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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Biliary Tract Cancer: Challenges and Strategies in Centralizing Care for Rare Tumors
edited by Angela Lamarca
submission deadline 31 Oct 2026 | Viewed by 185 | Submission Open
Keywords: biliary tract cancer; centralization of care; recommendations
Progress in Skin Cancer: Diagnostics, Therapy, and Outcomes
edited by Marco Ardigo and Francesco Piscazzi
submission deadline 31 Oct 2026 | Viewed by 184 | Submission Open
Keywords: skin cancer; dermoscopy; reflectance confocal microscopy (RCM); line-field confocal optical coherence tomography (LC-OCT); non-invasive diagnostics; systemic therapy; locally advanced skin cancer; minimally invasive treatments; tumor prediction; clinical outcomes
Hepatocellular Carcinoma—from Molecular Insight to Surgical Strategy
edited by
submission deadline 31 Oct 2026 | Viewed by 169 | Submission Open
Keywords: hepatocellular carcinoma (HCC); clinical diagnosis; molecular biology; biomarkers; surgical strategy; liver transplantation; prognosis
Optimizing Breast Cancer Treatment: Integration of Systemic Therapy, Surgical Innovation, and De-Escalation Strategies
edited by
submission deadline 31 Oct 2026 | Viewed by 164 | Submission Open
Keywords: breast cancer; chemotherapy; neoadjuvant therapy; adjuvant therapy; axillary management; surgical innovation; energy devices; de-escalation; personalized medicine; multidisciplinary care
Advances in Virus-Associated Head and Neck Cancer submission deadline 1 Nov 2026 | 3 articles | Viewed by 13881 | Submission Open
Keywords: onco-virus; virus-associated cancer; head and neck cancers; diagnosis; pathogenesis; epidemiology; prevalence; treatment; HPV; EBV
(This special issue belongs to the Section Infectious Agents and Cancer)
Urologic Cancer: Endoscopic, Laparoscopic, and Robot-Assisted Surgery Management (2nd Edition)
edited by Kouji Izumi
submission deadline 1 Nov 2026 | 1 articles | Viewed by 6132 | Submission Open
Keywords: prostate cancer; urothelial cancer; kidney cancer; adrenal cancer; transurethral technique; ureteroscopy; ureteral stent
(This special issue belongs to the Section Cancer Therapy)
Epigenetic Mechanisms Linking Aging and Cancer: Molecular Drivers, Hallmarks and Therapeutic Perspectives, with a Focus on Hepatocellular Carcinoma
edited by
submission deadline 1 Nov 2026 | 1 articles | Viewed by 1227 | Submission Open
Keywords: aging; cancer; epigenetics; life span; health span
Cellular Immunotherapy for Hematological Malignancies
edited by
submission deadline 1 Nov 2026 | Viewed by 257 | Submission Open
Keywords: cellular immunotherapy; CAR-T cell therapy; translational biomarkers; immune monitoring; cell manufacturing; hematological malignancies; clinical outcomes
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
New Perspectives on Claudins and Tight Junction Complexes: From Membrane Architecture to Targeted Cancer Therapy submission deadline 1 Nov 2026 | Viewed by 245 | Submission Open
Keywords: cancer; claudins; tight junction; metastasis; drug resistance; biomarkers; prognostic; tumour microenvironment; epithelial barrier function; epithelial–mesenchymal transition (EMT); targeted cancer therapy
(This special issue belongs to the Section Molecular Cancer Biology)
Pediatric Cancer Surgery—New Techniques and Innovations
edited by Elisabeth T. Tracy
submission deadline 2 Nov 2026 | Viewed by 186 | Submission Open
Keywords: pediatric cancer; solid tumor; surgical oncology; operative techniques; complex tumor; 3D modeling; intraoperative localization
(This special issue belongs to the Section Pediatric Oncology)
Immune Cells Within the Tumor Microenvironment
edited by Diego Carlos dos Reis
submission deadline 3 Nov 2026 | Viewed by 267 | Submission Open
Keywords: tumor microenvironment; tumor-infiltrating lymphocytes; macrophage polarization; T cell exhaustion; immune evasion; cancer immunotherapy; single-cell transcriptomics; spatial pathology; immune checkpoint; innate and adaptive immunity
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Advances in Radiation Therapy for Brain Metastases
edited by Luis A. Pérez-Romasanta
submission deadline 5 Nov 2026 | 3 articles | Viewed by 4646 | Submission Open
Keywords: brain metastasis; metastatic brain tumor; imaging; radiotherapy; stereotactic radiosurgery; radiomics; machine learning; magnetic resonance imaging; positron emission tomography
(This special issue belongs to the Section Cancer Therapy)
Clinical and Molecular Biomarkers in Breast Cancer Management
edited by Zahi I. Mitri
submission deadline 5 Nov 2026 | 4 articles | Viewed by 4511 | Submission Open
Keywords: prognostic biomarkers; predictive biomarkers; molecular assays; therapeutics; special situations in breast cancer
(This special issue belongs to the Section Cancer Biomarkers)
Novel Insights into Glioma Immunotherapy
edited by
submission deadline 5 Nov 2026 | Viewed by 255 | Submission Open
Keywords: glioma immunotherapy; tumor microenvironment; immune evasion; microglia; checkpoint inhibitors; CAR‑T; neoantigen vaccines
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Exosomes in Cancer Metastasis (2nd Edition) submission deadline 10 Nov 2026 | 3 articles | Viewed by 5104 | Submission Open
Keywords: exosomes; biomarkers; cancer metastasis
(This special issue belongs to the Section Cancer Metastasis)
Systematic Reviews and Meta-Analyses in Cancer Research: The Therapeutic Potential of Phytochemicals and Bioactive Compounds with Defined Mechanisms and Safety Profiles submission deadline 10 Nov 2026 | 2 articles | Viewed by 2215 | Submission Open
Keywords: phytochemicals in cancer therapy; bioactive natural compounds; systematic reviews and meta-analyses; molecular mechanisms of anticancer agents; translational oncology; pharmacokinetics and toxicity of natural products; evidence-based integrative oncology; natural product drug discovery; chemoprevention and cancer therapeutics; mechanistic and safety profiling of phytochemicals
(This special issue belongs to the Section Systematic Review or Meta-Analysis in Cancer Research)
Anticancer Drug Discovery and Development: Integrating Natural Compounds, Synthetic Chemistry, Nanotechnology and Computational Approaches
edited by Cheng-Hao Jin
submission deadline 12 Nov 2026 | Viewed by 209 | Submission Open
Keywords: anticancer drug development; natural compounds; synthetic chemistry; nanotechnology; cancer therapy
(This special issue belongs to the Section Cancer Drug Development)
Artificial Intelligence for Cancer Precision Medicine
edited by Chenyang Shen and
submission deadline 13 Nov 2026 | 1 articles | Viewed by 1338 | Submission Open
Keywords: artificial intelligence; cancer; radiomics
(This special issue belongs to the Section Methods and Technologies Development)
New Advances in Flow Cytometry: From Diagnosis to Disease Monitoring in Acute Leukemia
edited by , and Raffaele Palmieri
submission deadline 13 Nov 2026 | Viewed by 289 | Submission Open
Keywords: flow cytometry; multiparametric flow cytometry (MFC); acute leukemia; measurable residual disease (MRD); prognostic biomarker; MRD monitoring
Recent Advances in Endoscopic, Metabolomic, and Ultrasound Approaches to Gastrointestinal, Hepatic, and Pancreatic Tumors
edited by Ciprian Brisc and Nadim Al Hajjar
submission deadline 15 Nov 2026 | 2 articles | Viewed by 8314 | Submission Open
Keywords: gastrointestinal, hepatic and pancreatic tumors; metabolomics; endoscopy; ultrasound; elastography; molecular investigations and treatment; robotic surgery; laparoscopic surgery; early lesions; radiofrequency and microwave ablation; irreversible electroporation; cryoablation; targeted chemo- or radio-embolization
(This special issue belongs to the Section Cancer Therapy)
Molecular and Genetic Diagnosis and Targeted Therapy of Myeloproliferative Neoplasms (2nd Edition)
edited by and
submission deadline 15 Nov 2026 | 3 articles | Viewed by 6877 | Submission Open
Keywords: myeloproliferative neoplasm; chronic myeloid leukemia; polycythemia vera; essential thrombocythemia; primary myelofibrosis; MPN; CML; PMF; PV; ET
(This special issue belongs to the Section Molecular Cancer Biology)
Advances in Locoregional Therapies for Gastrointestinal Cancer Metastases submission deadline 15 Nov 2026 | 3 articles | Viewed by 3216 | Submission Open
Keywords: gastrointestinal cancer metastases; locoregional therapies; interventional radiology; endoscopy; radiation therapy; invasive operations; cytoreductive surgery (CRS); intraperitoneal chemotherapy (IP); heated intraperitoneal chemotherapy (HIPEC); tumor debulking; stereotactic body radiation therapy (SBRT); selective internal radiation therapy (SIRT)
(This special issue belongs to the Section Methods and Technologies Development)
Oncogenesis of Lymphoma (2nd Edition)
edited by and Giancarlo Pruneri
submission deadline 15 Nov 2026 | 1 articles | Viewed by 1031 | Submission Open
Keywords: lymphomagenesis; molecular genetics; immunology; molecular virology; KSHV/HHV8; EBV; HIV; pathogenetic pathways; genotypic subgroups; tumor microenvironment; follicular lymphoma; mantle cell lymphoma; diffuse large B-cell lymphoma; targeted therapy; drug target
(This special issue belongs to the Section Molecular Cancer Biology)
Translational Research and Clinical Trials in Gastric Cancer: Advances and Future Directions
edited by Yanghee Woo
submission deadline 15 Nov 2026 | 1 articles | Viewed by 952 | Submission Open
Keywords: gastric cancer; multidisciplinary management; conversion gastrectomy; molecular biomarker testing; diagnostic laparoscopy; neoadjuvant therapy; upfront surgery; intraperitoneal treatment
(This special issue belongs to the Section Clinical Research in Cancer)
Targeting Head and Neck Cancer: From Tumor Microenvironment to Therapy Resistance
edited by and
submission deadline 15 Nov 2026 | Viewed by 482 | Submission Open
Keywords: head and neck squamous cell carcinoma (HNSCC); tumor microenvironment (TME); therapy resistance; HPV-associated cancers; immunotherapy; cancer-associated fibroblasts (CAFs); tumor heterogeneity; precision oncology; biomarkers; metastasis
Gene Editing and Delivery for Cancer Therapy (2nd Edition)
edited by and
submission deadline 15 Nov 2026 | Viewed by 480 | Submission Open
Keywords: gene therapy; gene editing; gene delivery; oncolytic viruses; nanomaterial; peptides; nanostructures; exosomes; translational science
(This special issue belongs to the Section Cancer Therapy)
Evaluating the Clinical Impact of Robotic Surgery in the Management of Colorectal Cancer
edited by and Miguel Leon-Arellano
submission deadline 15 Nov 2026 | Viewed by 454 | Submission Open
Keywords: robotic surgery; colorectal cancer; oncological outcomes; surgical technique; laparoscopic comparison; margin status; postoperative recovery; quality of life; intraoperative imaging; surgical navigation; learning curve; complications; cost-effectiveness; surgical training; technological innovation
(This special issue belongs to the Section Clinical Research in Cancer)
Impact of Anesthetic/Analgetic Drugs on Cancer Recurrence submission deadline 15 Nov 2026 | Viewed by 206 | Submission Open
Keywords: effect of amide-type local anesthetics; role of IV and analgesic drugs; opioids: pro or anti-cancer
Personalization of Non-Melanoma Skin Cancer Treatment
edited by and Frederik Penzien Wainer Mamsen
submission deadline 20 Nov 2026 | 1 articles | Viewed by 871 | Submission Open
Keywords: personalized medicine; non-melanoma skin cancer; local treatment
(This special issue belongs to the Section Cancer Therapy)
The Pathologic Diagnosis and Clinical Therapy of Neuroendocrine Tumors: 2nd Edition submission deadline 20 Nov 2026 | Viewed by 299 | Submission Open
Keywords: neuroendocrine neoplasms; molecular mechanisms; cancer pathogenesis; tumorigenesis; diagnosis; molecular and cellular heterogeneity; predictive biomarkers; animal models and of neuroendocrine cancer; diagnostic clinical oncology; genomic characterization; clinical biomarkers; biomarkers of drug response; epigenetic biomarkers; targeted therapy; tumor immunity; molecular oncology; clinical therapy
Contemporary Surgical Management of Thyroid Cancer: Toward Precision and Multidisciplinary Care
edited by Marco Puccini and Benard Gjeloshi
submission deadline 20 Nov 2026 | Viewed by 268 | Submission Open
Keywords: thyroid cancer; surgery
(This special issue belongs to the Section Cancer Therapy)
Advances in Molecular Mechanisms of Gastrointestinal Tumors (2nd Edition)
edited by
submission deadline 25 Nov 2026 | 5 articles | Viewed by 10056 | Submission Open
Keywords: molecular mechanism; gastrointestinal tumor; gastric cancer; colorectal cancer; esophageal cancer; tumor microenvironment; molecular network; molecular pathway; pathway network; signal transduction
(This special issue belongs to the Section Molecular Cancer Biology)
Radiologic Staging and Surgical Decision-Making in the Era of Neoadjuvant Therapy for Breast Cancer
edited by
submission deadline 25 Nov 2026 | 1 articles | Viewed by 783 | Submission Open
Keywords: radiologic staging; neoadjuvant therapy; breast cancer; breast-conserving surgery; mastectomy; targeted axillary dissection; sentinel lymph node biopsy; axillary lymph node dissection; magnetic resonance imaging; surgical de-escalation
(This special issue belongs to the Section Cancer Therapy)
Infectious Pathogens and Cancer
edited by
submission deadline 25 Nov 2026 | Viewed by 311 | Submission Open
Keywords: infectious cancer pathogens; related topics in immunology; virology; epidemiology; (therapeutic) vaccines; oncogenesis; screening; therapy
(This special issue belongs to the Section Infectious Agents and Cancer)
Cancer Cells Fostered Microenvironment in Metastasis (2nd Edition)
edited by
submission deadline 25 Nov 2026 | Viewed by 288 | Submission Open
Keywords: cancer cells; tumour microenvironment; metastasis; fibroblast; immune cells; extracellular ma-trix; adhesion; migration; invasion; drug resistance; target therapy
(This special issue belongs to the Section Cancer Metastasis)
Treatment and Prognosis of Pediatric Medulloblastoma
edited by Marwa Ismail
submission deadline 25 Nov 2026 | Viewed by 233 | Submission Open
Keywords: pediatric medulloblastoma; proteomics; radiogenomics
(This special issue belongs to the Section Pediatric Oncology)
Breast Cancer Screening: Global Practices and Future Directions
edited by Rudolf Morant
submission deadline 26 Nov 2026 | 3 articles | Viewed by 6677 | Submission Open
Keywords: mammography screening; organized screening programs; tomosynthesis; 2D mammography; artificial intelligence; personalized screening
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
The Role of Cysteine Cathepsins in Cancer Progression
edited by and Ramadan Faried Abdelaziz
submission deadline 26 Nov 2026 | Viewed by 330 | Submission Open
Keywords: cysteine cathepsins; cancer progression; tumor microenvironment; metastasis; lysosomal enzymes; protease inhibitors; drug resistance; targeted therapy
(This special issue belongs to the Section Molecular Cancer Biology)
Diagnosis and Treatment of Myeloid Neoplasms
edited by Laura Cicconi
submission deadline 27 Nov 2026 | 2 articles | Viewed by 2033 | Submission Open
Keywords: myeloid neoplasms; diagnostic approaches; prognostication; heterogeneous
New Insights in Esophageal Cancer Diagnosis and Treatment
edited by
submission deadline 27 Nov 2026 | 1 articles | Viewed by 1831 | Submission Open
Keywords: esophageal cancer; diagnosis; targeted screening; endoscopic treatment
(This special issue belongs to the Section Cancer Therapy)
Breast Cancer Bone Metastasis
edited by Allan Lipton and Louis Costa
submission deadline 27 Nov 2026 | 1 articles | Viewed by 508 | Submission Open
Keywords: bone metastases in breast cancer; mechanisms; prevention; treatment; bone-targeted agents; imaging; surgery of bone metastases; radiotherapy of bone metastases
(This special issue belongs to the Section Cancer Metastasis)
Perioperative Care in Gynecologic Oncology: 2nd Edition
edited by Nikolaos Thomakos and
submission deadline 28 Nov 2026 | 2 articles | Viewed by 8072 | Submission Open
Keywords: enhanced recovery; ERAS; immunonutrition; prehabilitation; gynecologic oncology; minimally invasive surgery
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Human Papillomavirus (HPV) and Related Cancer
edited by
submission deadline 30 Nov 2026 | 12 articles | Viewed by 28292 | Submission Open
Keywords: HPV; carcinogenesis; methods of virus identification diagnostics; prognostification
(This special issue belongs to the Section Infectious Agents and Cancer)
Infectious Agents and Cancer in Children and Adolescents
edited by and Eleni Tsotridou
submission deadline 30 Nov 2026 | 4 articles | Viewed by 20077 | Submission Open
Keywords: infectious agents; immune system; tumor development; immunological memory; oncolytic viruses
(This special issue belongs to the Section Infectious Agents and Cancer)
Epidemiology of Cancer and Risk Factors: Pushing Boundaries in Public Health Research and Policy
edited by
submission deadline 30 Nov 2026 | 8 articles | Viewed by 17055 | Submission Open
Keywords: cancer epidemiology; risk factors; public health policy; cancer prevention; early detection; genetic determinants; environmental exposures; behavioral health; interdisciplinary approaches; innovative methodologies
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
New Findings in Targeting Cancer Proteins (Second Edition) submission deadline 30 Nov 2026 | 3 articles | Viewed by 10917 | Submission Open
Keywords: monoclonal antibodies; protein target; immunotherapy; signaling blockade; targeted therapy
(This special issue belongs to the Section Cancer Therapy)
Advances in the Diagnosis and Treatment of Prostate Cancer: From Biomarkers to Precision Surgery
edited by Stamatios N. Katsimperis and
submission deadline 30 Nov 2026 | 7 articles | Viewed by 8997 | Submission Open
Keywords: prostate cancer; precision medicine; molecular biomarkers; risk stratification; robotic surgery; artificial intelligence; genomics; personalized treatment; imaging modalities; multidisciplinary approach
(This special issue belongs to the Section Cancer Therapy)
The Genetic Analysis and Clinical Therapy in Lung Cancer: 2nd Edition
edited by and Frullanti Elisa
submission deadline 30 Nov 2026 | 1 articles | Viewed by 8633 | Submission Open
Keywords: lung cancer; biomarkers; genetic variants; innovative technologies; targeted therapy; immunotherapy; personalized therapy; survival; liquid biopsy pharmacogenomics
(This special issue belongs to the Section Cancer Therapy)
Next-Generation Cancer Therapies
edited by , Ioannis Lamprou and Erasmia Xanthopoulou
submission deadline 30 Nov 2026 | 2 articles | Viewed by 8404 | Submission Open
Keywords: cancer; current therapies; cancer cells metabolism; autophagy; immunotherapy; targeted treatments; oncolytic viruses; vaccines
(This special issue belongs to the Section Cancer Therapy)
Image-Guided Treatment of Liver Tumors
edited by and Niek Wijnen
submission deadline 30 Nov 2026 | 6 articles | Viewed by 7624 | Submission Open
Keywords: liver; thermal ablation; radioembolization; TACE; yttrium-90; portal vein embolization; radiation oncology; interventional oncology
(This special issue belongs to the Section Cancer Therapy)
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