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The Roles of Ubiquitin-Binding Protein Shuttles in the Degradative Fate of Ubiquitinated Proteins in the Ubiquitin-Proteasome System and Autophagy
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Cells 2019, 8(1), 44;

Is Autophagy Involved in the Diverse Effects of Antidepressants?

Max Planck Institute of Psychiatry, Munich 80804, Germany
Received: 15 December 2018 / Revised: 8 January 2019 / Accepted: 9 January 2019 / Published: 12 January 2019
(This article belongs to the Special Issue Proteostasis and Autophagy)
Full-Text   |   PDF [268 KB, uploaded 12 January 2019]   |   Review Reports


Autophagy has received increased attention as a conserved process governing cellular energy and protein homeostasis that is thus relevant in a range of physiological and pathophysiological conditions. Recently, autophagy has also been linked to depression, mainly through its involvement in the action of antidepressants. Some antidepressant drugs and psychotropic medication have been reported to exert beneficial effects in other diseases, for example, in cancer and neurodegenerative diseases. This review collates the evidence for the hypothesis that autophagy contributes to the effects of antidepressants beyond depression treatment. View Full-Text
Keywords: autophagy; antidepressants; depression; cancer; FKBP51 autophagy; antidepressants; depression; cancer; FKBP51
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Rein, T. Is Autophagy Involved in the Diverse Effects of Antidepressants? Cells 2019, 8, 44.

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