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Cells 2018, 7(12), 278; https://doi.org/10.3390/cells7120278

Autophagy: An Essential Degradation Program for Cellular Homeostasis and Life

Department of Oral Biochemistry and Molecular Biology, School of Dentistry, Kyung Hee University, Seoul 02447, Korea
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Received: 2 December 2018 / Revised: 18 December 2018 / Accepted: 18 December 2018 / Published: 19 December 2018
(This article belongs to the Special Issue Proteostasis and Autophagy)
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Abstract

Autophagy is a lysosome-dependent cellular degradation program that responds to a variety of environmental and cellular stresses. It is an evolutionarily well-conserved and essential pathway to maintain cellular homeostasis, therefore, dysfunction of autophagy is closely associated with a wide spectrum of human pathophysiological conditions including cancers and neurodegenerative diseases. The discovery and characterization of the kingdom of autophagy proteins have uncovered the molecular basis of the autophagy process. In addition, recent advances on the various post-translational modifications of autophagy proteins have shed light on the multiple layers of autophagy regulatory mechanisms, and provide novel therapeutic targets for the treatment of the diseases. View Full-Text
Keywords: autophagy; autophagy adaptor; AMPK-mTORC1-ULK1 triad; PIK3C3/VPS34; regulatory modifications autophagy; autophagy adaptor; AMPK-mTORC1-ULK1 triad; PIK3C3/VPS34; regulatory modifications
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Chun, Y.; Kim, J. Autophagy: An Essential Degradation Program for Cellular Homeostasis and Life. Cells 2018, 7, 278.

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