Organs-on-Chips and Organoids: From Disease Modeling to Advanced Therapeutics
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 30 June 2026 | Viewed by 12
Special Issue Editor
2. Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA
Interests: organ-on-chips; toxicology; complex in vitro models; organoids; spheroids; cellular mechanotransduction; mechanobiology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Organs-on-chips replicate tissue microenvironments and dynamic forces, while organoids capture complex multicellular architecture. Together, they provide unprecedented platforms for investigating human physiology and pathology. They are transforming fundamental research by enabling precise studies of disease mechanisms, cellular interactions, and drug responses in a human-relevant context. By offering greater physiological accuracy than traditional models (e.g., cell lines and animal models), these systems are advancing drug discovery and toxicology screening. However, significant challenges remain, including improving the functional maturity, reproducibility, and scalability of these models, as well as integrating multi-organ systems for holistic biological studies.
To address these critical challenges and accelerate translational progress, this Special Issue of Cells, titled “Organs-on-Chips and Organoids: From Disease Modeling to Advanced Therapeutics”, aims to showcase cutting-edge research and comprehensive reviews that explore the mechanisms, innovations, and applications of organs-on-chips and organoids. We welcome contributions that address cellular reprogramming, organoid-based disease modeling, tissue engineering, and clinical translation, fostering a multidisciplinary dialogue to drive breakthroughs in regenerative medicine and precision therapeutics.
You may choose our Joint Special Issue in Organoids.
Dr. Gautam Mahajan
Guest Editor
Manuscript Submission Information
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Keywords
- organs-on-chips
- organoids
- disease modeling
- tissue engineering
- cellular reprogramming
- regenerative medicine
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