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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Modern Approach to Oral Cancer submission deadline 30 Aug 2026 | 12 articles | Viewed by 66752 | Submission Open
Keywords: oral cancer; neoplasm; oral surgery oncogenesis; dentistry oral health
(This special issue belongs to the Section Cancer Therapy)
Tumor Suppressor and Targeted Therapy in Hepatocellular Carcinoma: From Diagnosis to Treatment (2nd Edition)
edited by , and I-Cheng Lee
submission deadline 30 Aug 2026 | 2 articles | Viewed by 4452 | Submission Open
Keywords: tumor suppressor; targeted therapy; hepatocellular carcinoma
(This special issue belongs to the Section Tumor Microenvironment)
Pathology of Gynecological Cancers (2nd Edition)
edited by
submission deadline 30 Aug 2026 | 1 articles | Viewed by 1798 | Submission Open
Keywords: endometrial cancer; ovarian cancer; vulvar cancer; cervical cancer; vaginal cancer
(This special issue belongs to the Section Cancer Pathophysiology)
Pathology of Acute Myeloid Leukemia (AML)
edited by Olga K. Weinberg
submission deadline 30 Aug 2026 | Viewed by 1598 | Submission Open
(This special issue belongs to the Section Cancer Pathophysiology)
Challenges and Opportunities in Developing Therapies for Drug Resistance and Other Malignancies
edited by
submission deadline 30 Aug 2026 | 1 articles | Viewed by 1012 | Submission Open
Keywords: cancer; chemotherapy; multidrug resistance; innovative therapy
Advances in Clinical and Treatment of Bladder Cancer
edited by Roberto Contieri and
submission deadline 30 Aug 2026 | 1 articles | Viewed by 900 | Submission Open
Keywords: bladder cancer; urologic oncology; radical cystectomy; perioperative care; surgical outcomes; complications; rehabilitation; digital health; ERAS; patient safety
Proteometabolomics in Cancer submission deadline 30 Aug 2026 | Viewed by 514 | Submission Open
Keywords: proteomics; metabolomics; cancer biology; tumor microenvironment; biomarkers; therapeutics
(This special issue belongs to the Section Molecular Cancer Biology)
Robotic and Laparoscopic Surgery in Colorectal Cancer: Current Trends and Future Perspectives
edited by , Quentin Denost and Barbara Noiret
submission deadline 30 Aug 2026 | Viewed by 469 | Submission Open
Keywords: robotic surgery; laparoscopic surgery; colorectal cancer; minimally invasive surgery; comparative outcomes (perioperative, oncologic, functional); conversion rates; open surgery; learning curve and surgical training; cost‐effectiveness and health economics; technological innovations (e.g., AI, imaging, instrumentation); quality of life and long‐term patient‐reported outcomes
(This special issue belongs to the Section Cancer Therapy)
Research on Fluorescence-Guided Surgery in Cancer Treatment (2nd Edition)
edited by
submission deadline 30 Aug 2026 | Viewed by 346 | Submission Open
Keywords: fluorescence-guided surgery; fluorescent agents; tumor fluorescence; tumor margin detection; residual tumor assessment; glioma surgery; fluorescein sodium; 5-aminolevulinic acid; confocal endomicroscopy; Raman spectroscopy
(This special issue belongs to the Section Cancer Therapy)
Minimally Invasive Treatment of Lung Cancer Video-Assisted Thoracoscopic Therapy and Prognosis
edited by
submission deadline 30 Aug 2026 | Viewed by 304 | Submission Open
Keywords: VATS; uniportal; lung cancer; lobectomy; sleeve; segmentectomy; neo-adjuvant treatment; immunotherapy
(This special issue belongs to the Section Cancer Therapy)
Gastrointestinal Malignancy: Epidemiology and Risk Factors
edited by Patrick Okolo and Chengu Niu
submission deadline 31 Aug 2026 | 9 articles | Viewed by 49261 | Submission Open
Keywords: gastrointestinal cancer; epidemiology; risk factors; molecular markers; genetic factors; therapeutic advancements; prevention strategies; public health; interdisciplinary approaches; clinical impact
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Long-Term Cancer Survivors: Rehabilitation and Quality of Life submission deadline 31 Aug 2026 | 9 articles | Viewed by 25079 | Submission Open
Keywords: long term; cancer survivors; quality of life; rehabilitation; physical activity; cognition; non-pharmacological therapies
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Advancing Horizons in Colorectal Surgery: Innovative Approaches and Outcomes
edited by Petros I. Bangeas and Vasileios N. Papadopoulos
submission deadline 31 Aug 2026 | 5 articles | Viewed by 23692 | Submission Open
Keywords: colorectal surgery; postoperative pain; surgical site infections; anastomotic leaks; minimally invasive techniques; robotic surgery
(This special issue belongs to the Section Cancer Therapy)
Feature Review Paper Special Issue in Section Molecular Cancer Biology
edited by
submission deadline 31 Aug 2026 | 4 articles | Viewed by 15770 | Submission Open
Keywords: molecular biology; cell biology; cancer; tumor; cancer cell
(This special issue belongs to the Section Molecular Cancer Biology)
Personalized Radiotherapy in Cancer Care (2nd Edition)
edited by and
submission deadline 31 Aug 2026 | 9 articles | Viewed by 13449 | Submission Open
Keywords: predictive biomarkers; treatment-related toxicity; radiation treatments; radiation dose and volume; personalized radiation therapy
(This special issue belongs to the Section Methods and Technologies Development)
Cancer Stem Cells: The Origin of Tumor Relapse and Metastasis submission deadline 31 Aug 2026 | 3 articles | Viewed by 8843 | Submission Open
Keywords: metastasis; cancer stem cell; tumor microenvironment; tumor heterogeneity; plasticity; immune evasion; therapeutic resistance
(This special issue belongs to the Section Molecular Cancer Biology)
Oral Cancer: Prevention and Early Detection (2nd Edition) submission deadline 31 Aug 2026 | 2 articles | Viewed by 7638 | Submission Open
Keywords: oral cancer; oral squamous cell carcinoma; alcohol and tobacco; human papillomavirus (HPV); biomarkers; biopsy and liquid biopsy; oral potentially malignant disorders (OPMDs); oral pathology and oral medicine; oral and maxillofacial surgery; radiotherapy and chemotherapy
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
New Insights into Microbial-Based Cancer Therapy
edited by Amitabha Ray
submission deadline 31 Aug 2026 | 3 articles | Viewed by 7541 | Submission Open
Keywords: microbial therapy; cancer immunotherapy; bioengineering; immune modulation; tumor microenvironment
(This special issue belongs to the Section Cancer Therapy)
Renal Cell Carcinoma: Genetics, Surgical Management, and Systemic Therapy
edited by Alejandro Remigio Rodríguez, Stênio C. Zequi and Maxwell Sandberg
submission deadline 31 Aug 2026 | 6 articles | Viewed by 7462 | Submission Open
Keywords: renal cell carcinoma; robotics; laparoscopy; systemic therapy; genetics; surgery; urology; disparities; tumor thrombus; cryotherapy; global health
Neoadjuvant Therapy in Hepatopancreatobiliary Malignancies: Current Trends and Future Directions submission deadline 31 Aug 2026 | 4 articles | Viewed by 6347 | Submission Open
Keywords: neoadjuvant therapy; hepatopancreatobiliary malignancies; hepatocellular carcinoma; pancreatic cancer; cholangiocarcinoma; chemotherapy; radiotherapy; immunotherapy; targeted therapies; personalized treatment
(This special issue belongs to the Section Cancer Therapy)
Advances in the Management and Prognosis of Brain Metastases submission deadline 31 Aug 2026 | 5 articles | Viewed by 6277 | Submission Open
Keywords: immunotherapy; target therapy; stereotactic radiotherapy; prognosis; quality of life
(This special issue belongs to the Section Cancer Therapy)
Screening and Surveillance of Gastrointestinal and Pancreatic Cancers
edited by Darina Kohoutová and
submission deadline 31 Aug 2026 | 2 articles | Viewed by 6080 | Submission Open
Keywords: screening; surveillance; GI cancer; pancreatic precancerous lesions
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Prediction of Melanoma
edited by
submission deadline 31 Aug 2026 | 3 articles | Viewed by 5939 | Submission Open
Keywords: melanoma; melanoma genetics; biomarkers; predictive tools; risk prediction; risk factors; artificial intelligence
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Therapy for HER2 Breast Cancer
edited by and Sandra M. Swain
submission deadline 31 Aug 2026 | 3 articles | Viewed by 5303 | Submission Open
Keywords: antibody–drug conjugate; trastuzumab; pertuzumab; tyrosine kinase inhibitor; trastuzumab deruxtecan
(This special issue belongs to the Section Cancer Therapy)
Advances in the Diagnosis and Treatment of Genitourinary Cancers (2nd Edition)
edited by Piotr Radziszewski and
submission deadline 31 Aug 2026 | 2 articles | Viewed by 4493 | Submission Open
Keywords: genitourinary cancer; point-of-care diagnostics; personalized treatment; immunotherapy
(This special issue belongs to the Section Cancer Therapy)
AI-Enhanced Radiotherapy in Oncology: Optimization from Planning to Clinical Impact
edited by Christian Fiandra and Linda Rossi
submission deadline 31 Aug 2026 | 5 articles | Viewed by 4383 | Submission Open
Keywords: radiotherapy; oncology; artificial intelligence (AI); image segmentation; dose prediction and monitoring; deep learning; treatment planning optimization; adaptive radiotherapy; clinical decision support; personalized cancer treatment
(This special issue belongs to the Section Methods and Technologies Development)
Transforming Liver Cancer Care: From Molecular Understanding to Novel Therapeutic Strategies
edited by
submission deadline 31 Aug 2026 | 2 articles | Viewed by 3428 | Submission Open
Keywords: liver cancer; molecular research; biomarkers; targeted therapy; translational research
CAR T-Cell Therapy and Multiple Myeloma
edited by Jo Caers
submission deadline 31 Aug 2026 | 3 articles | Viewed by 3224 | Submission Open
Keywords: multiple myeloma; CAR-T immunotherapy; toxicity; efficacy; tumor models; safety
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
New Advances and Approaches in Thyroid Cancer
edited by and José Manuel Rodríguez
submission deadline 31 Aug 2026 | 2 articles | Viewed by 2982 | Submission Open
Keywords: thyroid cancer; medullary thyroid cancer; papillary thyroid cancer; follicular thyroid cancer; poorly differentiated thyroid tumours; novel approaches; prognostic biomarkers; risk stratification
(This special issue belongs to the Section Cancer Therapy)
Discovery and Development of New Anticancer Drugs and Delivery Systems: Special Emphasis on Artificial Intelligence, Machine-Learning, and Big Data Analysis submission deadline 31 Aug 2026 | 1 articles | Viewed by 2981 | Submission Open
Keywords: artificial intelligence; machine learning; big-data analytics; natural compounds; translational oncology; drug delivery systems
(This special issue belongs to the Section Cancer Drug Development)
Insulin Resistance, Diabetes, and Cancer: An Overview of the Pathogenetic Mechanisms submission deadline 31 Aug 2026 | 2 articles | Viewed by 2917 | Submission Open
Keywords: insulin resistance; type 2 diabetes; hyperinsulinemia; IGF-1 signaling; tumor microenvironment; metabolic inflammation; adipokines; antidiabetic drugs; cancer metabolism; phytocompounds; bioactive molecules; hormone regulation; intracellular signalling pathways
(This special issue belongs to the Section Cancer Pathophysiology)
Roles of the Tumor Microenvironment on Liquid Biopsy (2nd Edition)
edited by
submission deadline 31 Aug 2026 | 1 articles | Viewed by 2763 | Submission Open
Keywords: liquid biopsy; CTCs, CTC characterization and CTC clustering; ctDNA and ctDNA profiling; exosomes/extracellular vesicles and biology; tumor microenvironment; bone marrow cellular/molecular heterogeneity; CTCs/blood/BM cells crosstalk; analytical validity, clinical validity, and clinical utility of liquid biopsy; liquid biopsy interplaying dormancy and metastasis
(This special issue belongs to the Section Tumor Microenvironment)
Diagnosis and Biomarkers for Hematologic Malignancies submission deadline 31 Aug 2026 | 2 articles | Viewed by 2646 | Submission Open
Keywords: hematologic malignancies; diagnosis; biomarkers
(This special issue belongs to the Section Cancer Biomarkers)
Cervical Cancer: Screening and Treatment in 2026 submission deadline 31 Aug 2026 | 2 articles | Viewed by 2504 | Submission Open
Keywords: cervical cancer; fertility sparing; screening; early stage cervical cancer; locally advanced cervical cancer; sentinel lymph node; staging lymphadenectomy; trachelectomy; immunotherapy in cervical cancer; target therapy in cervical cancer
Hypoxia-Targeting Strategies to Improve Cancer Therapy Outcomes
edited by Roben Gieling and Ayse Latif
submission deadline 31 Aug 2026 | 1 articles | Viewed by 2123 | Submission Open
Keywords: tumor hypoxia; cancer therapy resistance; hypoxia-targeted therapy; hypoxia-inducible factors (HIFs); hypoxia-activated prodrugs; oxygen-modifying agents; combination therapy; precision drug delivery; tumor microenvironment; translational cancer research
(This special issue belongs to the Section Cancer Therapy)
From Molecular Genomics and the Tumor Microenvironment to Precision Diagnosis and Therapy in Liver Cancer
edited by and Yuman Tsui
submission deadline 31 Aug 2026 | 2 articles | Viewed by 1885 | Submission Open
Keywords: tumor heterogeneity; cancer genomics; sequencing; molecular landscapes; tumor microenvironment; cancer stem cell; liquid biopsy; diagnostics; biomarker; treatment and resistance
Clinical and Research Progress in the Resection of Gastro-Esophageal Cancer (2nd Edition)
edited by Biniam Kidane
submission deadline 31 Aug 2026 | 1 articles | Viewed by 1571 | Submission Open
Keywords: gastro-esophageal cancer resection; multi-modal management; surgical morbidity and mortality; treatment-related toxicities; perioperative outcomes
(This special issue belongs to the Section Clinical Research in Cancer)
The Unseen Burden: Incidence and Outcomes of Infections in Leukemia submission deadline 31 Aug 2026 | 1 articles | Viewed by 1159 | Submission Open
Keywords: infection management; infectious risk; antimicrobial therapy; antimicrobial prophylaxis
(This special issue belongs to the Section Infectious Agents and Cancer)
Emergencies in Gastrointestinal Surgical Oncology submission deadline 31 Aug 2026 | 1 articles | Viewed by 1113 | Submission Open
Keywords: surgical oncology; emergencies; emergency surgery; acute care surgery; palliation; futility in surgery
(This special issue belongs to the Section Clinical Research in Cancer)
Heat Shock Proteins in Metastatic Cancer: From Molecular Mechanisms to Clinical Targeting
edited by Daniel Jay and
submission deadline 31 Aug 2026 | 1 articles | Viewed by 1050 | Submission Open
Keywords: HSPs and eHSPs (Hsp90, Hsp70, Hsp60, Hsp40 and Hsp27); HSF1; chaperone; cancer metastasis; EMT; tumor microenvironment; ECM remodelling; anoikis resistance; circulating tumor cell survival; premetastatic niche; metastatic colonisation; extracellular vesicles; exosomes; cancer stem cells; therapy resistance; metastatic biomarkers; immunotherapy; HSP-targeted therapy
Clinical Outcomes in Urologic Cancers (2nd Edition)
edited by and Pierre Karakiewicz
submission deadline 31 Aug 2026 | 1 articles | Viewed by 531 | Submission Open
Keywords: bladder cancer; prostate cancer; kidney cancer; upper tract urothelial carcinoma; adrenocortical cancer
(This special issue belongs to the Section Clinical Research in Cancer)
Cutaneous T-Cell Lymphomas in Special Populations
edited by and Caroline Myers
submission deadline 31 Aug 2026 | 1 articles | Viewed by 506 | Submission Open
Keywords: cutaneous T-cell lymphoma; adult T-cell leukemia/lymphoma; lymphoproliferative disorder; hematopoietic stem cell transplant; secondary malignancy; pediatric lymphoma; skin of color; health care disparities; translational research
Hereditary Cancer: State of the Art
edited by Joanne Ngeow, Jianbang Chiang and
submission deadline 31 Aug 2026 | Viewed by 488 | Submission Open
Keywords: hereditary cancer syndromes; inherited cancers; cancer genetics and genomics; germline variants; surveillance
(This special issue belongs to the Section Cancer Pathophysiology)
Clinical Application of Proton Pencil Beam Scanning Radiotherapy in Cancer
edited by Pavel Vítek
submission deadline 31 Aug 2026 | Viewed by 400 | Submission Open
Keywords: proton radiotherapy; pencil beam scanning; randomized trial; dosimetry; plan robustness; LET—linear energy transfer; RBE—radiobiologic equivalence; lymphocyte; immunologic reaction
(This special issue belongs to the Section Clinical Research in Cancer)
Clinical Trials for T-Cell Lymphoma
edited by Jasmine M. Zain
submission deadline 31 Aug 2026 | Viewed by 351 | Submission Open
Keywords: peripheral T cell lymphoma; EZH2 inhibitors; JAK STAT pathways; tumor microenvironment; immunotherapy
(This special issue belongs to the Section Clinical Research in Cancer)
Human Carcinogens—Chemical Agents, Occupational Exposure and Health Impact
edited by Jun-Pyo Myong
submission deadline 31 Aug 2026 | Viewed by 329 | Submission Open
Keywords: occupational exposure; chemical carcinogens; risk assessment; epidemiology; biomarkers; exposure assessment; preventive strategies; workplace safety; occupational health; regulatory measures
(This special issue belongs to the Section Infectious Agents and Cancer)
Advances in the Early Diagnosis and Treatment of Gastric Cancer (2nd Edition)
edited by Sharona B. Ross
submission deadline 31 Aug 2026 | Viewed by 326 | Submission Open
Keywords: gastric cancer; tumor resection; liver tumors
(This special issue belongs to the Section Cancer Therapy)
The Invasion and Metastasis in Skin Cancer
edited by Emanuela Passoni, and
submission deadline 31 Aug 2026 | Viewed by 288 | Submission Open
Keywords: melanoma; skin cancer; basal cell carcinoma; squamous cell carcinoma; Kaposi’s sarcoma; dermoscopy; photoprotection; skin cancer prevention
Cancer Survivorship: Transforming Challenges into Quality Living
edited by and Tania Estapé
submission deadline 31 Aug 2026 | Viewed by 285 | Submission Open
Keywords: cancer survivorship; psychological adjustment; emotional well-being; coping; quality of life; family relationships; couple functioning; sexuality; return to work; psychosocial interventions; financial toxicity
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
The Role of Artificial Intelligence in Detection and Treatment of Head and Neck Cancer
edited by
submission deadline 31 Aug 2026 | Viewed by 281 | Submission Open
Keywords: artificial intelligence; machine learning; deep learning; large language models; multimodal integration; computer vision; pathomics; image-derived biomarkers
(This special issue belongs to the Section Methods and Technologies Development)
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