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Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Recent Advances in Extracellular-Intracellular Communication and Cancer Therapies
edited by Ana Rita Carlos
submission deadline 30 Jun 2026 | Viewed by 290 | Submission Open
Keywords: extracellular matrix; ECM– cell communication; integrins; cytoskeleton; cancer therapies
Nuclear Pore Complex in Nanomedicine: Third Edition
edited by
submission deadline 30 Jun 2026 | Viewed by 281 | Submission Open
Keywords: intracellular transport; NPC; mitosis; nano; cancer; brain
The Cross-Talk Between Obesity and Metabolism
edited by
submission deadline 30 Jun 2026 | Viewed by 233 | Submission Open
Keywords: obesity; metabolic disorders; insulin resistance; adipose tissue; inflammation; glucose metabolism; lipid metabolism; cardiovascular disease; type 2 diabetes; therapeutic targets
Crossroad Between Oxidative Stress and DNA Damage and Repair in Stroke
edited by , and Moorthi Ponnusamy
submission deadline 30 Jun 2026 | Viewed by 232 | Submission Open
Keywords: oxidative stress; DNA damage; DNA repair; stroke; ischemic stroke; neuroinflamamtion; intracranial hemorrhagic stroke; neuronal death
(This special issue belongs to the Section Cellular Neuroscience)
Neuromuscular Disorders: Advances in Cellular and Molecular Understanding, Emerging Therapies, and Outcome Measures
edited by and
submission deadline 30 Jun 2026 | Viewed by 192 | Submission Open
Keywords: neuromuscular disorders; pathophysiology; biomarkers; treatment; impairment and disability measures; outcome measures
(This special issue belongs to the Section Tissues and Organs)
Hematopoietic Cell Lines as Models for Leukemia and Lymphoma
edited by Stefan Nagel
submission deadline 30 Jun 2026 | Viewed by 191 | Submission Open
Keywords: hematopoiesis; leukemia; lymphoma; transcription factor; homeobox genes
The Role of PPARs in Disease - Volume IV submission deadline 30 Jun 2026 | Viewed by 186 | Submission Open
Keywords: PPAR; immune function; liver; adipose tissue; cardiovascular system; muscle; brain; neurological disease; psychiatric diseases; cancer; transcriptional regulation; ligands; agonists/antagonists
(This special issue belongs to the Section Cells of the Cardiovascular System)
Extracellular Vesicles in Neurodegenerative Diseases: From Biomarker Discovery to Precision Therapeutics
edited by Mangesh Dattu Hade
submission deadline 30 Jun 2026 | Viewed by 161 | Submission Open
Keywords: neurodegenerative diseases; extracellular vesicles; Alzheimer's disease; Parkinson's disease; multiple sclerosis; blood– brain barrier; neuroinflammation; biomarker discovery; EV-based therapeutics; precision medicine
(This special issue belongs to the Section Cellular Aging)
Cellular and Molecular Mechanisms of Hepatobiliary Diseases submission deadline 30 Jun 2026 | Viewed by 159 | Submission Open
Keywords: hepatobiliary diseases; bile metabolism; hepatobiliary models; artificial intelligence; cholestatic diseases; systems medicine; spatio-temporal liver models
(This special issue belongs to the Section Tissues and Organs)
Thoracic Tumors: Decoding Cellular Heterogeneity, Tumor Microenvironment Crosstalk, and Therapeutic Vulnerabilities
edited by and Dragana Jovanovic
submission deadline 30 Jun 2026 | Viewed by 157 | Submission Open
Keywords: NSCLC; SCLC; mesothelioma; thymoma; thymic carcinoma; immunotherapy; molecular therapy; chemotherapy
(This special issue belongs to the Section Cell Microenvironment)
Mitochondrial Dynamics and Remodelling
edited by Edmund Carvalho
submission deadline 30 Jun 2026 | Viewed by 132 | Submission Open
Keywords: mitochondrial dynamics; fission; fusion; mitophagy; cristae remodeling; bioenergetics; ER– mitochondria contacts; immune reprogramming; signaling pathways; therapeutic targeting
Cellular Signalling Pathways in the Endocrine Pancreas and Diabetes
edited by
submission deadline 30 Jun 2026 | Viewed by 123 | Submission Open
Keywords: diabetes; cell signalling; molecular mechanisms; cell stress; endocrine pancreas; β -cells
(This special issue belongs to the Section Cell Signaling)
Translating Extracellular Vesicle Science submission deadline 30 Jun 2026 | Viewed by 120 | Submission Open
Keywords: extracellular vesicles (EVs); EV isolation; EV purification; EV characterization; EV images; EV tracking; EV-based diagnostics; EV-based monitoring; EV therapeutics; blood biomarkers; translational medicine; exosomes; cell signaling
Nuclear Organization and Nucleocytoplasmic Transport in Neuronal Development and Disease: Mechanisms and Therapeutic Opportunities submission deadline 30 Jun 2026 | Viewed by 119 | Submission Open
Keywords: nuclear organization; nucleocytoplasmic transport; neuronal development; neurodegeneration; nuclear pore complex (NPC); nuclear lamina; RNA trafficking; chromatin regulation; therapeutic targeting; neurodevelopmental disorders
(This special issue belongs to the Section Cellular Neuroscience)
Bone and Tooth Biology: Development and Regeneration
edited by Xiaofang Wang
submission deadline 30 Jun 2026 | Viewed by 119 | Submission Open
Keywords: bone; tooth; osteogenesis; odontogenesis; enamel; dentin; cementum; amelogenesis; dentinogenesis; regeneration; stem cells  
Molecular Basis of Gynecological Disorders and Associated Infertility submission deadline 30 Jun 2026 | Viewed by 115 | Submission Open
Keywords: gynecological disorders; endometriosis; polycystic ovary syndrome (PCOS); cervical cancer; ovarian cancer; uterine and vaginal pathologies
(This special issue belongs to the Section Cellular Pathology)
Tau Pathobiology and Excitotoxicity in Neurodegeneration and Epilepsy
edited by Janet Van Eersel
submission deadline 30 Jun 2026 | Viewed by 98 | Submission Open
Keywords: tau; excitotoxicity; dementia; epilepsy; seizures; hyperexcitation
Advances in Cell-Based Studies and Therapeutic Approaches for Tissue Regeneration—Second Edition submission deadline 30 Jun 2026 | Viewed by 89 | Submission Open
Keywords: soft/hard tissue regeneration; therapeutic approaches; cell culture studies; inflammation-based diseases; degenerative diseases
(This special issue belongs to the Section Tissues and Organs)
The Immunology of Allergy and Asthma submission deadline 30 Jun 2026 | Viewed by 89 | Submission Open
Keywords: type 2 immunity; rhinitis; food allergy; anaphylaxis; drug allergy; dermatitis; eczema; airway inflammation; IgE response; tissue remodelling; disease remission
Synaptic Condensates: Liquid–Liquid Phase Separation of Pre- and Postsynaptic Scaffold Proteins in Synapse Development and Memory Formation
edited by Norbert Bencsik and
submission deadline 30 Jun 2026 | Viewed by 86 | Submission Open
Keywords: liquid– liquid phase separation (LLPS); synaptic plasticity; synapse development; postsynaptic density (PSD); scaffold proteins; synaptic dysfunction; neural circuits
(This special issue belongs to the Section Cellular Neuroscience)
Neural Stem Cells and Progenitors: Mechanisms of Neurogenesis and Regenerative Potential
edited by Lidia De Filippis and Maurizio Gelati
submission deadline 30 Jun 2026 | Viewed by 86 | Submission Open
Keywords: neural stem cells; cancer stem cells; neuroregeneration; neurodegenerative diseases; CNS; neurorepair; neurogenesis; neuroinflammation
Advances in the Biology and Treatment of T-Cell Lymphoma submission deadline 30 Jun 2026 | Viewed by 84 | Submission Open
Keywords: T-cell lymphoma; cancer biology; oncogenic signaling; cellular mechanisms; cell– cell interactions; targeted therapy
(This special issue belongs to the Section Cellular Immunology)
Role of Macrophages in Tissue Repair
edited by
submission deadline 30 Jun 2026 | Viewed by 80 | Submission Open
Keywords: macrophages; inflammation; tissue repair; phagocytosis
(This special issue belongs to the Section Tissues and Organs)
Multifaceted Nature of Immune Responses to Viral Infection
edited by Homayon Ghiasi and Susmit Suvas
submission deadline 30 Jun 2026 | Viewed by 78 | Submission Open
Keywords: viral infection; innate and adaptive immunity; protection; RNA and DNA viruses; autoimmunity; immune escape
Inflammation in Target Organs—Second Edition
edited by
submission deadline 30 Jun 2026 | Viewed by 78 | Submission Open
Keywords: inflammation; fibrosis; cardio-renal; vascular; liver; brain
(This special issue belongs to the Section Cellular Immunology)
Sex Hormone-Driven Cancers: Molecular Pathogenesis, Metabolic Reprogramming and Therapeutic Frontiers submission deadline 30 Jun 2026 | Viewed by 68 | Submission Open
Keywords: sex hormones; androgen; estrogen; progesterone; breast cancer; ovarian cancer; endometrial cancer; prostate cancer; metabolic reprogramming; tumor microenvironment; drug resistance; cancer metabolism; metastasis
(This special issue belongs to the Section Cellular Pathology)
Cell Metabolism in Endocrine Diseases
edited by Ranjodh Gill
submission deadline 30 Jun 2026 | Viewed by 66 | Submission Open
Keywords: endocrine system; hormones; metabolism; cellular pathways; homeostasis; diabetes mellitus; insulin resistance; thyroid disorders; hypothyroidism; hyperthyroidism; cortisol; Cushing's syndrome
(This special issue belongs to the Section Cellular Metabolism)
Plant Stress Biology Under Biotic and Abiotic Environment submission deadline 30 Jun 2026 | Viewed by 60 | Submission Open
Keywords: abiotic stress; microscopy; molecular biology; photosynthesis; phytohormnes; plant-pathogen interaction; plant physiology; plant biology; transcriptomics
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Melatonin in Neuroprotection: Mechanisms, Mitochondria, and Therapeutic Potential submission deadline 30 Jun 2026 | Viewed by 55 | Submission Open
Keywords: neurodegenerative disorders; melatonin; neuroprotection; mitochondria; oxidative stress; neuroinflammation; mitochondrial dynamics; therapeutic potential
(This special issue belongs to the Section Mitochondria)
The Study of Skeletal Diseases
edited by Weiguang Wang
submission deadline 30 Jun 2026 | Viewed by 52 | Submission Open
Keywords: skeletal diseases; bone; cartilage; synovium; tendon; ligament; spine; craniofacial skeleton; immune– skeletal interaction; vascular and neural networks; stem and progenitor cells; artificial intelligence (AI); single-cell and spatial genomics; imaging and bioengineering; regenerative medicine
(This special issue belongs to the Section Cellular Pathology)
Pulmonary Hypertension: From the Molecular Mechanisms to Novel Therapies
edited by Mohamed Ahmed
submission deadline 30 Jun 2026 | Viewed by 51 | Submission Open
Keywords: molecular pathways; multi-omics in PH; new therapeutic targets; innovative therapy
(This special issue belongs to the Section Cellular Pathology)
Cell Cycle Dysregulation in Cancer: From Basic Mechanisms to Therapeutic Targeting
edited by Toshiyuki Sakamaki
submission deadline 30 Jun 2026 | Viewed by 50 | Submission Open
Keywords: cell cycle; cancer; cyclin-dependent kinases; checkpoint control; targeted therapy; therapeutic resistance; precision oncology; biomarker
(This special issue belongs to the Section Cell Proliferation and Division)
Organs-on-Chips and Organoids: From Disease Modeling to Advanced Therapeutics
edited by
submission deadline 30 Jun 2026 | Viewed by 48 | Submission Open
Keywords: organs-on-chips; organoids; disease modeling; tissue engineering; cellular reprogramming; regenerative medicine
Mitochondrial Dynamics in Cancer Metabolism: Mechanisms and Functional Consequences
edited by Che-Chia Hsu
submission deadline 30 Jun 2026 | Viewed by 47 | Submission Open
Keywords: mitochondrial fission; mitochondrial fusion; mitophagy; mitochondrial transport; mitochondrial transfer; mitochondrial diseases
(This special issue belongs to the Section Mitochondria)
Innovations in mRNA Delivery Vectors submission deadline 30 Jun 2026 | Viewed by 47 | Submission Open
Keywords: mRNA delivery systems; lipid nanoparticles (LNPs); non-viral vectors; targeted RNA delivery; extracellular vesicles
Epithelial-Immune Cell Interactions in Gut Homeostasis and Inflammation
edited by Neeraj Kapur
submission deadline 30 Jun 2026 | Viewed by 43 | Submission Open
Keywords: gut homeostasis; epithelial barrier; immune cell crosstalk; barrier dysfunction; intestinal inflammation; microbiota; dysbiosis
(This special issue belongs to the Section Cellular Immunology)
Targeting Retinal Neurogliovascular Injury: Mechanisms and Therapeutic Strategies submission deadline 30 Jun 2026 | Viewed by 40 | Submission Open
Keywords: retinal neurogliovascular injury; retinal neurogliovascular disease; mechanisms; therapeutic strategies
(This special issue belongs to the Section Cellular Pathology)
Cellular Reprogramming and Epigenetic Control in Tissue Regeneration
edited by Sanjeeb Kumar Sahu
submission deadline 30 Jun 2026 | Viewed by 39 | Submission Open
Keywords: cellular reprogramming; epigenetic regulation; tissue regeneration; epigenetic rejuvenation; cellular plasticity; stem cell biology; regenerative medicine; DNA methylation
(This special issue belongs to the Section Tissues and Organs)
Novel Insights into Myeloid Leukemias submission deadline 30 Jun 2026 | Viewed by 39 | Submission Open
Keywords: leukemogenesis; bone marrow microenvironment; leukemia stem cells; immune evasion; hematopoiesis and myeloid differentiation; targeted therapy
(This special issue belongs to the Section Cellular Pathology)
Immunometabolic Mechanisms in Aging and Chronic Inflammatory Diseases: From Senescence to Autoimmunity submission deadline 30 Jun 2026 | Viewed by 34 | Submission Open
Keywords: immuno-metabolic; immune response; senescence; inflammation; immune cells; cell differentiation; cell maturation; autoimmunity; cancer
(This special issue belongs to the Section Cellular Immunology)
Gene Regulation in Epithelial Cells
edited by Jennifer Zhang
submission deadline 30 Jun 2026 | Submission Open
Keywords: epithelial cells; gene regulation; epigenetic regulation; epithelium– immune crosstalk; epithelium– microbial interaction
(This special issue belongs to the Section Cell and Gene Therapy)
Chronic Coronary Syndromes: Cellular Pathways, Comorbidities, and Prognostic Determinants
edited by Chowdhury H. Ahsan
submission deadline 1 Jul 2026 | Viewed by 16 | Submission Open
Keywords: chronic coronary syndromes; microvascular dysfunction; endothelial injury; vascular biology; inflammation; cardiometabolic comorbidities; ischemic heart disease; risk stratification; precision cardiology
(This special issue belongs to the Section Cells of the Cardiovascular System)
Innate-Like T Cells: The Variegated Roles of Semi-Invariant TCRs in Health and Disease
edited by and Akshat Sharma
submission deadline 5 Jul 2026 | 1 articles | Viewed by 2561 | Submission Open
Keywords: innate-like T cells; cancer; autoimmunity; cytokines; immune mechanisms
(This special issue belongs to the Section Cellular Pathology)
Biochemical Interaction and Supramolecular Complexes of Receptors in Cell Membranes submission deadline 8 Jul 2026 | 1 articles | Viewed by 1658 | Submission Open
Keywords: membrane receptors; molecular complex; membrane microdomains
Experimental Systems to Model Aging Processes
edited by , and Ralf Dahm
submission deadline 10 Jul 2026 | 4 articles | Viewed by 10201 | Submission Open
Keywords: aging; ageing; age-related; longevity; model; animal; signalling pathway; mechanism; in vitro; in vivo; cell culture; marker
(This special issue belongs to the Section Cellular Aging)
Advances in Human Pluripotent Stem Cells submission deadline 10 Jul 2026 | 3 articles | Viewed by 4228 | Submission Open
Keywords: human pluripotent stem cells; embryonic stem cells; induced pluripotent stem cells  
(This special issue belongs to the Section Stem Cells)
Ripening and Degradation Mechanisms of Neutrophil Extracellular Traps
edited by and Maximilian Dölling
submission deadline 10 Jul 2026 | Viewed by 594 | Submission Open
Keywords: neutrophil extracellular traps; degradation of NETs; ripening of NETs
(This special issue belongs to the Section Cellular Immunology)
The Role of Mitochondria in Health, Disease, and Ageing submission deadline 10 Jul 2026 | Viewed by 58 | Submission Open
Keywords: mitochondrial dysfunction; metabolism; mitochondrial genetics; aging and senescence; bioenergetics; mitophagy; neurodegeneration; cardiomyopathy; metabolic syndrome; ocular diseases
(This special issue belongs to the Section Mitochondria)
Cellular Signaling Networks in Development, Homeostasis, and Disease
edited by , and Chia-Yang Liu
submission deadline 10 Jul 2026 | Viewed by 44 | Submission Open
Keywords: cell fate determination; cell migration and survival; cell proliferation and differentiation; development and homeostasis; developmental disorders; disease mechanisms; regenerative medicine; signal transduction; signaling crosstalk; spatial transcriptomics
(This special issue belongs to the Section Cell Signaling)
Hypoxia and the Immune Landscape in Infection and Cancer
edited by Bernard Burke
submission deadline 10 Jul 2026 | Viewed by 41 | Submission Open
Keywords: hypoxia; tumor; infection; HIFs; immune checkpoint proteins; immune evasion; metabolic dysregulation; leukocyte recruitment; effector cell function; acidosis
(This special issue belongs to the Section Cellular Immunology)
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