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Foods
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Bioactive Ingredients in Functional Foods—Their Role in Lipid Metabolism
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Bioactive Ingredients in Functional Foods—Their Role in Lipid Metabolism

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Food Nutrition".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 2749

Special Issue Editors

Prof. Dr. Jailane De Souza Aquino

E-Mail Website
Guest Editor
Laboratório de Nutrição Experimental (LANEX), Departamento de Nutrição (DEPNUT), Universidade Federal da Paraíba UFPB, João Pessoa, Brazil
Interests: animal models; anti-inflammatory markers; antioxidants; bioactive compounds; byproducts; dyslipidemia; diabetes; gut–brain axis; gut–liver axis; obesity; non-conventional food plants; plant-based products; phytochemicals
Dr. Kamila Sabino Batista

E-Mail Website
Guest Editor Assistant
Instituto Nacional do Semiárido (INSA), Ministério da Ciência Tecnologia e Inovação, Campina Grande, Brazil
Interests: anti-inflammatory; antioxidants; bioactive compounds; byproducts; dyslipidemia; chronic diseases; functional foods; gut modulation; nutraceutical potential

Special Issue Information

Dear Colleagues,

Lipid metabolism, a complex process crucial for maintaining physiological balance, has garnered significant attention due to its implications for health and disease. In parallel, functional foods, rich in bioactive compounds, have emerged as promising tools for influencing lipid metabolism and addressing associated disorders such as dyslipidemia, obesity, and cardiovascular diseases. However, comprehensive understanding is still lacking regarding the mechanisms through which these compounds exert their effects and their impact on the absorption, synthesis, transport, excretion, and oxidation of lipids in the body. Therefore, this Special Issue aims to explore the potential of functional foods, abundant in bioactives, to prevent and treat disorders related to lipid metabolism, encompassing both preventive and therapeutic approaches.

We welcome original articles or reviews addressing, but not limited to, the following topics:

  • The influence of bioactive compounds (e.g., phenolics, omega-3 fatty acids, prebiotic fibers, phytosterols) on lipid metabolism pathways;
  • The identification and characterization of bioactive compounds with properties for modulating lipids in cell models, pre-clinical, and clinical studies;
  • The molecular mechanisms of action of bioactive compounds and assessment of their bioavailability and effectiveness;
  • Investigation of synergistic interactions among bioactive ingredients and assessment of their impact on lipid metabolism in cell models, pre-clinical, and clinical studies.

Prof. Dr. Jailane De Souza Aquino
Guest Editor

Dr. Kamila Sabino Batista
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Foods is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antioxidants
  • lipid profile management
  • lipid metabolism enzymes
  • cholesterol and fatty acid metabolism
  • dyslipidemia and cardiovascular diseases
  • plant-based foods
  • obesity
  • animal models
  • clinical studies
  • cell lines

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Published Papers (3 papers)

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19 pages, 4791 KiB  
Article
Green Radish Polysaccharides Ameliorate Hyperlipidemia in High-Fat-Diet-Induced Mice via Short-Chain Fatty Acids Production and Gut Microbiota Regulation
by Xiong Geng, Weina Tian, Miaomiao Zhuang, Huayan Shang, Ziyi Gong and Jianrong Li
Foods 2024, 13(24), 4113; https://doi.org/10.3390/foods13244113 - 19 Dec 2024
Cited by 1 | Viewed by 951
Abstract
The objective of this study was to examine the hypolipidemic effect and potential mechanism of action of green radish polysaccharide (GRP) in hyperlipidemic mice. We found that in mice fed a high-fat diet, supplementing with GRP reduced body weight and liver index, significantly [...] Read more.
The objective of this study was to examine the hypolipidemic effect and potential mechanism of action of green radish polysaccharide (GRP) in hyperlipidemic mice. We found that in mice fed a high-fat diet, supplementing with GRP reduced body weight and liver index, significantly improved serum lipid levels and markers of liver damage, and mitigated oxidative stress and inflammation. Mechanistically, in these hyperlipidemic mice, the size of fat cells was reduced by GRP, and the abnormal accumulation of lipid droplets was reduced. We also found that GRP regulates the composition of the intestinal microbiota, including the ratio of Firmicutes to Mycobacteria F/B and the levels of Blautia spp., which have been shown to alleviate liver damage and treat hyperlipidemia. Metabolite pathway analysis using the Kyoto Encyclopedia of Genes and Genomes identified the glycolysis/glycolytic metabolism and propionate metabolism pathways as potential targets for GRP in the amelioration of hyperlipidemia. Full article
(This article belongs to the Special Issue Bioactive Ingredients in Functional Foods—Their Role in Lipid Metabolism)
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19 pages, 8014 KiB  
Article
Hepatoprotective, Lipid-Lowering and Antioxidant Effects of Mangaba Powder (Hancornia speciosa) Administered to Rats Fed a High-Fat Diet
by Bernadete de Lourdes de Araújo Silva, Margarida Angélica da Silva Vasconcelos, Kamila Sabino Batista, Fabiane Rabelo da Costa Batista, Hassler Clementino Cavalcante, Lydiane de Lima Tavares Toscano, Alexandre Sérgio Silva, Aline Barbosa D’Oliveira, Adriano Francisco Alves and Jailane de Souza Aquino
Foods 2024, 13(23), 3773; https://doi.org/10.3390/foods13233773 - 25 Nov 2024
Cited by 1 | Viewed by 1107
Abstract
The aim of this study was to evaluate the potential effects of administering mangaba powder on liver function and somatic, oxidative and lipid metabolism parameters in rats fed a high-fat diet. Prepared mangaba powder has important amounts of phenolic compounds, vitamin C, dietary [...] Read more.
The aim of this study was to evaluate the potential effects of administering mangaba powder on liver function and somatic, oxidative and lipid metabolism parameters in rats fed a high-fat diet. Prepared mangaba powder has important amounts of phenolic compounds, vitamin C, dietary fiber and oligosaccharides. A total of 32 adult Wistar rats were initially randomized into two groups for the biological assay: normal-fat (NF, n = 16) and high-fat (HF, n = 16) diets for 21 days. These rats were subsequently subdivided into four groups: NF (n = 8), HF (n = 8), normal-fat diet with mangaba powder administration (NFMG, n = 8) and high-fat diet with mangaba powder administration (HFMG, n = 8). The treatment with mangaba powder (400 mg/kg) lasted an additional 28 days. Compared to the HF rats, the HFMG rats showed an 8% reduction in the body mass index. Treatment with mangaba reduced the serum cholesterol by 18%, as well as the hepatic deposition of triacylglycerides by 26% and cholesterol by 25%, in addition to increasing bile acid synthesis by 77% in this organ. Mangaba powder consumption attenuated the degree of hepatic steatosis, reduced lipid peroxidation and increased the serum and hepatic antioxidant capacity in HFMG rats. These results show that the consumption of mangaba powder had lipid-lowering, hepatoprotective and antioxidant effects, especially in HFMG rats, which may be associated with an additive and synergistic action between the bioactive compounds present in the product. Full article
(This article belongs to the Special Issue Bioactive Ingredients in Functional Foods—Their Role in Lipid Metabolism)
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22 pages, 2840 KiB  
Systematic Review
Lipid-Lowering Effects of Alpha-Mangostin: A Systematic Review and Meta-Analysis in Hyperlipidemic Animal Models
by Moragot Chatatikun, Aman Tedasen, Phichayut Phinyo, Pakpoom Wongyikul, Passakorn Poolbua, Wiyada Kwanhian Klangbud, Jason C. Huang, Rattana Leelawattana and Atthaphong Phongphithakchai
Foods 2025, 14(11), 1880; https://doi.org/10.3390/foods14111880 - 26 May 2025
Viewed by 126
Abstract
Hyperlipidemia is a major risk factor for cardiovascular and metabolic diseases. Although pharmacologic treatments are effective, their adverse effects have spurred interest in natural alternatives. Alpha-mangostin (AM), a xanthone from Garcinia mangostana, has shown lipid-lowering effects in animal studies, but its overall [...] Read more.
Hyperlipidemia is a major risk factor for cardiovascular and metabolic diseases. Although pharmacologic treatments are effective, their adverse effects have spurred interest in natural alternatives. Alpha-mangostin (AM), a xanthone from Garcinia mangostana, has shown lipid-lowering effects in animal studies, but its overall efficacy remains unclear. This systematic review and meta-analysis, conducted in accordance with PRISMA 2020 guidelines, evaluated AM’s impact on lipid profiles in hyperlipidemic animal models. Databases including Scopus, PubMed, ScienceDirect, Cochrane Library, and Web of Science were searched for relevant controlled studies. Nine studies (N = 226 animals) met inclusion criteria, reporting data on triglycerides (TG), total cholesterol (TC), LDL-C, and HDL-C. Risk of bias, assessed using the Cochrane RoB 2 tool, was generally low-to-moderate. Meta-analysis using a random-effects model revealed that AM significantly reduced TG, TC, and LDL-C, while increasing HDL-C. Stronger effects were observed at doses <50 mg/kg/day. Subgroup and sensitivity analyses confirmed robustness and highlighted the influence of species, region, and treatment duration. These findings suggest that AM is a promising lipid-lowering agent in animal models. Further clinical trials are needed to validate efficacy in humans and determine optimal dosing. Full article
(This article belongs to the Special Issue Bioactive Ingredients in Functional Foods—Their Role in Lipid Metabolism)
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