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Risk Factors of Kidney Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Epidemiology and Prevention".

Deadline for manuscript submissions: 31 October 2026 | Viewed by 2354

Editors

Department of Cancer Prevention & Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY 14203, USA
Interests: cancer health disparities; kidney cancer; prostate cancer; cancer prevention
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Kidney Cancer Association, Houston, TX 77019, USA
Interests: children’s tumor; kidney cancer

Special Issue Information

Dear Colleagues,

Incidence of kidney cancer is rising worldwide, and some countries and subgroups of populations experience uneven burdens of kidney cancer with sharper increase in incidence rates compared to the others. Kidney cancer mortality rates have declined over the years with improvement of effective treatments, but not all populations have equally benefited from these advancements. Established risk factors of kidney cancer development include excess body weight and adiposity, hypertension, smoking, kidney disease, race and ethnicity, genetics, and environmental and occupational exposures, and being male. Risk factors, such as diabetes and physical inactivity, increase the risk of poorer survival. Social and structural drivers of health are underlying factors of high incidence and mortality that influence risk factors as well as access to healthcare. This access is critical for early detection in individuals with multiple risk factors, as the 5-year survival rate for localized disease is approximately 93%, compared to only 15% for advanced metastatic cancer. However, additional risk factors show conflicting evidence of association with incidence and mortality. The impact of risk factors for kidney cancer development on patient survival also warrants further investigation.

For this Special Issue, we welcome a wide range of studies, from prevention and early detection to population-based, clinical, and molecular studies, both original investigations and reviews, that investigate how risk factors, synergistically, interactively, and/or independently, increase kidney cancer incidence and mortality. Further understanding the risk factors will inform future studies that focus on preventing kidney cancer incidence and mortality.

Dr. Ken Batai
Dr. Salvatore La Rosa
Guest Editors

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • prevention
  • survivorship
  • renal cell carcinoma
  • kidney cancer epidemiology

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Published Papers (1 paper)

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Review

33 pages, 1168 KB  
Review
Kidney Cancer Trends, Risk Factors, and Interventions in American Indian and Alaska Native Populations: The Kidney Cancer Association Scientific Statement
by Salvatore La Rosa, Pavlos Msaouel, Andrew J. Sedgewick, Nathan Maulding, Alejandro Recio-Boiles, William O. Carson, Rodney C. Haring and Ken Batai
Cancers 2026, 18(9), 1454; https://doi.org/10.3390/cancers18091454 - 1 May 2026
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Abstract
American Indian and Alaska Native (AI/AN) populations experience disproportionately high kidney cancer incidence and mortality compared to other groups in the United States. Literature was reviewed to explore the factors contributing to the unequally higher kidney cancer burden in AI/AN communities and to [...] Read more.
American Indian and Alaska Native (AI/AN) populations experience disproportionately high kidney cancer incidence and mortality compared to other groups in the United States. Literature was reviewed to explore the factors contributing to the unequally higher kidney cancer burden in AI/AN communities and to develop recommendations to reduce these disparities. The incidence of kidney cancer has been rising over the past few decades, and this increase has been especially steep among AI/AN populations. Death rates in AI/AN populations are roughly twice those of the non-Hispanic White population. The elevated kidney cancer burden in AI/AN populations may be driven by both clinical and behavioral risk factors (obesity, diabetes, hypertension, chronic kidney disease, smoking, and environmental factors) and structural drivers of health, which can critically shape these disparities. Systemic inequalities limit AI/AN patients and community members’ access to chronic disease management, smoking cessation programs, primary and specialty care for early detection, and ultimately, treatment. AI/AN patients may have mistrust or other cultural barriers to engaging with the healthcare system and providers, while implicit bias in healthcare providers may lead to undertreatment. Therefore, key interventions and tailored programs aimed at reducing kidney cancer incidence and mortality are needed. Here we highlight some current interventions, including access to disease management and smoking cessation programs, facilitating healthcare access and quality, adopting patient navigation and culturally competent education, and developing strategies for early detection. In partnership with AI/AN communities, a combination of prevention, early detection, and healthcare system improvements is needed to close the kidney cancer gap. Full article
(This article belongs to the Special Issue Risk Factors of Kidney Cancer)
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