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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Redefining Cancer Through Its Microenvironment: Mechanisms, Modeling, and Targeting Strategies

edited by Leandro Marcelo Martinez

submission deadline 31 Jan 2027 | Viewed by 371 | Submission Open

Keywords: tumor microenvironment; solid cancer; hematologic malignancies; tumor initiation; tumor progression; therapeutic resistance; in-vitro models; personalized therapy

(This special issue belongs to the Section Tumor Microenvironment)

Nanomedicine for Cancer Treatment

edited by Youssef Wahib Naguib

submission deadline 31 Jan 2027 | Viewed by 336 | Submission Open

Keywords: cancer nanomedicine; CRISPR/CAS9 nanomedicine; immune checkpoint inhibitors; cancer immunotherapy; targeted therapeutics; targeted nanoparticles; cell-penetrating peptides

(This special issue belongs to the Section Cancer Drug Development)

The TGF-β Pathway in Hepatocellular Carcinoma

edited by Dan Feng

submission deadline 31 Jan 2027 | Viewed by 296 | Submission Open

Keywords: hepatocellular carcinoma; HCC; TGF-β

(This special issue belongs to the Section Cancer Pathophysiology)

Advances in Exosomes and Cancer Therapy

edited by

Nadir Arber

and

Shiran Shapira

submission deadline 31 Jan 2027 | Viewed by 293 | Submission Open

Keywords: exosomes; extracellular vesicles; isolation of exosomes; cancer therapy; tumor microenvironment; exosome engineering; drug delivery systems; cancer biomarkers; immunomodulation; precision oncology

(This special issue belongs to the Section Cancer Therapy)

Thoracic Surgical Oncology—Current Landscape and Future Directions

edited by Piergiorgio Solli and Alessia Stanzi

submission deadline 31 Jan 2027 | Viewed by 272 | Submission Open

Keywords: minimally invasive thoracic surgery; immunotherapy; liquid biopsy; lung cancer; mesothelioma; esophageal cancer; precision oncology

(This special issue belongs to the Section Clinical Research in Cancer)

Advances and Challenges in Charged Particle Therapy: Protons and Beyond

edited by Annie W. Chan

submission deadline 31 Jan 2027 | Viewed by 242 | Submission Open

Keywords: proton therapy; carbon ion therapy; helium ion therapy; charged particle therapy; relative biological effectiveness

(This special issue belongs to the Section Methods and Technologies Development)

Advances in Molecular Biology and Genetics of Prostate Cancer

edited by

Grinu Mathew

and

Maher Y. Abdalla

submission deadline 31 Jan 2027 | Viewed by 238 | Submission Open

Keywords: prostate cancer; treatment resistance; tumor microenvironment; genomic alterations; therapy progression mechanisms

(This special issue belongs to the Section Molecular Cancer Biology)

Paradigm Shifts and Patient-Centered Outcomes of Breast Cancer Surgery

edited by Rakhshanda Layeequr Rahman, Cathy Graham and Jaime Alberty

submission deadline 31 Jan 2027 | Viewed by 228 | Submission Open

Keywords: shared decision-making; precision medicine; surgical de-escalation; minimally invasive surgery; clinical approaches with modern technologies; quality of life after breast surgery; economic impact of breast cancer surgery; financial toxicity

(This special issue belongs to the Section Methods and Technologies Development)

Molecular and Genetic Drivers of Cancer: Organelle Dysfunction, Cancer Stem Cells, and Tumor Progression

edited by

Babak Behnam

and Maziar Ashrafian-Bonab

submission deadline 31 Jan 2027 | Viewed by 180 | Submission Open

Keywords: cancer progression; organelle dysfunction; cancer stem cells; mitochondria; microtubules; organelle crosstalk; tumor metabolism; therapeutic resistance

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in Anticancer Drugs and Pharmacotherapy of Cancer

edited by

Yong Weon Yi

submission deadline 31 Jan 2027 | Viewed by 146 | Submission Open

Keywords: anticancer; therapeutics; target therapy; immune-oncology; mode of action; molecular mechanisms; targeted protein degradation; antibody-drug conjugates; cell therapy; cancer parmacology

(This special issue belongs to the Section Cancer Drug Development)

Role of Cancer Biomarkers for Diagnosis, Prognosis and Targeted Therapy in Gastrointestinal Cancers: 2nd Edition

edited by

Ali Zaidi

and Neda Dadgar

submission deadline 31 Jan 2027 | Viewed by 128 | Submission Open

Keywords: liquid biopsy; esophageal cancer; gastric cancer; colorectal cancer; pancreatic cancer; hepatocellular cancer; appendiceal cancer; cancer biomarker; DNA sequencing; transcriptomics; proteomics; immunohistochemistry

(This special issue belongs to the Section Cancer Biomarkers)

Precision Oncology and Immunotherapy in Bone and Soft Tissue Sarcomas

edited by

Dana Borcherding

and

Ariana Mooradian

submission deadline 31 Jan 2027 | Viewed by 112 | Submission Open

Keywords: soft tissue sarcoma (STS); immunotherapy; precision medicine; cellular signaling; biomarkers; translational research; molecular profiling; survivorship; supportive care

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Endoscopic and Minimally Invasive Approaches in Neuro-Oncology

edited by Michael Karsy and

Nasser K. Yaghi

submission deadline 31 Jan 2027 | Viewed by 104 | Submission Open

Keywords: endoscopic neurosurgery; minimally invasive neuro-oncology; skull base tumors; surgical robotics and navigation; translational neuro-oncology

The Future Is Now: Novel Technologies in Use in Head and Neck Cancer Surgery

edited by Peter T. Dziegielewski, Daniel A. Benito, Austin S. Lam and Dustin Conrad

submission deadline 31 Jan 2027 | Viewed by 103 | Submission Open

Keywords: head and neck cancer; surgery; reconstruction

(This special issue belongs to the Section Cancer Therapy)

Advances in PET/CT-Guided Diagnosis and Treatment of Hematologic Malignancies

edited by

Domenico Albano

submission deadline 31 Jan 2027 | Viewed by 99 | Submission Open

Keywords: PET/CT; nuclear medicine; lymphoma; multiple myeloma; leukemia; hybrid imaging

Focal Adhesion Kinase Signaling in Cancers

edited by

Dwayne Stupack

submission deadline 31 Jan 2027 | Viewed by 98 | Submission Open

Keywords: focal adhesion kinase (FAK); tumor microenvironment (TME); fibrosis; chemoresistance; immunotherapy; KRAS; BRAF; epithelial–mesenchymal transition (EMT) homologous repair deficiency; FAK inhibitor; ifebemtinib; defactinib; narmafotinib; integrin; metastasis; mechanotransduction

(This special issue belongs to the Section Molecular Cancer Biology)

Diagnosis and Management of Diffuse Glioma

edited by Francesco Bruno

submission deadline 31 Jan 2027 | Viewed by 77 | Submission Open

Keywords: diffuse glioma; IDH-mutant glioma; molecular classification; advanced MRI; amino acid PET; radiomics; artificial intelligence; targeted therapy; brain tumour-related epilepsy; neurocognition; quality of life; neurosurgery; liquid biopsy

Psycho-Oncology and Supportive Care in Women with Cancer Across the Lifespan

edited by Michelle Peate and Zobaida Edib

submission deadline 31 Jan 2027 | Viewed by 29 | Submission Open

Keywords: survivorship; infertility; menopause; primary ovarian insufficiency; treatment-induced amenorrhoea; quality of life; supportive care; women with cancer

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Progress and Precision in Surgical Treatment for Hepatobiliary and Pancreatic Cancers

edited by Ajith K. Siriwardena, Samik Kumar Bandyopadhyay and Louise M. Finch

submission deadline 1 Feb 2027 | 1 articles | Viewed by 529 | Submission Open

Keywords: liver surgery; pancreas surgery; robotic surgery; ablation; irreversible electroporation; liver tumours

Targeted Therapies in Sarcomas: Overcoming Resistance and Improving Outcomes

edited by

Varun Monga

and Mohammed M. Milhem

submission deadline 8 Feb 2027 | Viewed by 460 | Submission Open

Keywords: sarcoma; targeted therapy; resistance mechanisms; combination therapy; biomarkers; precision oncology; translational research; clinical trials

(This special issue belongs to the Section Tumor Microenvironment)

Bridging Translational and Clinical Oncology in Gastrointestinal Cancers: Molecular Mechanisms to Therapeutic Advances

edited by

Stavros Papadakos

Ioannis Katsaros

and

Stamatios E. Theocharis

submission deadline 10 Feb 2027 | Viewed by 573 | Submission Open

Keywords: gastrointestinal cancers; translational oncology; molecular mechanisms; biomarkers; immunotherapy; radiomics; precision medicine; therapeutic advances

(This special issue belongs to the Section Methods and Technologies Development)

Cytoreduction in Gynecologic Oncology

edited by Sabrina Piedimonte

submission deadline 13 Feb 2027 | Viewed by 341 | Submission Open

Keywords: cytoreduction; ovarian cancer; endometrial cancer; minimally invasive surgery; AI

(This special issue belongs to the Section Cancer Therapy)

Minimally Invasive Therapies in Urologic Cancers

edited by Eric M. Walser and

Guglielmo Manenti

submission deadline 15 Feb 2027 | 5 articles | Viewed by 7731 | Submission Open

Keywords: laparoscopic surgery; robotic-assisted surgery; ablation; high-intensity focused ultrasound; partial nephrectomy; minimally invasive procedures; urologic cancers

(This special issue belongs to the Section Methods and Technologies Development)

Molecular Signatures of Therapy: Biomarkers Predicting Response and Relapse in Cancer

edited by

Antonis Giakountis

submission deadline 15 Feb 2027 | 5 articles | Viewed by 6657 | Submission Open

Keywords: molecular biomarkers; therapeutic response; disease relapse; precision oncology; liquid biopsy; predictive biomarkers; multi-omics integration; minimal residual disease; translational oncology

(This special issue belongs to the Section Cancer Biomarkers)

Utilizing the DNA Damage Response Mechanism for Cancer Treatments

edited by

Daniel Chi-Wei Chen

submission deadline 15 Feb 2027 | 2 articles | Viewed by 1270 | Submission Open

Keywords: DNA damage response; synthetic lethality; replication stress; DDR-targeted therapy; cancer metabolism; drug resistance; combination therapy

(This special issue belongs to the Section Cancer Therapy)

Neuroimaging of Adult-Type Diffuse Gliomas

edited by

Hirohito Yano

submission deadline 15 Feb 2027 | 1 articles | Viewed by 768 | Submission Open

Keywords: glioma; image diagnosis; molecular diagnosis; MRI; MRS; SPECT; PET

(This special issue belongs to the Section Methods and Technologies Development)

Immunotherapy for Hematologic Malignancies

edited by Rajesh Ramakrishnan Nair

submission deadline 15 Feb 2027 | Viewed by 450 | Submission Open

Keywords: immune evasion; immunotherapy; CAR-T cell therapy; BiTEs; immunomodulators; checkpoint; inhibitors; bone marrow microenvironment; refractory/relapsed; drug resistance; gene editing

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Pancreaticoduodenectomy in the Treatment of Pancreatic Cancer

edited by Piero Chirletti and Roberto L. Meniconi

submission deadline 15 Feb 2027 | Viewed by 291 | Submission Open

Keywords: pancreatic ductal adenocarcinoma (PDAC); surgical treatment; R0 exeresis; mesopancreas; lymphadenectomy; reconstruction technique

(This special issue belongs to the Section Clinical Research in Cancer)

Novel Advances in the Molecular Understanding of Myeloproliferative Neoplasms (MPNs): 2nd Edition

edited by Wei Chen, Fei Li and

Qiang Jeremy Wen

submission deadline 15 Feb 2027 | Viewed by 84 | Submission Open

Keywords: MPNs; ET; PV; PMF; post-PV-MF; post-ET-MF; MDS/MPN; JAK2

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in Stereotactic Body Radiation Therapy for Thoracic and Abdominopelvic Tumors

edited by

Yin Zhang

and

Kai Ding

submission deadline 19 Feb 2027 | 2 articles | Viewed by 2310 | Submission Open

Keywords: stereotactic body radiation therapy (SBRT); adaptive radiation therapy (ART); image-guided radiation therapy (IGRT); motion management; thoracic tumors; abdominopelvic tumors

(This special issue belongs to the Section Methods and Technologies Development)

Sarcoma Management in Orthopaedic Oncology

edited by

Vasileios Kontogeorgakos

and Jendrik Hardes

submission deadline 20 Feb 2027 | 5 articles | Viewed by 8520 | Submission Open

Keywords: orthopaedic surgical oncology; sarcoma; orthopaedic surgery; bone and soft tissue sarcoma; diagnose; neoadjuvant therapy; targeted therapy; immunotherapy

(This special issue belongs to the Section Methods and Technologies Development)

Advances in Surgery for Endocrine Cancers

edited by

Michael Bouvet

and Eren Berber

submission deadline 20 Feb 2027 | 1 articles | Viewed by 2250 | Submission Open

Keywords: thyroid cancer; thyroid surgery; hyperparathyroidism; adrenal tumors; adrenal surgery; pancreatic neuroendocrine tumors; fluorescence guided surgery; intraoperative imaging; surgical navigation; technological innovation

(This special issue belongs to the Section Methods and Technologies Development)

Advances in the Immunotherapy of Metastatic Cancer

edited by

Gianluca Tomasello

submission deadline 20 Feb 2027 | 1 articles | Viewed by 1652 | Submission Open

Keywords: metastatic cancer; immunotherapy; immune checkpoint inhibitors; CAR-T cells; tumor microenvironment; immune-related adverse events; biomarkers; combination therapy; resistance mechanisms

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Novel Strategies in the Prevention/Treatment of Colorectal Cancer: 2nd Edition

edited by

William H. Gmeiner

submission deadline 20 Feb 2027 | 1 articles | Viewed by 1392 | Submission Open

Keywords: colorectal cancer; chemotherapy; chemoprevention; targeted therapy; kinase inhibitor; immunotherapy

Advanced Immunotherapeutic Strategies and Clinical Developments in Hepatocellular Carcinoma and Gastrointestinal Cancers

edited by Kaushik Banerjee, Shayanki Lahiri and Lei Yang

submission deadline 20 Feb 2027 | 1 articles | Viewed by 1294 | Submission Open

Keywords: hepatocellular carcinoma; gastrointestinal cancers; clinical immunotherapy; immune checkpoint inhibitors; tumor immune microenvironment; biomarkers and precision oncology; immunotherapy resistance; immune-related adverse events; combination therapy; CAR-T and adoptive cell therapy; cancer vaccines; translational and clinical research; clinical trials; real-world evidence

HIV-Associated Lymphoid Neoplasms (2nd Edition)

edited by

José-Tomás Navarro

and

Kai Hübel

submission deadline 20 Feb 2027 | 1 articles | Viewed by 1206 | Submission Open

Keywords: B-cell lymphoma; HIV; AIDS; Epstein–Barr virus; epidemiology; pathogenesis; prognosis

(This special issue belongs to the Section Infectious Agents and Cancer)

Cellular Plasticity, Metabolic Adaptations and Therapeutic Strategies in Breast Cancer

edited by

Kunwar Somesh Vikramdeo

submission deadline 20 Feb 2027 | Viewed by 535 | Submission Open

Keywords: breast cancer; cellular plasticity; metabolic reprogramming; tumor microenvironment; therapy resistance; epithelial–mesenchymal transition (EMT); cancer stem cells; redox metabolism; mitochondrial pathways; targeted therapy

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in Targeted Therapies and Pharmacogenomics of Leukemia

edited by

Nicolas Nassar

submission deadline 20 Feb 2027 | Viewed by 467 | Submission Open

Keywords: blood cancer; targeted therapy; immunotherapy; primary and secondary resistance; pharmacogenetics; combination therapy; tumor microenvironment

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in Surgery of Liver Cancer

edited by Ho-Seong Han and Roberto Ivan Troisi

submission deadline 20 Feb 2027 | 1 articles | Viewed by 436 | Submission Open

Keywords: liver cancer surgery; hepatocellular carcinoma; minimally invasive liver resection; laparoscopic surgery; robotic surgery; anatomical resection; surgical oncology; precision surgery

(This special issue belongs to the Section Methods and Technologies Development)

Treatment Outcomes in Older Adults with Cancer (2nd Edition)

edited by

Mackenzi Pergolotti

submission deadline 25 Feb 2027 | 1 articles | Viewed by 865 | Submission Open

Keywords: older adults with cancer; geriatric oncology; geriatric assessment; supportive care; palliative care; cancer rehabilitation; nutrition; physical activity; functional status; survivorship

(This special issue belongs to the Section Cancer Therapy)

Digital Health Technologies in Oncology: 2nd Edition

edited by

Sorana D. Bolboacă

submission deadline 25 Feb 2027 | Viewed by 635 | Submission Open

Keywords: digital healthcare; digital health technologies; diagnosis; wearable devices; rehabilitation technologies; assistive technologies; robotic surgery; (remote) monitoring; precision medicine; data analytics; healthcare teleassistance; AI-driven diagnostics and monitoring; AI-driven analytics.

(This special issue belongs to the Section Methods and Technologies Development)

The Tumorigenesis Mechanism of Breast Cancer

edited by Swayam Prabha

submission deadline 25 Feb 2027 | Viewed by 485 | Submission Open

Keywords: breast cancer; tumor microenvironment; myeloid-derived suppressor cells; immune evasion; premetastatic niche; epithelial–mesenchymal transition; PI3K/AKT/mTOR; MAPK/ERK; Wnt/β-catenin; BRCA1/2; TP53; estrogen signaling; targeted therapy; nanomedicine; biologics; precision oncology; translational research

(This special issue belongs to the Section Molecular Cancer Biology)

The Role of Peptidases in Cancer

edited by

Natalia A. Ignatenko

submission deadline 25 Feb 2027 | Viewed by 352 | Submission Open

Keywords: signaling proteases; proteolytic pathways; proteases and tumor microenvironment; protease diagnostic and therapeutic modalities in cancer

(This special issue belongs to the Section Molecular Cancer Biology)

Advancements in “Cancer Biomarkers” for 2025–2026

edited by

Maxim V. Berezovski

submission deadline 28 Feb 2027 | 25 articles | Viewed by 46260 | Submission Open

Keywords: RNA biomarkers; miRNA biomarkers; DNA biomarkers; cell-free DNA (cfDNA); protein biomarkers; metabolomic biomarkers; mutational biomarkers; circulating tumor cells (CTCs); tumor-derived extracellular vesicle (tEV) biomarkers; cellular biomarkers; imaging biomarkers; clinical biomarkers; biomarkers of drug response; biomarkers of genetic predisposition to cancer; epigenetic biomarkers; biomarkers of cancer outcomes; mass spectrometry; next-generation sequencing (NGS); flow cytometry; positron emission tomography (PET); computed tomography (CT); magnetic resonance imaging (MRI); X-rays; ultrasound; electrocardiography (ECG/EKG); endoscopy; biopsy; pulmonary function tests (PFTs); histopathology; cytopathology; immunohistochemistry (IHC); in situ hybridization (ISH); fluorescence in situ hybridization (FISH); liquid biopsy; electron microscopy; digital pathology and image analysis

(This special issue belongs to the Section Cancer Biomarkers)

Radiotherapy for the Management of Brain Metastases

edited by Alla Gabriella Wernicke

submission deadline 28 Feb 2027 | 2 articles | Viewed by 7451 | Submission Open

Keywords: brain metastases; molecular profiles; imaging advancements; systemic treatment options; radiotherapeutic techniques; primary irradiation; re-irradiation; cutting-edge clinical research

(This special issue belongs to the Section Cancer Metastasis)

Modern Neurosurgical Management of Gliomas

edited by

Arthur Wagner

and

Chiara Negwer

submission deadline 28 Feb 2027 | 4 articles | Viewed by 7196 | Submission Open

Keywords: precision medicine; personalized oncological surgery; intraoperative imaging; fluorescence-guided surgery; intraoperative histopathology; liquid biopsy; minimally invasive oncological surgery; radiosurgery

(This special issue belongs to the Section Cancer Therapy)

Fertility Preservation in Gynecological Cancer

edited by

Giuseppe Gullo

and

Luigi Della Corte

submission deadline 28 Feb 2027 | 3 articles | Viewed by 6787 | Submission Open

Keywords: gynecological cancer; fertility preservation; surgery treatments; fertility sparing; psychological implication

(This special issue belongs to the Section Methods and Technologies Development)

Novel Diagnostic and Therapeutic Approaches in Urologic Oncology

edited by

Whi-An Kwon

submission deadline 28 Feb 2027 | 1 articles | Viewed by 5967 | Submission Open

Keywords: urologic oncology; liquid biopsy; immunotherapy; artificial intelligence; targeted therapy

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Neoantigen Vaccines for Cancer Therapy

edited by Takashi Morisaki

submission deadline 28 Feb 2027 | 3 articles | Viewed by 5482 | Submission Open

Keywords: neoantigens; vaccine; dendritic cells; cancer; immunotherapy; priming; CTL; helper T cells

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Long-Term Health Outcomes and Quality of Life in Survivors of Childhood Cancer

edited by

Esteban Orenes-Piñero

submission deadline 28 Feb 2027 | 2 articles | Viewed by 4150 | Submission Open

Keywords: acute lymphoblastic leukemia; brain tumors; childhood cancer survivors; pollutants; environment; quality of life; nutrition; chemotherapy; air and water purification

(This special issue belongs to the Section Pediatric Oncology)

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