Special Issue "Proteostasis and Autophagy"
Deadline for manuscript submissions: closed (15 November 2018)
Proteins belong to the most skilled but unstable components of the cell and their correct folding, ensuring the correct three-dimensional structure, is the basis of their function. Misfolding of proteins during translation, or as a consequence of internal or external challenges, calls for refolding mechanisms. Finally, if refolding fails, the rapid degradation of the target protein is mandatory. Therefore, folding, refolding, and degradation are the pillars of protein homeostasis (proteostasis) that needs to be tightly controlled to maintain proper cellular functions. A great effort has been made to understand the regulators of proteostasis, which has resulted in the definition of a fine-tuned network of factors, including molecular chaperones and the two main protein degradation routes, the ubiquitin proteasome system and the autophagy-lysosomal pathways. Recently, it became evident that both degradation pathways are not working independently of each other, but that there is cross-talk between them. While proteasomal degradation is rather well-defined, data on autophagic degradation of proteins and also intracellular organelles are currently exploding, precisely because there are many links of changes in autophagy to diseases, including neurodegeneration. The maintenance of cellular proteostasis and, in particular, the adequate degradation and removal of dysfunctional proteins is of distinct importance for post-mitotic cells such as neurons.
This Special Issue aims to depict the recent role of autophagy in the maintenance of proteostasis and the particular importance of the degradative pathway in cellular conditions or disorders that are linked to increased appearance of misfolded and aggregated proteins. We look forward to your contributions.
Prof. Dr. Christian Behl
Dr. Andreas Kern
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- selective macroautophagy
- protein misfolding / aggregation / degradation