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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Oral Cancer and Precancerous Lesions: Advances in Diagnosis, Prognosis, and Therapy

edited by

Maria Maddalena Marrapodi

submission deadline 31 Oct 2026 | Viewed by 115 | Submission Open

Keywords: potentially malignant oral disorders (PMODs); malignant transformation; oral cancer and precancerous lesions

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Synergistic Radiotherapy and Immunotherapy in Cancer Treatment

edited by

Xiaju Cheng

submission deadline 31 Oct 2026 | Viewed by 111 | Submission Open

Keywords: radiotherapy; immunotherapy; combination therapy; nanomedicine; immunogenic cell death; tumor microenvironment; immune checkpoint inhibitors; abscopal effect; systemic immunity; clinical trials

(This special issue belongs to the Section Cancer Therapy)

Signaling Networks and Systems Biology in Cancer

edited by

Rajesh Singh

and

Abhinava K. Mishra

submission deadline 31 Oct 2026 | Viewed by 96 | Submission Open

Keywords: cancer signaling; immuno-oncology; cancer nanotechnology; AI/ML in cancer; systems oncology

(This special issue belongs to the Section Molecular Cancer Biology)

Decoding the Tumor Microenvironment: From Mechanisms to Therapeutic Opportunities

edited by

Michele Zanoni

, Giacomo Miserocchi and

Tania Rossi

submission deadline 31 Oct 2026 | Viewed by 91 | Submission Open

Keywords: tumor microenvironment (TME); cancer immunology; tumor– stroma interactions Immune; evasion; therapy resistance; spatial and single-cell omics; biomarker discovery; translational oncology; 3D models

(This special issue belongs to the Section Tumor Microenvironment)

Radiotherapy and the Tumor Microenvironment: From Basic Mechanisms to Clinical Translation

edited by Eleanor J. Cheadle and

Jamie Honeychurch

submission deadline 31 Oct 2026 | Viewed by 90 | Submission Open

Keywords: radiotherapy; tumor microenvironment; immune response; biomarkers; stroma; immunogenic cell death

The Tumor Microenvironment and Its Role in Tumor Growth and Angiogenesis—2nd Edition

edited by

Roberto Tamma

submission deadline 31 Oct 2026 | Viewed by 87 | Submission Open

Keywords: tumor microenvironment; tumor angiogenesis; tumor targeted therapies; inflammation; immunotherapies

(This special issue belongs to the Section Tumor Microenvironment)

Molecular Imaging in Oncology: Recent Advances (2nd Edition)

edited by

Lioe-Fee de Geus-Oei

submission deadline 31 Oct 2026 | Viewed by 85 | Submission Open

Keywords: nuclear medicine; molecular imaging; PET; oncology; cancer; SPECT; precision medicine; personalized medicine; biomarker; targeted radionuclide therapies; personalized dosimetry

(This special issue belongs to the Section Cancer Therapy)

The Role of Lifestyle Choices in Cancer Risk

edited by Itunu O. Sokale, Aaron P. Thrift and

Xiaotao Zhang

submission deadline 31 Oct 2026 | Viewed by 83 | Submission Open

Keywords: cancer risk; lifestyle; behavioral factors; outcome; cancer prevention

Circulating Tumor Cells (CTCs) for Cancer Diagnosis and Prognosis

edited by

Athina N. Markou

submission deadline 31 Oct 2026 | Viewed by 82 | Submission Open

Keywords: CTCs; liquid biopsy; metastasis; biomarkers

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Exploring the Genetic and Epigenetic Factors in Leukemia and Lymphoma (2nd Edition)

edited by

Francesco E. Boccalatte

submission deadline 31 Oct 2026 | Viewed by 71 | Submission Open

Keywords: hematology; leukemia; lymphoma; epigenetics; bioinformatics; gene expression; chromatin conformation

(This special issue belongs to the Section Cancer Therapy)

AI-Driven Advanced Radiotherapy: Towards Personalized, Predictive and Adaptive Cancer Treatment

edited by Zhen Tian and Chaoqiong Ma

submission deadline 31 Oct 2026 | Viewed by 71 | Submission Open

Keywords: radiotherapy; artificial intelligence; machine learning; deep learning; outcome prediction; treatment planning; adaptive RT; personalized RT; radiomics

(This special issue belongs to the Section Methods and Technologies Development)

Metabolism and Precision Oncology

edited by Rays H.Y. Jiang and Gloria C. Ferreira

submission deadline 31 Oct 2026 | Viewed by 68 | Submission Open

Keywords: cancer metabolism; precision oncology; tumor microenvironment; immunometabolism; metabolic reprogramming; redox biology; metabolomics; lipid metabolism; mitochondrial function; therapeutic targeting

(This special issue belongs to the Section Cancer Pathophysiology)

Opportunities and Challenges in Cancer Immunotherapies

edited by

Gao Zhang

submission deadline 31 Oct 2026 | Viewed by 68 | Submission Open

Keywords: cancer immunotherapy; immune checkpoint inhibitors; cellular therapy; tumor microenvironment; therapeutic resistance

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Oxidative Stress in Cancer: From Mechanisms to Therapeutic Strategies

edited by

Francesco Marotta

and

Reza Rastmanesh

submission deadline 31 Oct 2026 | Viewed by 61 | Submission Open

Keywords: redox signaling; tumor microenvironment; senolytics; immunometabolism; gut microbiome; preventive oncology; drug delivery

(This special issue belongs to the Section Cancer Therapy)

Local, Systemic and Combined Therapy for Hepatocellular Carcinoma

edited by Xiaoqun Dong

submission deadline 31 Oct 2026 | Viewed by 58 | Submission Open

Keywords: hepatocellular carcinoma; immunotherapy; cell therapy; targeted therapy; local therapy; combination therapy; oncolytic virus; precision oncology; drug resistance; translational research

(This special issue belongs to the Section Cancer Therapy)

Pituitary Tumors: Molecular Insights, Diagnosis, and Targeted Therapy—Third Edition

edited by

Kazunori Kageyama

and

Mitsuru Nishiyama

submission deadline 31 Oct 2026 | Viewed by 56 | Submission Open

Keywords: acromegaly; adrenocorticotropic hormone; Cushing’ s disease; diagnosis; growth hormone; pituitary tumor; proliferation; transcriptional factor; treatment

Innovations in Surgical and Management Strategies for Complex and Advanced Gastric Cancer

edited by

Tsutomu Namikawa

and

Kazuhiro Hanazaki

submission deadline 31 Oct 2026 | Viewed by 48 | Submission Open

Keywords: advanced gastric cancer; surgical innovation; multimodal therapy; minimally invasive gastrectomy (robotic/laparoscopic); perioperative management; immunotherapy; precision medicine; peritoneal metastasis

(This special issue belongs to the Section Clinical Research of Cancer)

Advances in Imaging Techniques of Molecular Oncology (2nd Edition)

edited by

Angela Spanu

submission deadline 31 Oct 2026 | Viewed by 47 | Submission Open

Keywords: cancer; oncological imaging; molecular imaging; SPECT/TC; PET/CT; PET/MRI; DWI; DCE-MRI; nanotheranostics; artificial intelligence; radiomics; theranostics

(This special issue belongs to the Section Methods and Technologies Development)

Skin and Hair Side Effects of Cancer Treatment

edited by Ian W. Tattersall

submission deadline 31 Oct 2026 | Viewed by 46 | Submission Open

Keywords: oncodermatology; toxicity management; supportive oncology

(This special issue belongs to the Section Cancer Therapy)

Genetic Disorders and Cancer Susceptibility: Molecular Mechanisms, Risk Assessment, and Targeted Therapies

edited by Silmara de Lima

submission deadline 31 Oct 2026 | Viewed by 16 | Submission Open

Keywords: neurofibromatosis type-1; optic pathway glioma; retinal ganglion cell survival; myelination; vision loss; targeted therapies

(This special issue belongs to the Section Molecular Cancer Biology)

Non-Pharmacological Interventions in Oncology Supportive and Palliative Care

edited by

Leila Kozak

submission deadline 31 Oct 2026 | Viewed by 5 | Submission Open

Keywords: integrative palliative care; integrative therapies; non-pharmacological therapies; symptom management; palliative care; supportive care; massage; acupuncture; tai chi; virtual reality

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Novel Insights into Glioma Immunotherapy

edited by Tomasz Tykocki

submission deadline 5 Nov 2026 | Viewed by 31 | Submission Open

Keywords: glioma immunotherapy; tumor microenvironment; immune evasion; microglia; checkpoint inhibitors; CAR‑T; neoantigen vaccines

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Evaluating the Clinical Impact of Robotic Surgery in the Management of Colorectal Cancer

edited by

Héctor Guadalajara

and Miguel Leon-Arellano

submission deadline 15 Nov 2026 | Viewed by 126 | Submission Open

Keywords: robotic surgery; colorectal cancer; oncological outcomes; surgical technique; laparoscopic comparison; margin status; postoperative recovery; quality of life; intraoperative imaging; surgical navigation; learning curve; complications; cost-effectiveness; surgical training; technological innovation

(This special issue belongs to the Section Clinical Research of Cancer)

Recent Advances in Endoscopic, Metabolomic, and Ultrasound Approaches to Gastrointestinal, Hepatic, and Pancreatic Tumors

edited by Ciprian Brisc and Nadim Al Hajjar

submission deadline 15 Nov 2026 | Viewed by 41 | Submission Open

Keywords: gastrointestinal; hepatic and pancreatic tumors; metabolomics; endoscopy; ultrasound; elastography; molecular investigations and treatment; robotic surgery; laparoscopic surgery; early lesions; radiofrequency and microwave ablation; irreversible electroporation; cryoablation; targeted chemo- or radio-embolization

(This special issue belongs to the Section Cancer Therapy)

The Pathologic Diagnosis and Clinical Therapy of Neuroendocrine Tumors: 2nd Edition

edited by

Salvatore Tafuto

Ottavia Clemente

and

Annabella Di Mauro

submission deadline 20 Nov 2026 | Viewed by 47 | Submission Open

Keywords: neuroendocrine neoplasms; molecular mechanisms; cancer pathogenesis; tumorigenesis; diagnosis; molecular and cellular heterogeneity; predictive biomarkers; animal models and of neuroendocrine cancer; diagnostic clinical oncology; genomic characterization; clinical biomarkers; biomarkers of drug response; epigenetic biomarkers; targeted therapy; tumor immunity; molecular oncology; clinical therapy

Infectious Pathogens and Cancer

edited by

W. Martin Kast

submission deadline 25 Nov 2026 | Viewed by 39 | Submission Open

Keywords: infectious cancer pathogens; related topics in immunology; virology; epidemiology; (therapeutic) vaccines; oncogenesis; screening; therapy

(This special issue belongs to the Section Infectious Agents and Cancer)

Cancer Cells Fostered Microenvironment in Metastasis (2nd Edition)

edited by

Lin Ye

submission deadline 25 Nov 2026 | Viewed by 35 | Submission Open

Keywords: cancer cells; tumour microenvironment; metastasis; fibroblast; immune cells; extracellular ma-trix; adhesion; migration; invasion; drug resistance; target therapy

(This special issue belongs to the Section Cancer Metastasis)

Treatment and Prognosis of Pediatric Medulloblastoma

edited by Marwa Ismail

submission deadline 25 Nov 2026 | Viewed by 34 | Submission Open

Keywords: pediatric medulloblastoma; proteomics; radiogenomics

(This special issue belongs to the Section Pediatric Oncology)

Radiologic Staging and Surgical Decision-Making in the Era of Neoadjuvant Therapy for Breast Cancer

edited by

Damiano Gentile

submission deadline 25 Nov 2026 | Viewed by 32 | Submission Open

Keywords: radiologic staging; neoadjuvant therapy; breast cancer; breast-conserving surgery; mastectomy; targeted axillary dissection; sentinel lymph node biopsy; axillary lymph node dissection; magnetic resonance imaging; surgical de-escalation

(This special issue belongs to the Section Cancer Therapy)

New Findings in Targeting Cancer Proteins (Second Edition)

edited by

Maristella Maggi

and

Claudia Scotti

submission deadline 30 Nov 2026 | 1 articles | Viewed by 2863 | Submission Open

Keywords: monoclonal antibodies; protein target; immunotherapy; signaling blockade; targeted therapy

(This special issue belongs to the Section Cancer Therapy)

Artificial Intelligence and Machine Learning in Lung Cancer

edited by

Jianjun Zhang

Jia Wu

and

Morteza Salehjahromi

submission deadline 30 Nov 2026 | 1 articles | Viewed by 1283 | Submission Open

Keywords: artificial intelligence; machine learning; lung cancer screening; low-dose CT; early detection

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

In Vitro and In Vivo Pharmacology for Glioma Drug Discovery

edited by

Anna Bielecka-Wajdman

submission deadline 30 Nov 2026 | 1 articles | Viewed by 509 | Submission Open

Keywords: pre-clinical modern in vitro /in vivo glioma models; complementary glioma therapy; immunotherapy in glioma; inhibition of glioma recurrence

(This special issue belongs to the Section Cancer Drug Development)

Advances in Nanoparticle and Exosome Technology for Delivery of Payloads in CNS Tumors

edited by

Ali S. Arbab

submission deadline 30 Nov 2026 | Viewed by 150 | Submission Open

Keywords: glioblastoma; brain metastasis; nanoparticles; exosomes; viral therapy; delivery of payload; imaging probes

(This special issue belongs to the Section Cancer Drug Development)

New Approaches to Surgical Treatment and Care for Urological Cancer

edited by

Susanne Vahr Lauridsen

and Bente Thoft Jensen

submission deadline 30 Nov 2026 | Viewed by 121 | Submission Open

Keywords: bladder cancer; prostate cancer; kidney cancer; penile cancer; patient perspective; patient education; enhanced recovery after surgery (ERAS) protocols; prehabilitation rehabilitation; sexual health

(This special issue belongs to the Section Clinical Research of Cancer)

New Clinical Insights into Gastrointestinal Cancers

edited by Dai Shida

submission deadline 30 Nov 2026 | Viewed by 94 | Submission Open

(This special issue belongs to the Section Clinical Research of Cancer)

After Cancer Remission: Tracking Minimal Residual Disease and Relapse

edited by

Andriani Charpidou

Ioannis P. Trontzas

and

Emmanouil Panagiotou

submission deadline 30 Nov 2026 | Viewed by 80 | Submission Open

Keywords: minimal residual disease (MRD); cancer relapse; liquid biopsy; circulating tumor DNA (ctDNA); biomarkers; molecular monitoring; post-remission surveillance; translational oncology; multi-omics; personalized cancer care; precision medicine

Acute Myeloid Leukemia: Novel Therapeutic Agents and Clinical Trials

edited by Wieslaw W. Jedrzejczak

submission deadline 30 Nov 2026 | Viewed by 65 | Submission Open

Keywords: acute leukemia; targeted therapy; antibody– drug conjugates

(This special issue belongs to the Section Clinical Research of Cancer)

Advances in the Management of Pelvic Tumors: 2nd Edition

edited by Giorgia Gaia and

Maria Chiara Sighinolfi

submission deadline 30 Nov 2026 | Viewed by 63 | Submission Open

Keywords: pelvic cancer; prostate cancer; bladder cancer; uterine cancer; ovarian cancer; rectal cancer; anal cancer

(This special issue belongs to the Section Cancer Therapy)

Intraoperative Radiotherapy in Cancer Treatment

edited by

Falk Roeder

submission deadline 30 Nov 2026 | Viewed by 42 | Submission Open

Keywords: intraoperative radiation therapy; image-guided IORT; IOERT; kV-IORT; HDR-IORT; FLASH

(This special issue belongs to the Section Cancer Therapy)

Advances in Adoptive Cell Therapy for Cancer

edited by Andrew Furness

submission deadline 30 Nov 2026 | Viewed by 28 | Submission Open

Keywords: CAR-T cells; adoptive cell therapy; tumor microenvironment; immunotherapy; translational oncology

Update in Pathology of Gynaecologic Cancer

edited by

Mona El-Bahrawy

submission deadline 30 Nov 2026 | Viewed by 13 | Submission Open

Keywords: gynaecological; cancer; pathology; diagnosis

(This special issue belongs to the Section Cancer Pathophysiology)

Innovations and Current Evidence in Radiotherapy for Urological Cancers

edited by

Tomoyuki Makino

submission deadline 30 Nov 2026 | Viewed by 1 | Submission Open

Keywords: radiotherapy; urological cancer; prostate cancer; kidney cancer; urothelial cancer; testicular cancer; penile cancer; palliative; metastases; salvage

(This special issue belongs to the Section Cancer Therapy)

Clinical Treatment and Prognostic Factors of Urologic Cancer

edited by

Hiroaki Iwamoto

submission deadline 15 Dec 2026 | 13 articles | Viewed by 39046 | Submission Open

Keywords: prostate cancer; bladder cancer; urothelial carcinoma; upper urinary tract tumors; kidney cancer; renal cell carcinoma; testicular tumors; molecular markers; diagnosis; systemic treatment

(This special issue belongs to the Section Cancer Therapy)

The Evolving Landscape of Squamous Cell Carcinoma of the Anal Canal: State of the Art, Current Challenges and Future Perspectives

edited by

Alessandra Boccaccino

and Francesco Vasuri

submission deadline 15 Dec 2026 | Viewed by 70 | Submission Open

Keywords: squamous cell anal carcinoma; anal cancer; HIV; HPV

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Treatment-Induced Metabolic and Inflammatory Responses in Cancer

edited by

Anis Ahmad

submission deadline 15 Dec 2026 | Viewed by 6 | Submission Open

Keywords: radiation therapy; chemotherapy; immunotherapy; normal tissue toxicity; metabolic reprogramming; chronic inflammation; lipid dysregulation; treatment resistance; inflammatory signaling

Cancer Genetics and Epigenetics: Their Roles and Clinical Implications (2nd Edition)

edited by

Armita Bahrami

and

Ying Qing

submission deadline 20 Dec 2026 | 1 articles | Viewed by 535 | Submission Open

Keywords: cancer genetics; cancer epigenetics; carcinogenesis; cancer prognosis; cancer therapeutics; genetic mutations; DNA methylation; histone modifications; RNA methylation

(This special issue belongs to the Section Molecular Cancer Biology)

Hematological Malignancies: From Translational Discoveries to Clinical Trends

edited by

Arati Sharma

and Charyguly Annageldiyev

submission deadline 20 Dec 2026 | Viewed by 91 | Submission Open

Keywords: hematological malignancies; leukemia; lymphoma; myeloma; translational research; preclinical studies; clinical outcomes; molecular biomarkers; targeted therapy; precision medicine

(This special issue belongs to the Section Cancer Therapy)

The State of the Art in Cardio-Oncology

edited by

Fabio Maria Turazza

submission deadline 20 Dec 2026 | Viewed by 77 | Submission Open

Keywords: cardio-oncology; cardiotoxicity; cancer therapeutics; reverse cardio-oncology; precision cardio-oncology; genetics in cardio-oncology

Retroviruses and Cancer Development: Molecular Mechanisms and Therapeutic Prospects

edited by Donna D'Agostino and