Pancreaticoduodenectomy in the Treatment of Pancreatic Cancer
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Clinical Research in Cancer".
Deadline for manuscript submissions: 15 February 2027 | Viewed by 257
Editors
Interests: surgical oncology; pancreatoduodenectomy; digestive surgery; emergency surgery; trauma management
Special Issue Information
Dear Colleagues,
Pancreatic cancer is currently the sixth leading cause of cancer-related death worldwide, with approximately 511,000 new diagnoses annually and an incidence rate steadily increasing—up to 3% per year—accompanied by an almost equivalent mortality rate. The rise in incidence and the earlier onset of the disease, now often occurring in the sixth decade of life, earlier than in previous years, have spurred the search for new diagnostic and therapeutic strategies for reducing tumor unresectability, lowering recurrence rates, and prolonging long-term survival, thereby altering the natural history of this highly aggressive disease.
Improved biomolecular knowledge of ductal carcinoma and the identification of specific genetic risk factors have paved the way for new antitumor agents, including biological drugs that, in phase I trials, have shown considerable promise and good efficacy, particularly in borderline resectable tumors.
Excluding advanced-stage tumors—currently under investigation in phase II trials with different chemotherapy protocols—this Special Issue will not only evaluate the best pancreaticoduodenectomy techniques, both in traditional surgery and robotic surgery, in patients with localized and resectable tumors, but also underline how pancreaticoduodenectomy R0, with Total Mesopancreas Excision (TMpE) and appropriate lymphadenectomy, represents the most advantageous therapeutic choice. Adherence to these technical principles translates into reduced recurrences, prolonged disease-free intervals, and a positive impact on long-term survival, even in pancreatic cancers undergoing neoadjuvant chemotherapy.
We welcome articles and reviews related to, but not limited to, the following:
- Optimizing R0 Resection in Pancreaticoduodenectomy: Principles and Surgical Strategies;
- Pancreaticoduodenectomy in Multimodal Treatment: Neoadjuvant and Adjuvant Strategies;
- Reconstruction and Functional Outcomes After Pancreatoduodenectomy;
- Perioperative Risk, Morbidity, and Complication Prevention.
Prof. Dr. Piero Chirletti
Dr. Roberto L. Meniconi
Guest Editors
Manuscript Submission Information
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Keywords
- pancreatic ductal adenocarcinoma (PDAC)
- surgical treatment
- R0 exeresis
- mesopancreas
- lymphadenectomy
- reconstruction technique
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