Sex Hormone-Driven Cancers: Molecular Pathogenesis, Metabolic Reprogramming and Therapeutic Frontiers
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: 30 June 2026
Special Issue Editors
Interests: inflammation and cancer biology; immunology and bacterial pathogenesis; mitochondrial metabolism; post-translational modification; dietary agents; drug discovery; protein structure biology; life-style and environmental cancer; risk factors
Special Issues, Collections and Topics in MDPI journals
Interests: nuclear hormone receptors; androgen receptor; glucocorticoid receptor; antiandrogens; glucocorticoids; urothelial cancer; prostate cancer; genitourinary pathology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Sex steroids, including androgens, estrogens, and progestogens, are known to modulate not only a wide range of physiological processes beyond the reproductive system but also the development and progression of various cancers. Sex hormone-associated neoplasms, including breast, ovarian, endometrial, and prostate cancers, continue to represent a major global health burden. In the United States, breast and prostate cancers remain the most frequently diagnosed malignancies in women and men, respectively, while ovarian cancer, though less common, remains one of the most lethal gynecologic malignancies. Despite advances in early detection and targeted therapy with novel agents, hormone-driven cancers exhibit remarkable molecular plasticity, metabolic rewiring, and therapeutic resistance. Tumor evolution often involves the reprogramming of androgen-, estrogen-, or progesterone-mediated signaling pathways, along with alterations in mitochondrial and purine metabolism, immune evasion, and complex tumor–microenvironment interactions.
This Special Issue will highlight recent advances in basic, translational, and across a spectrum of cancers that exhibit endocrine regulation. We welcome original research articles and comprehensive reviews addressing sex hormone signaling and/or receptor biology in any malignancy.
Dr. Anil K Yadav
Prof. Dr. Hiroshi Miyamoto
Guest Editors
Manuscript Submission Information
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Keywords
- sex hormones
- androgen
- estrogen
- progesterone
- breast cancer
- ovarian cancer
- endometrial cancer
- prostate cancer
- metabolic reprogramming
- tumor microenvironment
- drug resistance
- cancer metabolism
- metastasis
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