE; LN; organ damage; pathogenesis; biomarkers; genomic; transcriptomic; metabolomic; treatments; therapeutic

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Insight in Reproductive Immunology

edited by Ruben Motrich

submission deadline 30 Apr 2026 | Viewed by 44 | Submission Open

Keywords: reproductive immunology; immune tolerance; male reproductive tract; female reproductive tract; fertility disorders; inflammation; pregnancy complications; immunoregulation

(This special issue belongs to the Section Molecular Immunology)

Inflammatory Bowel Disease: Molecular Advances in Pathogenesis and Therapies, 2nd Edition

edited by

Rafał Filip

submission deadline 30 Apr 2026 | Viewed by 43 | Submission Open

Keywords: Crohn’ s disease; inflammatory bowel disease; immunologic and molecular mechanisms; therapies in IBD; ulcerative colitis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Advance in Xenobiotic Toxicology

edited by Marcelo Arbo

submission deadline 30 Apr 2026 | Viewed by 43 | Submission Open

Keywords: xenobiotics; toxicity tests; biotransformation; drug effects; signal transduction; environmental pollutants; chemically induced- injury; toxicogenomics; biomarkers; risk assessment

(This special issue belongs to the Section Molecular Toxicology)

Regenerative Medicine: Biomaterials and Stem Cell Research: 2nd Edition

edited by Silvia María Díaz-Prado

submission deadline 30 Apr 2026 | Viewed by 43 | Submission Open

Keywords: regenerative medicine; stem cell; biomaterial; bioprinting; tissue engineering; tissue and organ transplant; organ scarcity

(This special issue belongs to the Section Materials Science)

Artificial Intelligence, Machine Learning, and Bioinformatics in Molecular Mechanisms of Human Health and Disease

edited by

Santosh Anand

submission deadline 30 Apr 2026 | Viewed by 42 | Submission Open

Keywords: artificial intelligence; machine learning; bioinformatics; molecular mechanisms; human health; human disease; multi-omics data; molecular pathways; personalized medicine; disease biomarkers

(This special issue belongs to the Section Molecular Informatics)

Radiobiology: New Challenges and Advances

edited by Lorenzo Manti and

Pavel Bláha

submission deadline 30 Apr 2026 | Viewed by 42 | Submission Open

Keywords: strategies for overcoming cancer radioresistance and normal-tissue damage mitigation; combined approaches: BNCT; proton– boron capture therapy; radioimmunotherapy; emerging technologies and novel temporal regimes: FLASH RT mechanisms and radiobiology of laser-accelerated particles; radiobiology of new ions and of novel dose-delivery modalities in particle radiotherapy; limphopoenia in radiotherapy and biomarkers of radiation response; three-dimensional models; microdosimetry: standardising measurements; DNA damage/repair; tumour microenvironment: autophagy; ferroptosis; fibroblast activation protein; non-cancer effects and non-targeted effects

(This special issue belongs to the Section Molecular Biology)

Metabolomics as a Window into Human Disease Mechanisms

edited by

Paolo Iadarola

submission deadline 30 Apr 2026 | Viewed by 42 | Submission Open

Keywords: biomarker discovery; metabolomics; disease mechanisms

(This special issue belongs to the Section Molecular Informatics)

Emerging Targeted Therapies and Evolving Treatment Paradigms in Non-Small Cell Lung Cancer

edited by Luis E. Raez

submission deadline 30 Apr 2026 | Viewed by 41 | Submission Open

Keywords: non-small cell lung cancer (NSCLC); targeted therapies; human epidermal growth factor receptor 2 (HER2); mesenchymal-epithelial transition factor (MET); anaplastic lymphoma kinase (ALK); C-ROS oncogene 1 receptor tyrosine kinase (ROS1); rearranged during transfection (RET); neurotrophic tyrosine receptor kinase (NTRK); B-Raf proto-oncogene serine/threonine kinase V600 mutation (BRAFv600); Kirsten rat sarcoma viral oncogene homolog (KRAS); epidermal growth factor receptor (EGFR)

(This special issue belongs to the Section Molecular Oncology)

From Molecule to Mind: Neuropharmacology of Psychoactive Alkaloids and Next-Generation Neuroactives

edited by Kyoko Koshibu

submission deadline 30 Apr 2026 | Viewed by 41 | Submission Open

Keywords: psychoactive alkaloids; neuropharmacology; bioactive compounds; performance enhancement; addiction; translational research; cognitive modulation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Mechanistic Insights into the Ubiquitin System’s Role in Cellular Signal Transduction and Homeostasis

edited by Michael Massiah

submission deadline 30 Apr 2026 | Viewed by 40 | Submission Open

Keywords: ubiquitination; protein homeostasis; deubiquitinases; E3-associated diseases; autophagy; ubiquitin dysregulation; proteasome-targeting; protac

(This special issue belongs to the Section Molecular Biology)

The Role of Complement Regulation in Kidney Disease

edited by Jasmina Marković Lipkovski

submission deadline 30 Apr 2026 | Viewed by 40 | Submission Open

Keywords: complement system; kidney disease; glomerulonephritis; C3 glomerulopathy; membranous nephropathy; complement regulation; innate immunity; molecular pathology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Dietary Interventions for Type 2 Diabetes: Current Evidence and Emerging Perspectives on Underlying Molecular Mechanisms

edited by Caterina Formichi

submission deadline 30 Apr 2026 | Viewed by 39 | Submission Open

Keywords: type 2 diabetes; nutritional intervention; dietary strategies; nutrients; personalized nutrition; diet; metabolic health

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Genomic and Epigenetic Determinants of Circulating Cell-Free DNA Release in Cancer

edited by

Federica Maione

submission deadline 30 Apr 2026 | Viewed by 39 | Submission Open

Keywords: genomic alterations; epigenetic modifications; chromosomal instability; aneuploidy and DNA fragmentation; tumor cell-derived cell-free DNA release; chromosome methylation; liquid biopsy; gene-gene interactions; cell death

(This special issue belongs to the Section Molecular Oncology)

Bioactive Phenolic Compounds in Human Health and Disease: Second Edition

edited by

Andrei Lobiuc

submission deadline 30 Apr 2026 | Viewed by 39 | Submission Open

Keywords: novel sources; synthesis; biological activity; molecular interactions; pharmacodynamics; pharmacokinetics; assay development; microbiota; sources and intake

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Cutting Edge Advances in Wound Healing

edited by Fui Ping Lim

submission deadline 30 Apr 2026 | Viewed by 38 | Submission Open

Keywords: wound repair; molecular pathways; regenerative biology; tissue remodelling; inflammation modulation

(This special issue belongs to the Section Molecular Biology)

Molecular Advances on Gut Microbiota in Human Health

edited by

Sanda Cretoiu

submission deadline 30 Apr 2026 | Viewed by 37 | Submission Open

Keywords: gut microbiota; dysbiosis; metabolomics; host– microbe interaction; molecular pathways; inflammation; personalized medicine

(This special issue belongs to the Section Molecular Microbiology)

Nanoscale Materials for Advanced Electrocatalysts

edited by

Safia Khan

submission deadline 30 Apr 2026 | Viewed by 36 | Submission Open

Keywords: nanomaterials; electrocatalysis; electrocatalysts; energy conversion; fuel cells

(This special issue belongs to the Section Molecular Nanoscience)

Bioactive Food Components in Human Health

edited by

Kamila Rachwał

and Klaudia Gustaw

submission deadline 30 Apr 2026 | Viewed by 35 | Submission Open

Keywords: bioactive compounds; functional food; phytochemicals; bioactive peptides; health-promoting foods; food chemistry; polyphenols; natural products; human health; prebiotic compounds; bioavailability; nutraceuticals; bioaccessibility

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recent Advances in Sperm Physiology and Genetics

edited by Jordi Ribas-Maynou and Ariadna Delgado Bermudez

submission deadline 30 Apr 2026 | Viewed by 33 | Submission Open

Keywords: sperm; DNA; chromatin; physiology; reproduction

(This special issue belongs to the Section Molecular Genetics and Genomics)

New Perspectives in Cardiovascular Disease: From Molecular Mechanisms to Clinical Innovations

edited by

Yunglung Chen

submission deadline 30 Apr 2026 | Viewed by 32 | Submission Open

Keywords: cardiovascular disease; molecular mechanisms; biomarkers; atrial fibrillation; translational medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Electrochemical Detection: A Molecular-Level Perspective

edited by Katarzyna Fendrych and

Joanna Smajdor-Baran

submission deadline 30 Apr 2026 | Viewed by 32 | Submission Open

Keywords: electrochemical detection; molecular sensing; biosensors; nanostructured electrodes; biomolecular interactions; electroanalytical chemistry; molecular electrochemistry

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Interdisciplinary Molecular Design: Catalysis, Therapeutics, and Biomaterials

edited by

Zhiwei Yang

submission deadline 30 Apr 2026 | Viewed by 32 | Submission Open

Keywords: intelligent molecular design; computational catalysis; antibody and protein engineering; biomaterials design; molecular dynamics simulations; AI in drug discovery

(This special issue belongs to the Section Molecular Biophysics)

Emerging Biological Markers and Molecular Targets in Bladder Cancer

edited by Stanislav Žiaran

submission deadline 30 Apr 2026 | Viewed by 30 | Submission Open

Keywords: bladder cancer; biomarkers; urothelial carcinoma; molecular pathways; liquid biopsy; extracellular matrix; omics profiling; precision medicine; tissue engineering; translational urology

(This special issue belongs to the Section Molecular Oncology)

Stem Cells for Biomedical Applications

edited by

Sorina Dinescu

submission deadline 30 Apr 2026 | Viewed by 29 | Submission Open

Keywords: stem cells biology; stem cells differentiation; stem cell-based regenerative therapies; stem cells exosomes; personalized medicine; stem cell-based 3D models

(This special issue belongs to the Section Molecular Biology)

Composites of Cellulose and Cellulose Derivatives: Engineering and Applications

edited by

Omar A. El Seoud

submission deadline 30 Apr 2026 | Viewed by 28 | Submission Open

Keywords: cellulose composites: engineering and applications; composites of cellulose esters: engineering and applications; composites of cellulose ethers: engineering and applications; molecular interactions within cellulose and its derivatives; molecular interactions within composites of cellulose and its derivatives

(This special issue belongs to the Section Macromolecules)

Design, Synthesis and Development of Anticancer Drugs Targeting the Tumor Microenvironment

edited by

Yoshihiro Uto

submission deadline 30 Apr 2026 | Viewed by 28 | Submission Open

Keywords: anticancer drugs; tumor microenvironment; in vivo model; cancer-associated fibroblast; tumor-associated macrophage; tumor hypoxia; tumor endothelial cells

(This special issue belongs to the Section Molecular Oncology)

Research Advances in Plant Interactions with Bacteria and Fungi: From Molecular to Ecological Perspectives

edited by

Jessie Fernandez

submission deadline 30 Apr 2026 | Viewed by 27 | Submission Open

Keywords: plant-microbe interactions; plant-bacteria interactions; plant-fungi interactions; biocontrol; beneficial microbes; endophytes; microbiome; plant growth-promoting microbes; synthetic microbial communities

(This special issue belongs to the Section Molecular Plant Sciences)

Insulin Resistance Mechanisms: From Epigenetics to Receptor-Mediated Signaling Pathways

edited by

Angélica Rueda

and