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The Role of ATG16 in Autophagy and The Ubiquitin Proteasome System

Institute of Biomedical Sciences, Shanxi University, No.92 Wucheng Road, Taiyuan 030006, China
Center for Biochemistry, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 52, 50931 Cologne, Germany
Authors to whom correspondence should be addressed.
Received: 9 November 2018 / Revised: 17 December 2018 / Accepted: 18 December 2018 / Published: 20 December 2018
(This article belongs to the Special Issue Proteostasis and Autophagy)
Autophagy and the ubiquitin proteasome system (UPS) are the two major cellular degradation pathways, which are critical for the maintenance of cell homeostasis. The two pathways differ in their mechanisms and clients. The evolutionary conserved ATG16 plays a key role in autophagy and appears to link autophagy with the UPS. Here, we review the role of ATG16 in different species. We summarize the current knowledge of its functions in autophagosome membrane expansion and autophagosome formation, in Crohn’s disease, and in bacterial sequestration. In addition, we provide information on its autophagy-independent functions and its role in the crosstalk between autophagy and the UPS. View Full-Text
Keywords: ATG16; autophagy; ubiquitin proteasome system; UPS; crosstalk ATG16; autophagy; ubiquitin proteasome system; UPS; crosstalk
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MDPI and ACS Style

Xiong, Q.; Li, W.; Li, P.; Yang, M.; Wu, C.; Eichinger, L. The Role of ATG16 in Autophagy and The Ubiquitin Proteasome System. Cells 2019, 8, 2.

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