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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Retinoic Acid and Retinoid X Receptors - Series II

edited by

Michael Schubert

and

Pierre Germain

submission deadline 30 Jun 2026 | Viewed by 478 | Submission Open

Keywords: nuclear receptor signaling; retinoic acid receptor; retinoid X receptor; pharmacology; structure/function relationships; genomic and non-genomic signaling; post-translational modification; homeostasis and disease; development; origin and evolution

(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)

Kidney and Lung Disorders: The Role of Tubular and Alveolar Epithelia in Health, Disease, Infection, and Organ Crosstalk

edited by Aparna Renigunta and

Poornima Mahavadi

submission deadline 30 Jun 2026 | Viewed by 323 | Submission Open

Keywords: renal tubular disorders; alveolar lung diseases; transport mechanism; intracellular signaling; viral infection; crosstalk; dialysis; ventilation

Nuclear Pore Complex in Nanomedicine: Third Edition

edited by

Richard W. Wong

submission deadline 30 Jun 2026 | Viewed by 263 | Submission Open

Keywords: intracellular transport; NPC; mitosis; nano; cancer; brain

Cellular and Molecular Mechanisms in Reproductive Biology and Fertility

edited by

Giorgio Maria Baldini

and Antonio Malvasi

submission deadline 30 Jun 2026 | Viewed by 262 | Submission Open

Keywords: gametogenesis; fertilization; fertility; endocrinology; implantation; gametogenesis regulation; embryo– maternal interaction; reproductive signaling; IVF; in vitro fertilization; ovarian stimulation

(This special issue belongs to the Section Reproductive Cells and Development)

Crossroad Between Oxidative Stress and DNA Damage and Repair in Stroke

edited by

William James Antonisamy

Zahoor Shah

and Moorthi Ponnusamy

submission deadline 30 Jun 2026 | Viewed by 217 | Submission Open

Keywords: oxidative stress; DNA damage; DNA repair; stroke; ischemic stroke; neuroinflamamtion; intracranial hemorrhagic stroke; neuronal death

(This special issue belongs to the Section Cellular Neuroscience)

The Cross-Talk Between Obesity and Metabolism

edited by

Hong Shi

submission deadline 30 Jun 2026 | Viewed by 217 | Submission Open

Keywords: obesity; metabolic disorders; insulin resistance; adipose tissue; inflammation; glucose metabolism; lipid metabolism; cardiovascular disease; type 2 diabetes; therapeutic targets

Neuromuscular Disorders: Advances in Cellular and Molecular Understanding, Emerging Therapies, and Outcome Measures

edited by

Ivo Bozovic

and

Bogdan Bjelica

submission deadline 30 Jun 2026 | Viewed by 181 | Submission Open

Keywords: neuromuscular disorders; pathophysiology; biomarkers; treatment; impairment and disability measures; outcome measures

(This special issue belongs to the Section Tissues and Organs)

Hematopoietic Cell Lines as Models for Leukemia and Lymphoma

edited by Stefan Nagel

submission deadline 30 Jun 2026 | Viewed by 180 | Submission Open

Keywords: hematopoiesis; leukemia; lymphoma; transcription factor; homeobox genes

The Role of PPARs in Disease - Volume IV

edited by

Kay-Dietrich Wagner

and

Nicole Wagner

submission deadline 30 Jun 2026 | Viewed by 175 | Submission Open

Keywords: PPAR; immune function; liver; adipose tissue; cardiovascular system; muscle; brain; neurological disease; psychiatric diseases; cancer; transcriptional regulation; ligands; agonists/antagonists

(This special issue belongs to the Section Cells of the Cardiovascular System)

Extracellular Vesicles in Neurodegenerative Diseases: From Biomarker Discovery to Precision Therapeutics

edited by Mangesh Dattu Hade

submission deadline 30 Jun 2026 | Viewed by 147 | Submission Open

Keywords: neurodegenerative diseases; extracellular vesicles; Alzheimer's disease; Parkinson's disease; multiple sclerosis; blood– brain barrier; neuroinflammation; biomarker discovery; EV-based therapeutics; precision medicine

(This special issue belongs to the Section Cellular Aging)

Understanding Nasal Inflammation: The Interplay of Diagnosis, Endotypes, and Environmental Shifts

edited by Simonetta Masieri and

Carlo Cavaliere

submission deadline 30 Jun 2026 | Viewed by 143 | Submission Open

Keywords: rhinology; allergy; immunology; environment; pollution; microbiome; inflammation; united airway disease; lymphocyte cells; interleukins

(This special issue belongs to the Section Tissues and Organs)

Thoracic Tumors: Decoding Cellular Heterogeneity, Tumor Microenvironment Crosstalk, and Therapeutic Vulnerabilities

edited by

Vesna Ceriman Krstic

and Dragana Jovanovic

submission deadline 30 Jun 2026 | Viewed by 142 | Submission Open

Keywords: NSCLC; SCLC; mesothelioma; thymoma; thymic carcinoma; immunotherapy; molecular therapy; chemotherapy

(This special issue belongs to the Section Cell Microenvironment)

Cellular and Molecular Mechanisms of Hepatobiliary Diseases

edited by

Stefan Hoehme

and

Jan G. Hengstler

submission deadline 30 Jun 2026 | Viewed by 139 | Submission Open

Keywords: hepatobiliary diseases; bile metabolism; hepatobiliary models; artificial intelligence; cholestatic diseases; systems medicine; spatio-temporal liver models

(This special issue belongs to the Section Tissues and Organs)

Cellular Signalling Pathways in the Endocrine Pancreas and Diabetes

edited by

Catharina Alam

submission deadline 30 Jun 2026 | Viewed by 112 | Submission Open

Keywords: diabetes; cell signalling; molecular mechanisms; cell stress; endocrine pancreas; β -cells

(This special issue belongs to the Section Cell Signaling)

Mitochondrial Dynamics and Remodelling

edited by Edmund Carvalho

submission deadline 30 Jun 2026 | Viewed by 105 | Submission Open

Keywords: mitochondrial dynamics; fission; fusion; mitophagy; cristae remodeling; bioenergetics; ER– mitochondria contacts; immune reprogramming; signaling pathways; therapeutic targeting

Translating Extracellular Vesicle Science

edited by

Masato Mitsuhashi

and

Theresa L. Whiteside

submission deadline 30 Jun 2026 | Viewed by 102 | Submission Open

Keywords: extracellular vesicles (EVs); EV isolation; EV purification; EV characterization; EV images; EV tracking; EV-based diagnostics; EV-based monitoring; EV therapeutics; blood biomarkers; translational medicine; exosomes; cell signaling

Bone and Tooth Biology: Development and Regeneration

edited by Xiaofang Wang

submission deadline 30 Jun 2026 | Viewed by 100 | Submission Open

Keywords: bone; tooth; osteogenesis; odontogenesis; enamel; dentin; cementum; amelogenesis; dentinogenesis; regeneration; stem cells

Nuclear Organization and Nucleocytoplasmic Transport in Neuronal Development and Disease: Mechanisms and Therapeutic Opportunities

edited by

Masood Sepehrimanesh

submission deadline 30 Jun 2026 | Viewed by 94 | Submission Open

Keywords: nuclear organization; nucleocytoplasmic transport; neuronal development; neurodegeneration; nuclear pore complex (NPC); nuclear lamina; RNA trafficking; chromatin regulation; therapeutic targeting; neurodevelopmental disorders

(This special issue belongs to the Section Cellular Neuroscience)

Tau Pathobiology and Excitotoxicity in Neurodegeneration and Epilepsy

edited by Janet Van Eersel

submission deadline 30 Jun 2026 | Viewed by 82 | Submission Open

Keywords: tau; excitotoxicity; dementia; epilepsy; seizures; hyperexcitation

Neural Stem Cells and Progenitors: Mechanisms of Neurogenesis and Regenerative Potential

edited by Lidia De Filippis and Maurizio Gelati

submission deadline 30 Jun 2026 | Viewed by 72 | Submission Open

Keywords: neural stem cells; cancer stem cells; neuroregeneration; neurodegenerative diseases; CNS; neurorepair; neurogenesis; neuroinflammation

Advances in Cell-Based Studies and Therapeutic Approaches for Tissue Regeneration—Second Edition

edited by

Andreea-Mariana Negrescu

and

Anişoara Cîmpean

submission deadline 30 Jun 2026 | Viewed by 65 | Submission Open

Keywords: soft/hard tissue regeneration; therapeutic approaches; cell culture studies; inflammation-based diseases; degenerative diseases

(This special issue belongs to the Section Tissues and Organs)

Role of Macrophages in Tissue Repair

edited by

Guochang Hu

submission deadline 30 Jun 2026 | Viewed by 62 | Submission Open

Keywords: macrophages; inflammation; tissue repair; phagocytosis

(This special issue belongs to the Section Tissues and Organs)

The Immunology of Allergy and Asthma

edited by

Charles Pilette

and

Valerie Hox

submission deadline 30 Jun 2026 | Viewed by 62 | Submission Open

Keywords: type 2 immunity; rhinitis; food allergy; anaphylaxis; drug allergy; dermatitis; eczema; airway inflammation; IgE response; tissue remodelling; disease remission

Multifaceted Nature of Immune Responses to Viral Infection

edited by Homayon Ghiasi and Susmit Suvas

submission deadline 30 Jun 2026 | Viewed by 61 | Submission Open

Keywords: viral infection; innate and adaptive immunity; protection; RNA and DNA viruses; autoimmunity; immune escape

Inflammation in Target Organs—Second Edition

edited by

Itamar Raz

submission deadline 30 Jun 2026 | Viewed by 49 | Submission Open

Keywords: inflammation; fibrosis; cardio-renal; vascular; liver; brain

(This special issue belongs to the Section Cellular Immunology)

Synaptic Condensates: Liquid–Liquid Phase Separation of Pre- and Postsynaptic Scaffold Proteins in Synapse Development and Memory Formation

edited by Norbert Bencsik and

Michel Baudry

submission deadline 30 Jun 2026 | Viewed by 47 | Submission Open

Keywords: liquid– liquid phase separation (LLPS); synaptic plasticity; synapse development; postsynaptic density (PSD); scaffold proteins; synaptic dysfunction; neural circuits

(This special issue belongs to the Section Cellular Neuroscience)

Cell Metabolism in Endocrine Diseases

edited by Ranjodh Gill

submission deadline 30 Jun 2026 | Viewed by 37 | Submission Open

Keywords: endocrine system; hormones; metabolism; cellular pathways; homeostasis; diabetes mellitus; insulin resistance; thyroid disorders; hypothyroidism; hyperthyroidism; cortisol; Cushing's syndrome

(This special issue belongs to the Section Cellular Metabolism)

The Study of Skeletal Diseases

edited by Weiguang Wang

submission deadline 30 Jun 2026 | Viewed by 36 | Submission Open

Keywords: skeletal diseases; bone; cartilage; synovium; tendon; ligament; spine; craniofacial skeleton; immune– skeletal interaction; vascular and neural networks; stem and progenitor cells; artificial intelligence (AI); single-cell and spatial genomics; imaging and bioengineering; regenerative medicine

(This special issue belongs to the Section Cellular Pathology)

Epithelial-Immune Cell Interactions in Gut Homeostasis and Inflammation

edited by Neeraj Kapur

submission deadline 30 Jun 2026 | Viewed by 29 | Submission Open

Keywords: gut homeostasis; epithelial barrier; immune cell crosstalk; barrier dysfunction; intestinal inflammation; microbiota; dysbiosis

(This special issue belongs to the Section Cellular Immunology)

Novel Insights into Myeloid Leukemias

edited by

Bernhard Zdársky

submission deadline 30 Jun 2026 | Viewed by 20 | Submission Open

Keywords: leukemogenesis; bone marrow microenvironment; leukemia stem cells; immune evasion; hematopoiesis and myeloid differentiation; targeted therapy

(This special issue belongs to the Section Cellular Pathology)

Cellular Reprogramming and Epigenetic Control in Tissue Regeneration

edited by Sanjeeb Kumar Sahu

submission deadline 30 Jun 2026 | Viewed by 20 | Submission Open

Keywords: cellular reprogramming; epigenetic regulation; tissue regeneration; epigenetic rejuvenation; cellular plasticity; stem cell biology; regenerative medicine; DNA methylation

(This special issue belongs to the Section Tissues and Organs)

Immunometabolic Mechanisms in Aging and Chronic Inflammatory Diseases: From Senescence to Autoimmunity

edited by

Christian Jorgensen

submission deadline 30 Jun 2026 | Viewed by 16 | Submission Open

Keywords: immuno-metabolic; immune response; senescence; inflammation; immune cells; cell differentiation; cell maturation; autoimmunity; cancer

(This special issue belongs to the Section Cellular Immunology)

Melatonin in Neuroprotection: Mechanisms, Mitochondria, and Therapeutic Potential

edited by

Walter Balduini

Silvia Carloni

and

Walter Manucha

submission deadline 30 Jun 2026 | Viewed by 11 | Submission Open

Keywords: neurodegenerative disorders; melatonin; neuroprotection; mitochondria; oxidative stress; neuroinflammation; mitochondrial dynamics; therapeutic potential

(This special issue belongs to the Section Mitochondria)

Targeting Retinal Neurogliovascular Injury: Mechanisms and Therapeutic Strategies

edited by

Ruth B. Caldwell

and

Syed A. H. Zaidi

submission deadline 30 Jun 2026 | Viewed by 9 | Submission Open

Keywords: retinal neurogliovascular injury; retinal neurogliovascular disease; mechanisms; therapeutic strategies

(This special issue belongs to the Section Cellular Pathology)

Plant Stress Biology Under Biotic and Abiotic Environment

edited by

Violetta Katarzyna Macioszek

and

Andrzej K. Kononowicz

submission deadline 30 Jun 2026 | Viewed by 6 | Submission Open

Keywords: abiotic stress; microscopy; molecular biology; photosynthesis; phytohormnes; plant-pathogen interaction; plant physiology; plant biology; transcriptomics

(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)

Innovations in mRNA Delivery Vectors

edited by

Jacques P. Tremblay

submission deadline 30 Jun 2026 | Submission Open

Keywords: mRNA delivery systems; lipid nanoparticles (LNPs); non-viral vectors; targeted RNA delivery; extracellular vesicles

Advances in the Biology and Treatment of T-Cell Lymphoma

edited by

Pier Paolo Piccaluga

submission deadline 30 Jun 2026 | Submission Open

Keywords: T-cell lymphoma; cancer biology; oncogenic signaling; cellular mechanisms; cell– cell interactions; targeted therapy

(This special issue belongs to the Section Cellular Immunology)

Innate-Like T Cells: The Variegated Roles of Semi-Invariant TCRs in Health and Disease

edited by

Ethan Shevach

and Akshat Sharma

submission deadline 5 Jul 2026 | Viewed by 2342 | Submission Open

Keywords: innate-like T cells; cancer; autoimmunity; cytokines; immune mechanisms

(This special issue belongs to the Section Cellular Pathology)

Biochemical Interaction and Supramolecular Complexes of Receptors in Cell Membranes

edited by

Michela Corsini

and

Stefania Mitola

submission deadline 8 Jul 2026 | 1 articles | Viewed by 1457 | Submission Open

Keywords: membrane receptors; molecular complex; membrane microdomains

Experimental Systems to Model Aging Processes

edited by

Natascia Tiso

Giovanni Risato

and Ralf Dahm

submission deadline 10 Jul 2026 | 4 articles | Viewed by 9591 | Submission Open

Keywords: aging; ageing; age-related; longevity; model; animal; signalling pathway; mechanism; in vitro; in vivo; cell culture; marker

(This special issue belongs to the Section Cellular Aging)

Ripening and Degradation Mechanisms of Neutrophil Extracellular Traps

edited by

Martin Herrmann

and Maximilian Dölling

submission deadline 10 Jul 2026 | Viewed by 554 | Submission Open

Keywords: neutrophil extracellular traps; degradation of NETs; ripening of NETs

(This special issue belongs to the Section Cellular Immunology)

The Role of Mitochondria in Health, Disease, and Ageing

edited by

Arunkumar Venkatesan

and

Ritva Tikkanen

submission deadline 10 Jul 2026 | Viewed by 29 | Submission Open

Keywords: mitochondrial dysfunction; metabolism; mitochondrial genetics; aging and senescence; bioenergetics; mitophagy; neurodegeneration; cardiomyopathy; metabolic syndrome; ocular diseases

(This special issue belongs to the Section Mitochondria)

Hypoxia and the Immune Landscape in Infection and Cancer

edited by Bernard Burke

submission deadline 10 Jul 2026 | Viewed by 24 | Submission Open

Keywords: hypoxia; tumor; infection; HIFs; immune checkpoint proteins; immune evasion; metabolic dysregulation; leukocyte recruitment; effector cell function; acidosis

(This special issue belongs to the Section Cellular Immunology)

Cellular Signaling Networks in Development, Homeostasis, and Disease

edited by

Ying Xia

Mei Xin

and Chia-Yang Liu

submission deadline 10 Jul 2026 | Viewed by 19 | Submission Open

Keywords: cell fate determination; cell migration and survival; cell proliferation and differentiation; development and homeostasis; developmental disorders; disease mechanisms; regenerative medicine; signal transduction; signaling crosstalk; spatial transcriptomics

(This special issue belongs to the Section Cell Signaling)

Neuromodulatory Signaling in Brain Disorders: State-of-the-Art Insights

edited by

Kohji Fukunaga

and

Wenbin Jia

submission deadline 15 Jul 2026 | 3 articles | Viewed by 7099 | Submission Open

Keywords: neuromodulatory signaling; neural circuit; synaptic plasticity; neurotransmitter; signal transduction; neurodegenerative diseases; neuroinflammatory disorder; substance use disorder; neurodevelopmental disorder; targeted therapy

(This special issue belongs to the Section Tissues and Organs)

Tumor Stroma Interaction

edited by

Vladimir Jurisic

submission deadline 15 Jul 2026 | 1 articles | Viewed by 3386 | Submission Open

Keywords: cells; cancer; inflammation; exocytosis; immune system; tumor stroma

Inflammation in the Brain: From Molecular and Cellular Mechanisms to Therapeutic Strategies

edited by Sujatha Kannan and

Elizabeth Winans Tucker

submission deadline 15 Jul 2026 | 1 articles | Viewed by 1362 | Submission Open

Keywords: neuroinflammation; microglia; astrocytes; immune signaling; neurodegeneration; neuroimmunology; brain injury; therapeutic strategies

Recent Advances in the Understanding of Neuropsychiatric Illnesses

edited by

Junnan Li

and

Wanli Smith

submission deadline 15 Jul 2026 | Viewed by 414 | Submission Open

Keywords: neuropsychiatric disorders; neurodegeneration; synaptic plasticity; neuroinflammation; biomarkers; molecular mechanisms; translational neuroscience; intracellular signaling; neuroimaging

(This special issue belongs to the Section Cellular Neuroscience)

Functions of Cilia

edited by

Raj Luxmi

submission deadline 15 Jul 2026 | Viewed by 270 | Submission Open

Keywords: cilia; cilia-derived vesicles; ciliopathies; neuronal cilia; motile cilia; primary cilia; ciliary secretion; peptidergic signaling; ectosomes

Role of Hippo Signaling in Cancer

edited by

Dimpi Mukhopadhyay

and

Alessio D'Alessio

submission deadline 15 Jul 2026 | Viewed by 91 | Submission Open

Keywords: angiogenesis; cancer metabolism; cancer stemness; chemoresistance; endothelial cell plasticity; epithelial-to-mesenchymal transition (EMT); hippo signaling pathway; immunotherapy; mechanotransduction; targeted cancer therapy; TEAD transcription factors; therapeutic resistance; tumor microenvironment; tumorigenesis; YAP/TAZ; new therapeutic modalities to target YAP/TAZ-driven tumors including ferroptosis

(This special issue belongs to the Section Cell Signaling)

Displaying special issue 551-600 on page 12 of 14.

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