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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Epigenetic Alterations in Human Tumors

edited by Mihalis I. Panayiotidis and

Young Kyung Park

submission deadline 31 May 2026 | Viewed by 8 | Submission Open

Keywords: cancer; DNA methylation; post-translational histone modifications; miRNAs; genome reorganization; multi-omics; experimental/translational therapeutics

(This special issue belongs to the Section Molecular Cancer Biology)

Adjuvant Therapy and The Cytotoxic Effects in Colorectal Cancers

edited by William H. Gmeiner

submission deadline 31 May 2026 | Viewed by 7 | Submission Open

Keywords: colorectal cancer; adjuvant chemotherapy; targeted therapy; immunotherapy; metastatic colorectal cancer; drug resistance; combination therapy; cytotoxic effects

(This special issue belongs to the Section Cancer Therapy)

Machine Learning and Artificial Intelligence in Leukemia

edited by Garrett M. Dancik and

Spiros Vlahopoulos

submission deadline 31 May 2026 | Viewed by 5 | Submission Open

Keywords: cancer genomics; genomic sequencing; biomarkers; predictive modeling; machine learning; artificial intelligence; leukemia; computer vision; natural language processing

(This special issue belongs to the Section Methods and Technologies Development)

T-Cell Lymphoma: From Diagnosis to Treatment

edited by Lubomir Sokol and Yumeng Zhang

submission deadline 31 May 2026 | Viewed by 1 | Submission Open

Keywords: cutaneous T-cell lymphomas (CTCLs); peripheral T-cell lymphomas (PTCLs); Sezary syndrome (SS); mycosis fungoides (MF); genetic; epigenetic; therapeutic strategies

The Advance of Proton Therapy in Head-and-Neck Cancers

edited by

Nancy Lee

and Edward Christopher Dee

submission deadline 31 May 2026 | Submission Open

Keywords: proton therapy; head-and-neck cancer; clinical outcomes; toxicity reduction; multinational studies; reirradiation; skull base tumors; salivary gland cancers; prospective and retrospective cohorts

(This special issue belongs to the Section Cancer Therapy)

The Role of Medical Imaging in Gynecological Cancer

edited by Emma R. Allanson and Ming Yin Lin

submission deadline 1 Jun 2026 | 6 articles | Viewed by 14501 | Submission Open

Keywords: cervical cancer; endometrial cancer; ovarian cancer; staging; ultrasound; MRI; PET-CT; radiotherapy; image-guided brachytherapy

(This special issue belongs to the Section Methods and Technologies Development)

Drug Repurposing and Reformulation for Cancer Treatment: 2nd Edition

edited by

Arati Sharma

Dhimant Desai

and

Abhijit Date

submission deadline 1 Jun 2026 | 2 articles | Viewed by 12895 | Submission Open

Keywords: drug repurposing; cancer; drug resistance; metastasis; drug delivery; liposomes; nanoparticles; bioavailability; drug targeting; reformulation

(This special issue belongs to the Section Cancer Drug Development)

New Developments in Breast Cancer Surgery, Risk, and Related Quality of Life

edited by Vesna Bjelic-Radisic,

Maggie Banys-Paluchowski

and Constanze Elfgen

submission deadline 1 Jun 2026 | 3 articles | Viewed by 5249 | Submission Open

Keywords: oncoplastic breast surgery; breast reconstruction; quality of life

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Proton Therapy of Cancer Treatment

edited by Minglei Kang, Benjamin Durkee and Kuo Men

submission deadline 1 Jun 2026 | 3 articles | Viewed by 4170 | Submission Open

Keywords: proton therapy; FLASH radiotherapy; upright; pediatric cancer; head and neck cancer; affordable proton solutions; adaptive radiation therapy; treatment planning optimization; proton system commissioning

(This special issue belongs to the Section Cancer Therapy)

Looking for New Biochemical Mechanisms in Cancer: The New Dawn in the Omics Sciences

edited by

Alessia Maria Cossu

, Marco Bocchetti and

Michela Falco

submission deadline 1 Jun 2026 | 1 articles | Viewed by 2646 | Submission Open

Keywords: multi-omics; machine learning; sequencing; signal transduction; molecular mechanisms; circulating biomarker; cancer

(This special issue belongs to the Section Molecular Cancer Biology)

Novel Developments in Invasive Lobular Breast Cancer: Diagnosis, Prognosis and Therapy (2nd Edition)

edited by

Lubna Khaldi

and

Nektarios Koufopoulos

submission deadline 1 Jun 2026 | Viewed by 186 | Submission Open

Keywords: invasive lobular carcinoma; imaging; diagnosis; pathology; tumor microenvironment; treatment; metastasis

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Stereotactic Radiosurgery for Malignant Brain Tumors

edited by Stylianos Pikis, Jason P. Sheehan,

Yuki Shinya

and Georgios Mantziaris

submission deadline 1 Jun 2026 | Viewed by 138 | Submission Open

Keywords: radiosurgery; brain metastases; low-grade gliomas; high-grade gliomas; glioblastoma; malignant meningiomas

(This special issue belongs to the Section Clinical Research of Cancer)

Gastrointestinal Tumors: Prevention, Screening and Predictive Analytics

edited by Mohamed I. Elsaid,

Electra D. Paskett

and Vinod Rustgi

submission deadline 1 Jun 2026 | Viewed by 32 | Submission Open

Keywords: gastrointestinal and hepatobiliary cancers; prevention and screening; chemoprevention; risk stratification; biomarkers and liquid biopsy (ctDNA); imaging and radiomics; predictive analytics and machine learning; causal inference; population-based studies; implementation science and health equity

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Advances in the Immunotherapy of Metastatic Cancer

edited by

Gianluca Tomasello

submission deadline 5 Jun 2026 | Viewed by 82 | Submission Open

Keywords: metastatic cancer; immunotherapy; immune checkpoint inhibitors; CAR-T cells; tumor microenvironment; immune-related adverse events; biomarkers; combination therapy; resistance mechanisms

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

New Insights in Thymic Tumors

edited by Till Ploenes

submission deadline 5 Jun 2026 | Viewed by 22 | Submission Open

Keywords: thymic tumors; thymic carcinoma; thymomas; diagnostic; therapeutic approaches

Surgical Advances in the Treatment of Gliomas: Preserving Function and Quality of Life

edited by Francesco Vergani and José Pedro Lavrador

submission deadline 7 Jun 2026 | 3 articles | Viewed by 4530 | Submission Open

Keywords: neuro-oncology; brain mapping; neuroimaging; intraoperative neuro-monitoring; functional MRI; transcranial magnetic stimulation; neurorehabilitation

(This special issue belongs to the Section Cancer Therapy)

Histopathology of Urological Cancers

edited by Vikas Mehta, Antoun Toubaji and Vijayalakshmi Ananthanarayanan

submission deadline 10 Jun 2026 | 3 articles | Viewed by 7661 | Submission Open

Keywords: renal cell carcinoma; prostate; testis Ggrm cell tumors; urothelial carcinoma; artificial intelligence; ductal adenocarcinoma of prostate; neuroendocrine differentiation of prostate carcinoma; next-generation sequencing

(This special issue belongs to the Section Cancer Pathophysiology)

Extracellular Vesicles in Cancer Progression

edited by

Susana García-Silva

submission deadline 10 Jun 2026 | Viewed by 94 | Submission Open

Keywords: extracellular vesicles; cancer progression; tumor microenvironment; tumor– immune landscape; cross-talk pre-metastatic and metastatic niches immune surveillance; EV-based biomarkers; EV-based therapeutic development

(This special issue belongs to the Section Tumor Microenvironment)

Innovative Surgical Strategies for Thoracic Malignancies

edited by

Gregor J. Kocher

and

Fabrizio Minervini

submission deadline 10 Jun 2026 | Viewed by 56 | Submission Open

Keywords: robotic thoracic surgery; RATS; uRATS; NSCLC; thoracic malignancies; video-assisted thoracic surgery; VATS; uVATS

(This special issue belongs to the Section Methods and Technologies Development)

Systematic Reviews and Meta-Analyses in Cancer Research: The Therapeutic Potential of Phytochemicals and Bioactive Compounds with Defined Mechanisms and Safety Profiles

edited by

Lucas Fornari Laurindo

submission deadline 10 Jun 2026 | Viewed by 56 | Submission Open

Keywords: phytochemicals in cancer therapy; bioactive natural compounds; systematic reviews and meta-analyses; molecular mechanisms of anticancer agents; translational oncology; pharmacokinetics and toxicity of natural products; evidence-based integrative oncology; natural product drug discovery; chemoprevention and cancer therapeutics; mechanistic and safety profiling of phytochemicals

(This special issue belongs to the Section Systematic Review or Meta-Analysis in Cancer Research)

Nursing and Supportive Care for Cancer Survivors

edited by

Michela Piredda

submission deadline 12 Jun 2026 | 2 articles | Viewed by 2073 | Submission Open

Keywords: cancer survivorship; oncology nursing; symptom management; quality of life; supportive care; psycho-existential distress; pain catastrophizing; palliative care; caregiver support; advanced cancer; patient-centred care

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Brain Metastases: From Mechanisms to Treatment

edited by Dawen Zhao and Michael Chan

submission deadline 15 Jun 2026 | 7 articles | Viewed by 15440 | Submission Open

Keywords: brain metastasis; the tumor microenvironment; blood– tumor barrier; novel biomarkers and therapeutics; radiation therapy

(This special issue belongs to the Section Cancer Metastasis)

Recent Studies on Oral Cancer: Diagnostic Technologies, Pathology, and Surgery

edited by

Luisa Limongelli

Gianfranco F. Favia

and

Fabio Dell’Olio

submission deadline 15 Jun 2026 | 4 articles | Viewed by 6985 | Submission Open

Keywords: oral cancer; oral squamous cell carcinoma; oral potentially malignant disorders; diagnostic technologies; oral surgery; maxillo-facial surgery; oncology; radiology; immunohistochemistry; molecular biology

(This special issue belongs to the Section Clinical Research of Cancer)

Application of Large-Scale Genome Data in Identifying Clinically Actionable Targets in Cancer

edited by

Arezou A. Ghazani

submission deadline 15 Jun 2026 | 3 articles | Viewed by 4180 | Submission Open

Keywords: genome; cancers; oncology

(This special issue belongs to the Section Molecular Cancer Biology)

Current Updates and Future Directions in Neuroendocrine Neoplasms (NENs): Understanding Biology, Diagnosis, Management and Research Efforts in NENs (2nd Edition)

edited by

Jaydira del Rivero

and Aman Chauhan

submission deadline 15 Jun 2026 | 1 articles | Viewed by 2447 | Submission Open

Keywords: neuroendocrine neoplasms; NENs; neuroendocrine carcinomas; tumor biology; clinical management; therapeutic management

(This special issue belongs to the Section Cancer Therapy)

Metastatic Progression of Human Melanoma: 2nd Edition

edited by

Jozsef Timar

and

Andrea Ladányi

submission deadline 15 Jun 2026 | 2 articles | Viewed by 2343 | Submission Open

Keywords: human melanoma; metastasis models; oncogenic signaling; organ metastasis; genomics; immune microenvironment; prognosticators; predictors of target therapies

(This special issue belongs to the Section Cancer Pathophysiology)

Advances in Radiotherapy of Gastrointestinal Cancers

edited by

Sunil Krishnan

submission deadline 15 Jun 2026 | Viewed by 104 | Submission Open

Keywords: gastrointestinal cancer; radiotherapy; IMRT; SBRT; MR-guided; proton therapy; adaptive radiotherapy; treatment planning; radiomics; artificial intelligence; combination therapy; immunotherapy; toxicity management; quality of life; personalized medicine

(This special issue belongs to the Section Methods and Technologies Development)

Nanocarriers as an Emerging Platform for Cancer Therapy

edited by

Andrea Markus

and Fernanda Ramos-Gomes

submission deadline 15 Jun 2026 | Viewed by 97 | Submission Open

Keywords: nanoparticles; cancer therapy; nanomedicine; theranostics; chemotherapy; nanocarriers; drug delivery; nanotechnology

(This special issue belongs to the Section Cancer Therapy)

Surgical Strategies in the Era of Perioperative Immunotherapy for Thoracic Cancer

edited by Tomoyuki Hishida

submission deadline 15 Jun 2026 | Viewed by 70 | Submission Open

Keywords: lung cancer; perioperative treatment; immunotherapy; innmue checkpoint inhibitors; surgery

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Current Progress in Radiotherapy and Particle Therapy of Cancer

edited by

Carla Hajj

submission deadline 16 Jun 2026 | Viewed by 167 | Submission Open

Keywords: radiotherapy; particle therapy; proton therapy; heavy ion therapy; radiobiological; carbon ion therapy

(This special issue belongs to the Section Cancer Therapy)

Novel Insights into Cancer-Related Cognitive Impairment

edited by Danielle Tometich

submission deadline 20 Jun 2026 | 3 articles | Viewed by 6036 | Submission Open

Keywords: cognitive impairment; cognitive dysfunction; cancer survivorship; quality of life; neuropsychological assessment; cognitive rehabilitation

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

p53 Family in Cancer: How Close Are We to the Clinic? (2nd Edition)

edited by

Lucília Saraiva

and

Marco M. Candeias

submission deadline 20 Jun 2026 | 1 articles | Viewed by 605 | Submission Open

Keywords: p53; p63; p73; proteins; protein-coding and non-coding genes; genetics; drug discovery; cancer; targeted anticancer therapy

(This special issue belongs to the Section Cancer Therapy)

Advances in Squamous Cell Carcinoma: From Pathogenesis to Treatment

edited by Carolin Götz

submission deadline 20 Jun 2026 | Viewed by 129 | Submission Open

Keywords: squamous cell carcinoma (SCC); oncological surgery; carcinogenesis; tumor microenvironment; HPV; immunotherapy; molecular targets; precision oncology; biomarkers; head and neck cancer; translational oncology

(This special issue belongs to the Section Cancer Pathophysiology)

Genetic Predisposition to Hematological Malignancies

edited by

Danika Di Giacomo

submission deadline 20 Jun 2026 | Viewed by 55 | Submission Open

Keywords: leukemia predisposition; germline variants; inherited syndromes; myelodysplastic syndrome (MDS); acute myeloid leukemia (AML); precision medicine

(This special issue belongs to the Section Molecular Cancer Biology)

The Next Cutting-Edge Technologies in Abdominal Solid Tumor Treatment

edited by Jerome Canady, Saravana R.K. Murthy, Aviram Nissan and

Michael Keidar

submission deadline 20 Jun 2026 | Viewed by 40 | Submission Open

Keywords: multi-visceral surgical resection for complex advanced gastrointestinal tumors; cytoreductive surgery; colon and gynecological cancers; pancreatic cancer; cold atmospheric plasma (CAP); robotic AI CAP surgical delivery systems; targeted immunotherapies; irreversible electroporation; HIPEC (hyperthermic intraperitoneal chemotherapy); PIPAC (pressurized intraperitoneal aerosol chemotherapy)

(This special issue belongs to the Section Methods and Technologies Development)

Decoding and Remodeling the Suppressive Tumor Immune Microenvironment in Head and Neck Cancer

edited by Andrew G. Sikora and Jennifer L. Anderson

submission deadline 20 Jun 2026 | Viewed by 7 | Submission Open

Keywords: tumor immune microenvironment (TIME); cancer-mediated immunosuppression; myeloid cells; regulatory T cells; cytokines; anti-tumor immunity; immune modulation

(This special issue belongs to the Section Tumor Microenvironment)

Angiogenesis and Anti-Angiogenic Therapies in Cancer

edited by

Girolamo Ranieri

and Giovanni Mastrandrea

submission deadline 24 Jun 2026 | Viewed by 107 | Submission Open

Keywords: angiogenesis; anti-angiogenic therapies; cancer; tumor vasculature; therapeutic strategies

(This special issue belongs to the Section Tumor Microenvironment)

Advances in Soft Tissue and Bone Sarcoma (2nd Edition)

edited by

Catrin Sian Rutland

submission deadline 25 Jun 2026 | 3 articles | Viewed by 2570 | Submission Open

Keywords: bone sarcoma; soft tissue sarcoma; prognosis; diagnosis; detection; molecular biomarkers; histopathology; treatment

(This special issue belongs to the Section Cancer Therapy)

Digital Pathology in Precision Oncology: Emerging Tools for Diagnosis and Treatment Guidance

edited by Daniela Hartmann and

Maximilian Deussing

submission deadline 25 Jun 2026 | Viewed by 170 | Submission Open

Keywords: dermatology ; digital pathology ; ex vivo confocal microscopy ; artificial intelligence ; machine learning ; virtual biopsy ; teledermatology ; histopathological images; image analysis algorithms

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Clinical and Translational Research in Head and Neck Cancer—2nd Edition

edited by Young J. Kim

submission deadline 25 Jun 2026 | Viewed by 80 | Submission Open

Keywords: head and neck cancer; immunotherapy; translation; combinatorial clinical trials; oncologic therapeutics

(This special issue belongs to the Section Clinical Research of Cancer)

Surgery for Thoracic Cancer

edited by Andrea Billé and Louisa Patel

submission deadline 25 Jun 2026 | Viewed by 60 | Submission Open

Keywords: thoracic surgery; lung cancer; mesothelioma; thymic malignancies; minimally invasive surgery; robotic-assisted thoracic surgery; multimodal therapy; immunotherapy; perioperative management; surgical outcomes

(This special issue belongs to the Section Cancer Therapy)

Immune Deficiency-Associated Lymphoma

edited by

Régis Thierry Costello

submission deadline 25 Jun 2026 | Viewed by 21 | Submission Open

Keywords: lymphoma; immune; HIV infection

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

New Strategies for Molecular Targeted Therapy in Multiple Myeloma

edited by Daniele Caracciolo

submission deadline 26 Jun 2026 | 1 articles | Viewed by 724 | Submission Open

Keywords: multiple myeloma; molecular target; drug target; signaling pathway; immunotherapeutic strategy; drug resistance

(This special issue belongs to the Section Cancer Therapy)

Clinical Epidemiology and Risk Prediction for Gastrointestinal Cancers

edited by

Holli Loomans-Kropp

submission deadline 30 Jun 2026 | 11 articles | Viewed by 34548 | Submission Open

Keywords: gastrointestinal cancers; genetic risk; polygenic risk scores; exposome; lifestyle risk factors; biomarkers; chemoprevention

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

New Challenges for Gastric Cancer—Gut Microbiota, Post-eradication and Chemotherapy

edited by Kazunari Murakami and

Kazuhiro Mizukami

submission deadline 30 Jun 2026 | 7 articles | Viewed by 22644 | Submission Open

Keywords: gastric cancer; microbiota; Helicobacter pylori; after Helicobacter pylori eradication therapy; chemotherapy; immune checkpoint inhibitor

(This special issue belongs to the Section Cancer Therapy)

Hematologic Malignancies and Related Disorders: Challenges from Diagnosis to Treatment

edited by

Ioanna Sakellari

and

Eleni Gavriilaki

submission deadline 30 Jun 2026 | 9 articles | Viewed by 22630 | Submission Open

Keywords: hematopoietic cell transplantation; cell therapy; acute myeloid leukemia; graft-versus-host disease; hematologic malignancies; thrombosis; complement; lymphoma; myeloma; COVID-19

(This special issue belongs to the Section Cancer Therapy)

Advances in the Prevention and Treatment of Liver Cancer

edited by Ewa Janczewska

submission deadline 30 Jun 2026 | 8 articles | Viewed by 22252 | Submission Open

Keywords: new screening techniques; enhanced imaging; biomarker tests; radiofrequency ablation; transarterial chemoembolization

(This special issue belongs to the Section Cancer Therapy)

Advances in Bacteria and Cancer

edited by

Alain P. Gobert

submission deadline 30 Jun 2026 | 4 articles | Viewed by 17541 | Submission Open

Keywords: pathogenic bacteria; microbiota; tumor-associated bacteria; probiotics; oncogenesis; metastasis; chemotherapy; cancerous cells; tumor microenvironment; cell signaling

(This special issue belongs to the Section Tumor Microenvironment)

New Insights into Thyroid Cancer Surgery

edited by

Maurizio Iacobone

and Francesca Torresan

submission deadline 30 Jun 2026 | 6 articles | Viewed by 13420 | Submission Open

Keywords: total thyroidectomy; differentiated thyroid cancer; lymph node dissection; parathyroid autofluorescence; medullary thyroid carcinoma; recurrent laryngeal nerve neuromonitoring

(This special issue belongs to the Section Cancer Therapy)

Gynecologic Oncology: Clinical and Translational Research

edited by

Gennaro Daniele

, Pasquale Lombardi and Gaia Giannone

submission deadline 30 Jun 2026 | 7 articles | Viewed by 13355 | Submission Open

Keywords: gynecological cancer; ovarian cancer; translational research; effectiveness; toxicity; immunotherapy; PARP inhibitors

(This special issue belongs to the Section Cancer Therapy)

Displaying special issue 751-800 on page 16 of 24.

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