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Hematological Malignancy-Derived Small Extracellular Vesicles and Tumor Microenvironment: The Art of Turning Foes into Friends

Tumor-Stroma Interactions, Department of Oncology, Luxembourg Institute of Health, 84, val fleuri, L-1526 Luxembourg, Luxembourg
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Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Cells 2019, 8(5), 511; https://doi.org/10.3390/cells8050511
Received: 2 April 2019 / Revised: 24 May 2019 / Accepted: 25 May 2019 / Published: 27 May 2019
(This article belongs to the Special Issue Tumor Microenvironment: Interaction and Metabolism)
Small extracellular vesicles (small EVs) are commonly released by all cells, and are found in all body fluids. They are implicated in cell to cell short- and long-distance communication through the transfer of genetic material and proteins, as well as interactions between target cell membrane receptors and ligands anchored on small EV membrane. Beyond their canonical functions in healthy tissues, small EVs are strategically used by tumors to communicate with the cellular microenvironment and to establish a proper niche which would ultimately allow cancer cell proliferation, escape from the immune surveillance, and metastasis formation. In this review, we highlight the effects of hematological malignancy-derived small EVs on immune and stromal cells in the tumor microenvironment. View Full-Text
Keywords: tumor-derived small EVs; exosomes; tumor microenvironment; hematological malignancies; leukemia; lymphoma; myeloma; immunity tumor-derived small EVs; exosomes; tumor microenvironment; hematological malignancies; leukemia; lymphoma; myeloma; immunity
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MDPI and ACS Style

Gargiulo, E.; Paggetti, J.; Moussay, E. Hematological Malignancy-Derived Small Extracellular Vesicles and Tumor Microenvironment: The Art of Turning Foes into Friends. Cells 2019, 8, 511.

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