Challenges and Opportunities in Developing Therapies for Drug Resistance and Other Malignancies

Dear Colleagues,

Cancer remains one of the leading causes of mortality worldwide, and the development of effective and affordable therapies continues to be a central goal for researchers and clinicians. Chemotherapy is still considered a key treatment modality for reducing the global cancer burden; however, its effectiveness is frequently limited by the emergence of resistance within tumor cells. Such resistance not only diminishes therapeutic efficacy but also contributes to enhanced tumor aggressiveness, disease progression, and metastasis. Multidrug resistance (MDR) therefore represents a major challenge in modern oncology and a critical barrier to successful treatment outcomes. This Special Issue welcomes both original research articles and comprehensive reviews addressing therapeutic innovations, mechanisms of resistance, and strategies to overcome MDR or improve cancer therapy more broadly.

Dr. Erzsébet Mernyák
Guest Editor

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