Smart Biomolecular Nanocarriers for Precision Cancer Therapy and Diagnosis

Dear Colleagues,

Recent advances in biomolecular engineering and nanotechnology have revolutionized cancer treatment and diagnosis. Smart biomolecular nanocarriers constructed from proteins, peptides, nucleic acids, polysaccharides, exosomes, and hybrid biopolymers are emerging as powerful tools for precision oncology. These nanosystems enable targeted, image-guided, and controlled delivery of therapeutics while simultaneously providing diagnostic functionality, making them ideal for theranostic applications.

Despite significant progress, challenges such as limited in vivo stability, immune clearance, and large-scale manufacturing continue to hinder clinical translation. Ongoing research focuses on designing stimuli-responsive, tumour-microenvironment-adaptive, and multifunctional nanocarriers with enhanced selectivity, biosafety, and therapeutic efficacy. Moreover, biosynthetic hybrid nanostructures that combine molecular specificity with physicochemical robustness are gaining attention as next-generation platforms for personalized cancer therapy.

This Special Issue invites original research articles and comprehensive reviews highlighting the latest developments in smart biomolecular nanocarriers for precision cancer therapy and diagnosis.

Potential topics include, but are not limited to, the following:

• Protein, peptide, nucleic acid, and exosome-based nanocarriers;
• Stimuli-responsive and tumour targeted nanoplatforms;
• Multifunctional and imaging guided drug delivery systems;
• Hybrid biosynthetic nanostructures for theranostics;
• Translational and clinical perspectives in nanomedicine.

Dr. Atul Garkal
Guest Editor

Manuscript Submission Information

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