Edible-Medicinal Foods: Functional Food Innovation and Mechanistic Health Efficacy Evaluation

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Nutraceuticals, Functional Foods, and Novel Foods".

Deadline for manuscript submissions: 9 July 2026 | Viewed by 347

Special Issue Editors

Institute of Food Science and Technology, Fujian Academy of Agricultural Sciences, Fuzhou 350003, China
Interests: probiotics; functional food; nutrition; bioactive peptides
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
College of Food Science, Fujian Agriculture and Forestry University, Fuzhou 350002, China
Interests: functional foods; aquatic products; bioactive peptides
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The concept of edible-medicinal foods stands as a cornerstone of traditional medicine, embodying the profound principle that numerous foods inherently possess therapeutic properties. As global healthcare paradigms shift decisively toward prevention and personalized nutrition, modern advancements in food science, nutrigenomics, and systems biology now enable rigorous scientific validation of these time-honored resources. This Special Issue aims to establish a comprehensive international platform that bridges ancient wisdom with cutting-edge innovations, welcoming original research articles and systematic reviews focusing on the following themes: (1) identification and mechanistic elucidation of bioactive compounds (e.g., peptides, polyphenols, flavonoids, polysaccharides) derived from edible-medicinal plant and animal resources; (2) probiotic fermentation and biotransformation mechanisms, including systematic metabolic pathway analysis, degradation of antinutritional factors, and structure–function modifications of bioactive components; (3) health-promoting effects and underlying molecular mechanisms in metabolic and inflammatory conditions, validated through standardized disease models and multi-omics approaches; (4) innovative processing technologies and formulation strategies for edible-medicinal food development; (5) in vitro, in vivo, and clinical efficacy evaluation models for functional validation; (6) interactions between edible-medicinal ingredients and gut microbiota, and the regulatory roles they play in metabolism and immunity; (7) standardization, quality control systems, and safety assessment of edible-medicinal foods; (8) functional effects such as regulation of glucose/lipid metabolism, anti-inflammation, and antiaging; and (9) industrial application practices, market trends, and regulatory frameworks for edible-medicinal functional foods. We warmly invite scholars worldwide to contribute their high-quality research to help advance this interdisciplinary field, fostering synergies between traditional knowledge and modern science.

Dr. Qi Wang
Prof. Dr. Yafeng Zheng
Guest Editors

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Keywords

  • medicinal and edible homology
  • functional food innovation
  • health efficacy evaluation
  • bioactive compounds
  • gut health
  • immunomodulation
  • standardization

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Published Papers (1 paper)

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Research

20 pages, 3904 KB  
Article
Nutritional Components and Anti-Alcoholic Liver Disease Activity of Selenium-Enriched Agaricus subrufescens
by Hua Chen, Ziyi Wang, Conghui Zhang, Shien Wang, Linghong Zeng, Fang Zheng, Haichen Huang, Jiali Deng, Xucong Lv and Penghu Liu
Foods 2026, 15(11), 1833; https://doi.org/10.3390/foods15111833 - 22 May 2026
Abstract
Agaricus subrufescens (AS) is a medicinal mushroom with notable bioactivity and the capacity to accumulate trace elements. In this study, selenium-enriched A. subrufescens (SAS) was cultivated, and its protective effects against alcoholic liver disease (ALD) were investigated, with an emphasis on clarifying the [...] Read more.
Agaricus subrufescens (AS) is a medicinal mushroom with notable bioactivity and the capacity to accumulate trace elements. In this study, selenium-enriched A. subrufescens (SAS) was cultivated, and its protective effects against alcoholic liver disease (ALD) were investigated, with an emphasis on clarifying the underlying mechanisms. The results showed that the yield and antioxidant capacity of mushrooms in a 10 mg·kg−1 Se treatment group were increased. Nutritional analysis revealed that SAS contained considerable levels of crude protein (350.00 g·kg−1), crude fiber (7.8%), free amino acids (250.20 g·kg−1), and other bioactive constituents. Furthermore, the hepatoprotective effects of AS/SAS were studied in male Kunming mice with alcohol-induced liver injury. The body growth, liver index, serum and liver biochemical parameters, histopathological features of liver, hepatic mRNA levels and liver metabolomics were investigated. The results demonstrated that SAS significantly reduced hepatic lipid accumulation, enhanced antioxidant capacity, regulated the mRNA expression of key genes involved in lipid metabolism, oxidative stress, and inflammatory responses, and modulated liver metabolic characteristics. These findings provide theoretical evidence for the potential of SAS as a functional food against alcohol-induced liver injury. Full article
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