Bioactive Compounds of Plant Food Origin in the Era of Metabolic Diseases

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Food Nutrition".

Deadline for manuscript submissions: 31 May 2026 | Viewed by 1334

Special Issue Editors


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Guest Editor
Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, Magdalenka, Poland
Interests: animal; plant resources; metabolic diseases; antioxidants; functional foods; healthy diet; bioactive compounds

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Guest Editor
1. Alentejo Biotechnology Center for Agriculture and Agro-Food (CEBAL)/Polythechnic Institute of Beja (IPBeja), 7801-908 Beja, Portugal
2. Mediterranean Institute for Agriculture, Environment and Development–MED, CEBAL, 7081-908 Beja, Portugal
Interests: agro-industry subproducts valorization; non-conventional extraction methodologies, phytochemicals bio-based solutions
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Special Issue Information

Dear Colleagues,

Metabolic diseases pose a huge challenge for healthcare systems worldwide. Recently, the number of metabolic disease cases and related deaths has increased dramatically. One of the main problems contributing to this state of affairs is bad eating habits. To this end, it is necessary to promote a diet containing an adequate amount of bioactive compounds, which play a key role in human health due to their diverse biological properties, such as antioxidant, anticancer, antimutagenic, anti-inflammatory, antimicrobial and antiallergic properties. Bioactive compounds of plant origin include, among others, biologically active proteins, polyphenols, carotenoids, etc. It has been proven that the compounds’ actions are beneficial for the proper functioning of human health, which effectively reduces the risk of inflammation and subsequent development of many related disorders, including metabolic diseases such as diabetes.

This special issue may address the potential of bioactive compounds of plant origin by describing, among others, aspects of their isolation and structural characterization; their biological activity; possible interactions with other substances, e.g., drugs; and ways for determining their positive impact on limiting the development of metabolic diseases, which may constitute a background for developing innovative therapeutic strategies, such as selecting appropriate bioactive ingredients of plant origin for developing functional foods to counteract metabolic diseases.

Dr. Magdalena Koszarska
Dr. Maria Fátima Duarte
Guest Editors

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Keywords

  • plant resources
  • metabolic diseases
  • antioxidants
  • functional foods
  • healthy diet
  • bioactive compounds
  • nutrition
  • added-value products

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Published Papers (1 paper)

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Review

26 pages, 597 KB  
Review
Apple Pomace as a Promising By-Product with High Antioxidant Potential in the Prevention of Aging Processes
by Kamil Wysocki, Maima Matin, Magdalena Koszarska, Cyprian Tomasik, Bogumiła Zima-Kulisiewicz and Nina Strzałkowska
Foods 2026, 15(7), 1174; https://doi.org/10.3390/foods15071174 - 31 Mar 2026
Viewed by 870
Abstract
Aging is closely linked to oxidative stress and inflammation. This review provides a critical overview of the antioxidant compounds present in apple pomace and explores how they may mitigate age-related oxidative damage and inflammatory responses. We focus on the nutritional profile of apple [...] Read more.
Aging is closely linked to oxidative stress and inflammation. This review provides a critical overview of the antioxidant compounds present in apple pomace and explores how they may mitigate age-related oxidative damage and inflammatory responses. We focus on the nutritional profile of apple pomace including its macro- and micronutrients, with particular focus on polyphenols, such as procyanidin tannins, quercetin glycosides (rutin, quercetin-3-glucoside), phloridzin, dietary fiber, vitamins, and lipids alongside current techniques for isolating its bioactive components. Special attention is given to biological pathways through which these compounds influence aging: redox regulation via Nrf2, inflammatory modulation via NF-κB, and metabolic regulation via AMPK, SIRT1 and PI3K/Akt/mTOR. Evidence from in vitro cellular models (HepG2, CCD-986Sk fibroblasts), in vivo rodent studies and limited human pilot trials is summarized, as well as existing and emerging applications of apple pomace in functional foods, cosmeceuticals, and other sectors. Finally, we discuss the challenges and future opportunities in harnessing this by-product of the food industry. Although clinical data remain limited, preclinical findings support the repurposing of apple pomace as a sustainable functional ingredient contributing to healthier aging and circular economy goals. Future long-term randomized controlled trials are necessary to confirm efficacy in humans. Full article
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