Targeting Retinal Neurogliovascular Injury: Mechanisms and Therapeutic Strategies
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: 30 June 2026 | Viewed by 185
Special Issue Editors
Interests: retinal neurovascular injury; diabetic retinopathy; retinopathy of prematurity; inflammation; vascular biology; angiogenesis; ischemia; arginase pathway; nitric oxide
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The retina, with its exquisite neurovascular unit, is uniquely vulnerable to insults that disrupt the intricate balance between neurons, glia, and blood vessels. Injury to this unit is a central pathological feature of major blinding diseases, including diabetic retinopathy, age-related macular degeneration, retinal vein occlusions, and glaucoma. While historically viewed as separate vascular or neuronal disorders, a paradigm shift recognizes these conditions as manifestations of coupled neurovascular injury, where pathological crosstalk between compromised vessels, inflamed glia, and degenerating neurons drives a vicious cycle of disease progression.
This Special Issue, “Targeting Retinal Neurogliovascular Injury: Mechanisms and Therapeutic Strategies”, seeks to compile cutting-edge research and insightful reviews that illuminate the complex, multifactorial mechanisms underlying this injury nexus. We invite contributions exploring novel pathways involving oxidative stress, neuroinflammation, glutamate excitotoxicity, mitochondrial dysfunction, and the breakdown of the blood–retinal barrier. A key focus will be on the dynamic roles of microglia, astrocytes, and pericytes in health and disease.
Furthermore, we emphasize translational and therapeutic research. Both original research articles and high-quality reviews are welcomed on innovative strategies, including novel pharmacologic agents (e.g., neuroprotectants, anti-inflammatories), gene and cell-based therapies, advanced drug delivery systems, and biomarker discovery aimed at halting or reversing neurovascular damage. By integrating mechanistic insights with therapeutic innovation, this Special Issue aims to foster a deeper understanding and inspire new, targeted interventions to preserve vision in retinal diseases.
Prof. Dr. Ruth B. Caldwell
Dr. Syed A. H. Zaidi
Guest Editors
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- retinal neurogliovascular injury
- retinal neurogliovascular disease
- mechanisms
- therapeutic strategies
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