Use, Quality and Safety of Food Supplements: Scientific and Regulatory Perspectives

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Food Nutrition".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 1237

Special Issue Editors


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Guest Editor
CBIOS—Universidade Lusófona’s Research Center for Biosciences & Health Technologies, Campo Grande 376, 1749-024 Lisboa, Portugal
Interests: food toxicology; food safety; bioactive compounds; antioxidants; oxidative stress; mycotoxins; cancer; pharmacology; toxicology
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Department of Bromatology, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia
Interests: food chemistry; functional food; nutraceuticals; bioactive compounds; antioxidants
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Food and dietary supplements are consumed globally, but their usage patterns, composition, and safety profiles can differ widely. Thanks to recent progress in analytical chemistry, biochemistry, and regulatory science, we now have more effective tools to verify ingredients, measure active compounds, and detect contaminants or adulteration. Even so, important challenges remain, particularly in achieving unified quality standards, maintaining consistent post-market monitoring, and establishing evidence-based safety thresholds.

The reasons for using food supplements, which contain nutrients, biologically active compounds, or plant-based extracts, are shaped by a mix of demographic, lifestyle, and clinical factors. This diversity highlights the importance of incorporating real-world data into the assessments of risks and benefits.

This Special Issue invites original research, reviews, and policy analyses that explore various aspects of food supplements, ranging from consumption trends to quality control and safety regulation. We welcome contributions on topics such as prevalence, patterns, and attitudes regarding the use of food supplements; advanced analytical and innovative methods for product validation; standardization of botanical and micronutrient formulations; clinical and toxicological studies; interactions between food supplements, foods, and drugs; post-market surveillance systems; comparative regulatory analyses across countries; and frameworks for assessing risk and benefit to guide consumers. By bringing together interdisciplinary insights, this Special Issue aims to support science-informed policymaking, foster regulatory alignment, and help protect public health.

Dr. João G. Costa
Prof. Dr. Bojana Vidović
Guest Editors

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Keywords

  • food supplements
  • dietary supplements
  • consumption patterns
  • quality control
  • safety assessment
  • regulatory frameworks
  • analytical methods
  • risk-benefit analysis
  • nutrigenomics
  • post‑market surveillance

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Published Papers (1 paper)

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Research

21 pages, 872 KB  
Article
Towards Botanical Authentication of Ginkgo Food Supplements: A Holistic Approach Based on Phytochemical and Genomic Markers
by Liliana Grazina, Paula Paíga, Joana S. Amaral, Joana Costa, Manuela M. Moreira, Cristina Delerue-Matos and Isabel Mafra
Foods 2025, 14(17), 3111; https://doi.org/10.3390/foods14173111 - 5 Sep 2025
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Abstract
Ginkgo biloba is one of the most consumed medicinal plants and broadly included as an ingredient in plant food supplements (PFS) and herbal infusions, being potential targets for economically motivated adulteration. This work aimed at comparing the use of DNA and phytochemical markers [...] Read more.
Ginkgo biloba is one of the most consumed medicinal plants and broadly included as an ingredient in plant food supplements (PFS) and herbal infusions, being potential targets for economically motivated adulteration. This work aimed at comparing the use of DNA and phytochemical markers to authenticate the botanical origin of ginkgo-leaf extracts and PFS. Quantitative real-time PCR was used to detect ginkgo DNA, while ultra-high performance liquid chromatography with tandem mass spectrometry detection (UHPLC-MS/MS) determined its main phytochemicals (terpene lactones and flavonol aglycones). DNA was detected in all ginkgo leaf extracts, mainly water, while the highest levels of phytochemicals were obtained using ethanol or acetone as solvents. The results suggested that 4 out of a total of 19 PFS samples were adulterated, with two samples evidencing the addition of quercetin from sources other than ginkgo. The other two samples showed low amounts of ginkgo phytochemicals, which was corroborated by low DNA content, suggesting the use of reduced amounts of G. biloba leaf material. Full article
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