Next Article in Journal
Can We Design a Nogo Receptor-Dependent Cellular Therapy to Target MS?
Next Article in Special Issue
The Role of ATG16 in Autophagy and The Ubiquitin Proteasome System
Previous Article in Journal / Special Issue
Autophagy: An Essential Degradation Program for Cellular Homeostasis and Life
Article Menu
Issue 12 (December) cover image

Export Article

Open AccessReview
Cells 2018, 7(12), 279; https://doi.org/10.3390/cells7120279

Role of Autophagy in Proteostasis: Friend and Foe in Cardiac Diseases

Department of Physiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Cardiovascular Sciences, 1081 HV Amsterdam, The Netherlands
*
Authors to whom correspondence should be addressed.
Received: 20 November 2018 / Revised: 13 December 2018 / Accepted: 18 December 2018 / Published: 19 December 2018
(This article belongs to the Special Issue Proteostasis and Autophagy)
Full-Text   |   PDF [1309 KB, uploaded 20 December 2018]   |  
  |   Review Reports

Abstract

Due to ageing of the population, the incidence of cardiovascular diseases will increase in the coming years, constituting a substantial burden on health care systems. In particular, atrial fibrillation (AF) is approaching epidemic proportions. It has been identified that the derailment of proteostasis, which is characterized by the loss of homeostasis in protein biosynthesis, folding, trafficking, and clearance by protein degradation systems such as autophagy, underlies the development of common cardiac diseases. Among various safeguards within the proteostasis system, autophagy is a vital cellular process that modulates clearance of misfolded and proteotoxic proteins from cardiomyocytes. On the other hand, excessive autophagy may result in derailment of proteostasis and therefore cardiac dysfunction. Here, we review the interplay between autophagy and proteostasis in the healthy heart, discuss the imbalance between autophagy and proteostasis during cardiac diseases, including AF, and finally explore new druggable targets which may limit cardiac disease initiation and progression. View Full-Text
Keywords: proteostasis; autophagy; cardiac disease; atrial fibrillation proteostasis; autophagy; cardiac disease; atrial fibrillation
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Li, J.; Zhang, D.; Wiersma, M.; Brundel, B.J.J.M. Role of Autophagy in Proteostasis: Friend and Foe in Cardiac Diseases. Cells 2018, 7, 279.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Cells EISSN 2073-4409 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top