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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Gene Regulation in Endocrine Disease, 2nd Edition

edited by

Alberto Falchetti

submission deadline 20 Jun 2026 | Viewed by 144 | Submission Open

Keywords: gene regulation; endocrine disease; endocrinology; diabetes mellitus; thyroid disorders

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advancements in Cardiovascular Health Research: Investigating Novel Biomaterials, Cellular Responses, and Therapeutic

edited by Magdalena Wawrzyńska

submission deadline 20 Jun 2026 | Viewed by 139 | Submission Open

Keywords: cardiovascular biomaterials; nanomaterials; surface coatings; drug delivery systems; polymers; biocompatibility; hemocompatibility; molecular response

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Microbial Bioconversion of Agri-Food Waste for the Production of Pharmacologically Active Compound

edited by Alicia Paz

submission deadline 20 Jun 2026 | Viewed by 139 | Submission Open

Keywords: microbial bioconversion; agri-food waste valorization; bioactive compounds; bioprocess optimization; pharmaceuticals; functional foods; cosmetic bioactives

(This special issue belongs to the Section Molecular Microbiology)

Genetic Susceptibility in Human Diseases

edited by Xiaowu Gai

submission deadline 20 Jun 2026 | Viewed by 138 | Submission Open

Keywords: bioinformatics; genomics; genetic susceptibility to disease; genetic variation; gene– environment interactions; biomarkers; epigenetic mechanisms; pharmacogenomics; population genetics; bioinformatics tools and databases; novel diagnostics; targeted therapies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Mechanisms of Stem Cell-Mediated Tendon Regeneration: From Signaling Pathways to Therapeutic Applications

edited by

Mohammad El Khatib

submission deadline 20 Jun 2026 | Viewed by 133 | Submission Open

Keywords: regenerative medicine; tissue engineering; stem cells; scaffolds; 3D in vitro models; tenogenic differentiation; tendon regeneration; molecular mechanisms; intercellular crosstalk; paracrine signaling; extracellular matrix remodeling

(This special issue belongs to the Section Molecular Biology)

From Discovery to Clinic: Overcoming Barriers in Antimicrobial Peptide Development

edited by José M. Pérez De la Lastra

submission deadline 20 Jun 2026 | Viewed by 132 | Submission Open

Keywords: antimicrobial peptides (AMPs); translational challenges; in vivo efficacy; drug delivery and formulation; computational approaches; pharmacokinetics; toxicity prediction; antibiotic resistance; animal models; nanotechnology

(This special issue belongs to the Section Molecular Microbiology)

Stress Adaptation and Immune Surveillance: Extracellular Vesicles, Autophagy, and Inflammasomes in Cancer and Neurodegeneration

edited by Seema Singh

submission deadline 20 Jun 2026 | Viewed by 131 | Submission Open

Keywords: autophagy; ferroptosis; inflammasome activation; extracellular vesicle (EV); cancer; neurodegeneration; chronic infections

(This special issue belongs to the Section Molecular Immunology)

Nanobiotechnology: Breaking Barriers in Phytomedicine

edited by

Maria Aparecida Medeiros Maciel

submission deadline 20 Jun 2026 | Viewed by 129 | Submission Open

Keywords: nanotechnology; nanobiotechnology; phytocompounds; phytochemistry; natural products

(This special issue belongs to the Section Molecular Nanoscience)

Epigenetic Alterations in Hepatocellular Carcinoma

edited by

Yonghwan Shin

submission deadline 20 Jun 2026 | Viewed by 127 | Submission Open

Keywords: hepatocellular carcinoma (HCC); epigenetics; DNA methylation; histone modification; chromatin remodeling; non-coding RNAs epigenetic biomarkers; cancer progression

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms Underlying the Pathogenesis and Treatment of Gastrointestinal Disorders

edited by

Andrzej Pławski

submission deadline 20 Jun 2026 | Viewed by 125 | Submission Open

Keywords: gastrointestinal disorders; molecular mechanisms; diagnosis; treatment; precision medicine; biomarkers; gastrointestinal cancer

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Wired for Change: Neurotransmitter Plasticity and Circuit Dynamics in Health and Disease

edited by Alessandra Porcu

submission deadline 20 Jun 2026 | Viewed by 124 | Submission Open

Keywords: neurotransmitter; behavioral neuroscience; neuropsychiatric disorders; neurological disorders; neuroplasticity; neuronal circuit

(This special issue belongs to the Section Molecular Neurobiology)

Recent Advances in Metabolism of Alzheimer’s Disease

edited by

Rebecca Piccarducci

and Maria Letizia Trincavelli

submission deadline 20 Jun 2026 | Viewed by 120 | Submission Open

Keywords: Alzheimer’ s disease; brain metabolism; insulin resistance; lipid metabolism; APOE ε 4; metabolic targets; insulin-sensitizing drugs; lifestyle and metabolic interventions

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Targeted Therapies and Immunometabolic Pathways in Cancer

edited by Medhi Wangpaichitr

submission deadline 20 Jun 2026 | Viewed by 119 | Submission Open

Keywords: immunotherapy; targeted therapy; tumor metabolism pathway; tumor microenvironment; immune checkpoint blockade; immune evasion; glucose/amino acids/lipid metabolism

(This special issue belongs to the Section Molecular Immunology)

Artificial Intelligence and Data Science for the Discovery of Anticancer Targets and Decision Support

edited by

Soumia Ziti

submission deadline 20 Jun 2026 | Viewed by 116 | Submission Open

Keywords: artificial intelligence in oncology; data science and decision support in cancer therapy; target discovery and biomarker identification; machine learning and multi-omics integration; predictive modeling in precision medicine

(This special issue belongs to the Section Molecular Informatics)

Structure and Function of Subcellular Organelle and Protein-Membrane Systems

edited by

Chikara Sato

submission deadline 20 Jun 2026 | Viewed by 111 | Submission Open

Keywords: immuno-electron microscopy; cell signaling; comparative anatomy; diagnosis; molecular recognition; molecular complexes; electro-chemistry; liquid-phase synthesis; metal sedimentation; membrane endoskeleton

(This special issue belongs to the Section Molecular Biophysics)

Anticancer Drugs: Current Status and Future Directions

edited by

Mariano Martínez-Vázquez

submission deadline 20 Jun 2026 | Viewed by 108 | Submission Open

Keywords: anticancer drugs; hybrids; combinations; nanoparticles

(This special issue belongs to the Section Molecular Pharmacology)

Molecular and Adaptive Mechanisms in Plant Genetics

edited by

Gennaro Lettieri

submission deadline 20 Jun 2026 | Viewed by 104 | Submission Open

Keywords: forest genetics; breeding techniques; molecular breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Deciphering the Molecular Mechanisms That Regulate Plant Disease and Immunity

edited by Bourlaye Fofana and

Champa Wijekoon

submission deadline 20 Jun 2026 | Viewed by 98 | Submission Open

Keywords: plants; biotic stressors; molecular mechanisms; omics technologies; plant immunity

(This special issue belongs to the Section Molecular Plant Sciences)

Unravelling Molecular Pathways in Ocular Disease and Degeneration

edited by

Zala Lužnik Marzidovšek

submission deadline 20 Jun 2026 | Viewed by 93 | Submission Open

Keywords: molecular mechanisms; ocular disease; biomarkers; therapeutic targets; regenerative; gene therapies; corneal degeneration; retinal degeneration; optic nerve pathology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Medicinal Plants, Animal-Derived Products, and Natural Compounds: Roles in Health and Disease

edited by

Vitor Engrácia Valenti

submission deadline 20 Jun 2026 | Viewed by 47 | Submission Open

Keywords: natural bioactive compounds; medicinal plants; animal-derived products; marine natural products; chronic diseases; inflammation; oxidative stress; molecular mechanisms; therapeutic peptides; natural toxins; antioxidant activity; anti-inflammatory agents; nanoformulations; nanodelivery systems; drug delivery; pharmacological properties; translational research; integrative medicine; natural therapeutics; disease prevention

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Evolution, Genetics and Pathogenesis of Viruses, 2nd Edition

edited by

Marta Szabat

submission deadline 20 Jun 2026 | Viewed by 28 | Submission Open

Keywords: viruses; genome structure; viral RNA/DNA; replication viral cycle; recombination; viral infection; antiviral agents

(This special issue belongs to the Section Molecular Microbiology)

New Molecular Mechanisms and Markers in Inflammatory Disorders, 4th Edition

edited by

Elena Vianello

submission deadline 20 Jun 2026 | Viewed by 27 | Submission Open

Keywords: inflammation; inflammatory disorders; biomarkers; molecular mechanism of inflammation; molecular signaling

(This special issue belongs to the Section Molecular Immunology)

Natural Products: Pharmacological Insights and Advances

edited by

Jialuo Huang

submission deadline 20 Jun 2026 | Viewed by 5 | Submission Open

Keywords: natural products; biological activity; pharmacology; mechanism of action; molecular targets

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Genetic Mechanism of Stress Resistance in Plants

edited by Mohammad Nurul Matin

submission deadline 21 Jun 2026 | Viewed by 4 | Submission Open

Keywords: stress response and resistance; environmental adaptation; abiotic and biotic stress; gene regulation network; functional genomics; molecular signalling pathways; CRISPR/cas systems; epigenetic regulation; transcriptome profiling; metabolic reprogramming; stress-responsive genes

(This special issue belongs to the Section Molecular Genetics and Genomics)

Functions and Applications of Natural Products: 2nd Edition

edited by

Seung-Hong Lee

submission deadline 25 Jun 2026 | 1 articles | Viewed by 591 | Submission Open

Keywords: natural products; biomedicine/phytomedicine; biologically active extracts and compounds; pharmacological and toxicological mechanisms of action

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Research in Pregnancy-Related Complications

edited by Kallirhoe Kalinderi

submission deadline 25 Jun 2026 | Viewed by 241 | Submission Open

Keywords: preeclampsia; gestetional diabetes mellitus; pregnancy; complications; gene; molecular; pathways; biomarkers; diagnosis; therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Colorectal Cancer: A Molecular Genetics Perspective (2nd Edition)

edited by

Ehsan Gharib

submission deadline 25 Jun 2026 | Viewed by 102 | Submission Open

Keywords: colorectal cancer; chromosomal and microsatellite instability; CpG island methylator phenotype; molecular characteristics; early diagnosis; targeted therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mitochondrial Function in Human Health and Disease: 3rd Edition

edited by

Yumay Chen

submission deadline 25 Jun 2026 | Viewed by 82 | Submission Open

Keywords: mitochondial genesis and disease; mitochondrial function and aging; mitochondrial dysfunction and cancer; mitochondrial function and apoptosis; mitophage; autophage; mitochondrial AKT

(This special issue belongs to the Section Biochemistry)

Molecular Progression of Gut Microbiota—2nd Edition

edited by

Emina Pustijanac

submission deadline 25 Jun 2026 | Viewed by 78 | Submission Open

Keywords: gut microbiota; microbiome; differences in gut microflora; molecular techniques; gut microbiota’ s role and composition; healthy state; dysbiosis

(This special issue belongs to the Section Molecular Microbiology)

Glycosylation in Tumor Microenvironment: Roles, Mechanisms and Interventions

edited by

Koichi Furukawa

submission deadline 25 Jun 2026 | Viewed by 3 | Submission Open

Keywords: glycoproteins; glycolipids; signaling; cell– cell interaction; cell membrane

(This special issue belongs to the Section Molecular Oncology)

Current Research on Cancer Biology and Therapeutics: Fourth Edition

edited by

Rafael Coveñas Rodríguez

submission deadline 29 Jun 2026 | 4 articles | Viewed by 2041 | Submission Open

Keywords: cancer and anticancer peptides; substance P/neurokinin-1 receptor system; neurokinin-1 receptor antagonists

(This special issue belongs to the Section Molecular Oncology)

Plant Growth: Molecular Mechanisms

edited by

Zulfiqar Ali Sahito

and

Afsheen Zehra

submission deadline 29 Jun 2026 | Viewed by 78 | Submission Open

Keywords: plant growth; hormonal crosstalk; epigenetics; CRISPR/Cas9 genome editing technologies; metabolomics; transcriptomics

(This special issue belongs to the Section Molecular Plant Sciences)

State-of-the-Art Molecular Immunology in Chile, 2nd Edition

edited by

Marcela Hernandez Ríos

Juan C. Aguillon

, María Rosa Bono,

Nicolas Dutzan

Rolando Vernal

and

Leandro J. Carreño

submission deadline 30 Jun 2026 | 7 articles | Viewed by 15258 | Submission Open

Keywords: innate immunity; adaptive immunity; host– pathogen interactions; immunopathology; osteoimmunology; immunosenescence; immunotherapy; antibody; vaccines; Chile

(This special issue belongs to the Section Molecular Immunology)

Wnt/β-Catenin Signaling in Cancer

edited by

Teresa Catalano

and

Gitana Maria Aceto

submission deadline 30 Jun 2026 | 1 articles | Viewed by 6684 | Submission Open

Keywords: Wnt/β -catenin pathway; tumors; gene expression; molecular targets; tumor microenvironment; carcinogenesis and metastasis; biomarkers; therapeutic approaches

(This special issue belongs to the Section Molecular Oncology)

Cirrhosis: From Molecular Mechanisms to Therapeutic Strategies

edited by

Hongqun Liu

submission deadline 30 Jun 2026 | 4 articles | Viewed by 6453 | Submission Open

Keywords: liver; fibrogenesis; cirrhosis; portal hypertension; complications; molecular mechanisms; pathway; therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Preclinical and Translational Research in Thyroid Cancer

edited by

Marialuisa Appetecchia

and

Giulia Puliani

submission deadline 30 Jun 2026 | 2 articles | Viewed by 5853 | Submission Open

Keywords: thyroid cancers; pathogenesis; molecular bases of thyroid cancer; precision medicine; gender medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Natural Products for Cancer Therapy

edited by María Jesus Rodríguez-Yoldi

submission deadline 30 Jun 2026 | 1 articles | Viewed by 3675 | Submission Open

Keywords: apoptosis; antioxidant; anti-inflammatory; cancer; cell viability; food-by-products; natural products; polyphenols

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Pathogenesis and Antiviral Treatment of Emerging and Reemerging Viral Infections

edited by

Luciana Barros de Arruda

submission deadline 30 Jun 2026 | 1 articles | Viewed by 2964 | Submission Open

Keywords: viral replication; antiviral; inflammation; vaccine; arbovirus; respiratory virus; hemorrhagic virus; neurotropic virus

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Hormone Receptor in Breast Cancer: 2nd Edition

edited by

Rocío García-Becerra

submission deadline 30 Jun 2026 | 2 articles | Viewed by 2638 | Submission Open

Keywords: estradiol; progesterone; calcitriol; androgen; resveratrol; phytoestrogens; therapeutic targets; fulvestrant; treatment response; SERM; estrogen receptor isoforms; selective ligands; hormonal carcinogenesis; breast cancer prevention; hormone signaling; endocrine disruptor compounds; ER-negative breast cancer; ER-positive breast cancer; aromatase inhibitors

(This special issue belongs to the Section Molecular Oncology)

Molecular Endocrine Regulation in Health and Diseases

edited by Fady Hannah-Shmouni

submission deadline 30 Jun 2026 | 1 articles | Viewed by 2616 | Submission Open

Keywords: exposome and endocrine disruptors; endocrine-disrupting chemicals (EDCs); environmental toxicology and hormonal health; epigenetics and endocrine function; endocrine regulation and chronic disease; public health and exposure mitigation; endocrine disruptors in the home and community

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Functional Genomics and Molecular Mechanisms of Plant Stress Responses

edited by

Zupeng Wang

submission deadline 30 Jun 2026 | 1 articles | Viewed by 666 | Submission Open

Keywords: plant stress responses; abiotic stress; biotic stress; molecular mechanisms; functional genomics

(This special issue belongs to the Section Molecular Plant Sciences)

Oxidative Stress Unveiled: Mechanisms and Implications in Cardiac Pathologies

edited by Sukkum Ngullie Chang and Vernat Exil

submission deadline 30 Jun 2026 | Viewed by 507 | Submission Open

Keywords: reactive oxygen species (ROS); electron transport chain (ETC); mitochondrial permeability transition pore (mPTP); endothelial– cardiomyocyte– fibroblast crosstalk; metabolic adaptation; inflammation; cardiovascular disease (CVD)

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

RNA Modifications in Response to Physical Activity: Implications for Rehabilitation and Disease Management

edited by Roberto Tedeschi and Francesca Gorini

submission deadline 30 Jun 2026 | Viewed by 350 | Submission Open

Keywords: RNA modifications; non-coding RNAs (ncRNAs); physical activity; gene expression; rehabilitation and disease management; epigenetic regulation; exercise-induced RNA expression; miRNA in inflammation control

(This special issue belongs to the Section Molecular Biology)

Genetic Regulation of Plant Growth and Protection (2nd Edition)

edited by

Yuxuan Hou

and

Zhiyong Li

submission deadline 30 Jun 2026 | Viewed by 195 | Submission Open

Keywords: molecular regulation; genetic resources; functional genomics; plant growth and development; abiotic and biotic stresses; plant– microbe interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Molecular Genetics and Molecular Therapy for Gastric Cancers

edited by

Binnari Kim

submission deadline 30 Jun 2026 | Viewed by 174 | Submission Open

Keywords: gastric cancer; molecular genetics; targeted therapy; tumor microenvironment; immunotherapy; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomaterials and Nanotechnology in Cancer Therapy and Regenerative Medicine

edited by Manoochehr Rasekh

submission deadline 30 Jun 2026 | Viewed by 155 | Submission Open

Keywords: biomaterials; nanoparticle drug delivery; cancer therapy; stimuli-responsive nanocarriers; targeted therapeutics; regenerative medicine; tissue engineering; theranostics

(This special issue belongs to the Section Materials Science)

Nanodrug Bioavailability and Biocompatibility in Cancer and CNS Disorders

edited by

Athina Angelopoulou

submission deadline 30 Jun 2026 | Viewed by 147 | Submission Open

Keywords: nanomedicine; bioavailability; biocompatibility; tumor microenvironment; Blood– Brain Barrier; targeted drug delivery; neurodegenerative diseases

(This special issue belongs to the Section Molecular Nanoscience)

Unraveling Neurodevelopmental Disorders: A Molecular Perspective

edited by Marija-Magdalena Petrinovic

submission deadline 30 Jun 2026 | Viewed by 106 | Submission Open

Keywords: neurodevelopmental disorders; molecular neuroscience; genetics; epigenetics; functional MRI (fMRI); magnetic resonance spectroscopy (MRS); PET imaging; imaging biomarkers; translational neuroscience; precision medicine

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanism and Therapeutics in Human Cancer

edited by

Rachel Bar-Shavit

submission deadline 30 Jun 2026 | Viewed by 104 | Submission Open

Keywords: oncogenes; Wnt/b-catenin; G-protein-coupled receptors (GPCR); translational means; cancer stem cells; ubiquitination and deubiquitinating in cancer

(This special issue belongs to the Section Molecular Oncology)

From DNA Damage to Cell Death: Emerging Drug Targets and Therapeutic Opportunities

edited by

Mateusz Kciuk

and Beata Marciniak

submission deadline 30 Jun 2026 | Viewed by 100 | Submission Open

Keywords: apoptosis; cancer therapy; cell death pathways; chemoresistance; DNA damage response (DDR); DNA repair inhibitors; drug discovery; ferroptosis; genomic instability; therapeutic targets

(This special issue belongs to the Section Molecular Biology)

Displaying special issue 3201-3250 on page 65 of 68.

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