Pathological Diagnosis and Surgical Treatment of Cholangiocarcinoma: Current Status and Novel Perspectives
A special issue of Cancers (ISSN 2072-6694).
Deadline for manuscript submissions: 30 October 2026 | Viewed by 529
Editor
Interests: cholangiocarcinoma; intrahepatic cholangiocarcinoma; hepatobiliary surgery; fluorescence-guided surgery; tumor microenvironment
Special Issue Information
Dear colleagues,
Cholangiocarcinoma (CCA) remains one of the most aggressive malignancies of the hepatobiliary system, characterized by late diagnosis, limited treatment options, and poor prognosis. Recent advances in systemic therapy, particularly the introduction of immune checkpoint inhibitors (ICIs), have opened new horizons, leading to encouraging outcomes, including successful conversion surgeries in initially unresectable cases. Nevertheless, reliable predictive biomarkers for treatment response and long-term outcomes remain insufficiently established.
CCA comprises a heterogeneous group of tumors that arise in both intrahepatic and extrahepatic bile ducts. Intrahepatic cholangiocarcinoma (iCCA) itself can be further subdivided into small-duct and large-duct types, each with distinct clinicopathological and molecular features. This diversity within CCA poses significant challenges to uniform diagnosis and treatment, and may in part explain the slow progress in establishing robust biomarkers and tailored therapeutic strategies.
This Special Issue aims to provide an updated and multidisciplinary overview of the pathological diagnosis, molecular biomarkers, and surgical strategies in CCA, fostering discussion on how pathological and translational insights can guide future therapeutic developments. We welcome original research articles, clinical studies, and comprehensive reviews that explore innovative diagnostic methods, biomarkers for patient stratification, and novel surgical or multimodal treatment approaches.
We look forward to receiving your valuable contributions.
Dr. Masahiko Kinoshita
Guest Editor
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Keywords
- cholangiocarcinoma
- intrahepatic cholangiocarcinoma
- small-duct type
- large-duct type
- immune checkpoint inhibitor
- conversion surgery
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