Advancing Fermentation Bioprocesses for Microbial Natural Products

Dear Colleagues,

Fermentation remains the cornerstone of efforts to produce high-value microbial bioactives, including antibiotics, enzymes, pigments, and other secondary metabolites. Efficient and scalable fermentation processes are essential to translate discoveries from laboratory benches to industrial manufacturing while maintaining product quality, yield, and process robustness.

This Special Issue of Fermentation invites original research articles, reviews, and perspectives that advance our understanding and application of fermentation bioprocesses. We welcome contributions on, but not limited to, the following areas:

• Bench- to pilot-scale process development.
• Fed-batch, continuous, or two-stage fermentation strategies.
• Process monitoring, control, and automation.
• Oxygen transfer, mixing, and heat removal in bioreactors.
• Downstream integration and in situ product recovery.
• High-cell-density cultivation and process intensification.
• Sustainable fermentation and alternative feedstock utilization.
• Scale-up strategies and reproducibility from laboratory to manufacturing.

The focus of this publication is on process innovation, optimization, and engineering, providing a platform to share best practices and cutting-edge approaches in fermentation process design and scale-up.

We welcome submissions that deliver actionable insights for both academic researchers and industrial practitioners seeking to enhance microbial bioactive production.

Dr. Mekala Venkatachalam
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Fermentation is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.