Food Toxins: Their Toxicity, Biochemistry, and Metabolism

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Food Toxicology".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 1661

Special Issue Editors


E-Mail Website
Guest Editor
Departament of Preclinic Sciences, Faculty of Veterinary Medicine, University of Agronomic Sciences and Veterinary Medicine of Bucharest, Bucharest, Romania
Interests: mycotoxins; functional foods development; oxidative stress and inflammation; signaling pathways in cancer and diabetes
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Laboratory of Animal Biology, National Institute for Research and Development for Biology and Animal Nutrition, Calea Bucuresti No. 1, Balotesti, 077015 Ilfov, Romania
Interests: swine; immunomodulation; immunonutrition; intestinal health; biochemistry; nutritional biochemistry; mycotoxins
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Food toxins are chemical compounds that can contaminate food products during manufacturing, processing, transit, and storage, or they may originate from the raw materials. Natural toxins are produced by bacteria (e.g., cholera toxins, enterotoxins, Shiga toxins, Botulinum toxins), marine algae (e.g., marine biotoxins such as saxitoxins, brevetoxins, domoic acid, okadaic acid, and azaspiracids that accumulate in fish or bivalve molluscs), fungi (e.g., mycotoxins such as aflatoxins, ochratoxin, fumonisins, zearalenone, and deoxynivalenol), and plant-derived toxins like alkaloids and glycoalkaloids. These toxins exhibit diverse chemical structures, biological functions, and toxic activities. In recent years, there has been growing interest in understanding their mechanisms of toxicity and biotransformation due to their impact on human and animal health, as well as concerns about their effects on food security and nutrition. This Special Issue invites original research papers and reviews that provide novel insights into the toxicity, biochemistry, and metabolism of food toxins, aiming to shed light on these critical aspects.

Dr. Andreea Iren Serban
Dr. Gina Pistol
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Foods is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • food toxins
  • toxins’ mechanisms of action
  • toxicity
  • toxin metabolism
  • food safety
  • health issue

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

22 pages, 4876 KiB  
Article
Protective Effects of Carotenoid-Loaded Nanostructured Lipid Carriers Against Ochratoxin-A-Induced Cytotoxicity
by Nicola Pinna, Pilar Vila-Donat, Denisia Pașca, Francesca Blasi, Aurélie Schoubben and Lara Manyes
Foods 2024, 13(21), 3351; https://doi.org/10.3390/foods13213351 - 22 Oct 2024
Cited by 2 | Viewed by 1136
Abstract
Ochratoxin A (OTA) is a mycotoxin produced by Aspergillus ochraceous and various Penicillium species, which are known for contaminating agricultural products and posing significant health risks, which include immunotoxicity. This study aims to evaluate the potential of nanostructured lipid carriers (NLCs) loaded with [...] Read more.
Ochratoxin A (OTA) is a mycotoxin produced by Aspergillus ochraceous and various Penicillium species, which are known for contaminating agricultural products and posing significant health risks, which include immunotoxicity. This study aims to evaluate the potential of nanostructured lipid carriers (NLCs) loaded with a carotenoid-enriched extract from pumpkin peel (Cucurbita maxima L.) in mitigating the toxic effects of OTA. To address the poor bioavailability and instability of carotenoids, nanoencapsulation techniques were employed to enhance their delivery and efficacy. NLCs were formulated using hydrogenated sunflower oil, pumpkin oil, and soy lecithin using hot high-pressure homogenization. The in vitro study involved co-digesting OTA-contaminated bread with an NLC formulation and assessing the impact of the encapsulated carotenoid on OTA bioaccessibility, bioavailability, and cellular toxicity using Caco-2 and Jurkat T cells. Even though no significant influence was observed on the bioaccessibility and bioavailability of OTA, carotenoid-loaded NLCs exhibited cytoprotective effects by improving cell viability and mitigating OTA-induced toxicity in both Caco-2 and Jurkat T cells. Particularly, the flow cytometry analysis highlighted the ability of carotenoids to mitigate OTA-induced cellular damage by decreasing ROS production and limiting mitochondrial mass changes. The study suggests that the encapsulation of carotenoids in NLCs represents a promising strategy to enhance their protective effects against OTA toxicity, potentially offering a novel approach to food safety and public health protection. The study underscores the potential of nanotechnology in improving the bioavailability and efficacy of natural antioxidants to mitigate mycotoxin-induced damage. Full article
(This article belongs to the Special Issue Food Toxins: Their Toxicity, Biochemistry, and Metabolism)
Show Figures

Graphical abstract

Back to TopTop