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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Diagnosis and Therapeutic Management of Gastrointestinal Cancers: 2nd Edition

edited by

Christian Sebesta

and

Harald Rosen

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3880 | Submission Open

Keywords: esophagus tumor; stomach tumor; liver tumor; colon tumor; rectum tumor; pancreato-biliary tumor; targeted immune and/or chemotherapy; surgical technology; multimodal approach; diagnosis; therapeutic management

(This special issue belongs to the Section Cancer Therapy)

Histopathology and Pathogenesis of Skin Cancer

edited by

Carlos Torres-Cabala

and

Alessio Giubellino

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3243 | Submission Open

Keywords: skin; tumor; cancer; histopathology; pathogenesis; molecular; immunohistochemistry; pathway; pathology

(This special issue belongs to the Section Cancer Pathophysiology)

Insights into the Pathogenesis of Cutaneous T-Cell Lymphoma and the Impact of These Potential Biomarkers on Future Diagnosis, Prognosis and Treatment

edited by Sean Whittaker

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2576 | Submission Open

Keywords: primary cutaneous T-cell lymphomas; CTCL; pathogenesis; biomarkers; diagnosis; prognosis; treatment

(This special issue belongs to the Section Cancer Biomarkers)

A Deeper Dive into Signaling Pathways in Cancers (2nd Edition)

edited by

Mari Masuda

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1623 | Submission Open

Keywords: signaling pathways; cancer; drug resistance; tumor microenvironment; molecularly targeted drug; epigenetic regulation; reverse-phase protein array

(This special issue belongs to the Section Tumor Microenvironment)

The Impact of Minimally Invasive Surgery on Gynecologic Cancers

edited by

Gabriel Levin

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1069 | Submission Open

Keywords: minimally invasive surgery; robotic-assisted surgery; gynecologic malignancy; laparoscopy

(This special issue belongs to the Section Cancer Therapy)

IBD-Associated Cancer

edited by Takayuki Ogino

submission deadline 20 Dec 2025 | Viewed by 291 | Submission Open

Keywords: IBD-associated cancer; Crohn’ s disease; ulcerative colitis; colorectal cancer; small bowel cancer; chemotherapy; radiotherapy

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Translational Cancer Research in Multiple Myeloma, with a Focus on Immune Therapies and Novel Agents – “The Bench Behind the Bedside”

edited by Paul G. Richardson,

Constantine S. Mitsiades

and Shonali Midha

submission deadline 20 Dec 2025 | Viewed by 163 | Submission Open

Keywords: multiple myeloma; immune microenvironment; signaling pathways; therapeutic targets; immune effector cell therapies; monoclonal antibodies; targeted agents; mechanisms of action; resistance mechanisms; treatment

(This special issue belongs to the Section Cancer Therapy)

Metastasis Associated Long Noncoding RNAs in Cancer Research

edited by

Kouhei Sakurai

submission deadline 21 Dec 2025 | Viewed by 332 | Submission Open

Keywords: lncRNA; metastasis; invasion; gene regulation; gene expression signature

(This special issue belongs to the Section Cancer Metastasis)

Tumor Immune Microenvironment in Gastric Cancers

edited by

Chandrani Sarkar

and

Debanjan Chakroborty

submission deadline 25 Dec 2025 | 4 articles | Viewed by 17100 | Submission Open

Keywords: tumor immune microenvironment; gastric cancer; therapeutic strategies; therapeutic response; tumor-associated macrophages

(This special issue belongs to the Section Tumor Microenvironment)

Study on Epidemiology of Childhood Cancer

edited by

Francesco Giusti

and

Carmen Martos

submission deadline 25 Dec 2025 | 5 articles | Viewed by 12901 | Submission Open

Keywords: childhood cancer; epidemiology; childhood cancer registries; incidence; prevalence; mortality; survival; time trends; special analysis; environmental factors; perinatal factors; inequalities

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Advances in Ovarian Cancer Research and Treatment: 2nd Edition

edited by

Maria Barbolina

submission deadline 25 Dec 2025 | 3 articles | Viewed by 6180 | Submission Open

Keywords: ovarian carcinoma metastasis; mechanisms of dissemination; chemotherapy resistance; novel treatments and therapeutic approaches; novel molecular targets

(This special issue belongs to the Section Cancer Therapy)

Advancements in the Diagnosis and Surgical Treatment of Prostate Cancer

edited by

Christian Peter Gilfrich

and Christian Thomas

submission deadline 25 Dec 2025 | 3 articles | Viewed by 5304 | Submission Open

Keywords: robotic-assisted radical prostatectomy; significance of pelvic lymph node dissection in the context of radical prostatectomy; complications of surgical therapy for prostate cancer; magnetic resonance imaging/ultrasound-guided target biopsy of the prostate; comparison of various robotic systems for radical prostatectomy; learning curves; hospital volume; prostate cancer centers

(This special issue belongs to the Section Clinical Research of Cancer)

Epigenetics in Endocrine-Related Cancer

edited by Jennie N Jeyapalan

submission deadline 25 Dec 2025 | 2 articles | Viewed by 3324 | Submission Open

Keywords: breast; ovarian; CRPC (castration-resistant prostate cancer); thyroid; histone modification; DNA methylation; epigenomics; chromatin; microRNAs; lncRNAs; epi-drugs

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Advances in Blood Cancers: How We Define Success

edited by

Stefano Molica

and

David Allsup

submission deadline 25 Dec 2025 | 1 articles | Viewed by 2415 | Submission Open

Keywords: blood cancers; research-driven advancements; cure rates; novel agents

(This special issue belongs to the Section Cancer Therapy)

Measurable Residual Disease in Cancer: 2nd Edition

edited by Krzysztof Jamroziak and

Bartosz Pula

submission deadline 25 Dec 2025 | Viewed by 195 | Submission Open

Keywords: MRD; measurable residual disease; minimal residual disease; cancer; tumor microenvironment; next generation sequencing; flow cytometry; imaging techniques

(This special issue belongs to the Section Cancer Drug Development)

Predictive Biomarkers for Lung Cancer

edited by Ole Hilberg

submission deadline 30 Dec 2025 | 10 articles | Viewed by 25385 | Submission Open

(This special issue belongs to the Section Cancer Biomarkers)

Class 2 Tumor Suppressor Gene Pathways for Therapeutic Applications in Hard-to-Treat Cancers

edited by

Edgar Dahl

submission deadline 30 Dec 2025 | 2 articles | Viewed by 5899 | Submission Open

Keywords: hard-to-treat cancers; HTT cancers; class 2 tumor suppressor genes; C2TSGs; DNA methylation driver; DNAme driver; epigenetic therapies; cancer drug development; personalized cancer therapy; tumor suppressor mimetics

(This special issue belongs to the Section Tumor Microenvironment)

Recent Advances in Hematological Malignancies in Children

edited by

Radosław Chaber

submission deadline 30 Dec 2025 | 3 articles | Viewed by 5767 | Submission Open

Keywords: acute lymphoblastic leukemia; acute myeloid leukemia; hematological malignancies in children; diagnostic and therapeutic methods; supportive care strategies

(This special issue belongs to the Section Pediatric Oncology)

Understanding the Complexities of Anticancer Drugs Resistance

edited by

Mariarosaria Conte

and

Nunzio Del Gaudio

submission deadline 30 Dec 2025 | 2 articles | Viewed by 4382 | Submission Open

(This special issue belongs to the Section Cancer Drug Development)

Transcription Factors in Breast Cancer

edited by

Sarah Walker

submission deadline 30 Dec 2025 | 2 articles | Viewed by 3772 | Submission Open

Keywords: breast cancer; transcription factors; signaling pathways; hormone receptors; targeted therapy

(This special issue belongs to the Section Molecular Cancer Biology)

Novel Surgical Treatment Approaches in Advanced Gastrointestinal Neoplasms

edited by Francesco Santullo and Agostino Maria De Rose

submission deadline 30 Dec 2025 | 2 articles | Viewed by 3035 | Submission Open

Keywords: advanced gastrointestinal neoplasms; colon cancer; cytoreductive surgery; gastric cancer; liver metastases; peritoneal metastases; HIPEC (hyperthermic intraperitoneal chemotherapy); PIPAC (pressurized intraperitoneal aerosol chemotherapy); pancreatic cancer

(This special issue belongs to the Section Cancer Therapy)

Palliative Radiotherapy for Cancer

edited by Rebecca Wong

submission deadline 30 Dec 2025 | 2 articles | Viewed by 2529 | Submission Open

Keywords: symptom relief; symptom control; radiation medicine; radiotheranostics; theranostics; external beam radiotherapy; palliation; oligometastases; oligoprogression; systematic reviews and meta-analyses; patient reported outcomes; abscopal effect; combined modality; education; clinical practice

(This special issue belongs to the Section Cancer Therapy)

Combination Therapy in Geriatric Population with Cancer (2nd Edition)

edited by

Lore Decoster

submission deadline 30 Dec 2025 | 1 articles | Viewed by 2109 | Submission Open

Keywords: older patients with cancer; surgery; radiotherapy; chemotherapy; immunotherapy; targeted therapy

(This special issue belongs to the Section Cancer Therapy)

Clinical Trials for Thoracic Cancers

edited by

Monica Casiraghi

submission deadline 30 Dec 2025 | 1 articles | Viewed by 586 | Submission Open

Keywords: lung cancer; thoracic oncology; thymoma; mesothelioma

(This special issue belongs to the Section Clinical Research of Cancer)

Cytokine and Growth Factor Signaling at the Interface between Immune Cells and Cancer

edited by

Subburaj Ilangumaran

and

Seung-Hwan Lee

submission deadline 30 Dec 2025 | Viewed by 575 | Submission Open

Keywords: cytokines; growth factors; chemokines; inflammation; oncogenic signaling; cancer initiation; cancer progression; tumor microenvironment; cancer immune suppression; antitumor immunity

(This special issue belongs to the Section Molecular Cancer Biology)

Insights from the Editorial Board Member

edited by

Carlos S. Moreno

submission deadline 31 Dec 2025 | 49 articles | Viewed by 117970 | Submission Open

Keywords: cancer therapeutics; cancer biomarkers; precision medicine; cancer genomics; cancer immunology; cancer biology; clinical trials; cancer epidemiology and prevention; tumor microenvironment and metastasis; cancer informatics

Lung Cancer: From Mechanisms of Action and Risk Factors in Disease Onset to Management

edited by

Roberto Fabiani

and

Irene Giacchetta

submission deadline 31 Dec 2025 | 19 articles | Viewed by 46299 | Submission Open

Keywords: non-small-cell lung cancer (NSCLC); small-cell lung cancer (SCLC); prevention; risk management; mechanisms

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Cervical Cancer: Screening and Treatment in 2024-2025

edited by

Fabrice Lécuru

and

Benedetta Guani

submission deadline 31 Dec 2025 | 8 articles | Viewed by 34073 | Submission Open

Keywords: cervical cancer; fertility sparing; screening; early stage cervical cancer; locally advanced cervical cancer; sentinel lymph node; staging lymphadenectomy; trachelectomy; immunotherapy in cervical cancer; target therapy in cervical cancer

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Disparities in Cancer Prevention, Screening, Diagnosis and Management

edited by

Eliza W. Beal

submission deadline 31 Dec 2025 | 17 articles | Viewed by 34023 | Submission Open

Keywords: social determinants of health (SDOH); financial toxicity; racial disparities; ethnic disparities; LGBTQIA+ disparities; cultural competency; cancer; health status disparities; healthcare disparities

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Advances in Skin Cancer: Diagnosis, Treatment and Prognosis

edited by Iris Zalaudek and

Roberta Giuffrida

submission deadline 31 Dec 2025 | 14 articles | Viewed by 33682 | Submission Open

Keywords: skin cancer; melanoma; basal cell carcinoma; cutaneous squamous cell carcinoma; diagnosis; noninvasive imaging; therapy; prognosis; immunotherapy; targeted therapy

(This special issue belongs to the Section Cancer Therapy)

Integrating Palliative Care in Oncology

edited by

Albert Tuca-Rodríguez

submission deadline 31 Dec 2025 | 12 articles | Viewed by 33415 | Submission Open

Keywords: early palliative care; advanced cancer; complexity of care needs; integration of palliative care in oncology; cancer pain; symptom control; end-of-life; advance care planning

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

New Perspectives in the Management of Breast Cancer

edited by

Sonia Santander Ballestín

and

María José Luesma

submission deadline 31 Dec 2025 | 12 articles | Viewed by 26379 | Submission Open

Keywords: breast cancer; treatment; nutrition; physical exercise; psychosocial impact

(This special issue belongs to the Section Cancer Therapy)

Advanced Diagnostics and Optical Imaging Technologies in Cancer Research

edited by Vlad Mihai Voiculescu

submission deadline 31 Dec 2025 | 12 articles | Viewed by 25685 | Submission Open

Keywords: digital diagnostics; advanced diagnostics; optical imaging; medical images; artificial intelligence; image analysis; laser technologies

(This special issue belongs to the Section Methods and Technologies Development)

PTEN: Regulation, Signalling and Targeting in Cancer

edited by

Mark G.H. Scott

Larissa Kotelevets

and

Éric Chastre

submission deadline 31 Dec 2025 | 7 articles | Viewed by 25239 | Submission Open

Keywords: PTEN; tumour suppressor; phosphatase; AKT signalling; genome integrity; apoptosis; proliferation; cancer; biomarker; precision medicine

(This special issue belongs to the Section Cancer Biomarkers)

Oral Potentially Malignant Disorders and Oral Cavity Cancer

edited by

I-Ta Lee

submission deadline 31 Dec 2025 | 8 articles | Viewed by 23183 | Submission Open

Keywords: OPMDs; oral cavity cancer; molecular biology; genomics; pathology; early detection; personalized therapy; immunotherapy; targeted treatment; translational medicine

(This special issue belongs to the Section Cancer Therapy)

Oncology: State-of-the-Art Research and Initiatives in Japan

edited by

Satoshi Ikeda

and

Tateaki Naito

submission deadline 31 Dec 2025 | 8 articles | Viewed by 22105 | Submission Open

Keywords: Japan; cancer; oncology; research; clinical trial; survivorship; patient support

Novel Therapeutic Strategies in Salivary Gland Tumor

edited by

Giovanni Salzano

Arianna Di Stadio

and

Luigi Angelo Vaira

submission deadline 31 Dec 2025 | 8 articles | Viewed by 20766 | Submission Open

Keywords: parotid gland; parotid tumors; facial nerve; novel therapeutic options; distant metastasis; liquid biopsy; prognostic factors; parotid robotic surgery; microRNA; imaging

(This special issue belongs to the Section Cancer Therapy)

Medical Imaging and Artificial Intelligence in Cancer

edited by Debiao Li and

Stephen J. Pandol

submission deadline 31 Dec 2025 | 11 articles | Viewed by 19934 | Submission Open

Keywords: cancer; medical imaging; magnetic resonance imaging; computed tomography; artificial intelligence; image analysis; cancer detection; cancer prediction; cancer characterization

(This special issue belongs to the Section Methods and Technologies Development)

Advances in Clinical Trials: Outcome, Innovations, Challenges, and Ethical Practice in Cancer Research 2024–2025

edited by

Naoto T. Ueno

and David R. Gandara

submission deadline 31 Dec 2025 | 4 articles | Viewed by 19704 | Submission Open

Keywords: phase I; phase II; phase III; phase IV; clinical trials; features; design; implementation; outcomes

(This special issue belongs to the Section Clinical Research of Cancer)

Molecular Biology, Diagnosis and Management of Cervical Cancer

edited by

Georgios Androutsopoulos

Georgios Michail

, Thomas Vrekoussis and

George Valasoulis

submission deadline 31 Dec 2025 | 6 articles | Viewed by 15969 | Submission Open

Keywords: cervical cancer; molecular biology; lymph node dissection; sentinel lymph node mapping; sentinel lymph node dissection; surgery; systemic therapy; radiotherapy; fertility preservation; molecular targeted therapies

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in Chronic Lymphocytic Leukaemia (CLL) Research

edited by

H. Denis Alexander

submission deadline 31 Dec 2025 | 5 articles | Viewed by 14331 | Submission Open

Keywords: chronic lymphocytic leukaemia; CLL; aetiology; oncogenic transformation; survival; cure

(This special issue belongs to the Section Cancer Therapy)

Updates in Neuroendocrine Neoplasms

edited by Jonathan Strosberg

submission deadline 31 Dec 2025 | 8 articles | Viewed by 13914 | Submission Open

Keywords: neuroendocrine tumors; neuroendocrine neoplasms; neuroendocrine carcinomas; therapy; germline mutations; somatic mutations

(This special issue belongs to the Section Cancer Therapy)

Long-Term Cancer Survivors: Rehabilitation and Quality of Life

edited by

Juan Rodríguez-Mansilla

Blanca Gonzalez-Sanchez

and

María Jiménez-Palomares

submission deadline 31 Dec 2025 | 7 articles | Viewed by 12325 | Submission Open

Keywords: long term; cancer survivors; quality of life; rehabilitation; physical activity; cognition; non-pharmacological therapies

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

State-of-the-Art Treatment on Chemotherapy and Immunotherapy for Urological Cancer

edited by

Kouji Izumi

and Hiroshi Yaegashi

submission deadline 31 Dec 2025 | 5 articles | Viewed by 11797 | Submission Open

Keywords: chemotherapy; immunotherapy; antibody– drug conjugate; radioligand therapy; urological cancer; prostate cancer; kidney cancer; urothelial cancer; urachal cancer; penile cancer; adrenal cancer; sarcoma; clinical trial; basic research

(This special issue belongs to the Section Tumor Microenvironment)

Robotic Surgery in Colorectal Cancer

edited by James Chi Yong Ngu

submission deadline 31 Dec 2025 | 3 articles | Viewed by 11770 | Submission Open

Keywords: robotic surgery; colorectal cancer; minimally invasive surgery; therapeutic endoscopy; laparoscopy

(This special issue belongs to the Section Clinical Research of Cancer)

Surgery for Colorectal Cancer

edited by

Antonio V. Sterpetti

and

Raimondo Gabriele

submission deadline 31 Dec 2025 | 7 articles | Viewed by 11617 | Submission Open

Keywords: clinical and oncologic outcomes after new forms of therapy for colon– rectal cancer; colon cancer; rectal cancer; colorectal cancer

(This special issue belongs to the Section Cancer Therapy)

Feature Papers in Section "Tumor Microenvironment"

edited by

Sanjay Gupta

submission deadline 31 Dec 2025 | 6 articles | Viewed by 11527 | Submission Open

Keywords: tumor microenvironment; cancer progression; interactions; therapeutic targeting; immune response

(This special issue belongs to the Section Tumor Microenvironment)

The Applications of Artificial Intelligence in Gastroenterology

edited by

Marcello F. Maida

Ciro Celsa

and Louis H. S. Lau

submission deadline 31 Dec 2025 | 3 articles | Viewed by 11156 | Submission Open

Keywords: artificial intelligence; gastroenterology; endoscopy; inflammatory bowel diseases

(This special issue belongs to the Section Cancer Therapy)

The Advance of Biomarker-Driven Targeted Therapies in Cancer

edited by

Tianshun Zhang

, Qiushi Wang and Ann Bode

submission deadline 31 Dec 2025 | 5 articles | Viewed by 10950 | Submission Open

Keywords: biomarkers; targeted therapies; precision medicine; cancer treatment; molecular profiling; personalized medicine; genomic alterations; therapeutic interventions; tumor microenvironment; immune therapy

(This special issue belongs to the Section Cancer Therapy)

Advancements in Preclinical Models for Solid Cancers

edited by

Ewa Krawczyk

and Paula Dobosz

submission deadline 31 Dec 2025 | 6 articles | Viewed by 10896 | Submission Open

Keywords: solid cancers; preclinical cancer models; in vitro cancer models; in vivo cancer models; translational cancer research; strengths and limitations of preclinical cancer models

(This special issue belongs to the Section Clinical Research of Cancer)

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