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Hypoxia- and MicroRNA-Induced Metabolic Reprogramming of Tumor-Initiating Cells

Molecular Disease Mechanisms Group, Life Sciences Research Unit, University of Luxembourg, L-4367 Belvaux, Luxembourg
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Cells 2019, 8(6), 528; https://doi.org/10.3390/cells8060528
Received: 15 April 2019 / Revised: 28 May 2019 / Accepted: 28 May 2019 / Published: 1 June 2019
(This article belongs to the Special Issue Tumor Microenvironment: Interaction and Metabolism)
Colorectal cancer (CRC), the second most common cause of cancer mortality in the Western world, is a highly heterogeneous disease that is driven by a rare subpopulation of tumorigenic cells, known as cancer stem cells (CSCs) or tumor-initiating cells (TICs). Over the past few years, a plethora of different approaches, aimed at identifying and eradicating these self-renewing TICs, have been described. A focus on the metabolic and bioenergetic differences between TICs and less aggressive differentiated cancer cells has thereby emerged as a promising strategy to specifically target the tumorigenic cell compartment. Extrinsic factors, such as nutrient availability or tumor hypoxia, are known to influence the metabolic state of TICs. In this review, we aim to summarize the current knowledge on environmental stress factors and how they affect the metabolism of TICs, with a special focus on microRNA (miRNA)- and hypoxia-induced effects on colon TICs. View Full-Text
Keywords: colorectal cancer; cancer stem cell; tumor-initiating cell; stemness; hypoxia; microRNA; miR-210; lactate; metabolic reprogramming colorectal cancer; cancer stem cell; tumor-initiating cell; stemness; hypoxia; microRNA; miR-210; lactate; metabolic reprogramming
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Ullmann, P.; Nurmik, M.; Begaj, R.; Haan, S.; Letellier, E. Hypoxia- and MicroRNA-Induced Metabolic Reprogramming of Tumor-Initiating Cells. Cells 2019, 8, 528.

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