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Gynecological Cancers: From Bench to Bedside

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Prof. Dr. Francesco Cosentino

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1. Department of Medicina e Scienze della Salute “V. Tiberio”, Università degli Studi del Molise, 86100 Campobasso, Italy
2. UO Oncology, Responsible Research Hospital, 86100 Campobasso, Italy
Interests: endometrial cancer; ovarian cancer; cervical cancer; gynecologic oncology; endometriosis

Special Issue Information

Dear Colleagues,

Gynecological cancers—including cervical, ovarian, endometrial, vulvar, and vaginal malignancies—remain a significant global health challenge, with ongoing advances in prevention, diagnosis, and treatment. In recent years, translational research has bridged the gap between basic science discoveries and clinical applications, leading to improvements in molecular profiling, biomarker discovery, immunotherapy, targeted therapy, and personalized medicine. At the same time, clinical research continues to refine surgical strategies, radiotherapy approaches, and systemic treatments, aiming to optimize patient outcomes and quality of life

This Special Issue, “Gynecological Cancers: From Bench to Bedside”, welcomes original research articles, clinical studies, and comprehensive reviews on all aspects of gynecologic oncology. Contributions may address novel molecular mechanisms, innovative diagnostic tools, translational models, therapeutic interventions, or multidisciplinary management strategies. By gathering insights from both basic and clinical research, this collection aims to foster collaboration across disciplines and to advance the field toward improved prevention, early detection, and patient-centered care

We look forward to your valuable contributions to this Special Issue

Prof. Dr. Francesco Cosentino
Guest Editor

Dr. Daniele Neola
Guest Editor Assistant
E-mail: danieleneola@gmail.com
Affiliation: Department of Neuroscience, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II, 80138 Naples, Italy
Website: https://scholar.google.com/citations?user=qzu8eo0AAAAJ&hl=it
Interests: endometrial cancer; ovarian cancer; gynecologic oncology; endometriosis; molecular medicine

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17 pages, 487 KB

Open AccessSystematic Review

Intestinal-Type Adenocarcinoma Is a Rare Histotype of Vulvar Neoplasm: Systematic Review of the Literature

by Alessio Colalillo, Dominga Boccia, Luigi Della Corte, Daniele Neola, Federica Rosato, Silvia D’Ippolito, Maria De Ninno, Damiano Arciuolo, Maurizio Guida, Giuseppe Bifulco and Francesco Cosentino

Cancers 2025, 17(24), 3989; https://doi.org/10.3390/cancers17243989 - 14 Dec 2025

Viewed by 153

Abstract

Background: Intestinal-type vulvar adenocarcinoma (VAIt) is an exceptionally rare form of primary vulvar cancer, characterized by histological features resembling mucinous colonic carcinomas, including villo-glandular structures composed of goblet and Paneth cells with intracytoplasmic mucin. Objective: To provide a comprehensive synthesis of the existing literature on VAIt and to also report a case from our institution in order to define its clinical, pathological, and immunohistochemical characteristics and its management and prognosis. Materials and Methods: A systematic review of the literature according to PRISMA guidelines was performed through searching five electronic databases (MEDLINE, EMBASE, Web of Science, SCOPUS and Cochrane Library), considering studies from 1998 to May 2025. In our research, we included all peer-reviewed studies which reported cases of VAIt. Data about VAIt were extracted by included studies and compared. Results: All in all, 32 studies with a total of 40 cases (including our case) of VAIt were assessed. The median age at diagnosis was 58 years. Most tumors arose in the labia or perineal structures, often mimicking benign lesions. Immunohistochemistry consistently showed CK20 and CDX2 positivity, with variable CK7 and p16 expression. FIGO stage IA was the most frequent stage at diagnosis. Surgical excision was the mainstay of treatment, while adjuvant therapy was less commonly reported. Lymph node metastases were present in about 31.5% of cases. Despite aggressive histology, most patients were disease-free at follow-up. Mortality due to disease occurred in 10% of cases. Conclusions: VAIt is a very rare histotype of vulvar cancer. Compared to vulvar squamous cell carcinomas, approximately 40% of early-stage clinical diseases reported in the literature presented positive inguinal lymph nodes with recurrence even after many years. The optimal treatment is not well defined and should be based on the individual clinical history of the patient, as there are no established guidelines. Further studies and longer follow-up periods are needed to clarify the best therapeutic management and its long-term prognosis. Full article

(This article belongs to the Special Issue Gynecological Cancers: From Bench to Bedside)

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