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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Combination Therapy for Lymphoma submission deadline 30 Sep 2026 | Viewed by 352 | Submission Open
Keywords: lymphoma; combination therapies; T-cell engagers; immuno-conjugates; targeted drugs
(This special issue belongs to the Section Cancer Therapy)
Advances in Clinical Trials and Precision Medicine for Neuro-Oncology
edited by Malaka Ameratunga
submission deadline 30 Sep 2026 | Viewed by 350 | Submission Open
Keywords: clinical trials; neuro-oncology; precision oncology; molecular targets; precision medicine
(This special issue belongs to the Section Clinical Research in Cancer)
New Approaches in the Treatment of Hepatocellular Carcinoma and Liver Tumor: 2nd Edition
edited by Riccardo Inchingolo, Stavros Spiliopoulos and Riccardo Memeo
submission deadline 30 Sep 2026 | Viewed by 324 | Submission Open
Keywords: hepatocellular carcinoma; cirrhosis; liver; interventional oncology; trans-arterial chemo embolization; selective internal radiation therapy; ablation; radiology
(This special issue belongs to the Section Cancer Therapy)
Roles of Circular RNAs (circRNAs) in Cancer Development and Progression
edited by
submission deadline 30 Sep 2026 | Viewed by 324 | Submission Open
Keywords: circular RNAs (circRNAs); cancer development; tumor progression; oncogenesis; gene regulation; metastasis; tumor microenvironment; therapeutic targets; biomarkers; molecular pathways
(This special issue belongs to the Section Molecular Cancer Biology)
Metabolomics Approaches in Cancer Diagnosis
edited by
submission deadline 30 Sep 2026 | Viewed by 314 | Submission Open
Keywords: metabolomics; metabolites; NMR metabolomics; mass spectrometry in metabolomics; cancer biomarkers; metabolomics methods
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Advanced Multimodal Neuroimaging and Computational Approaches in Brain Tumor Research
edited by
submission deadline 30 Sep 2026 | Viewed by 297 | Submission Open
Keywords: brain tumors; multimodal neuroimaging; artificial intelligence; radiomics; imaging genomics; diffusion MRI; functional MRI; precision oncology
Pancreatic Cancer Ultrasound: A Problem-Based Approach
edited by and Andrea Boccatonda
submission deadline 30 Sep 2026 | Viewed by 287 | Submission Open
Keywords: cancer; ultrasound; pancreas; CEUS; malignancy
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Tumor Microenvironment in Hematological Malignancies: Advances in Targeted Therapies and Cellular Mechanisms
edited by Carolina Simioni
submission deadline 30 Sep 2026 | Viewed by 273 | Submission Open
Keywords: hematological malignancies; tumor microenvironment; bone marrow niche; targeted therapy; signal transduction; drug resistance; tumor metabolism; cell plasticity; biomarkers; cell–cell interactions
(This special issue belongs to the Section Tumor Microenvironment)
Advances in Clinical Pharmacology in Lung Cancer—2nd Edition
edited by
submission deadline 30 Sep 2026 | Viewed by 273 | Submission Open
Keywords: lung cancer; target therapy; immunotherapy; antiangiogenic agent; chemotherapy; NGS
(This special issue belongs to the Section Cancer Drug Development)
Conventional and AI-Enabled Precision Medicine/Surgery in Oncology
edited by and Dimitris Bertsimas
submission deadline 30 Sep 2026 | Viewed by 270 | Submission Open
Keywords: precision medicine; precision surgery; surgical oncology; treatment effect heterogeneity; subgroup discovery; causal inference; real-world evidence; confounding; interpretable AI; clinical decision support
(This special issue belongs to the Section Cancer Informatics and Big Data)
Minimally Invasive Surgery for Gastric Cancer
edited by Steve Kwon
submission deadline 30 Sep 2026 | Viewed by 260 | Submission Open
Keywords: comparison of laparoscopic vs. robotic approaches in long-term oncological and perioperative outcomes; minimally invasive surgery vs. endoscopic resections in treatment of early gastric cancer; minimally invasive surgery vs. open approaches for advanced gastric cancer, including peritoneal carcinomatosis; the role of minimally invasive surgery in D2 lymphadenectomy; minimally invasive emergent gastrectomy for gastric cancer; minimally invasive surgery (or nonoperative management) for gastric cancer in the era of immunotherapy; learning curve of robotic gastrectomy and D2 lymphadenectomy; technical and review papers, e.g., anastomotic techniques and reconstruction methods; minimally invasive total gastrectomy; three-dimensional (3D) imaging in minimally invasive gastric cancer surgery
(This special issue belongs to the Section Methods and Technologies Development)
Advances in Diagnosis and Clinical Trials of Bladder Cancer
edited by Mutsuo Furihata
submission deadline 30 Sep 2026 | Viewed by 251 | Submission Open
Keywords: bladder cancer; pathological diagnosis; tumorigenesis; 5-aminolevulinic acid; photodynamic therapies; robot-assisted radical cystectomy; fluorescence navigation; artificial intelligence
Novel Strategies for Treating Castration-Resistant Prostate Cancer submission deadline 30 Sep 2026 | Viewed by 245 | Submission Open
Keywords: androgen receptor; CRPC; drug resistance; combination therapy; small molecules; chemoprevention
(This special issue belongs to the Section Cancer Therapy)
Therapy of Nasopharyngeal Carcinoma: Emphasizing Radiotherapy
edited by Yunfei Xia
submission deadline 30 Sep 2026 | Viewed by 233 | Submission Open
Keywords: nasopharyngeal carcinoma (NPC); radiotherapy; IMRT; adaptive radiotherapy; dose optimization; re-irradiation; radioresistance; radiomics; biomarkers; toxicity mitigation
(This special issue belongs to the Section Cancer Therapy)
Novel Insights into Platelet Cancer Crosstalk
edited by
submission deadline 30 Sep 2026 | Viewed by 221 | Submission Open
Keywords: platelet–tumor interactions; cancer-associated thrombosis; metastasis; tumor microenvironment; platelets; platelet activation; thromboinflammation; hemostasis
The Central Role of CD8+ T Cells in Cancer Immunotherapy: From Functional Remodeling to Clinical Translation
edited by
submission deadline 30 Sep 2026 | Viewed by 218 | Submission Open
Keywords: CD8+T cells; T cell exhaustiont; metabolic reprogramming; epigenetic regulation; tumor microenvironmen; immune checkpoint blockade
Advancements in Surgical and Multidisciplinary Management of Hepatopancreaticobiliary Cancer
edited by Hideki Takami
submission deadline 30 Sep 2026 | Viewed by 216 | Submission Open
Keywords: hepatopancreaticobiliary cancer; pancreatic cancer; biliary tract cancer; hepatocellular carcinoma; multidisciplinary treatment; systemic therapy; neoadjuvant therapy; conversion surgery; precision medicine
Biomarkers and Targeted Therapy in Malignant Pleural Mesothelioma: 2nd Edition
edited by
submission deadline 30 Sep 2026 | Viewed by 211 | Submission Open
Keywords: malignant mesothelioma; target therapy; biomarkers
Rare Tumors in Children: Trends in Diagnosis, Treatment and Prevention (2nd Edition) submission deadline 1 Oct 2026 | 5 articles | Viewed by 14176 | Submission Open
Keywords: pediatric oncology; pediatric drugs; clinical pharmacology
(This special issue belongs to the Section Pediatric Oncology)
Cervical Cancer Screening: Current Practices and Future Perspectives
edited by Kimon Chatzistamatiou
submission deadline 1 Oct 2026 | 5 articles | Viewed by 6278 | Submission Open
Keywords: cervical cancer screening; cervical carcinogenesis; human papillomavirus; HPV primary screening; self-sampling; triage of HPV-positive; post-conization follow-up; screening for immunocompromised women; screening for vac-cinated women
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
The Role of Surgery in Lung Cancer Treatment
edited by
submission deadline 1 Oct 2026 | 1 articles | Viewed by 1032 | Submission Open
Keywords: lung cancer surgery; thoracic surgery; minimally invasive surgery; robotic surgery; multimodality therapy; perioperative management; surgical outcomes; thoracic oncology
(This special issue belongs to the Section Clinical Research in Cancer)
Cancer Immunotherapy as Part of Precision Clinical Medicine
edited by and
submission deadline 10 Oct 2026 | 4 articles | Viewed by 9335 | Submission Open
Keywords: cancer; immunotherapy; tumor microenvironment; molecular biology and genetics
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Head and Neck Cancer Recurrence: Diagnosis, Treatment and Prognosis (2nd Edition)
edited by
submission deadline 10 Oct 2026 | 2 articles | Viewed by 5707 | Submission Open
Keywords: head and neck cancer; recurrence; squamous cell carcinoma; HPV; larynx; oral cavity; oropharynx
(This special issue belongs to the Section Cancer Therapy)
Advances in Diagnostics and Treatments for Glioblastoma
edited by Sied Kebir and
submission deadline 10 Oct 2026 | 2 articles | Viewed by 4065 | Submission Open
Keywords: glioblastoma; molecular diagnostics; neuro-oncology; imaging biomarkers; immunotherapy; targeted therapy; tumor-treating fields; radiotherapy; chemotherapy; translational research; machine learning; positron emission tomography
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Mitochondrial Metabolism in Cancer Immune Responses
edited by and Kiwon Lee
submission deadline 10 Oct 2026 | 2 articles | Viewed by 2647 | Submission Open
Keywords: mitochondria; cancer metabolism; immune response; tumor microenvironment (TME); immunometabolism; mitochondrial reprogramming; reactive oxygen species (ROS); cancer immunotherapy
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Multidisciplinary Advances and Surgical Impact in Brain and Central Nervous System Tumors: From Molecular Insights to Clinical Outcomes
edited by Paolo Tini, Salvatore Chibbaro and
submission deadline 10 Oct 2026 | 1 articles | Viewed by 1999 | Submission Open
Keywords: glioblastoma; low-grade gliomas; ependymomas; PNET; meningiomas; medulloblastomas; other brain tumors
Pioneering Advances in Neurosurgical Oncology: From Innovative Techniques to Better Patient Outcomes submission deadline 10 Oct 2026 | Viewed by 720 | Submission Open
Keywords: endoscope; 3D exoscope; tractography MRI; molecular biomarkers; stem cells; transoral; cordomas; skullbase
(This special issue belongs to the Section Methods and Technologies Development)
The Bone Marrow Microenvironment in Myelodysplastic Syndromes—Pathogenesis, Immune Evasion, and Therapeutic Opportunities submission deadline 15 Oct 2026 | 2 articles | Viewed by 7965 | Submission Open
Keywords: myelodysplastic syndromes; bone marrow microenvironment; hematopoietic stem cells; mesenchymal stromal cells; immune evasion; CD47; calreticulin; inflammatory cytokines; clonal hematopoiesis; microenvironment-targeted therapy
(This special issue belongs to the Section Tumor Microenvironment)
Advanced Insights into the Etiology of Lymphoma
edited by Susan L. Slager and James R. Cerhan
submission deadline 15 Oct 2026 | 4 articles | Viewed by 4883 | Submission Open
Keywords: lymphoma etiology; genetic predisposition; clonal hematopoiesis; precursor conditions; risk stratification; viral oncogenesis; non-Hodgkin lymphoma; Hodgkin lymphoma
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Brain Tumors—Related Cognitive Impairment submission deadline 15 Oct 2026 | 2 articles | Viewed by 2060 | Submission Open
Keywords: aphasia; cognition; brain tumor; surgery; adjuvant treatment; rehabilitation
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Outcomes in Glioblastoma Patients: From Diagnosis to Palliation: 2nd Edition
edited by and Giorgio Mantovani
submission deadline 15 Oct 2026 | 2 articles | Viewed by 1898 | Submission Open
Keywords: high-grade glioma; outcome assessment; prognostic factors; neuro-oncology; glioblastoma
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
New Strategies for the Treatment of Melanoma in Neoadjuvant and Adjuvant Settings
edited by Michele Del Vecchio
submission deadline 15 Oct 2026 | 2 articles | Viewed by 1220 | Submission Open
Keywords: melanoma; adjuvant therapy; neoadjuvant therapy; treatment
(This special issue belongs to the Section Cancer Therapy)
Cancer Rehabilitation and Physical Activity: Advancing Function, Recovery, and Quality of Life Across the Cancer Continuum
edited by Jennifer Michelle Jones
submission deadline 15 Oct 2026 | 1 articles | Viewed by 996 | Submission Open
Keywords: cancer rehabilitation; exercise science; physical activity; prehabilitation; adverse side effects
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
World Lung Cancer Awareness Month: 2nd Edition
edited by
submission deadline 15 Oct 2026 | 1 articles | Viewed by 800 | Submission Open
Keywords: lung cancer; tumor microenvironment; early detection; therapeutic targets; new therapeutic strategies; surgery; genetics
(This special issue belongs to the Section Cancer Therapy)
Genetic and Molecular Characterization of Lung Cancer
edited by Sk Kayum Alam
submission deadline 15 Oct 2026 | 1 articles | Viewed by 793 | Submission Open
Keywords: lung cancer; molecular subtypes of lung cancer; genetic alterations; next-generation sequencing; biomarker; oncogenic driver mutations; therapeutic landscapes; treatment resistance; metastasis
(This special issue belongs to the Section Molecular Cancer Biology)
Molecular Pathology-Driven Approaches to Improve Cancer Diagnostic Accuracy
edited by Ovidiu Laurean Pop
submission deadline 15 Oct 2026 | 1 articles | Viewed by 659 | Submission Open
Keywords: molecular pathology; cancer diagnostics; precision oncology; genomic profiling; digital pathology; artificial intelligence; predictive biomarkers; prognostic biomarkers; translational oncology
(This special issue belongs to the Section Cancer Pathophysiology)
RAS Pathways in Cancer Cells
edited by Geoffrey J. Clark
submission deadline 15 Oct 2026 | Viewed by 367 | Submission Open
Keywords: RAS; inhibitor; signaling; cancer
(This special issue belongs to the Section Molecular Cancer Biology)
Evolving Paradigms in Minimally Invasive and Ablative Endocrine Thyroid Surgery
edited by Gianlorenzo Dionigi and
submission deadline 15 Oct 2026 | Viewed by 351 | Submission Open
Keywords: minimally invasive thyroid surgery; transoral endoscopic thyroidectomy; TOETVA; MIVAT; percutaneous thermal ablation; radiofrequency ablation; microwave ablation; active surveillance; papillary thyroid microcarcinoma; benign thyroid nodules; complication prevention; intraoperative nerve monitoring; health economics in surgery; multidisciplinary approach; surgical innovation; temporal trends in surgery; molecular profiling thyroid; surgical outcomes
(This special issue belongs to the Section Clinical Research in Cancer)
Navigating Therapeutic Resistance in Lung Cancer
edited by
submission deadline 15 Oct 2026 | Viewed by 242 | Submission Open
Keywords: non-small cell lung cancer; small cell lung cancer; chemotherapy; targeted therapy; immune therapy; immune checkpoint inhibitors; drug persister cells; resistance; drug tolerance
(This special issue belongs to the Section Cancer Therapy)
A Renewed Understanding of Tumor Growth Modulation by Tumor Necrosis Factor (TNF)-Associated Pathways
edited by Chandra Shekhar Boosani
submission deadline 15 Oct 2026 | Viewed by 198 | Submission Open
Keywords: tumor; inflammation; epigenetics; immune system; inhibitors
(This special issue belongs to the Section Molecular Cancer Biology)
Neuroradiology of Brain Tumors: Radiomics Features and Imaging Technologies
edited by Harpreet Hyare
submission deadline 15 Oct 2026 | Viewed by 185 | Submission Open
Keywords: MRI; radiomics; PET; sodium; perfusion; diffusion; glioma; pediatrics; machine learning
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
The Role of Digital Platforms in Transforming Cancer Surgery and Patient Care
edited by Sang-ho Jeong and
submission deadline 16 Oct 2026 | 1 articles | Viewed by 1039 | Submission Open
Keywords: digital health platforms; surgical oncology; minimally invasive surgery; patient care management
Diagnosis and Therapy in Urothelial Cancer
edited by
submission deadline 20 Oct 2026 | 4 articles | Viewed by 4532 | Submission Open
Keywords: urothelial cancer; bladder cancer; biomarkers; robotic surgery; immunotherapy; upper tract urothelial carcinoma
(This special issue belongs to the Section Cancer Therapy)
Thyroid Cancer Recurrence: Integrating Surgical, Clinical, and Translational Research
edited by and Ioannis Koutelidakis
submission deadline 20 Oct 2026 | 2 articles | Viewed by 2970 | Submission Open
Keywords: thyroid cancer; recurrence; surgery; clinical management; aggressive subtypes; rare subtypes; biomarkers; imaging; translational research; targeted therapy
(This special issue belongs to the Section Clinical Research in Cancer)
Advancing Precision Oncology: From Biomarker Discovery to Clinical Validation
edited by and
submission deadline 20 Oct 2026 | 1 articles | Viewed by 648 | Submission Open
Keywords: precision medicine; biomarkers; clinical translation; medical oncology; liquid biopsy
(This special issue belongs to the Section Cancer Biomarkers)
The Future of Precision Radiotherapy for Cancer: Technology, Optimization, and Clinical Integration
edited by Thomas J. Fitzgerald
submission deadline 20 Oct 2026 | Viewed by 403 | Submission Open
Keywords: radiation; proton; photon; brachytherapy
(This special issue belongs to the Section Methods and Technologies Development)
The Robotic Revolution in Endometrial Cancer: Advancing Surgical Staging and Patient Care
edited by Roberto Berretta
submission deadline 20 Oct 2026 | Viewed by 377 | Submission Open
Keywords: endometrial cancer; robotic surgery; minimally invasive surgery; gynecologic oncology; surgical innovation; obesity; surgical staging; uterine cancer; lymphadenectomy; sentinel node mapping
(This special issue belongs to the Section Cancer Therapy)
Locally Advanced and Recurrent Pelvic Malignancy
edited by Paul Anthony Sutton
submission deadline 20 Oct 2026 | 1 articles | Viewed by 157 | Submission Open
Keywords: pelvic malignancy; locally advanced; recurrent; treament; translational research
Discovery of Novel Therapeutic Targets in Multiple Myeloma
edited by
submission deadline 23 Oct 2026 | Viewed by 254 | Submission Open
Keywords: multiple myeloma; therapeutic target; immunotherapy; drug resistance
Radiation Therapy for Brain Tumors
edited by
submission deadline 25 Oct 2026 | 4 articles | Viewed by 16010 | Submission Open
Keywords: radiosurgery; hypofractionated radiosurgery; spectroscopic MRI; proton radiation; image-guided radiotherapy; radiotherapy for benign tumors; radiotherapy for gliomas; gamma knife
(This special issue belongs to the Section Cancer Therapy)
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