Molecular and Physiological Effects of Exercise in Cachexia
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 April 2026
Special Issue Editor
Special Issue Information
Dear Colleagues,
Cachexia is a multifactorial metabolic syndrome characterized by a progressive loss of skeletal muscle mass and strength, frequently associated with chronic conditions such as cancer, heart failure, and chronic obstructive pulmonary disease. Growing evidence supports the role of exercise as a potent modulator of systemic inflammation and muscle metabolism in this condition. However, the precise molecular mechanisms underlying these effects remain incompletely understood.
This Special Issue aims to highlight recent advances in molecular research investigating how exercise influences key signaling pathways, mitochondrial function, protein turnover, and inflammatory mediators involved in cachexia progression. We welcome both experimental studies using animal models and translational investigations in humans, particularly those that elucidate mechanistic links between molecular adaptations and functional outcomes. Studies exploring sex-specific differences in the molecular and physiological effects of exercise in cachexia are also encouraged, as these may provide important insights for personalized therapeutic strategies.
We invite researchers to submit original manuscripts presenting novel molecular insights, mechanistic data, or translational findings that advance our understanding of exercise-induced effects in cachexia. By integrating perspectives from molecular biology, biochemistry, and physiology, this collection seeks to provide a comprehensive review of the molecular basis of exercise-induced benefits in cachexia and to identify potential therapeutic targets for its prevention and treatment.
Dr. Marilia Seelaender
Guest Editor
Manuscript Submission Information
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Keywords
- cachexia
- skeletal muscle mass
- skeletal muscle strength
- exercise
- muscle metabolism
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