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Diagnostics publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Deep Learning, Generative AI, and Explainable AI in Medical Diagnostics: From Data to Decisions

edited by

Steven L. Fernandes

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1819 | Submission Open

Keywords: deep learning; machine learning; generative AI; explainable AI; medical diagnostics; medical imaging processing and analysis

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

New Aspects of CTC Research for Basic Medicine and Clinical Application

edited by Hayao Nakanishi

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1708 | Submission Open

Keywords: CTC; metastasis; mobilization; cluster heterogeneity; routine blood test; genetic analysis; CTC organoid

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Advances in the Diagnosis and Management of Breast Cancer: Second Edition

edited by

Fulvio Borella

and

Isabella Castellano

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1689 | Submission Open

Keywords: prognostic and predictive factors; breast carcinoma; phylloid tumor; immunohistochemistry; diagnosis; breast cancer

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Advanced Diagnostic and Therapeutic Digestive Endoscopy

edited by Pier Alberto Testoni

submission deadline 31 Aug 2026 | Viewed by 1587 | Submission Open

Keywords: gastroenterology; digestive tract diseases; gastrointestinal endoscopy; early diagnosis; endocavitary therapy

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advances in Echocardiography Diagnostics

edited by Hatem Soliman Aboumarie

submission deadline 31 Aug 2026 | 3 articles | Viewed by 1567 | Submission Open

Keywords: echocardiography innovations; cardiac imaging advancements; strain echocardiography; 3D/4D cardiac ultrasound

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advances in Pain Medicine: Diagnostic and Management Innovations

edited by Yuchen Lee, Dongwoo Nam and Cheng-Hao Tu

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1345 | Submission Open

Keywords: pain medicine; chronic pain; neuropathic pain; nociplastic pain; biomarkers; imaging; quantitative sensory testing; artificial intelligence; digital health; multimodal analgesia; neuromodulation; precision medicine

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in Diagnostic Pathways for Pregnancy Complications and Gynecologic Disease

edited by Argyro Papadopoulou

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1310 | Submission Open

Keywords: pregnancy complications; prenatal diagnosis; placental disorders; preeclampsia prediction; infertility evaluation; endometriosis diagnosis; minimally invasive techniques; biomarkers; women’s views; gynecologic oncology

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Innovations in Diagnostic Radiology: AI, Advanced Imaging and Precision Medicine

edited by

Thomas Frauenfelder

submission deadline 31 Aug 2026 | 2 articles | Viewed by 1280 | Submission Open

Keywords: medical imaging; worklfow optimization; vision-language models; clinical decision support; diagnostic radiology; AI agents in healthcare; explainable AI

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Laboratory Diagnosis of Emerging and Recent Infectious Diseases

edited by

Chaeseung Lim

and

Woongsik Jang

submission deadline 31 Aug 2026 | Viewed by 1263 | Submission Open

Keywords: emerging infectious diseases; laboratory diagnostics; molecular testing; immunoassays; point-of-care testing; pathogen detection; public health surveillance

(This special issue belongs to the Section Clinical Laboratory Medicine)

Diagnostic Approaches to Temporomandibular Disorders

edited by

Yiu Yan Leung

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1170 | Submission Open

Keywords: temporomandibular disorders; TMD; diagnostic approaches; imaging modalities; clinical assessment; TMJ; facial pain, MRI, CBCT; orofacial pain

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advances in Musculoskeletal Imaging and Exercise Metabolism

edited by Jimin Ren

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1086 | Submission Open

Keywords: quantitative musculoskeletal MRI/MRS; exercise physiology; muscle bioenergetics; pH and metabolic flux; oxygenation and perfusion; rehabilitation and training; aging and sarcopenia; mineral metabolism and lipid infiltration

(This special issue belongs to the Section Medical Imaging and Theranostics)

Orthopedics and the Musculoskeletal System: Clinical Diagnosis and Management

edited by

Nahum Rosenberg

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1051 | Submission Open

Keywords: imaging diagnosis; AI-assisted diagnostic tools; biomarkers; shoulder pathology; bone healing; fracture management; spine disorders

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Clinical Diagnosis and Prognosis of Urologic Oncology

edited by

Juan Gómez Rivas

and Jesús Moreno Sierra

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1035 | Submission Open

Keywords: urologic cancers; prostate; bladder; kidney; testicular malignancies

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

New Technologies in Advanced Cytopathological and Histopathological Diagnostics

edited by

Giuseppe Donato

and

Paolo Zaffino

submission deadline 31 Aug 2026 | Viewed by 1018 | Submission Open

Keywords: digital pathology; molecular markers; cytopathology; histopathology; multimodal analysis

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Role of Magnetic Resonance Imaging in Obesity and Diabetes: 2nd Edition

edited by

Per Lav Madsen

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1017 | Submission Open

Keywords: magnetic resonance imaging (MRI); obesity and diabetes; diabetic foot complications; brain atrophy; diabetic kidney disease (DKD); functional MRI; non-invasive imaging; early diagnosis

(This special issue belongs to the Section Medical Imaging and Theranostics)

Recent Advances in Epidemiological Diagnostics: Detecting and Controlling Infectious Diseases, 2nd Edition

edited by

Sri Banerjee

and W. Sumner Davis

submission deadline 31 Aug 2026 | 1 articles | Viewed by 991 | Submission Open

Keywords: epidemiological diagnostics; disease control; clinical practice and patient care; public health; infectious diseases

(This special issue belongs to the Section Diagnostic Microbiology and Infectious Disease)

Rare Cancers: Improving Diagnosis and Prognosis Through Collaborative Research

edited by Chen-Wang Chang

submission deadline 31 Aug 2026 | 2 articles | Viewed by 957 | Submission Open

Keywords: rare cancer; diagnosis and prognosis; biomarker; early detection; precision medicine

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

New Advances in the Diagnosis and Management of Skin Diseases and Skin Quality Enhancement

edited by

Peter Hsien Li Peng

and Leihong Flora Xiang

submission deadline 31 Aug 2026 | 1 articles | Viewed by 854 | Submission Open

Keywords: diagnostic focus: non-invasive diagnostics (dermoscopy, ultrasound(sonography), and OCT), dermatopathology; management focus: precision dermatology, lasers, energy based devices (EBDs), injectables; enhancement focus: skin quality, dermal remodeling

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Diagnosis and Management of Hepatobiliary Diseases

edited by

Ivan Romic

submission deadline 31 Aug 2026 | 1 articles | Viewed by 700 | Submission Open

Keywords: hepatobiliary diseases; liver diagnostics; biliary diagnostics; cirrhosis; malignancies

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Diagnostic Innovations in Endodontics and Regenerative Dental Medicine

edited by

Paulo J. Palma

submission deadline 31 Aug 2026 | Viewed by 562 | Submission Open

Keywords: endodontic diagnostics; regenerative endodontics; nanomaterials; magnetic resonance imaging; cone-beam computed tomography (CBCT); optical coherence tomography (OCT); dental imaging innovations; pulp vitality biomarkers; periapical disease profiling; artificial intelligence in dentistry; predictive diagnostics

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Diagnostic Advances in Neurodegenerative Diseases

edited by

Giulia Bivona

submission deadline 31 Aug 2026 | Viewed by 555 | Submission Open

Keywords: Alzheimer’s disease (AD); Parkinson’s disease (PD); amyotrophic lateral sclerosis (ALS); prognosis; diagnosis; biomarkers

(This special issue belongs to the Section Clinical Laboratory Medicine)

Non-Ionizing Imaging in Oral and Maxillofacial Radiology: Advances in MRI and Ultrasound

edited by

Gürkan Ünsal

submission deadline 31 Aug 2026 | Viewed by 478 | Submission Open

Keywords: dental MRI; high-field MRI; TMJ imaging; ultrasound; elastography; salivary gland imaging; point-of-care imaging

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advances in Forensic Medicine and Postmortem Diagnosis

edited by

Hiroshi Ikegaya

submission deadline 31 Aug 2026 | Viewed by 470 | Submission Open

Keywords: forensic pathology; postmortem diagnosis; cause of death; postmortem imaging; forensic DNA analysis; forensic anthropology; toxicological analysis

Diagnosis and Prognosis of Gynecological Diseases: Advances and Challenges

edited by Stefano Bettocchi and Stefania Carlucci

submission deadline 31 Aug 2026 | Viewed by 449 | Submission Open

Keywords: gynecological diseases; hysteroscopy; diagnostic technologies; prognostic evaluation; biomarkers; imaging techniques; artificial intelligence

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Novel Approaches for Artificial Intelligence in Neuroimaging Applications, 2nd Edition

edited by

Kwang-Sig Lee

submission deadline 31 Aug 2026 | Viewed by 420 | Submission Open

Keywords: neuroimaging; machine learning; deep learning; explainable artificial intelligence; SHAP; GradCAM; generative artificial intelligence; BERT; GPT; multi-modal reinforcement learning

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Multidisciplinary Approaches to Oral Cancer Diagnosis

edited by

Siu Wai Choi

submission deadline 31 Aug 2026 | Viewed by 411 | Submission Open

Keywords: oral cancer diagnosis; oral cancer progression; machine learning; prediction models; biomarkers; early prediction

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Advanced Radiomics in Precision Oncology

edited by

Shahin Zandieh

submission deadline 31 Aug 2026 | Viewed by 350 | Submission Open

Keywords: radiomics; deep radiomics; medical imaging; artificial intelligence (AI); precision medicine; quantitative imaging; deep learning; feature extraction; image analytics; big data

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Diagnosis and Management of Lung Cancer—2nd Edition

edited by

Savvas Lampridis

and

Marco Scarci

submission deadline 31 Aug 2026 | 1 articles | Viewed by 349 | Submission Open

Keywords: lung cancer; diagnosis; screening; imaging; pathology; biomarkers

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Multimodality Cardiac Imaging: Enhancing Precision in Cardiology

edited by

Sanjeev Bhattacharyya

and Apostolos Vrettos

submission deadline 31 Aug 2026 | Viewed by 328 | Submission Open

Keywords: multimodality cardiac imaging; echocardiography; cardiac CT; cardiac MRI; transcatheter interventions; precision cardiology; imaging biomarkers

(This special issue belongs to the Section Medical Imaging and Theranostics)

Precision Medicine in Cardiology: Applications in Risk Stratification, Diagnostics, Prognosis, and Management

edited by Aman Goyal and Zhuqing Shi

submission deadline 31 Aug 2026 | Viewed by 313 | Submission Open

Keywords: biomarkers; precision medicine; personalized medicine; diagnostics; risk; prognosis; cardiovascular medicine; heart failure; atrial fibrillation; coronary artery disease

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advanced Diagnosis of Acute Kidney Injury

edited by

Rolando Claure-Del Granado

and Nuttha Lumlertgul

submission deadline 31 Aug 2026 | Viewed by 287 | Submission Open

Keywords: AKI biomarkers; point-of-care testing; multi-omics integration; machine learning risk prediction; urinary proteomics; biomarker-guided decision support; functional renal imaging

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Point-of-Care Echocardiography in Emergency and Critical Care

edited by

Alfredo Mauriello

submission deadline 31 Aug 2026 | Viewed by 270 | Submission Open

Keywords: pocus; echocardiography; intensive cardiac care; shock; acute coronary syndrome

(This special issue belongs to the Section Point-of-Care Diagnostics and Devices)

Diagnosis and Management of Hypertrophic Cardiomyopathy

edited by Ibraim Masciarelli Francisco Pinto

submission deadline 31 Aug 2026 | Viewed by 252 | Submission Open

Keywords: hypertrophic cardiomyopathy; multimodality imaging; genetic testing; cardiac MRI; risk stratification; myosin inhibitor; septal reduction therapy; sudden cardiac death; echocardiography; precision cardiology

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

New Insights into the Diagnosis and Management of Head and Neck Cancer

edited by Yung-An Tsou

submission deadline 31 Aug 2026 | Viewed by 232 | Submission Open

Keywords: oropharyngeal cancer; HPV; radiotherapy optimization; multidisciplinary approaches; transoral robotics surgery

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Functional Gastrointestinal Disorders (FGIDs): Diagnosis and Pathophysiology, Second Edition

edited by Gengqing Song

submission deadline 30 Sep 2026 | 4 articles | Viewed by 31431 | Submission Open

Keywords: functional gastrointestinal disorders; diagnosis; treatment approach; ROME criteria

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Clinical Presentation, Management and Prognosis of Infective Endocarditis

edited by

Arian Arjomandi Rad

, Alexander Weymann and Thanos Athanasiou

submission deadline 30 Sep 2026 | 2 articles | Viewed by 16587 | Submission Open

Keywords: infective endocarditis; clinical presentation; diagnostic modalities; antibiotic stewardship; surgical interventions; prognostic indicators

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in Infectious Disease Diagnosis Technologies

edited by

Dakai Liu

and Fermina Maria Mazzella

submission deadline 30 Sep 2026 | 7 articles | Viewed by 15573 | Submission Open

Keywords: molecular diagnosis; biomarkers; microbial culture and identification; high-throughput sequencing; infectious diseases; artificial intelligence; digital image; radiological imaging; point-of-care testing

(This special issue belongs to the Section Diagnostic Microbiology and Infectious Disease)

Advances in Diagnostic Methods for Laboratory Medicine

edited by

Syed M. Shahid

submission deadline 30 Sep 2026 | 3 articles | Viewed by 14103 | Submission Open

Keywords: diabetes mellitus; clinical diagnostics; biomarkers; prevision medicine; glycemic control; digital health

(This special issue belongs to the Section Clinical Laboratory Medicine)

Soft Tissue Sarcoma: From Diagnosis to Prognosis

edited by

Consolato M. Sergi

submission deadline 30 Sep 2026 | 3 articles | Viewed by 12811 | Submission Open

Keywords: soft tissue; mesenchyme; bone; pathogenesis; miRNA; imaging; diagnosis; therapy

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Diagnosis and Prognosis of Hematological Disease

edited by Sapha Shibeeb

submission deadline 30 Sep 2026 | 5 articles | Viewed by 11843 | Submission Open

Keywords: hematological diseases; leukaemia; molecular diagnostics; next-generation sequencing (NGS); precision medicine; predictive biomarkers; AI-assited diagnosis

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Artificial Intelligence in Diagnostics: From Algorithms to Clinical Impact

edited by

Ali Athar

, David Brown and

Hanem Ellethy

submission deadline 30 Sep 2026 | 10 articles | Viewed by 11307 | Submission Open

Keywords: machine learning in healthcare; artificial intelligence in diagnostics; medical imaging and deep learning; generative AI in medicine; multimodal data integration; explainable and trustworthy AI; translational medical AI; clinical decision support systems; secure and privacy-compliant data utilization

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Innovative Diagnostic Approaches in Retinal Diseases

edited by

Benedetto Falsini

and Andrea Cusumano

submission deadline 30 Sep 2026 | 6 articles | Viewed by 9547 | Submission Open

Keywords: retinal diseases; electrophysiology; imaging; optical coherence tomography

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in Diagnosis and Management of Endometrial Diseases

edited by

Kotaro Kitaya

submission deadline 30 Sep 2026 | 5 articles | Viewed by 9220 | Submission Open

Keywords: endometrial diseases; artificial intelligence; hysteroscopy; ultrasound; minimally invasive surgery

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Diagnosis and Management of Hematologic Malignancies

edited by

Ankur Varma

submission deadline 30 Sep 2026 | 5 articles | Viewed by 8238 | Submission Open

Keywords: acute myeloid leukemia; chronic myeloid leukemia; myelodysplastic syndrome; myeloproliferative neoplasm; Hodgkin's lymphoma; non-Hodgkin's lymphoma; acute lymphocytic leukemia; chronic lymphocytic leukemia; bone marrow failure syndrome; juvenile myelomonocytic leukemia

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Advances in Imaging Diagnosis of Dermatology

edited by Linda Tognetti

submission deadline 30 Sep 2026 | 4 articles | Viewed by 8142 | Submission Open

Keywords: high-resolution imaging; non-invasive diagnosis; LC-OCT; RCM; OCT; US

(This special issue belongs to the Section Medical Imaging and Theranostics)

Revolutionizing Male Infertility: Novel Mechanistic Insights, Diagnostic Innovations, and Management Strategies

edited by

Athanasios Zachariou

submission deadline 30 Sep 2026 | 4 articles | Viewed by 7980 | Submission Open

Keywords: male infertility; andrology; reproductive health; testis; spermatozoa; semen analysis; TESE; mTESE; ultrasound; artificial intelligence; IVF

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in Sleep and Respiratory Medicine

edited by Cheng-Yu Tsai

submission deadline 30 Sep 2026 | 4 articles | Viewed by 7451 | Submission Open

Keywords: sleep and respiratory disorders; chest medicine; AI in healthcare; digital technology; precision diagnostics

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Applications of Optical Coherence Tomography and Optical Coherence Tomography Angiography in Ophthalmology

edited by

Daniela Bacherini

submission deadline 30 Sep 2026 | 5 articles | Viewed by 6606 | Submission Open

Keywords: OCT; OCTA; ophthalmology; diagnostics; clinical applications

(This special issue belongs to the Section Biomedical Optics)

Digital Innovation in Salivary Diagnostics for Oral and Systemic Health

edited by

Corina Marilena Cristache

submission deadline 30 Sep 2026 | 2 articles | Viewed by 5842 | Submission Open

Keywords: saliva diagnosis; oral disease; systemic diseases; artificial intelligence; AI driven diagnosis

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

New Trends in Cardiovascular Imaging: 2nd Edition

edited by

Hans-Christoph Becker

submission deadline 30 Sep 2026 | 5 articles | Viewed by 5792 | Submission Open

Keywords: cardiac CT; cardiac MRI; hybrid and multimodality imaging; artificial intelligence and machine learning; coronary artery disease; myocardial tissue characterization; congenital heart disease

(This special issue belongs to the Section Medical Imaging and Theranostics)

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