Next Article in Journal
Extracellular Histones Activate Plasma Membrane Toll-Like Receptor 9 to Trigger Calcium Oscillations in Rat Pancreatic Acinar Tumor Cell AR4-2J
Next Article in Special Issue
The Autophagy-Lysosomal Pathways and Their Emerging Roles in Modulating Proteostasis in Tumors
Previous Article in Journal
Can We Design a Nogo Receptor-Dependent Cellular Therapy to Target MS?
Previous Article in Special Issue
Role of Autophagy in Proteostasis: Friend and Foe in Cardiac Diseases
Article Menu

Export Article

Open AccessFeature PaperReview

The Role of ATG16 in Autophagy and The Ubiquitin Proteasome System

1
Institute of Biomedical Sciences, Shanxi University, No.92 Wucheng Road, Taiyuan 030006, China
2
Center for Biochemistry, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 52, 50931 Cologne, Germany
*
Authors to whom correspondence should be addressed.
Received: 9 November 2018 / Revised: 17 December 2018 / Accepted: 18 December 2018 / Published: 20 December 2018
(This article belongs to the Special Issue Proteostasis and Autophagy)
Full-Text   |   PDF [1808 KB, uploaded 20 December 2018]   |  

Abstract

Autophagy and the ubiquitin proteasome system (UPS) are the two major cellular degradation pathways, which are critical for the maintenance of cell homeostasis. The two pathways differ in their mechanisms and clients. The evolutionary conserved ATG16 plays a key role in autophagy and appears to link autophagy with the UPS. Here, we review the role of ATG16 in different species. We summarize the current knowledge of its functions in autophagosome membrane expansion and autophagosome formation, in Crohn’s disease, and in bacterial sequestration. In addition, we provide information on its autophagy-independent functions and its role in the crosstalk between autophagy and the UPS. View Full-Text
Keywords: ATG16; autophagy; ubiquitin proteasome system; UPS; crosstalk ATG16; autophagy; ubiquitin proteasome system; UPS; crosstalk
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Xiong, Q.; Li, W.; Li, P.; Yang, M.; Wu, C.; Eichinger, L. The Role of ATG16 in Autophagy and The Ubiquitin Proteasome System. Cells 2019, 8, 2.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Cells EISSN 2073-4409 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top