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Mitophagy in Cancer: A Tale of Adaptation

1
Laboratory of Cell Death Research and Therapy, Department for Cellular and Molecular Medicine, Campus Gasthuisberg, University of Leuven (KU Leuven), Herestraat 49, B-3000 Leuven, Belgium
2
Laboratory of Cell Death Research and Therapy, VIB-KU Leuven Center for Cancer Biology, 3000 Leuven, Belgium
*
Author to whom correspondence should be addressed.
Cells 2019, 8(5), 493; https://doi.org/10.3390/cells8050493
Received: 2 May 2019 / Revised: 18 May 2019 / Accepted: 21 May 2019 / Published: 22 May 2019
(This article belongs to the Special Issue Tumor Microenvironment: Interaction and Metabolism)
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Abstract

In the past years, we have learnt that tumors co-evolve with their microenvironment, and that the active interaction between cancer cells and stromal cells plays a pivotal role in cancer initiation, progression and treatment response. Among the players involved, the pathways regulating mitochondrial functions have been shown to be crucial for both cancer and stromal cells. This is perhaps not surprising, considering that mitochondria in both cancerous and non-cancerous cells are decisive for vital metabolic and bioenergetic functions and to elicit cell death. The central part played by mitochondria also implies the existence of stringent mitochondrial quality control mechanisms, where a specialized autophagy pathway (mitophagy) ensures the selective removal of damaged or dysfunctional mitochondria. Although the molecular underpinnings of mitophagy regulation in mammalian cells remain incomplete, it is becoming clear that mitophagy pathways are intricately linked to the metabolic rewiring of cancer cells to support the high bioenergetic demand of the tumor. In this review, after a brief introduction of the main mitophagy regulators operating in mammalian cells, we discuss emerging cell autonomous roles of mitochondria quality control in cancer onset and progression. We also discuss the relevance of mitophagy in the cellular crosstalk with the tumor microenvironment and in anti-cancer therapy responses. View Full-Text
Keywords: mitophagy; mitochondria; autophagy; cancer; tumor microenvironment; anti-cancer therapy resistance; mitochondrial dynamics mitophagy; mitochondria; autophagy; cancer; tumor microenvironment; anti-cancer therapy resistance; mitochondrial dynamics
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Vara-Perez, M.; Felipe-Abrio, B.; Agostinis, P. Mitophagy in Cancer: A Tale of Adaptation. Cells 2019, 8, 493.

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