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Postbiotics from Fermented Plant Extracts: Chemistry, Functionality, and Food Applications

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Nutraceuticals, Functional Foods, and Novel Foods".

Deadline for manuscript submissions: closed (15 May 2026) | Viewed by 1129

Special Issue Editors


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Guest Editor
Faculty of Technology, University of Novi Sad, Bulevar cara Lazara 1, 21000 Novi Sad, Serbia
Interests: applied chemistry; chemistry of natural products; food chemistry; biologically active compounds; free radicals; antioxidants; encapsulation
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Faculty of Technology Novi Sad, University of Novi Sad, Bulevar cara Lazara 1, 21 000 Novi Sad, Serbia
Interests: polyphenols; in vitro digestion; bioavailability; anti-inflammatory activity; antihyperglycemic activity; bioactive compounds; natural pigments; antioxidant activity; food; antioxidants
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The growing demand for functional foods has stimulated increasing interest in the fermentation of plant-based extracts as an effective approach to enhance nutritional and technological properties of food products. During fermentation, herbal, fruit, and vegetable extracts undergo complex microbial transformations that generate postbiotics. These include non-viable microbial cells, cell wall fragments, and a wide range of fermentation-derived metabolites with proven functional roles in foods.

Postbiotics such as bioactive peptides, phenolic derivatives, organic acids, exopolysaccharides, and volatile compounds provide numerous benefits in food systems, including enhanced microbial safety, oxidative stability, and sensory quality. Moreover, postbiotics exhibit antioxidant, antimicrobial, immunomodulatory, and metabolic health effects while maintaining activity after processing or storage, ensuring consistent performance and safety in food matrices.

Fermented plant extracts represent particularly promising sources of postbiotics for use in functional foods and beverages, offering opportunities for natural preservation, clean-label development, and next-generation plant-based formulations. However, further understanding of their chemical complexity, structure–function relationships, mechanisms of action, and safety assessment within food systems is needed.

For this Special Issue, we welcome original research articles, reviews, and short communications on the chemistry, bioactivity, and technological applications of postbiotics derived from plant fermentation, as well as studies addressing regulatory perspectives, safety evaluation, consumer perception, and their integration into sustainable food systems.

Dr. Vanja Travičić
Dr. Gordana Ćetković
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • postbiotics
  • fermentation
  • fermented plant-based extracts
  • bioactive compounds
  • functional foods
  • antioxidant activity
  • microbial safety
  • clean-label formulation

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Published Papers (1 paper)

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Review

19 pages, 1048 KB  
Review
State-of-the-Art Perspectives on Postbiotic-Oriented Systems Derived from Fermented Medicinal Plant Extracts
by Vanja Travičić, Lato Pezo, Mirjana Sulejmanović, Dina Tenji, Milica Perović, Gordana Ćetković and Nenad Ćetković
Foods 2026, 15(5), 864; https://doi.org/10.3390/foods15050864 - 4 Mar 2026
Cited by 1 | Viewed by 681
Abstract
Fermentation is increasingly used as a controlled bioprocessing approach to modify medicinal plant extracts by selectively transforming phytochemicals while maintaining safety and compositional integrity. Controlled in vitro fermentation has gained attention as a practical method to generate stable, cell-independent bioactivity consistent with postbiotic [...] Read more.
Fermentation is increasingly used as a controlled bioprocessing approach to modify medicinal plant extracts by selectively transforming phytochemicals while maintaining safety and compositional integrity. Controlled in vitro fermentation has gained attention as a practical method to generate stable, cell-independent bioactivity consistent with postbiotic concepts. This review examines Scopus-indexed studies on fermented medicinal plant extracts, focusing on microbial platforms, fermentation strategies, dominant biotransformation pathways, and functional outcomes. Evidence indicates that fermentation is not a uniform process but follows platform-specific enzymatic pathways that reshape phenolics, flavonoids, alkaloids, and polysaccharides. Lactic acid bacteria (LAB) are most frequently applied due to their safety profile and enzymatic capacity, while yeasts and filamentous fungi enable complementary matrix restructuring and deeper chemical modification. Across systems, fermentation-driven biotransformation produces bioactive profiles that persist independently of microbial viability, supporting a postbiotic-oriented interpretation. Applications have been reported in food, nutraceutical, cosmetic, and animal nutrition contexts, although clinical translation remains limited. Remaining challenges include incomplete mechanistic understanding, limited standardization, and unclear regulatory positioning. Full article
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