Diagnosis and Management of Hypertrophic Cardiomyopathy
A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Diagnosis and Prognosis".
Deadline for manuscript submissions: 31 August 2026 | Viewed by 21
Special Issue Editor
Special Issue Information
Dear Colleagues,
Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disorder and presents a broad phenotypic spectrum that continues to challenge clinicians in everyday practice. Although multimodality imaging, genetic testing, and biomarker assessment have significantly improved diagnostic accuracy and risk stratification, important uncertainties remain—particularly in the interpretation of borderline phenotypes, early detection of disease, assessment of microvascular dysfunction, and the clinical significance of subtle imaging abnormalities.
Therapeutic decisions increasingly rely on precise diagnostic information. Imaging biomarkers, genetic profiles, and functional assessments play a central role in identifying patients who may benefit from disease-modifying therapy or referral for septal reduction procedures. However, several practical questions persist: How should clinicians integrate imaging and genetics for individualized decision making? Which diagnostic thresholds best identify candidates for invasive intervention? And how should atypical or mixed phenotypes be approached in real-world practice?
This Special Issue aims to explore these unresolved diagnostic challenges by bringing together contemporary insights across imaging, genetics, precision medicine, and decision-making pathways in HCM. We particularly welcome submissions addressing diagnostic uncertainties, imaging biomarkers, genetic testing, and risk stratification frameworks that guide therapeutic decisions.
Recommended Topics for Submission:
- Epidemiology, prevalence, and clinical presentation of hypertrophic cardiomyopathy;
- Multimodality imaging for diagnosis and risk stratification;
- Genetics and precision medicine in clinical practice;
- Diagnostic controversies: borderline hypertrophy, phenocopies, and early disease;
- Imaging and clinical markers guiding therapeutic decisions (pharmacologic or invasive);
- Diagnostic criteria for referral to septal reduction therapy;
- Sudden cardiac death prevention and modern risk prediction;
- Implementation challenges: translating diagnostic evidence into real-world practice.
Dr. Ibraim Masciarelli Francisco Pinto
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- hypertrophic cardiomyopathy
- multimodality imaging
- genetic testing
- cardiac MRI
- risk stratification
- myosin inhibitor
- septal reduction therapy
- sudden cardiac death
- echocardiography
- precision cardiology
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