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Plant Proteins: Functions in Disease Prevention and Treatment

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Plant Foods".

Deadline for manuscript submissions: closed (15 August 2025) | Viewed by 26725

Special Issue Editors


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Guest Editor
1. State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, China
2. College of Food Science and Technology, Nanchang University, Nanchang 330031, China
3. Jiangxi Province Key Laboratory of Edible and Medicinal Resources Exploitation, Nanchang University, Nanchang 330031, China
Interests: structured lipids; immobilized lipase; plant protein; functional foods; bioactive compounds; agricultural by-products; food preservation
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang 330047, China
2. College of Food Science and Technology, Nanchang University, Nanchang 330031, China
3. Jiangxi Province Key Laboratory of Edible and Medicinal Resources Exploitation, Nanchang University, Nanchang 330031, China
Interests: plant proteins; protein–phenolic interactions; protein hydrolysates; techno-functional properties; food processing
Special Issues, Collections and Topics in MDPI journals

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Guest Editor Assistant
School of Food Science and Engineering, Hainan University, Haikou 570228, China
Interests: plant proteins; protein–phenolic interactions; protein hydrolysates; techno-functional properties; food processing

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Guest Editor Assistant
School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China
Interests: emulsion gels; plant proteins; polysaccharide; protein-polysaccharide interactions; food processing

Special Issue Information

Dear Colleagues,

Plant proteins play a crucial role in promoting health and preventing disease, offering a sustainable and nutritionally rich alternative to animal-based proteins. They are abundant in essential amino acids, bioactive peptides, and functional components that can modulate various physiological pathways. Studies have shown that plant proteins, such as those derived from soy, pea, and buckwheat, exhibit antioxidant, anti-inflammatory, and cholesterol-lowering properties, which contribute to reducing the risk of chronic diseases like cardiovascular diseases, type 2 diabetes, and obesity. Furthermore, plant proteins often interact with bioactive compounds such as polyphenols, enhancing their stability and bioactivity, thereby amplifying their protective effects against oxidative stress and inflammation. Emerging research highlights their potential in managing gut health, modulating microbiota diversity, and even targeting specific conditions such as cancer and neurodegenerative diseases. As a versatile and eco-friendly option, plant proteins hold great promise in advancing functional foods and therapeutic interventions for disease prevention and treatment. Both original research articles and reviews are welcome for submission.

Prof. Dr. Zheling Zeng
Dr. Xianghui Yan
Guest Editors

Dr. Dongze Li
Dr. Xiujie Zhao
Guest Editor Assistants

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Keywords

  • plant proteins
  • disease prevention
  • functional activity
  • antioxidant properties
  • anti-inflammatory effects
  • immune modulation
  • gut microbiota
  • metabolic regulation
  • functional foods
  • dietary interventions

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Published Papers (3 papers)

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Research

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19 pages, 9249 KB  
Article
Bioinformatics-Assisted Discovery of Antioxidant Cyclic Peptides from Corn Gluten Meal
by Hongcheng Liu, Tong Sun, He Gao, Xiaolong Liu, Shanshan Zhang, Tingting Liu, Dawei Wang, Hongxiu Fan and Yanrong Zhang
Foods 2025, 14(10), 1709; https://doi.org/10.3390/foods14101709 - 12 May 2025
Cited by 3 | Viewed by 2012
Abstract
Using a multidisciplinary approach, this paper was designed to prepare, identify, and characterize novel maize antioxidant cyclic peptides from protein hydrolysate of corn gluten meal (CGM). A bioinformatics approach was used to identify the best protease, and the results showed that papain+subtilisin was [...] Read more.
Using a multidisciplinary approach, this paper was designed to prepare, identify, and characterize novel maize antioxidant cyclic peptides from protein hydrolysate of corn gluten meal (CGM). A bioinformatics approach was used to identify the best protease, and the results showed that papain+subtilisin was most likely to produce antioxidant cyclic peptides. The result of the enzymatic hydrolysis validation experiment showed that hydrolysate by papain+subtilisin yielded the highest concentration of cyclic peptide (67.14 ± 1.88%) and remarkable DPPH, ABTS, and hydroxyl radical scavenging rates (81.06 ± 2.23%, 82.82 ± 1.83%, and 47.44 ± 2.43%, respectively) compared to other hydrolysates. Eleven antioxidant cyclic peptides were identified in the protein hydrolysate of CGM through sequential purification and mass spectrometry analysis. The results of molecular docking analysis indicated that the cyclic peptides can form stable hydrogen bonds and hydrophobic interactions with the key amino acid residues of Kelch-like ECH-associated protein 1 (Keap1). Cyclic peptides may regulate the Keap1-Nrf2 pathway by occupying the Kelch domain of Keap1, inhibiting the ubiquitination degradation of Nrf2 (nuclear factor erythroid 2-related factor 2), thereby stabilizing the Nrf2 protein and activating the antioxidant gene network. This study underlined the bioinformatics approach for antioxidant cyclic peptide discovery, which is time- and cost-effective and promotes new cyclic peptide drugs or functional food development. Full article
(This article belongs to the Special Issue Plant Proteins: Functions in Disease Prevention and Treatment)
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Review

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22 pages, 1144 KB  
Review
Plant-Based Bigels for Functional Delivery: Advances in Structural Design and Stabilization Strategies
by Chao Cheng, Xianghui Yan, Dongze Li, Zheling Zeng, Qiangzhong Zhao, Xiujie Zhao and Shaoyun Wang
Foods 2025, 14(21), 3699; https://doi.org/10.3390/foods14213699 - 29 Oct 2025
Cited by 2 | Viewed by 1835
Abstract
As the increasing demand for clean-label, plant-based, and functional food systems, bigels, an innovative biphasic structured system composed of both hydrogels and oleogels, have emerged as promising research focus for delivering functional ingredients in the food, pharmaceutical, and cosmetic fields. Plant-based bigels, formulated [...] Read more.
As the increasing demand for clean-label, plant-based, and functional food systems, bigels, an innovative biphasic structured system composed of both hydrogels and oleogels, have emerged as promising research focus for delivering functional ingredients in the food, pharmaceutical, and cosmetic fields. Plant-based bigels, formulated from edible biopolymers and vegetable oils, represent a sustainable and regulatory-compliant delivery platform. This review critically reviews the recent advances in the structural design and stabilization of plant-based bigels, with an emphasis on the regulation of phase behavior and interfacial interactions. Advanced strategies, including stimuli-responsive gelation, Pickering interfaces, and semi-interpenetrating networks, are explored to improve stability and enable targeted gastrointestinal release. Applications in the delivery of polyphenols, omega-3 fatty acids, lipophilic vitamins, and probiotics are highlighted, underscoring the relationship between structural construction and delivery performance. Furthermore, current challenges and potential solutions concerning stability enhancement, bioavailability improvement, and industrial scalability are outlined. Future research directions are proposed to address existing gaps and to further exploit the potential of plant-based bigels for functional compound delivery. Full article
(This article belongs to the Special Issue Plant Proteins: Functions in Disease Prevention and Treatment)
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33 pages, 12871 KB  
Review
Dietary Plant-Based Protein Supplements: Sources, Processing, Nutritional Value, and Health Benefits
by Kartik Sharma, Wanli Zhang and Saroat Rawdkuen
Foods 2025, 14(18), 3259; https://doi.org/10.3390/foods14183259 - 19 Sep 2025
Cited by 10 | Viewed by 22173
Abstract
With the global population reaching 10 billion in 25 years, food production must increase 70% while addressing sustainability concerns. This review uniquely integrates advanced processing technologies—including precision fermentation, AI-driven optimization, and 3D printing—with comprehensive analysis of nutritional quality and health outcomes of plant-based [...] Read more.
With the global population reaching 10 billion in 25 years, food production must increase 70% while addressing sustainability concerns. This review uniquely integrates advanced processing technologies—including precision fermentation, AI-driven optimization, and 3D printing—with comprehensive analysis of nutritional quality and health outcomes of plant-based protein supplements (PBPSs). Common sources include legumes, cereals, and nuts/seeds, each with amino acid profiles requiring strategic protein complementation. Advanced processing technologies including high-pressure processing, ultrasound-assisted extraction, pulsed electric field, precision fermentation, and AI-driven optimization enhance protein digestibility, solubility, and functional properties while reducing antinutritional factors. PBPSs demonstrate comparable muscle protein synthesis to animal proteins while providing superior cardiovascular, metabolic, and gut health benefits due to bioactive compounds, fibers, and antioxidants. Integrating advanced processing with traditional methods presents opportunities to develop high-quality, sustainable protein supplements meeting global demands while promoting human health and environmental sustainability. Full article
(This article belongs to the Special Issue Plant Proteins: Functions in Disease Prevention and Treatment)
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