Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Emerging Insights into Natural Killer Cell Immunity in Infection and Cancer
edited by Sumit Sen Santara, , Weshely Kujur and Sachin Mulik
submission deadline 30 Nov 2025 | 4 articles | Viewed by 7747 | Submission Open
Keywords: CAR NK cells; cancer immunotherapy; cell therapy; viral infection; memory NK cells; NK cell targeted therapies; NK-immune cell crosstalk; exosomes
(This special issue belongs to the Section Cellular Immunology)
New Research on Immunity and Inflammation in Cardiovascular Disease
edited by Pavel Poredoš
submission deadline 30 Nov 2025 | 7 articles | Viewed by 7349 | Submission Open
Keywords: inflammation; atherosclerosis; coronary artery disease; peripheral arterial disease; cerebrovascular disease; venous thromboembolic disease; circulating biomarkers; anti-innflammatory treatment of cardiovascular disease
(This special issue belongs to the Section Cells of the Cardiovascular System)
Recent Advances in Metabolism and Oxidative Stress in Human Diseases: 2nd Edition
edited by and Vanessa Cossu
submission deadline 30 Nov 2025 | 4 articles | Viewed by 6994 | Submission Open
Keywords: antioxidant responses; redox balance; ROS; hematologic oncology; solid tumors; immune response; ATP; cancer cells; mitochondria-ER interactions; endoplasmic reticulum; glucose metabolism; inflammation; mitochondria; mitochondrial dynamics; autophagy; mitophagy; metabolic plasticity; metabolism
(This special issue belongs to the Section Cellular Metabolism)
Advances in Muscle Research in Health and Disease—2nd Edition
edited by
submission deadline 30 Nov 2025 | 3 articles | Viewed by 5710 | Submission Open
Keywords: skeletal muscle; cardiac muscle; smooth muscle; myocyte; vascular smooth muscle cell; stem cell; development; homeostasis; regeneration; biomarker; therapeutic target
(This special issue belongs to the Section Tissues and Organs)
Harnessing the Tumor Microenvironment and Signaling Pathways for Precision Cancer Therapy
edited by Behzad M. Toosi and
submission deadline 30 Nov 2025 | 2 articles | Viewed by 4716 | Submission Open
Keywords: tumor microenvironment (TME); signaling pathways; precision cancer therapy; immune evasion; metabolic pathways; tumor– stroma interactions; therapeutic targets; personalized medicine; cancer metastasis; molecular oncology
(This special issue belongs to the Section Cell Microenvironment)
Role of Calpains in Health and Diseases
edited by and Peter A. Greer
submission deadline 30 Nov 2025 | 4 articles | Viewed by 4557 | Submission Open
Keywords: calpain; physiology; biochemistry; disease; mutation; target; inhibitor
(This special issue belongs to the Section Cellular Pathology)
Retinal Pigment Epithelium in Degenerative Retinal Diseases
edited by Jian Liu and Shintaro Horie
submission deadline 30 Nov 2025 | 3 articles | Viewed by 4515 | Submission Open
Keywords: RPE; degenerative retinal diseases; macular degeneration; diabetic retinopathy; glaucoma; photoreceptor; vascular endothelium; microglia; macrophage; inflammation; oxidative stress; autophagy; mitochondria; lipid metabolism; senescence; neuropeptide; therapeutics; biomarkers
(This special issue belongs to the Section Cellular Pathology)
Cellular Mechanisms in Mitochondrial Function and Calcium Signaling
edited by Sergio De la Fuente and Jaime Santo-Domingo
submission deadline 30 Nov 2025 | 2 articles | Viewed by 3622 | Submission Open
Keywords: mitochondria; calcium; MCU; uniporter; NCLX; energy metabolism; disease; MAMs; signaling
(This special issue belongs to the Section Cellular Metabolism)
Genetic and Cellular Basis of Autoimmune Diseases
edited by
submission deadline 30 Nov 2025 | 2 articles | Viewed by 3567 | Submission Open
Keywords: autoimmune disease; break of tolerance; effector cells; immunodysregulation; risk genes
(This special issue belongs to the Section Cellular Immunology)
Osteoblasts, Osteoclasts and Bone Diseases: Cellular Crosstalk and Therapeutic Opportunities
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 3539 | Submission Open
Keywords: osteoblasts; osteoclasts; bone remodelling; osteoporosis; skeletal diseases; bone homeostasis; bone interactions; bone crosstalk; targeted therapies
(This special issue belongs to the Section Cellular Pathology)
Advances in Musculoskeletal Tissue Regeneration Using Mesenchymal Stromal/Stem Cells, Biomaterials, and Signaling Molecules: Second Edition submission deadline 30 Nov 2025 | 2 articles | Viewed by 3387 | Submission Open
Keywords: mesenchymal stromal/stem cells; extracellular vesicles; biomaterials; signalling molecules; microphysiological systems; musculoskeletal regeneration; immunomodulation; cell therapy; tissue engineering
(This special issue belongs to the Section Stem Cells)
CRISPR-Based Genome Editing Approaches in Cancer Therapy
edited by Martin Pal
submission deadline 30 Nov 2025 | 2 articles | Viewed by 2653 | Submission Open
Keywords: CRISPR; genome editing; cancer therapy; precision medicine
(This special issue belongs to the Section Cell and Gene Therapy)
Neuroinflammation in Developmental Brain Diseases submission deadline 30 Nov 2025 | 1 articles | Viewed by 2443 | Submission Open
Keywords: neuroinflammation; endothelial injury; blood brain barrier; microglia; immune dysfunction; oxidative stress; autism spectrum disorders; epilepsy; cerebral palsy; schizophrenia; neurodevelopment; neurovascular brain signaling; inflammatory cytokines; immune cells
(This special issue belongs to the Section Cells of the Nervous System)
Emerging Advances in Neurodegeneration: Innovations in Stem Cell and Organoid Research
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 2120 | Submission Open
Keywords: neurodegeneration; stem cells; induced pluripotent stem cells (iPSCs); brain organoids; disease modeling; therapeutic strategies; personalized medicine
(This special issue belongs to the Section Stem Cells)
Aging and Neurodegeneration: Molecular Insights and Emerging Strategies submission deadline 30 Nov 2025 | 1 articles | Viewed by 2117 | Submission Open
Keywords: Alzheimer’ s disease; biomarkers; endolysosomal pathway; extracellular vesicles; inflammation; mitophagy; neurodegeneration; neuroinflammation; Parkinson’ s disease; translational research
(This special issue belongs to the Section Cellular Aging)
Modulation of Senescence and Differentiation in Human Mesenchymal Stem Cells submission deadline 30 Nov 2025 | 1 articles | Viewed by 1775 | Submission Open
Keywords: tissue-specific mesenchymal stem cells; cell senescence; cell differentiation; natural and synthetic molecules; tissue engineering; regenerative medicine
(This special issue belongs to the Section Stem Cells)
Epigenetic Regulatory Networks in Cancer: Understanding the Mechanisms of Disease Progression
edited by and Sudheer Kumar Gara
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1757 | Submission Open
Keywords: cancer; epigenetics; miRNAs; BAP1; DNMTs; tumor suppressor; oncogenes; histone modification; chromatin remodeling
(This special issue belongs to the Section Cellular Pathology)
Myocardial Ischemia/Reperfusion Injury: Mechanisms and New Directions in Cardioprotection
edited by Sauri Hernandez-Resendiz
submission deadline 30 Nov 2025 | 2 articles | Viewed by 1469 | Submission Open
Keywords: myocardial infarction; heart failure; ischemia/reperfusion injury; no-reflow phenomenon; oxidative stress; cell death; cardiac metabolism; mitochondrial quality control; inflammation; cardioprotection
(This special issue belongs to the Section Tissues and Organs)
Updates of Stem Cell Applications in Bone Tissue Engineering
edited by Fahad Karim Kidwai
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1388 | Submission Open
Keywords: stem cells; bone tissue engineering; bone diseases; bone repair; bone defect; bone healing; bone regeneration; osteogenic progenitor cells
(This special issue belongs to the Section Stem Cells)
Molecular and Cellular Mechanisms of Brain Development and Neurodevelopmental Disorders
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1336 | Submission Open
Keywords: brain development; neural stem cells; neurodevelopmental disorders; brain diseases; cellular and molecular mechanisms; embryonic and adult brain
(This special issue belongs to the Section Cellular Pathology)
Non-Coding RNAs as Regulators of Cellular Function and Disease
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1227 | Submission Open
Keywords: non-coding RNAs; gene regulation; disease mechanisms; therapeutic targets; molecular mechanisms
Cellular and Molecular Mechanisms of Wound Repair
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 1042 | Submission Open
Keywords: wound healing; cellular mechanisms; tissue remodeling; growth factors; extracellular matrix; tissue regeneration
(This special issue belongs to the Section Cellular Pathology)
Adipose-Derived Stem Cells for Tissue Regeneration submission deadline 30 Nov 2025 | 1 articles | Viewed by 1013 | Submission Open
Keywords: adipose stem cells (ASCs); stromal vascular fraction (SVF); cell enriched lipotransfer (CELT and CELT-PLUS); extracellular vesicles (EVs); tissue processing; basic biology; mechanisms of action; regenerative medicine; cell-bases therapies
(This special issue belongs to the Section Tissues and Organs)
Brain Organoids for Disease Modeling
edited by
submission deadline 30 Nov 2025 | 1 articles | Viewed by 887 | Submission Open
Keywords: brain organoids; induced pluripotent stem cells (iPSCs); neurodevelopmental disorders; neurodegenerative diseases; neuronal activity; organoid-based drug screening
(This special issue belongs to the Section Stem Cells)
G Protein-Coupled Receptors and Diseases
edited by
submission deadline 30 Nov 2025 | Viewed by 559 | Submission Open
Keywords: G protein-coupled receptor; taste receptor; microbiome; cancer; aging; neurodegenerative disease; cardiovascular disease; pulmonary hypertension; cell survival; cell death; apoptosis; autophagy; necroptosis; ferroptosis; proliferation
Drug Resistance in Breast and Ovarian Cancers
edited by
submission deadline 30 Nov 2025 | Viewed by 387 | Submission Open
Keywords: breast cancer; endocrine resistance; ESR1 mutations; Trop-2; ovarian cancer; drug resistance; predictive biomarkers; personalized medicine
Hypoxia Pathway Proteins in the Immune System: Regulation, Disease, and Therapeutics
edited by Ben Wielockx
submission deadline 30 Nov 2025 | Viewed by 351 | Submission Open
Keywords: hypoxia; oxygen sensors; immune system; HIF; disease mechanisms; therapeutics; inflammation; autoimmunity; cancer immunology
(This special issue belongs to the Section Cellular Immunology)
Exploring Morphological Changes and Diversity in Cancer
edited by
submission deadline 30 Nov 2025 | Viewed by 286 | Submission Open
Keywords: morphology; heterogeneity; cancer; phenotype; shape
Exploring the Structural and Functional Diversity of Proteins: Foundations of Life and Biological Complexity
edited by Jiabei Lin
submission deadline 30 Nov 2025 | Viewed by 257 | Submission Open
Keywords: AAA+ protein; RNA-binding protein; protein kinase; PTMs; protein structure; function; and diseases; protein and RNA homeostasis; neurodegeneration; cancer
Molecular Research in Osteoporosis submission deadline 30 Nov 2025 | Viewed by 183 | Submission Open
Keywords: osteoporosis; osteosarcopenia; bone– muscle crosstalk; genetics; epigenetics; transcriptomics; biomarkers; therapeutic strategy
(This special issue belongs to the Section Cellular Pathology)
Crossroad Between Oxidative Stress and DNA Damage and Repair in Stroke
edited by , and Moorthi Ponnusamy
submission deadline 30 Nov 2025 | Viewed by 165 | Submission Open
Keywords: oxidative stress; DNA damage; DNA repair; stroke; ischemic stroke; neuroinflamamtion; intracranial hemorrhagic stroke; neuronal death
(This special issue belongs to the Section Cells of the Nervous System)
Redox Regulation by Nrf2 in Health and Disease
edited by Pandu Gangula
submission deadline 30 Nov 2025 | Viewed by 163 | Submission Open
Keywords: Nrf2; redox; cellular stress response; antioxidant gene regulation; signaling pathway crosstalk; oxidative stress response
ROS in Atherosclerosis and Cardiometabolic Disorders
edited by
submission deadline 30 Nov 2025 | Viewed by 158 | Submission Open
Keywords: reactive oxygen/nitrogen species; oxidative stress; atherosclerosis; cardiovascular; inflammation; endothelial dysfunction; obesity; dyslipidemia
(This special issue belongs to the Section Tissues and Organs)
Molecular Mechanisms of Drug Delivery in Ophthalmology
edited by Alekha K. Dash and Surabhi Shukla
submission deadline 30 Nov 2025 | Viewed by 132 | Submission Open
Keywords: drug delivery; ophthalmology; nanocarriers; ocular barriers; molecular transport; targeted therapy; ocular gene delivery
(This special issue belongs to the Section Tissues and Organs)
Lung Cancer: Molecular Mechanisms and Therapeutic Opportunities submission deadline 30 Nov 2025 | Viewed by 131 | Submission Open
Keywords: precision oncology; immunotherapy; targeted therapy; genomic characterization; biomarker; microenvironment; non-small cell lung cancer; small cell lung cancer
(This special issue belongs to the Section Cell Microenvironment)
Protein and RNA Regulation in Cells
edited by and
submission deadline 30 Nov 2025 | Viewed by 126 | Submission Open
Keywords: gene expression; post-transcriptional regulation; post-translational modifications; non-coding RNAs; regulatory networks; protein degradation; RNA decay
The Cellular and Molecular Basis of Lifestyle Factors in Cancer Progression and Prevention
edited by Vivek Kumar Kashyap and Himanshu Narayan Singh
submission deadline 30 Nov 2025 | Viewed by 125 | Submission Open
Keywords: lifestyle factors; smoking; alcohol consumption; cancer risk; cancer prevention recommendations; modifiable risk factors
(This special issue belongs to the Section Cellular Pathology)
Extracellular Vesicles in Neurodegenerative Diseases: From Biomarker Discovery to Precision Therapeutics
edited by Mangesh Dattu Hade
submission deadline 30 Nov 2025 | Viewed by 103 | Submission Open
Keywords: neurodegenerative diseases; extracellular vesicles; Alzheimer's disease; Parkinson's disease; multiple sclerosis; blood– brain barrier; neuroinflammation; biomarker discovery; EV-based therapeutics; precision medicine
(This special issue belongs to the Section Cellular Aging)
Cellular and Molecular Mechanisms of Hepatobiliary Diseases submission deadline 30 Nov 2025 | Viewed by 101 | Submission Open
Keywords: hepatobiliary diseases; bile metabolism; hepatobiliary models; artificial intelligence; cholestatic diseases; systems medicine; spatio-temporal liver models
(This special issue belongs to the Section Tissues and Organs)
Brain Insulin Resistance in Neurodegenerative Disorders and Its Treatments
edited by Konrad Talbot
submission deadline 30 Nov 2025 | Viewed by 100 | Submission Open
Keywords: Alzheimer’ s disease; brain insulin resistance; Down syndrome; incretin receptor agonist; insulin; insulin resistance; multiple system atrophy; neurodegenerative disease; Parkinson’ s disease
(This special issue belongs to the Section Cells of the Nervous System)
Emerging Cell Therapies and Regenerative Approaches in Pulmonary Medicine
edited by Renata Kelly Da Palma
submission deadline 30 Nov 2025 | Viewed by 97 | Submission Open
Keywords: cell therapy; lung diseases; tissue regeneration
(This special issue belongs to the Section Tissues and Organs)
New Advances in Cardiac and Vascular Physiology
edited by Robert M. Lust
submission deadline 30 Nov 2025 | Viewed by 86 | Submission Open
Keywords: environmental exposure; immune responses; remodeling; receptors; ischemia; pre-conditioning; post-conditioning; heart failure
(This special issue belongs to the Section Tissues and Organs)
Advances in Pulmonary Fibrosis
edited by Sergio Piñeiro Hermida
submission deadline 1 Dec 2025 | 1 articles | Viewed by 616 | Submission Open
Keywords: pulmonary fibrosis; animal models; biomarkers; experimental therapeutics
(This special issue belongs to the Section Cellular Pathology)
The Spatial and Temporal Dynamics of the Tumor Microenvironment
edited by , Abhishek Gupta, Anjali Trivedi and
submission deadline 1 Dec 2025 | Viewed by 468 | Submission Open
Keywords: tumor microenvironment; spatial heterogeneity; spatial transcriptomics; tumor evolution; immune landscape; extracellular matrix; tumor– immune crosstalk; cancer heterogeneity; intra-tumoral heterogeneity; tumor niches
(This special issue belongs to the Section Cell Microenvironment)
The Role of Macrophages and Neutrophils in Chronic Inflammation-Related Disorders submission deadline 5 Dec 2025 | 6 articles | Viewed by 16318 | Submission Open
Keywords: chronic inflammation; neutrophils; macrophages; Alzheimer’ s disease; aging; cardiovascular diseases; obesity; cancer; fibrosis; tissue injury and repair
(This special issue belongs to the Section Cellular Immunology)
New Targets and Therapeutic Approaches Based on Molecular Mechanisms in Tumorigenesis and Cancer Metastasis
edited by
submission deadline 10 Dec 2025 | 2 articles | Viewed by 4144 | Submission Open
Keywords: metastasis; cancer; therapy; precision medicine; cancer stem cells; immuno-oncology; tumor microenvironment; antibody
(This special issue belongs to the Section Cell Microenvironment)
Therapeutic Mechanism of Nervous System Inflammation—Second Edition submission deadline 10 Dec 2025 | 1 articles | Viewed by 2044 | Submission Open
Keywords: neuroinflammation; neurodegeneration; therapy; drug target; cell signaling; cells of nervous system
(This special issue belongs to the Section Cells of the Nervous System)
The Role of Stem Cells in Retinal Conditions
edited by , Theo Empeslidis and Lorenzo Motta
submission deadline 10 Dec 2025 | Viewed by 470 | Submission Open
Keywords: stem cells; retinal conditions; regenerative medicine; age-related macular degeneration (AMD); retinitis pigmentosa; diabetic retinopathy; induced pluripotent stem cells (iPSCs); cell differentiation; vision restoration; clinical trials
(This special issue belongs to the Section Stem Cells)
Cell Death Mechanisms and Therapeutic Opportunities in Glioblastoma
edited by
submission deadline 15 Dec 2025 | 21 articles | Viewed by 70988 | Submission Open
Keywords: apoptosis; autophagy; cell death mechanisms; cell signaling; glioblastoma; therapeutic opportunities
(This special issue belongs to the Section Cells of the Nervous System)
New Advances in Neuroinflammation
edited by and Michael Breckwoldt
submission deadline 15 Dec 2025 | 14 articles | Viewed by 54822 | Submission Open
Keywords: neuroinflammation; biomarkers; neurodegeneration; microglia; astrocytes; oligodendrocytes; neurological diseases; blood-brain barrier; imaging
(This special issue belongs to the Section Cells of the Nervous System)
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