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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Strategies for the Treatment of Melanoma in Neoadjuvant and Adjuvant Settings
edited by Michele Del Vecchio
submission deadline 15 Oct 2026 | 1 articles | Viewed by 1209 | Submission Open
Keywords: melanoma; adjuvant therapy; neoadjuvant therapy; treatment
(This special issue belongs to the Section Cancer Therapy)
Cancer Rehabilitation and Physical Activity: Advancing Function, Recovery, and Quality of Life Across the Cancer Continuum
edited by Jennifer Michelle Jones
submission deadline 15 Oct 2026 | 1 articles | Viewed by 987 | Submission Open
Keywords: cancer rehabilitation; exercise science; physical activity; prehabilitation; adverse side effects
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Pathological Features and Treatment Strategies of Head and Neck Cancer submission deadline 15 Oct 2026 | 1 articles | Viewed by 866 | Submission Open
Keywords: head and neck cancer (HNC); pathological features; treatment strategies; human papillomavirus (HPV); molecular profile; multimodal therapy; immune checkpoint inhibitors; prognostic markers
(This special issue belongs to the Section Clinical Research in Cancer)
Genetic and Molecular Characterization of Lung Cancer
edited by Sk Kayum Alam
submission deadline 15 Oct 2026 | 1 articles | Viewed by 783 | Submission Open
Keywords: lung cancer; molecular subtypes of lung cancer; genetic alterations; next-generation sequencing; biomarker; oncogenic driver mutations; therapeutic landscapes; treatment resistance; metastasis
(This special issue belongs to the Section Molecular Cancer Biology)
World Lung Cancer Awareness Month: 2nd Edition
edited by
submission deadline 15 Oct 2026 | 1 articles | Viewed by 774 | Submission Open
Keywords: lung cancer; tumor microenvironment; early detection; therapeutic targets; new therapeutic strategies; surgery; genetics
(This special issue belongs to the Section Cancer Therapy)
RAS Pathways in Cancer Cells
edited by Geoffrey J. Clark
submission deadline 15 Oct 2026 | Viewed by 364 | Submission Open
Keywords: RAS; inhibitor; signaling; cancer
(This special issue belongs to the Section Molecular Cancer Biology)
Evolving Paradigms in Minimally Invasive and Ablative Endocrine Thyroid Surgery
edited by Gianlorenzo Dionigi and
submission deadline 15 Oct 2026 | Viewed by 348 | Submission Open
Keywords: minimally invasive thyroid surgery; transoral endoscopic thyroidectomy; TOETVA; MIVAT; percutaneous thermal ablation; radiofrequency ablation; microwave ablation; active surveillance; papillary thyroid microcarcinoma; benign thyroid nodules; complication prevention; intraoperative nerve monitoring; health economics in surgery; multidisciplinary approach; surgical innovation; temporal trends in surgery; molecular profiling thyroid; surgical outcomes
(This special issue belongs to the Section Clinical Research in Cancer)
Navigating Therapeutic Resistance in Lung Cancer
edited by
submission deadline 15 Oct 2026 | Viewed by 239 | Submission Open
Keywords: non-small cell lung cancer; small cell lung cancer; chemotherapy; targeted therapy; immune therapy; immune checkpoint inhibitors; drug persister cells; resistance; drug tolerance
(This special issue belongs to the Section Cancer Therapy)
Molecular Pathology-Driven Approaches to Improve Cancer Diagnostic Accuracy
edited by Ovidiu Laurean Pop
submission deadline 15 Oct 2026 | 1 articles | Viewed by 197 | Submission Open
Keywords: molecular pathology; cancer diagnostics; precision oncology; genomic profiling; digital pathology; artificial intelligence; predictive biomarkers; prognostic biomarkers; translational oncology
(This special issue belongs to the Section Cancer Pathophysiology)
A Renewed Understanding of Tumor Growth Modulation by Tumor Necrosis Factor (TNF)-Associated Pathways
edited by Chandra Shekhar Boosani
submission deadline 15 Oct 2026 | Viewed by 197 | Submission Open
Keywords: tumor; inflammation; epigenetics; immune system; inhibitors
(This special issue belongs to the Section Molecular Cancer Biology)
Neuroradiology of Brain Tumors: Radiomics Features and Imaging Technologies
edited by Harpreet Hyare
submission deadline 15 Oct 2026 | Viewed by 181 | Submission Open
Keywords: MRI; radiomics; PET; sodium; perfusion; diffusion; glioma; pediatrics; machine learning
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
The Role of Digital Platforms in Transforming Cancer Surgery and Patient Care
edited by Sang-ho Jeong and
submission deadline 16 Oct 2026 | 1 articles | Viewed by 1021 | Submission Open
Keywords: digital health platforms; surgical oncology; minimally invasive surgery; patient care management
Diagnosis and Therapy in Urothelial Cancer
edited by
submission deadline 20 Oct 2026 | 4 articles | Viewed by 4468 | Submission Open
Keywords: urothelial cancer; bladder cancer; biomarkers; robotic surgery; immunotherapy; upper tract urothelial carcinoma
(This special issue belongs to the Section Cancer Therapy)
Thyroid Cancer Recurrence: Integrating Surgical, Clinical, and Translational Research
edited by and Ioannis Koutelidakis
submission deadline 20 Oct 2026 | 2 articles | Viewed by 2944 | Submission Open
Keywords: thyroid cancer; recurrence; surgery; clinical management; aggressive subtypes; rare subtypes; biomarkers; imaging; translational research; targeted therapy
(This special issue belongs to the Section Clinical Research in Cancer)
Advancing Precision Oncology: From Biomarker Discovery to Clinical Validation
edited by and
submission deadline 20 Oct 2026 | 1 articles | Viewed by 628 | Submission Open
Keywords: precision medicine; biomarkers; clinical translation; medical oncology; liquid biopsy
(This special issue belongs to the Section Cancer Biomarkers)
The Future of Precision Radiotherapy for Cancer: Technology, Optimization, and Clinical Integration
edited by Thomas J. Fitzgerald
submission deadline 20 Oct 2026 | Viewed by 398 | Submission Open
Keywords: radiation; proton; photon; brachytherapy
(This special issue belongs to the Section Methods and Technologies Development)
The Robotic Revolution in Endometrial Cancer: Advancing Surgical Staging and Patient Care
edited by Roberto Berretta
submission deadline 20 Oct 2026 | Viewed by 375 | Submission Open
Keywords: endometrial cancer; robotic surgery; minimally invasive surgery; gynecologic oncology; surgical innovation; obesity; surgical staging; uterine cancer; lymphadenectomy; sentinel node mapping
(This special issue belongs to the Section Cancer Therapy)
Locally Advanced and Recurrent Pelvic Malignancy
edited by Paul Anthony Sutton
submission deadline 20 Oct 2026 | Viewed by 152 | Submission Open
Keywords: pelvic malignancy; locally advanced; recurrent; treament; translational research
Discovery of Novel Therapeutic Targets in Multiple Myeloma
edited by
submission deadline 23 Oct 2026 | Viewed by 250 | Submission Open
Keywords: multiple myeloma; therapeutic target; immunotherapy; drug resistance
Radiation Therapy for Brain Tumors
edited by
submission deadline 25 Oct 2026 | 4 articles | Viewed by 15988 | Submission Open
Keywords: radiosurgery; hypofractionated radiosurgery; spectroscopic MRI; proton radiation; image-guided radiotherapy; radiotherapy for benign tumors; radiotherapy for gliomas; gamma knife
(This special issue belongs to the Section Cancer Therapy)
Advances in Interventional Oncology in Hepatocellular Carcinoma Treatment
edited by Edward W. Lee, XiaoLi Zhu and Frank Hao
submission deadline 25 Oct 2026 | 2 articles | Viewed by 2479 | Submission Open
Keywords: hepatocellular carcinoma; interventional oncology; HCC
(This special issue belongs to the Section Cancer Therapy)
Interpretable AI and Multiomics Integration for Cancer Treatment Response Prediction: Cutting-Edge Innovations and Overcoming Challenges
edited by
submission deadline 25 Oct 2026 | Viewed by 331 | Submission Open
Keywords: machine learning; genomic language models; multiomics integration; enhancer prediction; interpretable AI; tumour stratification; deep learning; translational oncology; cancer treatment response
(This special issue belongs to the Section Methods and Technologies Development)
Skin Cancer Prevention: Strategies, Challenges and Future Directions
edited by Véronique del Marmol, Mariano Suppa, Ana-Maria Forsea and Alexander Stratigos
submission deadline 30 Oct 2026 | 8 articles | Viewed by 18731 | Submission Open
Keywords: skin cancer prevention; photoprotection; early detection; screening; epidemiology; public health; behavioral interventions; sun exposure; artificial intelligence; risk factors
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Advances in Neurofibromatosis
edited by Yunjia Chen and Yulong Fu
submission deadline 30 Oct 2026 | 2 articles | Viewed by 12306 | Submission Open
Keywords: neurofibromatosis; schwannomatosis; NF1; NF2; SMARCB1; LZTR1
Adverse Effects During Cancer Treatment
edited by Yan Gong
submission deadline 30 Oct 2026 | 4 articles | Viewed by 3995 | Submission Open
Keywords: cancer; drug-induced adverse effects; cardiotoxicity of cancer treatment; cardiotoxicity of radiation therapy
(This special issue belongs to the Section Cancer Therapy)
Recent Advances and Strategies for the Management of CIN and HPV Eradication Strategies for the Prevention of Uterine Cervical Cancer
edited by
submission deadline 30 Oct 2026 | 1 articles | Viewed by 3751 | Submission Open
Keywords: CIN; 9-valent HPV vaccine; HPV L2-VLP vaccine; HPV therapeutic vaccine; endocervical conization; laser vaporization; PDT
Cancer Prevention and Screening: Innovations, Implementation, and Access
edited by and Rahma S. Mkuu
submission deadline 30 Oct 2026 | 3 articles | Viewed by 3219 | Submission Open
Keywords: cancer; prevention; screening; intervention; implementation
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Gynecologic Cancer: From Diagnosis to Treatment: 2nd Edition submission deadline 30 Oct 2026 | 2 articles | Viewed by 3151 | Submission Open
Keywords: endometrial cancer; cervical cancer; ovarian cancer; borderline ovarian tumor; diagnosis and treatment
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Gynecological Cancers: From Bench to Bedside submission deadline 30 Oct 2026 | 2 articles | Viewed by 2470 | Submission Open
Keywords: gynecologic oncology; translational research; molecular mechanisms; targeted therapy; immunotherapy; personalized medicine
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Epigenetic Modifiers in Cancer Treatment: Molecular Mechanisms and Clinical Applications
edited by and Umamaheswari Natarajan
submission deadline 30 Oct 2026 | 1 articles | Viewed by 2354 | Submission Open
Keywords: epigenetics; histones; DNA methylation; histone acetylations; chromatin remodeling; DNMTs (DNMT1, DNMT3A, DNMT3B); PRMTs; HDACs; miRNA; ncRNAs; lncRNA
(This special issue belongs to the Section Molecular Cancer Biology)
Neurosurgery Research on Brain Tumors
edited by
submission deadline 30 Oct 2026 | 3 articles | Viewed by 2346 | Submission Open
Keywords: neuro-oncology; neurosurgical technique; brain tumors; neuroimages
Unraveling Immune Dynamics and Novel Therapeutic Strategies in the Tumor Microenvironment
edited by Shahidul M. Islam
submission deadline 30 Oct 2026 | 1 articles | Viewed by 1747 | Submission Open
Keywords: tumor microenvironment; immune dynamics; tumor heterogeneity; immune checkpoints; CAR T; cancer immunology; adoptive cell transfer; resistance; biomarkers; combination therapy; machine learning; molecular modeling
(This special issue belongs to the Section Tumor Microenvironment)
Translational Insights into the Prevention and Treatment of Chemotherapy-Induced Peripheral Neuropathy: Integrating Mechanistic, Clinical and Therapeutic Advances
edited by Ellen M. Lavoie Smith
submission deadline 30 Oct 2026 | 2 articles | Viewed by 1640 | Submission Open
Keywords: chemotherapy-induced peripheral neuropathy; mechanisms; treatment; prevention; assessment; biomarkers
Solid Tumors, with a Focus on Urological Cancers: From Molecular Mechanisms to Predictive Biomarkers
edited by and
submission deadline 30 Oct 2026 | 2 articles | Viewed by 1618 | Submission Open
Keywords: solid tumors; urological cancers; tumor microenvironment; molecular mechanisms; predictive biomarkers
(This special issue belongs to the Section Cancer Biomarkers)
Clinical Research of Brachytherapy in Cancer
edited by Ludmiła Grzybowska-Szatkowska, and Aleksandra Kozłowska
submission deadline 30 Oct 2026 | 1 articles | Viewed by 1341 | Submission Open
Keywords: brachytherapy; LDR; HDR; genitourinary cancers; breast cancer; skin cancer; gastrointestinal cancers; oligometastatic disease; personalized treatment and neoplasm
(This special issue belongs to the Section Clinical Research in Cancer)
Innovative Therapeutics for Breast Cancer: Advancing Clinical and Translational Research
edited by and Tamer Saad Kaoud
submission deadline 30 Oct 2026 | 1 articles | Viewed by 1209 | Submission Open
Keywords: breast cancer; innovative therapeutics; translational clinical research; targeted therapy; immunotherapy; biomarkers; tumor microenvironment; drug resistance; clinical trials; translational preclinical research
(This special issue belongs to the Section Clinical Research in Cancer)
The Current Status of Brain Tumor Imaging: 2nd Edition
edited by
submission deadline 30 Oct 2026 | 1 articles | Viewed by 1039 | Submission Open
Keywords: neuro-oncology; glioma; brain metastasis; CT scan; MRI; radiogenomics; radiomics; artificial intelligence; MR spectroscopy; MR perfusion; fMRI
(This special issue belongs to the Section Cancer Therapy)
Research and Clinical Applications of Gynecologic Cancer Detection Technologies
edited by Porfyrios Korompelis
submission deadline 30 Oct 2026 | 1 articles | Viewed by 832 | Submission Open
Keywords: gynaecological cancer; early diagnosis; artificial intelligence; novel technologies
(This special issue belongs to the Section Methods and Technologies Development)
Advances in the Diagnosis, Pathology and Treatment of Metastatic Brain Tumors
edited by
submission deadline 30 Oct 2026 | 1 articles | Viewed by 720 | Submission Open
Keywords: brain metastases; diagnostic imaging; molecular pathology; targeted therapy; immunotherapy; precision oncology; multimodal treatment; translational research
(This special issue belongs to the Section Cancer Metastasis)
Pathological Diagnosis and Surgical Treatment of Cholangiocarcinoma: Current Status and Novel Perspectives
edited by
submission deadline 30 Oct 2026 | 1 articles | Viewed by 648 | Submission Open
Keywords: cholangiocarcinoma; intrahepatic cholangiocarcinoma; small-duct type; large-duct type; immune checkpoint inhibitor; conversion surgery
MYC Oncogene in Cancer: Cancer Cell Intrinsic and Immune Inhibitory Functions
edited by Wadie Mahauad Fernandez and Konstantinos V. Floros
submission deadline 30 Oct 2026 | Viewed by 623 | Submission Open
Keywords: MYC oncogene; molecular oncology; immuno-oncology; tumor microenvironment
(This special issue belongs to the Section Molecular Cancer Biology)
The Role of Sphingolipids in Cancer Progression
edited by
submission deadline 30 Oct 2026 | Viewed by 415 | Submission Open
Keywords: sphingolipids; tumorigenesis; tumor progression; metastasis; spatial transcriptomics; spatial metabolomics; spatial proteomics; transcriptomics; metabolomics; proteomics; drug development
(This special issue belongs to the Section Molecular Cancer Biology)
Hyperthermic Intraperitoneal Chemotherapy in Oncology: Current Clinical Applications and Future Directions
edited by Konstantinos I. Votanopoulos
submission deadline 30 Oct 2026 | Viewed by 315 | Submission Open
Keywords: HIPEC; cytoreductive surgery; peritoneal surface malignancies; colorectal cancer; appendiceal neoplasms; gastric cancer; ovarian cancer; peritoneal mesothelioma; intraperitoneal chemotherapy-organoids
(This special issue belongs to the Section Cancer Therapy)
Surgical Management of Colorectal Cancer: Current Standards and Future Directions
edited by Pedro Silva-Vaz and
submission deadline 30 Oct 2026 | Viewed by 302 | Submission Open
Keywords: colorectal cancer; colorectal surgery; robotic-assisted surgery; transanal surgery; organ preservation; neoadjuvant therapy; perioperative optimization; cancer imaging; artificial intelligence; multidisciplinary approach
(This special issue belongs to the Section Cancer Therapy)
Gastrointestinal Tumors: Screening and Prevention
edited by
submission deadline 30 Oct 2026 | Viewed by 289 | Submission Open
Keywords: cancer; early detection; esophageal; gastric; pancreatic; hepatocellular; colorectal; risk stratification; endoscopy; liquid biopsy
Innovations in Pancreatic Oncology: Surgical Outcomes, Biomarkers, and Artificial Intelligence
edited by Jayasree Chakraborty and Lily Saadat
submission deadline 30 Oct 2026 | Viewed by 277 | Submission Open
Keywords: pancreatic cancer; oncology; early detection; surgical outcome; biomarkers; multi-modal data; artificial intelligenec; clinical decision support system; precision medicine
Advances in Immunotherapy, Biomarkers, and Clinical Practice in Pleural Mesothelioma and Thoracic Cancers
edited by
submission deadline 30 Oct 2026 | Viewed by 260 | Submission Open
Keywords: pleural mesothelioma; thoracic cancers; immunotherapy; biomarkers; immunotherapy resistance; molecular and genetic testing; precision oncology; real-world clinical practice
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Molecular Biomarkers in Human Testicular Germ Cell Tumors: Targets for Therapeutic, Diagnostic and Follow-Up Strategies submission deadline 30 Oct 2026 | Viewed by 240 | Submission Open
Keywords: testicular germ cell tumors (TGCTs); molecular biomarkers; miRNA; liquid biopsy; circulating tumor DNA (ctDNA); diagnostic biomarkers; therapeutic targets; follow-up/surveillance
The Applications of Artificial Intelligence in Thoracic Cancers
edited by Xin Li
submission deadline 30 Oct 2026 | Viewed by 220 | Submission Open
Keywords: artificial intelligence; biomarkers; lung cancer; machine learning; deep learning; cancer; real-world data; imaging
(This special issue belongs to the Section Methods and Technologies Development)
Clinical Treatment Research of Acute Myeloid Leukemia (AML)
edited by Madelyn Burkart and
submission deadline 30 Oct 2026 | Viewed by 198 | Submission Open
Keywords: acute myeloid leukemia; measurable residual disease (MRD); targeted therapy; allogeneic hematopoietic stem cell transplant (HSCT); molecular diagnostics; immunotherapy
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