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The Role of Primary Cilia in the Crosstalk between the Ubiquitin–Proteasome System and Autophagy

Institute for Animal Developmental and Molecular Biology, Heinrich Heine University, 40225 Düsseldorf, Germany
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Author to whom correspondence should be addressed.
Cells 2019, 8(3), 241; https://doi.org/10.3390/cells8030241
Received: 29 December 2018 / Revised: 6 March 2019 / Accepted: 11 March 2019 / Published: 14 March 2019
(This article belongs to the Special Issue Proteostasis and Autophagy)
Protein degradation is a pivotal process for eukaryotic development and homeostasis. The majority of proteins are degraded by the ubiquitin–proteasome system and by autophagy. Recent studies describe a crosstalk between these two main eukaryotic degradation systems which allows for establishing a kind of safety mechanism. If one of these degradation systems is hampered, the other compensates for this defect. The mechanism behind this crosstalk is poorly understood. Novel studies suggest that primary cilia, little cellular protrusions, are involved in the regulation of the crosstalk between the two degradation systems. In this review article, we summarise the current knowledge about the association between cilia, the ubiquitin–proteasome system and autophagy. View Full-Text
Keywords: protein aggregation; neurodegenerative diseases; OFD1; BBS4; RPGRIP1L; hedgehog; mTOR; IFT; GLI protein aggregation; neurodegenerative diseases; OFD1; BBS4; RPGRIP1L; hedgehog; mTOR; IFT; GLI
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MDPI and ACS Style

Wiegering, A.; Rüther, U.; Gerhardt, C. The Role of Primary Cilia in the Crosstalk between the Ubiquitin–Proteasome System and Autophagy. Cells 2019, 8, 241. https://doi.org/10.3390/cells8030241

AMA Style

Wiegering A, Rüther U, Gerhardt C. The Role of Primary Cilia in the Crosstalk between the Ubiquitin–Proteasome System and Autophagy. Cells. 2019; 8(3):241. https://doi.org/10.3390/cells8030241

Chicago/Turabian Style

Wiegering, Antonia; Rüther, Ulrich; Gerhardt, Christoph. 2019. "The Role of Primary Cilia in the Crosstalk between the Ubiquitin–Proteasome System and Autophagy" Cells 8, no. 3: 241. https://doi.org/10.3390/cells8030241

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