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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Insights into Kidney Disease Development and Therapy Strategies submission deadline 31 Dec 2025 | 1 articles | Viewed by 2602 | Submission Open
(This special issue belongs to the Section Cancer Therapy)
Technical and Technological Innovations in Head and Neck Cancer Surgery
edited by Marta Filauro
submission deadline 31 Dec 2025 | 1 articles | Viewed by 2563 | Submission Open
Keywords: head and neck; squamous cell carcinoma; larynx; oral cavity; free flap; exoscope; TORS
(This special issue belongs to the Section Methods and Technologies Development)
New Insights into Microbial-Based Cancer Therapy
edited by Amitabha Ray
submission deadline 31 Dec 2025 | 2 articles | Viewed by 2533 | Submission Open
Keywords: microbial therapy; cancer immunotherapy; bioengineering; immune modulation; tumor microenvironment
(This special issue belongs to the Section Cancer Therapy)
Radioimmunotherapy, Neoadjuvant Immunotherapy, and Adjuvant Immunotherapy for Cancer submission deadline 31 Dec 2025 | 1 articles | Viewed by 2321 | Submission Open
Keywords: immunotherapy; radioimmunotherapy; neoadjuvant immunothearpy; radiopharmaceuticals
(This special issue belongs to the Section Cancer Therapy)
Advances in the Molecular Biology of Sarcoma and Drug Development
edited by Francis Hornicek and
submission deadline 31 Dec 2025 | 1 articles | Viewed by 2152 | Submission Open
Keywords: sarcoma; sarcoma models; kinases; drug development; multidrug resistance; targeted therapy; immunotherapy
(This special issue belongs to the Section Molecular Cancer Biology)
Advances in the Management of Oropharyngeal Cancer: Navigating the HPV-Associated Landscape
edited by Jon Mallen-St Clair
submission deadline 31 Dec 2025 | 1 articles | Viewed by 2063 | Submission Open
Keywords: oropharyngeal cancer; human papillomavirus; clinical trials; transoral robotic surgery; epidemiology; HPV-related oropharyngeal cancer
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Lymphoma Biology, Pathology and Stem Cells
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1984 | Submission Open
Keywords: lymphoma biology; pathology; CAR-T; immunotherapy; stem cell transplant
(This special issue belongs to the Section Cancer Pathophysiology)
Surgical Innovations in Advanced Gastric Cancer
edited by Ugo Elmore, Francesco Puccetti and Andrea Cossu
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1913 | Submission Open
Keywords: gastric cancer; gastrectomy; oligometastatic cancer; recurrence; peritoneal carcinomatosis; multimodal management
(This special issue belongs to the Section Cancer Therapy)
Advances in Cell and Gene Therapy in Tumors: From Bench to Bedside
edited by Shuhang Wang
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1899 | Submission Open
Keywords: cell therapy; gene therapy; genetically engineered cells; cancer treatment; clinical trials; pre-clinical study
(This special issue belongs to the Section Cancer Therapy)
New Insights in the Management of Resectable Esophageal Malignancy
edited by and Dimitrios A. Theodorou
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1891 | Submission Open
Keywords: esophageal cancer; perioperative chemotherapy; radiotherapy; immunotherapy; radical surgical resection
(This special issue belongs to the Section Methods and Technologies Development)
Feature Papers in the Section “Cancer Therapy” in 2025
edited by , Qiang Wang and
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1849 | Submission Open
Keywords: chemotherapy; immunotherapy for cancer; oncology; systemic treatment and targeted therapy.
(This special issue belongs to the Section Cancer Therapy)
Recent Advances in Peritoneal Carcinomatosis
edited by Neda Dadgar and Patrick L. Wagner
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1816 | Submission Open
Keywords: peritoneal carcinomatosis; tumor microenvironment; immunotherapy biomarkers; microbiome– host interactions; epithelial– mesenchymal transition (emt); intra-cavitary therapies; cytokine signaling; translational oncology; multiomics profiling; organoid
(This special issue belongs to the Section Clinical Research of Cancer)
Molecular Pathology and Human Cancers
edited by Stefano Marletta, Alessandro Russo and Giuliana Pavone
submission deadline 31 Dec 2025 | 2 articles | Viewed by 1804 | Submission Open
Keywords: molecular pathology; cancer pathogenesis; targeted therapy; personalized medicine; cancer signaling
(This special issue belongs to the Section Cancer Pathophysiology)
Challenges and New Developments in the Diagnosis and Treatment of Sarcoma
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1790 | Submission Open
Keywords: bone and soft tissue sarcoma; prognostic and predictive biomarker; transcriptomic/genomic profiling; immunotherapy; targeted treatment
(This special issue belongs to the Section Cancer Therapy)
Advanced Ovarian Cancer (2nd Edition)
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 1786 | Submission Open
Keywords: advanced ovarian cancer; medical treatment; surgical treatment; hyperthermic intraperitoneal chemotherapy; intraperitoneal chemotherapy
(This special issue belongs to the Section Cancer Therapy)
New Diagnostic and Therapeutic Perspectives of Gynecological Carcinomas
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1653 | Submission Open
Keywords: gynecologic oncology; surgical gynecology; biomarkers; endometrial carcinoma; ovarian carcinoma; cervical carcinoma
(This special issue belongs to the Section Cancer Therapy)
Chromatin-Remodeling Factors in Cancer Cells
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1503 | Submission Open
Keywords: chromatin remodeling; transcription factors; epigenetic therapy; cancer epigenomics; SWI/SNF complex; CRISPR functional screens; single-cell epigenomics; gene regulation in cancer; therapy resistance; targeted cancer therapies
(This special issue belongs to the Section Cancer Pathophysiology)
Molecular and Genetic Biomarkers in Oral Squamous Cell Carcinoma
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 1499 | Submission Open
Keywords: oral cancer; oropharyngeal cancer; biomarkers; liquid biopsy; genetic determinants
(This special issue belongs to the Section Cancer Biomarkers)
Advances in Breast Cancer Imaging: From Detection to Personalized Diagnosis submission deadline 31 Dec 2025 | 1 articles | Viewed by 1485 | Submission Open
Keywords: breast cancer imaging; artificial intelligence; radiomics; deep learning; personalized diagnosis; multimodal imaging; predictive modeling; early detection; treatment response; clinical applications
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
At the Interface of Genetics, Epigenetics, and Metabolism in Cancer: 2nd Edition
edited by and
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1406 | Submission Open
Keywords: cancer metabolism; epigenetic reprogramming; histone modification; DNA methylation; chromatin structure; intermediary metabolites; microenvironment; mTOR complexes; glioblastoma
(This special issue belongs to the Section Cancer Pathophysiology)
Innovations in Microsurgical Techniques for Breast Cancer Reconstruction
edited by and Robert J. Allen
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1338 | Submission Open
Keywords: breast reconstruction; autologous breast reconstruction; DIEP flap; robotic DIEP flap; sensibility; alternative flaps; post-mastectomy pain; PAP flap; LAP flap; GAP flap; LTP flap; perforator flap; latissimus flap; fat grafting; nerve repair
(This special issue belongs to the Section Methods and Technologies Development)
Accelerated Partial Breast Irradiation
edited by Roxolyana Abdah-Bortnyak
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1320 | Submission Open
Keywords: radiotherapy; accelerated partial breast irradiation; breast cancer; intraoperative radiotherapy; external beam radiotherapy; brachytherapy
(This special issue belongs to the Section Cancer Therapy)
Cutaneous Metastases: State-of-the-Art Research and Management
edited by Marios N. Papadakis and
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1320 | Submission Open
Keywords: cutaneous metastases; cancer skin metastasis; metastatic skin lesions; diagnosis of cutaneous metastases; oncology; skin oncology; patient outcomes
(This special issue belongs to the Section Cancer Metastasis)
Breast Cancer Research and Treatment
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1204 | Submission Open
Keywords: breast cancer; tumor microenvironment; immune microenvironment; intratumoral heterogeneity; immunotherapy
(This special issue belongs to the Section Tumor Microenvironment)
Emerging Concepts in Mesothelioma
edited by Georgios T. Stathopoulos and Tonia Adamides
submission deadline 31 Dec 2025 | 1 articles | Viewed by 1106 | Submission Open
Keywords: mesothelioma; asbestos; pleura; tumor suppressor; cell lines; patient-derived xenograft; surgery; chemotherapy; folate antagonist; immunotherapy
(This special issue belongs to the Section Clinical Research of Cancer)
Osteosarcoma: Individualized Precision Treatment and Effective Drug Discovery
edited by
submission deadline 31 Dec 2025 | 1 articles | Viewed by 775 | Submission Open
Keywords: osteosarcoma; bone cancer; tumor microenvironment; targeted therapies; precision medicine; 3D tumor models; drug screening
(This special issue belongs to the Section Cancer Drug Development)
Facial Paralysis in Cancer Patients—from Diagnosis to Treatment and Facial Reanimation
edited by , Niels van Heerbeek, Giulia Molinari and Benedikt Hofauer
submission deadline 31 Dec 2025 | Viewed by 553 | Submission Open
Keywords: facial nerve; facial nerve reanimation; head and neck cancer; facial reconstructive surgery
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Advanced Research in Surgical Treatment for Spinal Tumors
edited by Alessandro Gasbarrini, Stefano Bandiera and
submission deadline 31 Dec 2025 | 1 articles | Viewed by 536 | Submission Open
Keywords: spine oncology; primary tumors; metastatic tumors; spondylectomy; en bloc resection; minimally invasive surgery; anterior reconstruction; biomaterials; radiosurgery; electrochemotherapy
(This special issue belongs to the Section Cancer Therapy)
Innovations in Soft Tissue Sarcoma Diagnosis and Treatment (2nd Edition)
edited by Erlinda M. Gordon, and Frederick L. Hall
submission deadline 31 Dec 2025 | Viewed by 423 | Submission Open
Keywords: soft tissue sarcoma; gene therapy; natural killer cell therapy; immune and cell cycle checkpoint inhibitors; targeted therapy
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Stereotactic Body Radiotherapy in Gynecologic Malignancies—a Practical Framework of SBRT, Chemoradiotherapy and Immunotherapy
edited by Antonio Pontoriero
submission deadline 31 Dec 2025 | Viewed by 371 | Submission Open
Keywords: SBRT; gynecologic cancer; chemoradiotherapy; immunotherapy; oligometastatic; oligoecurrent; oligopersistent; reirradiation
(This special issue belongs to the Section Cancer Therapy)
Views and Perspectives of Robot-Assisted Liver Surgery (2nd Edition)
edited by , Ibrahim Dagher and
submission deadline 31 Dec 2025 | Viewed by 350 | Submission Open
Keywords: robotic; liver surgery; liver resection; hepatectomy; minimally invasive; artificial intelligence
(This special issue belongs to the Section Cancer Therapy)
Advances in the Pathogenesis of Hematopoietic Neoplasms submission deadline 31 Dec 2025 | Viewed by 348 | Submission Open
Keywords: B cell lymphoma; T cell lymphoma; Hodgkin lymphoma; leukemia; myeloma; pathogenesis; genomics; microenvironment
(This special issue belongs to the Section Cancer Pathophysiology)
Surgical Aspects of Ovarian/Tubal/Peritoneal Cancer Management submission deadline 31 Dec 2025 | Viewed by 343 | Submission Open
Keywords: primary cytoreduction; interval cytoreduction; neoadjuvant chemotherapy
(This special issue belongs to the Section Cancer Therapy)
Research Challenges in Adolescent and Young Adult Cancer
edited by and Jeremy Lewin
submission deadline 31 Dec 2025 | Viewed by 313 | Submission Open
Keywords: adolescents and young adults; research enrollment and retention; clinical trials; access; barriers
(This special issue belongs to the Section Pediatric Oncology)
Optimizing Surgical Procedures and Enhancing Outcomes in the Management of Gastrointestinal Cancer
edited by Tim Strate and
submission deadline 31 Dec 2025 | Viewed by 263 | Submission Open
Keywords: gastrointestinal malignancies; surgical oncology; postoperative outcome; quality of life; anastomotic leakage; anastomotic technique; HIPEC; PIPAC
(This special issue belongs to the Section Cancer Therapy)
The Role of Anatomical Resections in Secondary Lung Cancer: Indications, Techniques, and Outcomes submission deadline 31 Dec 2025 | Viewed by 257 | Submission Open
Keywords: anatomical resections; segmentectomy; lobectomy; secondary lung cancer; pulmonary metastases; thoracic surgery; minimally invasive surgery; surgical outcomes; lung neoplasms; personalized treatment
(This special issue belongs to the Section Clinical Research of Cancer)
Artificial Intelligence (AI), Robotics, and Cancer Surgery
edited by Zaid M. Abdelsattar
submission deadline 31 Dec 2025 | Viewed by 241 | Submission Open
Keywords: cancer surgery; artificial intelligence; robotics surgery; surgical outcome; decision-making
(This special issue belongs to the Section Methods and Technologies Development)
Clinical and Biological Studies of Pediatric Adrenocortical Tumors, Pheochromocytomas and Paragangliomas submission deadline 31 Dec 2025 | Viewed by 234 | Submission Open
Keywords: adrenal gland; pheochromocytoma; paraganglioma; adrenocortical adenoma; adrenocortical carcinoma; pediatric; adrenal tumor
(This special issue belongs to the Section Pediatric Oncology)
Head and Neck Cancer Surgery and Rehabilitation: A Bridge Between Medicine and Dentistry for Reconstruction with Regeneration
edited by and Samuel Ebele Udeabor
submission deadline 31 Dec 2025 | Viewed by 224 | Submission Open
Keywords: oral squamous cell carcinoma; oral cancer; head and neck cancer; odontogenic tumors; OSCC management; tumor recurrence; tumor metastasis; adjuvant therapy; biomaterials for maxillofacial reconstruction; tissue regeneration; cancer rehabilitation
(This special issue belongs to the Section Cancer Therapy)
Oxidative Stress-Mediated Regulation of Specific Signaling Pathways in Skin Cancers submission deadline 31 Dec 2025 | Viewed by 222 | Submission Open
Keywords: reactive oxygen species; reactive nitrogen species; oxidative stress; epigenetic regulation; UV-exposure; skin pigmentation; skin cancer; melanoma
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
New Insights in Parotid Tumors
edited by Chiara Gaudino and Stefan Rohde
submission deadline 31 Dec 2025 | Viewed by 218 | Submission Open
Keywords: advanced imaging in parotid tumors; artificial intelligence tools; parotid gland surgery; facial nerve preservation and reconstruction; chemotherapy in parotid gland malignant tumors; radiotherapy and proton therapy in malignant parotid gland tumors
(This special issue belongs to the Section Cancer Therapy)
Cancers in Chronic HIV Infection
edited by Diego Ripamonti
submission deadline 31 Dec 2025 | Viewed by 206 | Submission Open
Keywords: cancer; HIV; AIDS; cancer screening; hematologic malignancy; Kaposi sarcoma; HPV; anal cancer; lymphoma
(This special issue belongs to the Section Infectious Agents and Cancer)
Neoadjuvant Chemotherapy in Pancreatic Cancer submission deadline 31 Dec 2025 | Viewed by 203 | Submission Open
Keywords: neoadjuvant chemotherapy; pancreatic cancer; treatment decision
(This special issue belongs to the Section Cancer Therapy)
New Insights into Pheochromocytoma and Paraganglioma
edited by
submission deadline 31 Dec 2025 | Viewed by 192 | Submission Open
Keywords: pheochromocytoma; paraganglioma; diagnosis; genetics; imaging; long-term follow-up; standards
(This special issue belongs to the Section Clinical Research of Cancer)
Faulty Ribosome Biogenesis and Cancer: Mechanisms and Therapeutic Perspectives
edited by
submission deadline 31 Dec 2025 | Viewed by 179 | Submission Open
Keywords: ribosome biogenesis; ribosomal proteins; nucleolar stress; genomic instability; oncoribosome; ribosomapathies; ribosome-targeting drugs; cancer biomarkers; animal models
(This special issue belongs to the Section Cancer Biomarkers)
Contemporary Trends and Advances in Minimally Invasive and Endoscopic Management of Genitourinary Malignancies submission deadline 31 Dec 2025 | Viewed by 174 | Submission Open
Keywords: robotic surgery; laparoscopic surgery; endourology; urologic oncology; prostate cancer; urothelial cancer; kidney cancer; testicular cancer; single-port surgery; image-guided surgery; surgical outcomes; oncologic outcomes; advanced surgical techniques; precision medicine
(This special issue belongs to the Section Cancer Therapy)
Advances in Genitourinary Cancer: Biomarkers, Immunotherapy and Novel Therapeutics
edited by Lingbin Meng
submission deadline 31 Dec 2025 | Viewed by 171 | Submission Open
Keywords: genitourinary cancer; biomarkers; immunotherapy; targeted therapy; chemotherapy; drug resistance; tumor microenvironment; liquid biopsy; ctDNA; precision oncology
(This special issue belongs to the Section Cancer Therapy)
Patients’ Perspective in Gynecological Cancer
edited by
submission deadline 31 Dec 2025 | Viewed by 155 | Submission Open
Keywords: patient perspective; expectations; PROMs; quality of life; best supportive care
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Hippo Signaling in Cancer (2nd Edition)
edited by and
submission deadline 31 Dec 2025 | Viewed by 146 | Submission Open
Keywords: Hippo signaling; Salvador– Warts– Hippo (SWH) pathway; YAP/TAZ; cancer development; progression; metastasis; therapeutic resistance
(This special issue belongs to the Section Tumor Microenvironment)
Advances in Minimally Invasive Surgery for Colorectal Cancer
edited by Jonathan S. Abelson and Christine A. Schad
submission deadline 31 Dec 2025 | Viewed by 140 | Submission Open
Keywords: colorectal cancer; minimally invasive surgery; endoscopic surgery; endoluminal surgery; laparoscopic surgery; ro-botic surgery; single incision laparoscopic surgery; postoperative outcomes; survival
(This special issue belongs to the Section Cancer Therapy)
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